Reversible self-association increases the viscosity of a concentrated monoclonal antibody in aqueous solution

Journal of Pharmaceutical Sciences

Volumn 94, Issue 9, 2005, Pages 1928-1940

  Liu, Jun ^a   Nguyen, Mary D H ^a   Andya, James D ^a   Shire, Steven J ^a  

^a GENENTECH INC   (United States)

Author keywords

High protein concentration; Monoclonal antibody; Sedimentation equilibrium; Sedimentation velocity; Self association; Viscosity

Indexed keywords

AMMONIUM CHLORIDE; AMMONIUM SULFATE; CALCIUM CHLORIDE; MONOCLONAL ANTIBODY; SODIUM CHLORIDE; THIOCYANATE SODIUM; THIOCYANIC ACID DERIVATIVE;

ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DRUG SOLUTION; ELECTRICITY; FLOW MEASUREMENT; GEL PERMEATION CHROMATOGRAPHY; IONIC STRENGTH; LIGHT SCATTERING; NONHUMAN; PH; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; SEDIMENTATION; ULTRACENTRIFUGATION; VISCOMETER; VISCOSITY;

EID: 27644477360     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.20347     Document Type: Article

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