Do phosphoinositide 3-kinases direct lymphocyte navigation?

Trends in Immunology

Volumn 25, Issue 2, 2004, Pages 67-74

  Ward, Stephen G ^a  

^a University of Bath   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR3; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR6; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CCR8; CHEMOKINE RECEPTOR CCR9; CHEMOKINE RECEPTOR CXCR3; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR5; CHEMOKINE RECEPTOR CXCR6; G PROTEIN COUPLED RECEPTOR; INTERCELLULAR ADHESION MOLECULE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RANTES; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

CELL DIFFERENTIATION; CELL INFILTRATION; CELL POLARITY; HUMAN; LEUKOCYTE ADHERENCE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE MIGRATION; NATURAL KILLER CELL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REVIEW; SHEAR STRESS; T LYMPHOCYTE; VASCULAR ENDOTHELIUM;

EID: 0842346270     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.it.2003.12.003     Document Type: Review

References (58)

1. Mackay C.R. Chemokines: immunology's high impact factors. Nat. Immunol. 2:2001;95-101.
2. Campbell J.J., Butcher E.C. Chemokines in tissue-specific and microenvironment-specific lymphocyte homing. Curr. Opin. Immunol. 12:2000;336-341.
3. Graboovsky V., et al. Sub-second induction of integrin clustering by immobilised chemokines enhances leukocyte capture and rolling under flow prior to firm adhesion to endothelium. J. Exp. Med. 192:2000;495-505.
4. Sanchez-Madrid F., Del Pozo M.A. Leukocyte polarisation in cell migration and immune interactions. EMBO J. 18:1999;501-511.
5. Cinamon G., et al. Shear forces promote lymphocyte migration across vascular endothelium bearing apical chemokines. Nat. Immunol. 2:2001;515-521.
6. Lauffenberger D., Horwitz A. Cell migration: a physically integrated molecular process. Cell. 84:1996;359-369.
7. Iglesias, P.A. and Levchenko, A. (2002) Modelling the cell's guidance system. Sci Stke 10.1126/stke.2002.148.re12 ( www.stke.org ).
8. Okkenhaug K., Vanhaesebroeck B. PI3K in lymphocyte development, differentiation and activation. Nat. Rev. Immunol. 3:2003;317-330.
9. Li Z., et al. Roles of PLC-β2 and -β3 and PI3Kγ in chemoattractant-mediated signal transduction. Science. 287:2000;1046-1049.
10. Sasaki T., et al. Function of PI3Kγ in thymocyte development, T cell activation and neutrophil migration. Science. 287:2000;1040-1044.
11. Hirsch E., et al. Central role for G protein-coupled phosphoinositide 3-kinase-γ in inflammation. Science. 287:2000;1049-1053.
12. Hannigan M., et al. Neutrophils lacking phosphoinositide 3-kinase-γ show loss of directionality during N-formyl-Met-Leu-Phe- induced chemotaxis. Proc. Natl. Acad. Sci. U. S. A. 99:2002;3603-3608.
13. Costello P.S., et al. Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse. Nat. Immunol. 3:2002;1082-1089.
14. Merlot S., Firtel R.A. Leading the way: directional sensing through phosphatidylinositol 3-kinase and other signaling pathways. J. Cell Sci. 116:2003;3471-3478.
15. 3 to the leading edge of chemotaxing cells. Mol. Biol. Cell. 14:2003;1913-1922.
16. Wang F., et al. Lipid products of PI3Ks maintain persistent cell polarity and directed motility in neutrophils. Nat. Cell Biol. 4:2002;513-518.
17. Weiner O.D., et al. PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat. Cell Biol. 4:2002;509-512.
18. Iijima M., Devreotes P. Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell. 109:2002;599-610.
19. Funamoto S., et al. Spatial and temporal regulation of 3′-phosphoinositides by PI3K and PTEN mediates chemotaxis. Cell. 109:2002;611-623.
20. Li Z., et al. Directional sensing requires Gβγ-mediated PAK1 and PIXα-dependent activation of Cdc42. Cell. 114:2003;215-227.
21. Campbell R.B., et al. Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate. J. Biol. Chem. 278:2003;33617-33620.
22. Fox J.A., et al. Disruption of a single PTEN allele augments the lymphocytes to stromal cell-derived factor-1. J. Immunol. 169:2002;49-54.
23. Kim C.H., et al. Altered responsiveness to chemokines due to targeted disruption of SHIP. J. Clin. Invest. 104:1999;1751-1759.
24. Xu J., et al. Divergent signals and cytoskeletal assemblies regulate self-organising polarity in neutrophils. Cell. 114:2003;201-214.
25. Gomez-Mouton C., et al. Segregation of leading edge and uropod components into specific lipid rafts during T cell polarisation. Proc. Natl. Acad. Sci. U. S. A. 98:2001;9642-9647.
26. Astoul E., et al. PI3K and T cell activation: limitations of leukemic cell lines as signalling molecules. Trends Immunol. 22:2001;490-496.
27. Hooshman-Rad R., et al. The PI 3-kinase isoforms p110α and p110β have differential roles in PDGF- and insulin-mediated signaling. J. Cell Sci. 113:2000;207-214.
28. Sadhu C., et al. Essential role of phosphoinositide 3-kinase-δ in neutrophil directional movement. J. Immunol. 170:2003;2647-2654.
29. Curnock A.P., et al. Both class 1A and class 1B PI3Ks are required for optimal migratory responses of a leukemic T cell line to the CXC chemokine SDF-1. J. Immunol. 170:2003;4021-4030.
30. Sotsios Y., et al. The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes. J. Immunol. 163:1999;5954-5963.
31. Constantin G., et al. Chemokines trigger immediate β2 integrin affinity and mobility change: differential regulation and roles in lymphocyte arrest under flow. Immunity. 13:2000;759-769.
32. Sotsios Y., Ward S.G. Phosphoinositide 3-kinase: a key biochemical signal for cell migration in response to chemokines. Immunol. Rev. 177:2000;217-235.
33. Smit M.J., et al. CXCR3-mediated chemotaxis of human T cells is regulated by a Gi- and phospholipase C-dependent pathway and not via activation of MEK/p44/p42 MAPK nor Akt/PI-3-kinase. Blood. 102:2003;1959-1965.
34. Etienne-Manneville S., Hall A. Rho GTPases in cell biology. Nature. 420:2002;629-636.
35. del Pozo M., et al. Rho GTPases control migration and polarisation of adhesion molecules and cytoskeletal ERM components in T lymphocytes. Eur. J. Immunol. 29:1999;3609-3620.
36. Haddad E., et al. The interaction between cdc42 and WASP is required for SDF-1-induced T lymphocyte chemotaxis. Blood. 97:2001;33-38.
37. Welch H.C.E., et al. Phosphoinositide 3-kinase-dependent activation of Rac. FEBS Lett. 546:2003;93-97.
38. Reif K., Cyster J.G. The CDM protein DOCK-2 in lymphocyte migration. Trends Cell Biol. 12:2002;368-373.
39. Fukui Y., et al. Hematopoietic cell-specific CDM family protein DOCK-2 is essential for lymphocyte migration. Nature. 412:2001;826-831.
40. Nishihara H., et al. DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines. Blood. 100:2002;3968-3974.
41. Sanui, T. et al. (2003) DOCK2 regulates Rac activation and cytoskeletal reorganisation through the interaction with Elmo1. Blood 10.1182/blood-2003-01- 0173 ( www.bloodjournal.org/ ).
42. Gunn M.D., et al. Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localisation. J. Exp. Med. 189:1999;451-460.
43. Forster R., et al. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell. 99:1999;23-33.
44. Ansel K.M., et al. A chemokine driven positive feedback loop organises lymphoid follicles. Nature. 406:2000;309-314.
45. Ratner S., et al. Role of Rho-family GTPase cdc42 in polarised expression of lymphocyte appendages. J. Leukoc. Biol. 73:2003;830-840.
46. Shimonaka M., et al. Rap1 translates chemokine signals to integrin activation, cell polarisation and motility across vascular endothelium under flow. J. Cell Biol. 161:2003;417-427.
47. McLeod S.J., et al. The Rap GTPases regulate B cell migration toward the chemokine stromal cell-derived factor-1 (SDF-1): potential role for Rap2 in promoting B cell migration. J. Immunol. 169:2002;1365-1371.
48. Cullen P.J., Lockyer P.J. Integration of calcium and Ras signalling. Nat. Rev. Mol. Cell Biol. 3:2002;339-348.
49. Ballou L.M., et al. Activated Gαq inhibits p110α phosphatidylinositol 3-kinase and Akt. J. Biol. Chem. 278:2003;2472-23479.
50. Vicente-Manzanares M., et al. A role for the Rho-p160 Rho coiled coil kinase axis in the chemokine stromal cell-derived factor-1-induced lymphocyte actomyosin and microtubular organisation and chemotaxis. J. Immunol. 168:2002;400-410.
51. Bardi G., et al. Rho kinase is required for CCR7-mediated polarisation and chemotaxis of T lymphocytes. FEBS Lett. 542:2003;79-83.
52. O'Neill L.A.J. Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases. Curr. Opin. Pharmacol. 3:2003;396-403.
53. Tilton B., et al. Signal transduction by CXC chemokine SDF-1 stimulates prolonged protein kinase B and extracellular signal-regulated kinase-2 activation in T lymphocytes. J. Exp. Med. 192:2000;313-324.
54. Foxman E.F., et al. Integrating conflicting chemotactic signals: the role of memory in leukocyte navigation. J. Cell Biol. 147:1999;577-587.
55. Ward S.G., Finan P. Isoform-specific phosphoinositide 3-kinase inhibitors as therapeutic targets. Curr. Opin. Pharmacol. 3:2003;426-434.
56. Ward S.G., et al. Chemokines and T lymphocytes: more than an attraction. Immunity. 8:1998;1-9.
57. Lippert E., et al. Role of regulator of G protein signaling 16 in inflammation-induced T lymphocyte migration and activation. J. Immunol. 171:2003;1542-1555.
58. Beadling C., et al. Regulators of G protein signaling exhibit distinct patterns of gene expresion and target protein specificity in human lymphocytes. J. Immunol. 162:1999;2677-2682.