Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin

Oncogene

Volumn 31, Issue 6, 2012, Pages 787-798

  Hayashi, I ^a   Takatori, S ^a   Urano, Y ^b,i   Miyake, Y ^c   Takagi, J ^d   Sakata Yanagimoto, M ^c   Iwanari, H ^b,e   Osawa, S ^a   Morohashi, Y ^a   Li, T ^f   Wong, P C ^f   Chiba, S ^c   Kodama, T ^b   Hamakubo, T ^b   Tomita, T ^a,g   Iwatsubo, T ^a,g,h  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

^d OSAKA UNIVERSITY   (Japan)

^e Perseus Proteomics   (Japan)

^f JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^h UNIVERSITY OF TOKYO   (Japan)

ⁱ DOSHISHA UNIVERSITY   (Japan)

Author keywords

functional antibody; g secretase; intramembrane cleavage; membrane protein; Notch

Indexed keywords

ANTIGEN; ANTINEOPLASTIC AGENT; CHOLERA TOXIN B SUBUNIT; GAMMA SECRETASE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY A5201A; MONOCLONAL ANTIBODY A5226A; NICASTRIN; NOTCH RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN RECOGNITION; ANTINEOPLASTIC ACTIVITY; ARTICLE; BACULOVIRUS; CANCER CELL; CANCER INHIBITION; CANCER MODEL; CELL GROWTH; CELL MEMBRANE; CELL SURFACE; CONTROLLED STUDY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; FEMALE; IMMUNOCYTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; ANTIBODY SPECIFICITY; BIOCATALYSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HEK293 CELLS; HELA CELLS; HUMANS; IMMUNOBLOTTING; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MICE, SCID; NEOPLASMS; NEUTRALIZATION TESTS; PROTEIN BINDING; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84856966635     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.265     Document Type: Article

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