A systematic multitechnique approach for detection and characterization of reversible self-association during formulation development of therapeutic antibodies

Journal of Pharmaceutical Sciences

Volumn 102, Issue 9, 2013, Pages 3089-3099

  Esfandiary, Reza ^a   Hayes, David B ^a   Parupudi, Arun ^a   Casas Finet, Jose ^a   Bai, Shufeng ^a   Samra, Hardeep S ^a   Shah, Ambarish U ^a   Sathish, Hasige A ^a  

^a MEDIMMUNE   (United States)

Author keywords

Analytical ultracentrifugation; Biotechnology; Formulation; High throughput technologies; Intermolecular interaction; Light scattering (dynamic); Light scattering (static); Monoclonal antibody; Reversible self association; Screening

Indexed keywords

IMMUNOGLOBULIN G1; MONOCLONAL ANTIBODY;

ANALYTIC METHOD; ARTICLE; DYNAMIC LIGHT SCATTERING; GEL ELECTROPHORESIS; GEL PERMEATION CHROMATOGRAPHY; HYDRODYNAMICS; LIGHT SCATTERING; MULTIANGLE STATIC LIGHT SCATTERING; REVERSIBLE SELF ASSOCIATION; ULTRACENTRIFUGATION;

ANALYTICAL ULTRACENTRIFUGATION; BIOTECHNOLOGY; FORMULATION; HIGH-THROUGHPUT TECHNOLOGIES; INTERMOLECULAR INTERACTION; LIGHT SCATTERING (DYNAMIC); LIGHT SCATTERING (STATIC); MONOCLONAL ANTIBODY; REVERSIBLE SELF-ASSOCIATION; SCREENING;

ANTIBODIES, MONOCLONAL; CHEMISTRY, PHARMACEUTICAL; HUMANS; IMMUNOGLOBULIN G; LIGHT; SCATTERING, RADIATION; SOLUTIONS; ULTRACENTRIFUGATION;

EID: 84881588643     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23654     Document Type: Article

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