Replication of a common fragile site, FRA3B, occurs late in S phase and is delayed further upon induction: Implications for the mechanism of fragile site induction

Human Molecular Genetics

Volumn 7, Issue 4, 1998, Pages 755-761

  Le Beau, Michelle M ^a   Rassool, Feyruz V ^a   Neilly, Mary E ^a   Espinosa III, Rafael ^a   Glover, Thomas W ^b   Smith, David I ^c   McKeithan, Timothy W ^d  

^a SECTION OF HEMATOLOGY ONCOLOGY   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c MAYO CLINIC   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APHIDICOLIN; DNA POLYMERASE;

ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CHROMOSOME FRAGILITY; CONTROLLED STUDY; DNA REPLICATION; FLUORESCENCE IN SITU HYBRIDIZATION; GENE MAPPING; GENE SEQUENCE; HUMAN; HUMAN CELL; METAPHASE; PRIORITY JOURNAL; TRINUCLEOTIDE REPEAT;

APHIDICOLIN; BROMODEOXYURIDINE; CELLS, CULTURED; CHROMOSOME FRAGILE SITES; CHROMOSOME FRAGILITY; DNA REPLICATION; ENZYME INHIBITORS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; S PHASE;

EID: 0031924605     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/7.4.755     Document Type: Article

References (37)

1. Sutherland, G.R. and Hecht, F. (1985) Fragile Sites on Human Chromosomes. Oxford Monographs on Medical Genetics. Oxford University Press, Oxford.
2. Wenger, S.L., Hennessey, J.C. and Steele, M.W. (1987) Increased sister chromatid exchange frequency at Xq27 site in affected fragile X males. Am. J. Med. Genet., 26, 909-914.
3. Glover, T.W. and Stein, C.K. (1987) Induction of sister chromatid exchanges at common fragile sites. Am. J. Hum. Genet., 41, 882-890.
4. Yunis, J.J., Soreng, A.L. and Bowe, A. (1987) Fragile sites are targets for diverse mutagens and carcinogens. Oncogene, 1, 59-69.
5. Warren, S.T., Zhang, F., Licambi, G.R. and Peters, J.F. (1987) The fragile X site in somatic cell hybrids. Science, 237, 420-423.
6. Glover, T.W. and Stein, C.K. (1988) Chromosome breakage and recombination at fragile sites. Am. J. Hum. Genet., 43, 265-273.
7. Le Beau, M.M. and Rowley, J.D. (1984) Heritable fragile sites and cancer. Nature, 308, 607-608.
8. Warren, S.T. (1996) The expanding world of trinucleotide repeats. Science, 271, 1374-1375.
9. Yu, S., Mangelsdorf, M., Hewett, D., Hobson, L., Baker, E., Eyre, H.J., Lapsys, N., Le Paslier, D., Doggett, N.A., Sutherland, G.R. and Richards, R.I. (1997) Human chromosomal fragile site FRA16B is an amplified AT-rich minisatellite repeat. Cell, 88, 367-374.
10. Pieretti, M., Zhang, F., Fu, Y.-H., Warren, S.T., Oostra, B.A., Caskey, C.T. and Nelson, D.L. (1991) Absence of expression of the FMR-1 gene in fragile X syndrome. Cell, 66, 817-822.
11. Jones, C., Penny, L., Mattina, T., Yu, S., Baker, E., Voullaire, L., Langdon, W.Y, Sutherland, G.R., Richards, R.I. and Tunnacliffe, A. (1995) Association of a chromosome deletion syndrome with a fragile site within the proto-oncogene CBL2. Nature, 376, 145-149.
12. Laird, C., Jaffe, E., Karpen, G., Lamb, M. and Nelson, R. (1987) Fragile sites in human chromosomes as regions of late replicating DNA. Trends Genet., 3, 274-281.
13. Hansen, R.S., Canfield, T.K., Lamb, M.M., Gartler, S.M. and Laird, C.D. (1993) Association of fragile X syndrome with delayed replication of the FMR1 gene. Cell, 73, 1403-1409.
14. Hansen, R.S., Canfield, T.K., Fjeld, A.D., Mumm, S., Laird, C.D. and Gartler, S.M. (1997) A variable domain of delayed replication in FRAXA fragile X chromosomes: X inactivation-like spread of late replication. Proc. Natl Acad. Sci. USA, 94, 4587-4592.
15. Subramanian, P.S., Nelson, D.L. and Chinault, A.C. (1996) Large domains of apparent delayed replication timing associated with triplet repeat expansion at FRAXA and FRAXE. Am. J. Hum. Genet., 59, 407-416.
16. Usdin, K. and Woodford, K.J. (1995) CGG repeats associated with DNA instability and chromosome fragility form structures that block DNA synthesis in vitro. Nucleic Acids Res., 23, 4202-4209.
17. Glover, T.W., Berger, C., Coyle, J. and Echo, B. (1984). DNA polymerase α inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes. Hum. Genet., 67, 136-142.
18. Wilke, C.M., Hall, B.K., Hoge, A., Paradee, W., Smith, D.I. and Glover, T.W. (1996) FRA3B extends over a broad region and contains a spontaneous HPV16 integration site: direct evidence for the coincidence of viral integration sites and fragile sites. Hum. Mol. Genet., 5, 187-195.
19. Paradee, W., Wilke, C.M., Wang, L., Shridhar, R., Mullins, C.M., Hoge, A., Glover, T.W. and Smith, D.I. (1996) A 350-kb cosmid contig in 3p14.2 that crosses the t(3;8) hereditary renal cell carcinoma translocation breakpoint and 17 aphidicolin-induced FRA3B breakpoints. Genomics, 35, 87-93.
20. Wang, L., Paradee, W., Mullins, C., Shridhar, R., Rosati, R., Wilke, C.M., Glover, T.W. and Smith, D.I. (1997) Aphidicolin-induced FRA3B break-points cluster in two distinct regions. Genomics, 41, 485-488.
21. Rassool, F.V., Le Beau, M.M., Shen, M.-L., Neilly, M.E., Espinosa III, R., Ong, S.T., Boldog, F., Drabkin, H., McCarroll, R. and McKeithan, T.W. (1996) Direct cloning of DNA sequences from the common fragile site region at chromosome band 3p14.2. Genomics, 35, 109-117.
22. Ohta, M., Inoue, H., Cotticelli, M., Kastury, K., Baffa, R., Palazzo, J., Siprashvili, Z., Mori, MN., McCue, P., Druck, T., Croce, C. and Huebner, K. (1996) The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell, 84, 587-597.
23. Paradee, W., Mullins, C., He, Z., Glover, T., Wilke, C., Opalka, B., Schutte, J. and Smith, D.I. (1996) Precise localization of aphidicolin-induced break-points on the short arm of human chromosome 3. Genomics, 27, 358-361.
24. Boldog, F., Gemmill, R.M., West, J., Robinson, M., Robinson, L., Li, E., Roche. J., Todd, S., Waggoner, B., Lundstrom, R., Jacobson, J., Mullokandov, M.R., Klinger, H.P. and Drabkin, H.A. (1997) 3p14 homozygous deletions and sequence analysis of FRA3B. Hum. Mol. Genet., 6, 193-203.
25. Oguro, M., Suzuki-Hori, H., Nagano, H., Mano, Y. and Ikegami, S. (1979) The mode of inhibitory action by aphidicolin on eukaryotic DNA polymerase α. Ear. J. Biochem., 97, 603-607.
26. Selig, S., Okumura, K., Ward, D.C. and Cedar, H. (1992) Delineation of DNA replication time zones by fluorescence in situ hybridization. EMBO J., 11, 1217-1225.
27. Lichter, P., Boyle, A.L., Cremer, T. and Ward, D.C. (1991) Analysis of genes and chromosomes by non-isotopic in situ hybridization. Genet. Anal. Technol. Appl. 8, 24-35.
28. Kawame, H., Gartler, S.M. and Hansen, R.S. (1995) Allele-specific replication timing in imprinted domains: absence of asynchrony at several loci. Hum. Mol. Genet., 4, 2287-2293.
29. King, R.W., Jackson, P.K. and Kirschner, M.W. (1994) Mitosis in transition. Cell, 79, 563-571.
30. Michalowski A. (1964) Time-course of DNA synthesis in human leukocyte cultures. Exp. Cell Res., 32, 609-612.
31. Yunis, J.J., Sawyer, J.R. and Ball, D.W. (1978) The characterization of high-resolution G-banded chromosomes of man. Chromosoma, 67, 293-307.
32. Hansen, R.S., Canfield, T.K. and Gartler, S.M. (1995) Reverse replication timing for the XIST gene in human fibroblasts. Hum. Mol. Genet., 4, 813-820.
33. Hand, R. (1978) Eucaryotic DNA: organization of the genome for replication. Cell, 15, 317-325.
34. Kearsey, S.E., Labib, K. and Maiorano, D. (1996) Cell cycle control of eukaryotic DNA replication. Curr. Opin. Genet. Dev., 6, 208-214.
35. D'Urso, G., Grallert, B. and Nurse, P. (1995) DNA polymerase α, a component of the replication initiation complex, is essential for the checkpoint coupling S phase to mitosis in fission yeast. J. Cell Sci., 108, 3109-3118.
36. Le Beau, M.M., Espinosa III, R., Davis, E.M., Eisenbart, J.D., Larson, R.A. and Green, E.D. (1996) Cytogenetic and molecular delineation of a region of chromosome 7 commonly deleted in malignant myeloid diseases. Blood, 88, 1930-1935.
37. Liang, K.-Y. and Zeger, S.L. (1986) Longitudinal data analysis using generalized linear models. Biometrika, 73, 13-22.