Are common fragile sites merely structural domains or highly organized "functional" units susceptible to oncogenic stress?

Cellular and Molecular Life Sciences

Volumn 71, Issue 23, 2014, Pages 4519-4544

  Georgakilas, Alexandros G ^a   Tsantoulis, Petros ^b   Kotsinas, Athanassios ^c   Michalopoulos, Ioannis ^d   Townsend, Paul ^e,f   Gorgoulis, Vassilis G ^c,d,e,f,g  

^a NATIONAL TECHNICAL UNIVERSITY OF ATHENS   (Greece)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^c UNIVERSITY OF ATHENS   (Greece)

^d BIOMEDICAL RESEARCH FOUNDATION   (Greece)

^e UNIVERSITY OF MANCHESTER   (United Kingdom)

^f UNIVERSITY OF MANCHESTER   (United Kingdom)

^g UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Carcinogenesis; DNA elements; DNA repair; Fragile sites; Genomic instability; miRNAs

Indexed keywords

FRAGILE HISTIDINE TRIAD PROTEIN; MICRORNA; TRANSCRIPTION FACTOR CTCF;

BINDING SITE; CARCINOGENESIS; CCDC6 GENE; CHROMOSOMAL INSTABILITY; CHROMOSOME BREAKAGE; CHROMOSOME FRAGILE SITE; CHROMOSOME FRAGILITY; FHIT GENE; GENE; GENE FUNCTION; GENE REARRANGEMENT; GENETIC ASSOCIATION; GENETIC DAMAGE; GENETIC HETEROGENEITY; GENETIC SUSCEPTIBILITY; HISTONE MODIFICATION; HUMAN; NONHUMAN; ONCOGENE; ONCOGENE MYC; ONCOGENE PTC; ONCOGENE RET; ONCOGENIC STRESS; PROTEIN BINDING; REGULATORY MECHANISM; REVIEW; TUMOR GENE; WWOX GENE; ANIMAL; DNA REPAIR; DNA REPLICATION; GENETICS; NEOPLASM;

ANIMALS; CHROMOSOME FRAGILE SITES; DNA REPAIR; DNA REPLICATION; HUMANS; MICRORNAS; NEOPLASMS; ONCOGENES;

EID: 84922005439     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-014-1717-x     Document Type: Review

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