High-throughput assessment of thermal and colloidal stability parameters for monoclonal antibody formulations

Journal of Pharmaceutical Sciences

Volumn 100, Issue 12, 2011, Pages 5126-5141

  He, Feng ^a   Woods, Christopher E ^a   Becker, Gerald W ^a   Narhi, Linda O ^b   Razinkov, Vladimir I ^a  

^a AMGEN INC   (United States)

^b AMGEN INC   (United States)

Author keywords

Design of experiment; High concentration; High throughput technologies; Monoclonal antibody; Protein aggregation; Protein formulation; Stability; Thermal analysis

Indexed keywords

MONOCLONAL ANTIBODY; OLIGOMER;

ARTICLE; DIFFUSION; DRUG FORMULATION; HIGH THROUGHPUT SCREENING; HYDROPHOBICITY; MECHANICAL STRESS; PROTEIN AGGREGATION; PROTEIN STABILITY; TEMPERATURE STRESS; THERMOSTABILITY;

EID: 80054935483     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22712     Document Type: Article

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