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Volumn 182, Issue 9, 2009, Pages 5382-5392

Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CD22 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE LYN; PROTEIN TYROSINE PHOSPHATASE SHP; PROTEIN TYROSINE PHOSPHATASE SHP 1; CD22 PROTEIN, MOUSE; LYMPHOCYTE ANTIGEN RECEPTOR; LYN PROTEIN-TYROSINE KINASE; PROTEIN TYROSINE KINASE; PTPN6 PROTEIN, MOUSE;

EID: 66949130737     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0803941     Document Type: Article
Times cited : (67)

References (48)
  • 1
    • 4444274754 scopus 로고    scopus 로고
    • B lymphocyte signaling pathways in systemic autoimmunity: Implications for pathogenesis and treatment
    • DOI 10.1002/art.20487
    • Zouali, M., and G. Sarmay. 2004. B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment. Arthritis Rheum. 50:2730-2741. (Pubitemid 39209509)
    • (2004) Arthritis and Rheumatism , vol.50 , Issue.9 , pp. 2730-2741
    • Zouali, M.1    Sarmay, G.2
  • 2
    • 0035555161 scopus 로고    scopus 로고
    • Systemic lupus erythematosus: An autoimmune disease of B cell hyperactivity
    • Lipsky, P. E. 2001. Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity. Nat. Immunol. 2: 764-766.
    • (2001) Nat. Immunol. , vol.2 , pp. 764-766
    • Lipsky, P.E.1
  • 3
    • 12444331082 scopus 로고    scopus 로고
    • Lyn tyrosine kinase: Accentuating the positive and the negative
    • DOI 10.1016/j.immuni.2004.12.004, PII S1074761304003814
    • Xu, Y., K. W. Harder, N. D. Huntington, M. L. Hibbs, and D. M. Tarlinton. 2005. Lyn tyrosine kinase: accentuating the positive and the negative. Immunity 22: 9-18. (Pubitemid 40143447)
    • (2005) Immunity , vol.22 , Issue.1 , pp. 9-18
    • Xu, Y.1    Harder, K.W.2    Huntington, N.D.3    Hibbs, M.L.4    Tarlinton, D.M.5
  • 4
    • 0030740148 scopus 로고    scopus 로고
    • Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation
    • Chan, V. W., F. Meng, P. Soriano, A. L. DeFranco, and C. A. Lowell. 1997. Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. Immunity 7: 69-81.
    • (1997) Immunity , vol.7 , pp. 69-81
    • Chan, V.W.1    Meng, F.2    Soriano, P.3    DeFranco, A.L.4    Lowell, C.A.5
  • 5
    • 0032055828 scopus 로고    scopus 로고
    • Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection
    • Cornall, R. J., J. G. Cyster, M. L. Hibbs, A. R. Dunn, K. L. Otipoby, E. A. Clark, and C. C. Goodnow. 1998. Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection. Immunity 8: 497-508.
    • (1998) Immunity , vol.8 , pp. 497-508
    • Cornall, R.J.1    Cyster, J.G.2    Hibbs, M.L.3    Dunn, A.R.4    Otipoby, K.L.5    Clark, E.A.6    Goodnow, C.C.7
  • 7
    • 0032492994 scopus 로고    scopus 로고
    • Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes
    • Chan, V. W., C. A. Lowell, and A. L. DeFranco. 1998. Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes. Curr. Biol. 8: 545-553. (Pubitemid 28222888)
    • (1998) Current Biology , vol.8 , Issue.10 , pp. 545-553
    • Chan, V.W.F.1    Lowell, C.A.2    Defranco, A.L.3
  • 8
    • 0032550365 scopus 로고    scopus 로고
    • A double-edged kinase lyn: A positive and negative regulator for antigen receptor-mediated signals
    • DOI 10.1084/jem.187.8.1343
    • Nishizumi, H., K. Horikawa, I. Mlinaric-Rascan, and T. Yamamoto. 1998. A double-edged kinase Lyn: a positive and negative regulator for antigen receptormediated signals. J. Exp. Med. 187: 1343-1348. (Pubitemid 28189123)
    • (1998) Journal of Experimental Medicine , vol.187 , Issue.8 , pp. 1343-1348
    • Nishizumi, H.1    Horikawa, K.2    Mlinaric-Rascan, I.3    Yamamoto, T.4
  • 10
    • 0033809919 scopus 로고    scopus 로고
    • Negative regulation of B cell receptor-mediated signaling in B-1 cells through CD5 and Ly49 co-receptors via Lyn kinase activity
    • Ochi, H., and T. Watanabe. 2000. Negative regulation of B cell receptor-mediated signaling in B-1 cells through CD5 and Ly49 co-receptors via Lyn kinase activity. Int. Immunol. 12: 1417-1423.
    • (2000) Int. Immunol. , vol.12 , pp. 1417-1423
    • Ochi, H.1    Watanabe, T.2
  • 11
    • 0033592854 scopus 로고    scopus 로고
    • Constitutive tyrosine phosphorylation of the inhibitory paired Ig-like receptor PIR-B
    • Ho, L. H., T. Uehara, C. C. Chen, H. Kubagawa, and M. D. Cooper. 1999. Constitutive tyrosine phosphorylation of the inhibitory paired Ig-like receptor PIR-B. Proc. Natl. Acad. Sci. USA 96: 15086-15090.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 15086-15090
    • Ho, L.H.1    Uehara, T.2    Chen, C.C.3    Kubagawa, H.4    Cooper, M.D.5
  • 12
    • 0032523498 scopus 로고    scopus 로고
    • Cutting edge: The B cell surface protein CD72 recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation
    • Adachi, T., H. Flaswinkel, H. Yakura, M. Reth, and T. Tsubata. 1998. The B cell surface protein CD72 recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation. J. Immunol. 160: 4662-4665. (Pubitemid 28215297)
    • (1998) Journal of Immunology , vol.160 , Issue.10 , pp. 4662-4665
    • Adachi, T.1    Flaswinkel, H.2    Yakura, H.3    Reth, M.4    Tsubata, T.5
  • 13
    • 0034613151 scopus 로고    scopus 로고
    • Immune inhibitory receptors
    • Ravetch, J. V., and L. L. Lanier. 2000. Immune inhibitory receptors. Science 290: 84-89.
    • (2000) Science , vol.290 , pp. 84-89
    • Ravetch, J.V.1    Lanier, L.L.2
  • 16
    • 33748992038 scopus 로고    scopus 로고
    • Receptor editing in lymphocyte development and central tolerance
    • DOI 10.1038/nri1939, PII NRI1939
    • Nemazee, D. 2006. Receptor editing in lymphocyte development and central tolerance. Nat. Rev. Immunol. 6: 728-740. (Pubitemid 44453459)
    • (2006) Nature Reviews Immunology , vol.6 , Issue.10 , pp. 728-740
    • Nemazee, D.1
  • 18
    • 0027499537 scopus 로고
    • Receptor editing: An approach by autoreactive B cells to escape tolerance
    • Gay, D., T. Saunders, S. Camper, and M. Weigert. 1993. Receptor editing: an approach by autoreactive B cells to escape tolerance. J. Exp. Med. 177: 999-1008. (Pubitemid 23097389)
    • (1993) Journal of Experimental Medicine , vol.177 , Issue.4 , pp. 999-1008
    • Gay, D.1    Saunders, T.2    Camper, S.3    Weigert, M.4
  • 20
    • 0038783576 scopus 로고    scopus 로고
    • A conserved transcriptional enhancer regulates RAG gene expression in developing B cells
    • Hsu, L. Y., J. Lauring, H. E. Liang, S. Greenbaum, D. Cado, Y. Zhuang, and M. S. Schlissel. 2003. A conserved transcriptional enhancer regulates RAG gene expression in developing B cells. Immunity 19: 105-117.
    • (2003) Immunity , vol.19 , pp. 105-117
    • Hsu, L.Y.1    Lauring, J.2    Liang, H.E.3    Greenbaum, S.4    Cado, D.5    Zhuang, Y.6    Schlissel, M.S.7
  • 23
    • 24944563828 scopus 로고    scopus 로고
    • Evidence of marginal-zone B cell- Positive selection in spleen
    • DOI 10.1016/j.immuni.2005.08.007, PII S1074761305002670
    • Wen, L., J. Brill-Dashoff, S. A. Shinton, M. Asano, R. R. Hardy, and K. Hayakawa. 2005. Evidence of marginal-zone B cell-positive selection in spleen. Immunity 23: 297-308. (Pubitemid 41317797)
    • (2005) Immunity , vol.23 , Issue.3 , pp. 297-308
    • Wen, L.1    Brill-Dashoff, J.2    Shinton, S.A.3    Asano, M.4    Hardy, R.R.5    Hayakawa, K.6
  • 24
    • 0035887778 scopus 로고    scopus 로고
    • Unique signaling properties of B cell antigen receptor in mature and immature B cells: Implications for tolerance and activation
    • Benschop, R. J., E. Brandl, A. C. Chan, and J. C. Cambier. 2001. Unique signaling properties of B cell antigen receptor in mature and immature B cells: implications for tolerance and activation. J. Immunol. 167: 4172-4179.
    • (2001) J. Immunol. , vol.167 , pp. 4172-4179
    • Benschop, R.J.1    Brandl, E.2    Chan, A.C.3    Cambier, J.C.4
  • 25
    • 33749535412 scopus 로고    scopus 로고
    • Transitional B cell fate is associated with developmental stage-specific regulation of diacylglycerol and calcium signaling upon B cell receptor engagement
    • Hoek, K. L., P. Antony, J. Lowe, N. Shinners, B. Sarmah, S. R. Wente, D. Wang, R. M. Gerstein, and W. N. Khan. 2006. Transitional B cell fate is associated with developmental stage-specific regulation of diacylglycerol and calcium signaling upon B cell receptor engagement. J. Immunol. 177: 5405-5413.
    • (2006) J. Immunol. , vol.177 , pp. 5405-5413
    • Hoek, K.L.1    Antony, P.2    Lowe, J.3    Shinners, N.4    Sarmah, B.5    Wente, S.R.6    Wang, D.7    Gerstein, R.M.8    Khan, W.N.9
  • 26
    • 0037013718 scopus 로고    scopus 로고
    • BCR mediated signal transduction in immature and mature B cells
    • DOI 10.1016/S0165-2478(02)00017-2, PII S0165247802000172
    • Koncz, G., C. Bodor, D. Kovesdi, R. Gati, and G. Sarmay. 2002. BCR mediated signal transduction in immature and mature B cells. Immunol. Lett. 82: 41-49. (Pubitemid 34468033)
    • (2002) Immunology Letters , vol.82 , Issue.1-2 , pp. 41-49
    • Koncz, G.1    Bodor, C.2    Kovesdi, D.3    Gati, R.4    Sarmay, G.5
  • 27
    • 0035892228 scopus 로고    scopus 로고
    • Resolution of three nonproliferate immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation
    • Allman, D., R. C. Lindsley, W. DeMuth, K. Rudd, S. A. Shinton, and R. R. Hardy. 2001. Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation. J. Immunol. 167: 6834-6840. (Pubitemid 33144175)
    • (2001) Journal of Immunology , vol.167 , Issue.12 , pp. 6834-6840
    • Allman, D.1    Lindsley, R.C.2    Demuth, W.3    Rudd, K.4    Shinton, S.A.5    Hardy, R.R.6
  • 29
    • 0026644137 scopus 로고
    • Peripheral B cell maturation. I. Immature peripheral B cells in adults are heat-stable antigenhi and exhibit unique signaling characteristics
    • Allman, D. M., S. E. Ferguson, and M. P. Cancro. 1992. Peripheral B cell maturation. I. Immature peripheral B cells in adults are heat-stable antigenhi and exhibit unique signaling characteristics. J. Immunol. 149: 2533-2540.
    • (1992) J. Immunol. , vol.149 , pp. 2533-2540
    • Allman, D.M.1    Ferguson, S.E.2    Cancro, M.P.3
  • 30
    • 33947239920 scopus 로고    scopus 로고
    • Generation of peripheral B cells occurs via two spatially and temporally distinct pathways
    • Lindsley, R. C., M. Thomas, B. Srivastava, and D. Allman. 2007. Generation of peripheral B cells occurs via two spatially and temporally distinct pathways. Blood 109: 2521-2528.
    • (2007) Blood , vol.109 , pp. 2521-2528
    • Lindsley, R.C.1    Thomas, M.2    Srivastava, B.3    Allman, D.4
  • 33
    • 0027197067 scopus 로고
    • Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene
    • Shultz, L. D., P. A. Schweitzer, T. V. Rajan, T. Yi, J. N. Ihle, R. J. Matthews, M. L. Thomas, and D. R. Beier. 1993. Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. Cell 73: 1445-1454.
    • (1993) Cell , vol.73 , pp. 1445-1454
    • Shultz, L.D.1    Schweitzer, P.A.2    Rajan, T.V.3    Yi, T.4    Ihle, J.N.5    Matthews, R.J.6    Thomas, M.L.7    Beier, D.R.8
  • 34
    • 0036143404 scopus 로고    scopus 로고
    • Changes in gene expression profiles in developing B cells of murine bone marrow
    • DOI 10.1101/gr.201501
    • Hoffmann, R., T. Seidl, M. Neeb, A. Rolink, and F. Melchers. 2002. Changes in gene expression profiles in developing B cells of murine bone marrow. Genome Res. 12: 98-111. (Pubitemid 34065593)
    • (2002) Genome Research , vol.12 , Issue.1 , pp. 98-111
    • Hoffmann, R.1    Seidl, T.2    Neeb, M.3    Rolink, A.4    Melchers, F.5
  • 35
    • 0033583479 scopus 로고    scopus 로고
    • Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies
    • O'Keefe, T. L., G. T. Williams, F. D. Batista, and M. S. Neuberger. 1999. Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies. J. Exp. Med. 189: 1307-1313.
    • (1999) J. Exp. Med. , vol.189 , pp. 1307-1313
    • O'Keefe, T.L.1    Williams, G.T.2    Batista, F.D.3    Neuberger, M.S.4
  • 36
    • 34447624878 scopus 로고    scopus 로고
    • B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity
    • Pao, L. I., K. P. Lam, J. M. Henderson, J. L. Kutok, M. Alimzhanov, L. Nitschke, M. L. Thomas, B. G. Neel, and K. Rajewsky. 2007. B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity. Immunity 27: 35-48.
    • (2007) Immunity , vol.27 , pp. 35-48
    • Pao, L.I.1    Lam, K.P.2    Henderson, J.M.3    Kutok, J.L.4    Alimzhanov, M.5    Nitschke, L.6    Thomas, M.L.7    Neel, B.G.8    Rajewsky, K.9
  • 38
    • 0029838991 scopus 로고    scopus 로고
    • Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice
    • Wang, J., T. Koizumi, and T. Watanabe. 1996. Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice. J. Exp. Med. 184: 831-838. (Pubitemid 26313541)
    • (1996) Journal of Experimental Medicine , vol.184 , Issue.3 , pp. 831-838
    • Wang, J.1    Koizumi, T.2    Watanabe, T.3
  • 39
    • 0033526816 scopus 로고    scopus 로고
    • B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals
    • DOI 10.1084/jem.190.1.75
    • Loder, F., B. Mutschler, R. J. Ray, C. J. Paige, P. Sideras, R. Torres, M. C. Lamers, and R. Carsetti. 1999. B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals. J. Exp. Med. 190: 75-89. (Pubitemid 29330125)
    • (1999) Journal of Experimental Medicine , vol.190 , Issue.1 , pp. 75-89
    • Loder, F.1    Mutschler, B.2    Ray, R.J.3    Paige, C.J.4    Sideras, P.5    Torres, R.6    Lamers, M.C.7    Carsetti, R.8
  • 40
    • 0036498795 scopus 로고    scopus 로고
    • Transitional B lymphocyte subsets operate as distinct checkpoints in murine splenic B cell development
    • Su, T. T., and D. J. Rawlings. 2002. Transitional B lymphocyte subsets operate as distinct checkpoints in murine splenic B cell development. J. Immunol. 168: 2101-2110.
    • (2002) J. Immunol. , vol.168 , pp. 2101-2110
    • Su, T.T.1    Rawlings, D.J.2
  • 41
    • 0025971175 scopus 로고
    • Signaling through surface IgM in tolerance-susceptible immature murine B lymphocytes: Developmentally regulated differences in transmembrane signaling in splenic B cells from adult and neonatal mice
    • Yellen, A. J., W. Glenn, V. P. Sukhatme, X. M. Cao, and J. G. Monroe. 1991. Signaling through surface IgM in tolerance-susceptible immature murine B lymphocytes: developmentally regulated differences in transmembrane signaling in splenic B cells from adult and neonatal mice. J. Immunol. 146: 1446-1454.
    • (1991) J. Immunol. , vol.146 , pp. 1446-1454
    • Yellen, A.J.1    Glenn, W.2    Sukhatme, V.P.3    Cao, X.M.4    Monroe, J.G.5
  • 42
    • 60549105605 scopus 로고    scopus 로고
    • B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase
    • Cariappa, A., H. Takematsu, H. Liu, S. Diaz, K. Haider, C. Boboila, G. Kalloo, M. Connole, H. N. Shi, N. Varki, et al. 2009. B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase. J. Exp. Med. 206: 125-138.
    • (2009) J. Exp. Med. , vol.206 , pp. 125-138
    • Cariappa, A.1    Takematsu, H.2    Liu, H.3    Diaz, S.4    Haider, K.5    Boboila, C.6    Kalloo, G.7    Connole, M.8    Shi, H.N.9    Varki, N.10
  • 43
    • 0029845089 scopus 로고    scopus 로고
    • Molecular cloning of the cDNA encoding a murine sialic acid-specific 9-O-acetylesterase and RNA expression in cells of hematopoietic and non-hematopoietic origin
    • DOI 10.1093/nar/24.20.4003
    • Stoddart, A., Y. Zhang, and C. J. Paige. 1996. Molecular cloning of the cDNA encoding a murine sialic acid-specific 9-O-acetylesterase and RNA expression in cells of hematopoietic and non-hematopoietic origin. Nucleic Acids Res. 24: 4003-4008. (Pubitemid 26385333)
    • (1996) Nucleic Acids Research , vol.24 , Issue.20 , pp. 4003-4008
    • Stoddart, A.1    Zhang, Y.2    Paige, C.J.3
  • 44
    • 0038827018 scopus 로고    scopus 로고
    • A lipid raft environment enhances Lyn kinase activity by protecting the active site tyrosine from dephosphorylation
    • Young, R. M., D. Holowka, and B. Baird. 2003. A lipid raft environment enhances Lyn kinase activity by protecting the active site tyrosine from dephosphorylation. J. Biol. Chem. 278: 20746-20752.
    • (2003) J. Biol. Chem. , vol.278 , pp. 20746-20752
    • Young, R.M.1    Holowka, D.2    Baird, B.3
  • 45
    • 21844435223 scopus 로고    scopus 로고
    • Membrane cholesterol content accounts for developmental differences in surface B cell receptor compartmentalization and signaling
    • Karnell, F. G., R. J. Brezski, L. B. King, M. A. Silverman, and J. G. Monroe. 2005. Membrane cholesterol content accounts for developmental differences in surface B cell receptor compartmentalization and signaling. J. Biol. Chem. 280: 25621-25628.
    • (2005) J. Biol. Chem. , vol.280 , pp. 25621-25628
    • Karnell, F.G.1    Brezski, R.J.2    King, L.B.3    Silverman, M.A.4    Monroe, J.G.5
  • 46
    • 0035869458 scopus 로고    scopus 로고
    • Novel roles for Lyn in B cell migration and lipopolysaccharide responsiveness revealed using anti-double-stranded DNA Ig transgenic mice
    • Seo, S., J. Buckler, and J. Erikson. 2001. Novel roles for Lyn in B cell migration and lipopolysaccharide responsiveness revealed using anti-double-stranded DNA Ig transgenic mice. J. Immunol. 166: 3710-3716. (Pubitemid 32224893)
    • (2001) Journal of Immunology , vol.166 , Issue.6 , pp. 3710-3716
    • Seo, S.-J.1    Buckler, J.2    Erikson, J.3
  • 47
    • 8444244016 scopus 로고    scopus 로고
    • Impaired receptor editing in the primary B cell repertoire of BASH-deficient mice
    • Hayashi, K., T. Nojima, R. Goitsuka, and D. Kitamura. 2004. Impaired receptor editing in the primary B cell repertoire of BASH-deficient mice. J. Immunol. 173: 5980-5988. (Pubitemid 39487752)
    • (2004) Journal of Immunology , vol.173 , Issue.10 , pp. 5980-5988
    • Hayashi, K.1    Nojima, T.2    Goitsuka, R.3    Kitamura, D.4


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