Characterization of a 4-Mb region at chromosome 6q21 harboring a replicative senescence gene

Cancer Research

Volumn 57, Issue 19, 1997, Pages 4153-4157

  Morelli, Cristina ^a   Sherratt, Tim ^b   Trabanelli, Cecilia ^a   Rimessi, Paola ^a   Gualandi, Francesca ^a   Greaves, Martin J ^b   Negrini, Massimo ^a   Boyle, John M ^b   Barbanti Brodano, Giuseppe ^a,c  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF FERRARA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CHROMOSOME 6Q; GENE DELETION; GENE LOCATION; HUMAN; IN SITU HYBRIDIZATION; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENESCENCE; SEQUENCE ANALYSIS; VIRUS CELL TRANSFORMATION; YEAST ARTIFICIAL CHROMOSOME;

ANIMALS; BACTERIOPHAGE P1; CELL AGING; CHROMOSOME FRAGILE SITES; CHROMOSOME FRAGILITY; CHROMOSOME WALKING; CHROMOSOMES, ARTIFICIAL, YEAST; CHROMOSOMES, HUMAN, PAIR 6; CPG ISLANDS; DNA REPLICATION; GENE LIBRARY; GENES; GENETIC MARKERS; HUMANS; MICE; TRANSFECTION;

EID: 0030821491     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Mitelman, F. Chromosome 6. In: H. P. Klinger (ed.), Catalog of Chromosome Aberration in Cancer, Ed. 5, pp. 105-123. New York: Wiley-Liss, Inc., 1995.
2. Trent, J. M., Stanbridge, E. J., McBride, H. L., Meese, E. U., Casey, G., Araujo, D. E., Witkowski, C. M., and Nagle, R. B. Tumorigenicity in human melanoma cell lines controlled by introduction of human chromosome 6. Science (Washington DC), 247: 568-571, 1990.
3. Negrini, M., Sabbioni, S., Possati, L., Rattan, S., Corallini, A., Barbanti-Brodano, G., and Croce, C. M. Suppression of tumorigenicity of breast cancer cells by microcell-mediated chromosome transfer: studies on chromosomes 6 and 11. Cancer Res., 54: 1331-1336, 1994.
4. Robertson, G. P., Coleman, A. B., and Lugo, T. G. Mechanisms of human melanoma cell growth and tumor suppression by chromosome 6. Cancer Res., 56: 1635-1641, 1996.
5. Ray, F. A., and Kraemer, P. M. Frequent deletions in nine newly immortal human cell lines. Cancer Genet. Cytogenet., 59: 39-44, 1992.
6. Hubbard-Smith, K., Patsalis, P., Pardinas, J. R., Jha, K. K., Henderson, A. S., and Ozer, H. L. Altered chromosome 6 in immortal human fibroblasts. Mol. Cell. Biol., 12: 2273-2281, 1992.
7. Sandhu, A. K., Hubbard-Smith, K., Kaur, G. P., Jha, K. K., Ozer, H. L., and Athwal, R. S. Senescence of immortal human fibroblasts by the introduction of normal human chromosome 6. Proc. Natl. Acad. Sci. USA, 91: 5498-5502, 1994.
8. Sandhu, A. K., Kaur, G. P., Reddy, D. E., Rane, N. S., and Athwal, R. S. A gene on 6q14-21 restores senescence to immortal ovarian tumor cells. Oncogene, 12: 247-252, 1996.
9. Banga, S., Kim, S. H., Hubbard, K., Dasgupta, T., Jha, K. K., Patsalis, P., Hanptschein, R., Gamberi, B., Dalla Favera, R., Kraemer, P., and Ozer, H. L. SEN6, a locus for SV40-mediated immortalization of human cells, maps to 6q26-27. Oncogene, 14: 313-321, 1997.
10. Gualandi, F., Morelli, C., Pavan, J. V., Rimessi, P., Sensi, A., Bonfatti, A., Gruppioni, R., Possati, L., Stanbridge, E. J., and Barbanti-Brodano, G. Induction of senescence and control of tumorigenicity in BK virus transformed mouse cells by human chromosome 6. Genes Chromosomes Cancer, 10: 77-84, 1994.
11. Riley, J., Butler, R., Ogilvie, D., Finniear, R., Jenner, D., Powell, S., Anand, R., Smith, J. C., and Markham, A. F. A novel, rapid method for the isolation of terminal sequences from yeast artificial chromosome (YAC) clones. Nucleic Acids Res., 18: 2887-2890, 1990.
12. Hogg, A., Onadim, Z., Baird, P. N., and Cowell, J. K. Detection of heterozygous mutations in the RB1 gene in retinoblastoma patients using single-strand conformation polymorphism analysis and polymerase chain reaction sequencing. Oncogene, 7: 1445-1451, 1992.
13. Sambrook, J., Fritsch, E. F., and Maniatis, T. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1989.
14. Butler, R., Ogilvie, D. J., Elvin, P., Riley, J. H., Finniear, R. S., Slynn, G., Morten, J. E. N., Markham, A. F., and Anand, R. Walking, cloning, and mapping with yeast artificial chromosomes: a contig encompassing D21S13 and D21S16. Genomics, 12: 42-51, 1992.
15. Hoggard, N., Brintnell, B., Hey, Y., Jones, D., Weissenbach, J., Mitchell, E., and Varley, J. M. Establishment of the marker order pter-NRAS-NGFB-D1S189-D1S252-D1S440-D1S453-D1S514-CEN-D1S442-D1S498-qter in relation to the centromere on human chromosome 1. Chromosome Res., 3: 137-138, 1995.
16. Pereira-Smith, O. M., and Smith, J. R. Evidence for the recessive nature of cellular immortality. Science (Washington DC), 221: 964-966, 1983.
17. Pereira-Smith, O. M., and Smith, J. R. Genetic analysis of indefinite division in human cells: identification of four complementation groups. Proc. Natl. Acad. Sci. USA, 85: 6042-6046, 1988.
18. Pappas, G. J., Polymeropoulos, M. H., Boyle, J. M., and Trent, J. M. Regional assignment by hybrid mapping of 36 expressed sequence tags (ESTs) on human chromosome 6. Genomics, 25: 124-129, 1995.
19. Wise, C. A., Jabs, E. W., and Lovett, M. Isolating and mapping coding regions from complex genomes: direct cDNA selection. In: K. W. Adolph (ed.), Methods in Molecular Genetics, Volume 8: Human Molecular Genetics, pp. 189-206. New York: Academic Press, 1996.
20. Green, R. J., Phillips, D. L., Chen, A. T. L., Reidy, J. A., and Ragab, A. H. Effects of folate in culture medium on common fragile sites in lymphocyte chromosomes from normal and leukemic children. Hum. Genet., 81: 9-12, 1988.
21. Ohta, M., Inoue, H., Cotticelli, M. G., Kastury, K., Baffa, R., Palazzo, J., Siprashvili, Z., Mori, M., McCue, P., Druck, T., Croce, C. M., and Huebner, K. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell, 84: 587-597, 1996.
22. Sozzi, G., Alder, H., Tornielli, S., Corletto, V., Baffa, R., Veronese, M. L., Negrini, M., Pilotti, S., Pierotti, M. A., Huebner, K., and Croce, C. M. Aberrant FHIT transcripts in Merkel cell carcinoma. Cancer Res., 56: 2472-2474, 1996.
23. Sozzi, G., Veronese, M. L., Negrini, M., Baffa, R., Cotticelli, M. G., Inoue, H., Tornielli, S., Pilotti, S., De Gregorio, L., Pastorino, U., Pierotti, M. A., Ohta, M., Huebner, K., and Croce, C. M. The FHIT gene at 3p14.2 is abnormal in lung cancer. Cell, 85: 17-26, 1996.
24. Sasaki, M., Honda, T., Yamada, H., Wake, N., Barrett, J. C., and Oshimura, M. Evidence for multiple pathways to cellular senescence. Cancer Res., 54: 6090-6093, 1994.
25. Uejima, H., Mitsuya, K., Kugoh, H., Horikawa, I., and Oshimura, M. Normal human chromosome 2 induces cellular senescence in the human cervical carcinoma cell line SiHa. Genes Chromosomes Cancer, 14: 120-127, 1995.