Using empirical phase diagrams to understand the role of intramolecular dynamics in immunoglobulin G stability

Journal of Pharmaceutical Sciences

Volumn 98, Issue 7, 2009, Pages 2432-2447

  Ramsey, Joshua D ^a,c   Gill, Michelle L ^a   Kamerzell, Tim J ^a,d   Price, E Shane ^a   Joshi, Sangeeta B ^a   Bishop, Steven M ^b   Oliver, Cynthia N ^b   Middaugh, C Russell ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b MEDIMMUNE   (United States)

^c Oklahoma State University   (United States)

^d GENENTECH INC   (United States)

Author keywords

Empirical phase diagram; Immunoglobulin G; Molecular dynamics; Physical characterization; Physical stability

Indexed keywords

IMMUNOGLOBULIN G;

ACIDITY; ANISOTROPY; ARTICLE; CIRCULAR DICHROISM; DRUG STABILITY; FLUORESCENCE SPECTROSCOPY; LIGHT SCATTERING; MEASUREMENT; MOLECULAR DYNAMICS; PH; PHASE TRANSITION; TEMPERATURE; ULTRACENTRIFUGATION;

EID: 67650172580     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21619     Document Type: Article

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