Cooperative roles of hydrophilic loop 1 and the C-terminus of presenilin 1 in the substrate-gating mechanism of γ-secretase

Journal of Neuroscience

Volumn 35, Issue 6, 2015, Pages 2646-2656

  Takagi Niidome, Shizuka ^a   Sasaki, Tomoki ^a   Osawa, Satoko ^a   Sato, Takeshi ^b   Morishima, Kanan ^a   Cai, Tetsuo ^a   Iwatsubo, Takeshi ^a,c   Tomita, Taisuke ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Alzheimer; Amyloid; Enzyme; Intramembrane; Protease; Selectivity

Indexed keywords

AMYLOID BETA PROTEIN; GAMMA SECRETASE; PRESENILIN 1; AMYLOID PRECURSOR PROTEIN; SECRETASE;

ALPHA HELIX; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; BIOTINYLATION; CIRCULAR DICHROISM; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN CONFORMATION; PROTEIN DEGRADATION; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; ENZYME SPECIFICITY; GENETIC TRANSFECTION; GENETICS; KNOCKOUT MOUSE; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; HUMANS; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; PRESENILIN-1; PROTEIN STRUCTURE, SECONDARY; SUBSTRATE SPECIFICITY; TRANSFECTION;

EID: 84922572200     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3164-14.2015     Document Type: Article

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