The influence of charge distribution on self-association and viscosity behavior of monoclonal antibody solutions

Molecular Pharmaceutics

Volumn 9, Issue 4, 2012, Pages 791-802

  Yadav, Sandeep ^a   Laue, Thomas M ^b   Kalonia, Devendra S ^c   Singh, Shubhadra N ^c   Shire, Steven J ^a  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF NEW HAMPSHIRE   (United States)

^c UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

electrostatic surface potential; high concentration monoclonal antibody solution; hydrodynamic interaction parameter (H (q)); interaction parameter (k D); membrane confined electrophoresis; protein charge; second virial coefficient (B 22); static structure factor (S (q)); viscosity rheology

Indexed keywords

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 1; MONOCLONAL ANTIBODY 2; UNCLASSIFIED DRUG;

ARTICLE; COMPLEMENTARITY DETERMINING REGION; CONCENTRATION (PARAMETERS); DIFFUSION COEFFICIENT; ELECTRIC POTENTIAL; HYDRODYNAMICS; MOLECULAR INTERACTION; PH; PRIORITY JOURNAL; STATIC ELECTRICITY; SURFACE CHARGE; VISCOSITY;

ANTIBODIES, MONOCLONAL; SOLUTIONS; STATIC ELECTRICITY; VISCOSITY;

EID: 84859327683     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp200566k     Document Type: Article

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