Hydrogen-Deuterium Exchange Mass Spectrometry as an Emerging Analytical Tool for Stabilization and Formulation Development of Therapeutic Monoclonal Antibodies

Journal of Pharmaceutical Sciences

Volumn 104, Issue 2, 2015, Pages 327-345

  Majumdar, Ranajoy ^a   Middaugh, C Russell ^a   Weis, David D ^a   Volkin, David B ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

Chemical stability; Excipients; Formulation; IgG antibody; Mass spectrometry; Molecular dynamics; Monoclonal antibody; Physical characterization; Physical stability; Protein; Protein aggregation

Indexed keywords

IMMUNOGLOBULIN G1 ANTIBODY; MONOCLONAL ANTIBODY; PROTEIN;

CASE STUDY; CHEMICAL MODIFICATION; DEUTERIUM HYDROGEN EXCHANGE; DRUG DEGRADATION; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG STABILITY; DYNAMICS; ENVIRONMENTAL STRESS; HUMAN; HYDROGEN DEUTERIUM EXCHANGE MASS SPECTROMETRY; INFORMATION PROCESSING; MASS SPECTROMETRY; PHYSICAL CHEMISTRY; REVIEW; CHEMISTRY; MEDICINAL CHEMISTRY; PROCEDURES;

ANTIBODIES, MONOCLONAL; CHEMISTRY, PHARMACEUTICAL; DEUTERIUM EXCHANGE MEASUREMENT; DRUG STABILITY; HUMANS; MASS SPECTROMETRY;

EID: 84922933545     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24224     Document Type: Review

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