Contribution of the γ-secretase subunits to the formation of catalytic pore of presenilin 1 protein

Journal of Biological Chemistry

Volumn 287, Issue 31, 2012, Pages 25834-25843

  Takeo, Koji ^a   Watanabe, Naoto ^a   Tomita, Taisuke ^a,c   Iwatsubo, Takeshi ^a,b,c  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; CLOSE PROXIMITY; FUNCTIONAL STRUCTURE; HYDROPHILIC PORES; MEMBRANE PROTEIN COMPLEX; NICASTRIN; OPEN CONFORMATION; PORE FORMATION; PRESENILINS; SECRETASE COMPLEX; SECRETASES; TRANS-MEMBRANE DOMAINS;

HYDROPHILICITY; LIPID BILAYERS;

ACTIVATION ANALYSIS;

GAMMA SECRETASE; PRESENILIN 1;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; HYDROPHILICITY; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RESIDUE ANALYSIS; STRUCTURE ANALYSIS;

AMINO ACID SUBSTITUTION; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CATALYTIC DOMAIN; CELL LINE; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MUTAGENESIS, SITE-DIRECTED; PEPTIDE HYDROLASES; PRESENILIN-1; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; SPODOPTERA;

EID: 84864392474     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.336347     Document Type: Article

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