-
1
-
-
0021278143
-
DNA polymerase a inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes
-
PMID:6430783; DOI:10.1007/BF00272988
-
Glover TW, Berger C, Coyle J, Echo B. DNA polymerase a inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes. Hum Genet 1984; 67:136-42; PMID:6430783; DOI:10.1007/BF00272988.
-
(1984)
Hum Genet
, vol.67
, pp. 136-142
-
-
Glover, T.W.1
Berger, C.2
Coyle, J.3
Echo, B.4
-
2
-
-
77956539396
-
DNA instability at chromosomal fragile sites in cancer
-
PMID:21286310; DOI:10.2174/138920210791616699
-
Dillon LW, Burrow AA, Wang YH. DNA instability at chromosomal fragile sites in cancer. Curr Genomics 2010; 11:326-37; PMID:21286310; DOI:10.2174/138920210791616699.
-
(2010)
Curr Genomics
, vol.11
, pp. 326-337
-
-
Dillon, L.W.1
Burrow, A.A.2
Wang, Y.H.3
-
3
-
-
77953634888
-
Does interference between replication and transcription contribute to genomic instability in cancer cells?
-
PMID:20495385; DOI:10.4161/cc.9.10.11539
-
Tuduri S, Crabbe L, Tourriere H, Coquelle A, Pasero P. Does interference between replication and transcription contribute to genomic instability in cancer cells? Cell Cycle 2010; 9:1886-92; PMID:20495385; DOI:10.4161/cc.9.10. 11539.
-
(2010)
Cell Cycle
, vol.9
, pp. 1886-1892
-
-
Tuduri, S.1
Crabbe, L.2
Tourriere, H.3
Coquelle, A.4
Pasero, P.5
-
4
-
-
38049162608
-
Chromosome fragile sites
-
PMID:17608616; DOI:10.1146/annurev.genet.41.042007.165900
-
Durkin SG, Glover TW. Chromosome fragile sites. Annu Rev Genet 2007; 41:169-92; PMID:17608616; DOI:10.1146/annurev.genet.41.042007.165900.
-
(2007)
Annu Rev Genet
, vol.41
, pp. 169-192
-
-
Durkin, S.G.1
Glover, T.W.2
-
5
-
-
39449126238
-
Human chromosome fragility
-
PMID:18078840
-
Lukusa T, Fryns JP. Human chromosome fragility. Biochim Biophys Acta 2008; 1779:3-16; PMID:18078840.
-
(2008)
Biochim Biophys Acta
, vol.1779
, pp. 3-16
-
-
Lukusa, T.1
Fryns, J.P.2
-
6
-
-
27744530159
-
Mechanisms of common fragile site instability
-
PMID:16244318; DOI:10.1093/hmg/ddi265
-
Glover TW, Arlt MF, Casper AM, Durkin SG. Mechanisms of common fragile site instability. Hum Mol Genet 2005; 14:197-205; PMID:16244318; DOI:10.1093/hmg/ddi265.
-
(2005)
Hum Mol Genet
, vol.14
, pp. 197-205
-
-
Glover, T.W.1
Arlt, M.F.2
Casper, A.M.3
Durkin, S.G.4
-
7
-
-
13144283613
-
Molecular characterization of a common fragile site (FRA7H) on human chromosome 7 by the cloning of a simian virus 40 integration site
-
PMID:9653154; DOI:10.1073/pnas.95.14.8141
-
Mishmar D, Rahat A, Scherer SW, Nyakatura G, Hinzmann B, Kohwi Y, et al. Molecular characterization of a common fragile site (FRA7H) on human chromosome 7 by the cloning of a simian virus 40 integration site. Proc Natl Acad Sci USA 1998; 95:8141-6; PMID:9653154; DOI:10.1073/pnas.95.14.8141.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 8141-8146
-
-
Mishmar, D.1
Rahat, A.2
Scherer, S.W.3
Nyakatura, G.4
Hinzmann, B.5
Kohwi, Y.6
-
8
-
-
0141864371
-
Molecular basis for expression of common and rare fragile sites
-
PMID:14517285; DOI:10.1128/ MCB.23.20.7143-51.2003
-
Zlotorynski E, Rahat A, Skaug J, Ben-Porat N, Ozeri E, Hershberg R, et al. Molecular basis for expression of common and rare fragile sites. Mol Cell Biol 2003; 23:7143-51; PMID:14517285; DOI:10.1128/ MCB.23.20.7143-51.2003.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 7143-7151
-
-
Zlotorynski, E.1
Rahat, A.2
Skaug, J.3
Ben-Porat, N.4
Ozeri, E.5
Hershberg, R.6
-
9
-
-
34547205070
-
An AT-rich sequence in human common fragile site FRA16D causes fork stalling and chromosome breakage in S. cerevisiae
-
PMID:17679088; DOI:10.1016/j. molcel.2007.06.012
-
Zhang H, Freudenreich CH. An AT-rich sequence in human common fragile site FRA16D causes fork stalling and chromosome breakage in S. cerevisiae. Mol Cell 2007; 27:367-79; PMID:17679088; DOI:10.1016/j. molcel.2007.06.012.
-
(2007)
Mol Cell
, vol.27
, pp. 367-379
-
-
Zhang, H.1
Freudenreich, C.H.2
-
10
-
-
50249178177
-
Stably transfected common fragile site sequences exhibit instability at ectopic sites
-
PMID:18615677; DOI:10.1002/ gcc.20591
-
Ragland RL, Glynn MW, Arlt MF, Glover TW. Stably transfected common fragile site sequences exhibit instability at ectopic sites. Genes Chromosomes Cancer 2008; 47:860-72; PMID:18615677; DOI:10.1002/ gcc.20591.
-
(2008)
Genes Chromosomes Cancer
, vol.47
, pp. 860-872
-
-
Ragland, R.L.1
Glynn, M.W.2
Arlt, M.F.3
Glover, T.W.4
-
11
-
-
77953278318
-
Secondary structure formation and DNA instability at fragile site FRA16B
-
PMID:20071743; DOI:10.1093/nar/gkp1245
-
Burrow AA, Marullo A, Holder LR, Wang YH. Secondary structure formation and DNA instability at fragile site FRA16B. Nucleic Acids Res 2010; 38:2865- 77; PMID:20071743; DOI:10.1093/nar/gkp1245.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 2865-2877
-
-
Burrow, A.A.1
Marullo, A.2
Holder, L.R.3
Wang, Y.H.4
-
12
-
-
79959885574
-
Failure of origin activation in response to fork stalling leads to chromosomal instability at fragile sites
-
PMID:21726815; DOI:10.1016/j.molcel. 2011.05.019
-
Ozeri-Galai E, Lebofsky R, Rahat A, Bester AC, Bensimon A, Kerem B. Failure of origin activation in response to fork stalling leads to chromosomal instability at fragile sites. Mol Cell 2011; 43:122- 31; PMID:21726815; DOI:10.1016/j.molcel. 2011.05.019.
-
(2011)
Mol Cell
, vol.43
, pp. 122-131
-
-
Ozeri-Galai, E.1
Lebofsky, R.2
Rahat, A.3
Bester, A.C.4
Bensimon, A.5
Kerem, B.6
-
13
-
-
0031924605
-
Replication of a common fragile site, FRA3B, occurs late in S phase and is delayed further upon induction: Implications for the mechanism of fragile site induction
-
PMID:9499431; DOI:10.1093/ hmg/7.4.755
-
Le Beau MM, Rassool FV, Neilly ME, Espinosa R, 3rd, Glover TW, Smith DI, et al. Replication of a common fragile site, FRA3B, occurs late in S phase and is delayed further upon induction: implications for the mechanism of fragile site induction. Hum Mol Genet 1998; 7:755-61; PMID:9499431; DOI:10.1093/ hmg/7.4.755.
-
(1998)
Hum Mol Genet
, vol.7
, pp. 755-761
-
-
Le Beau, M.M.1
Rassool, F.V.2
Neilly, M.E.3
Espinosa III, R.4
Glover, T.W.5
Smith, D.I.6
-
14
-
-
0345283196
-
The role of late/slow replication of the FRA16D in common fragile site induction
-
PMID:14603443; DOI:10.1002/gcc.10290
-
Palakodeti A, Han Y, Jiang Y, Le Beau MM. The role of late/slow replication of the FRA16D in common fragile site induction. Genes Chromosomes Cancer 2004; 39:71-6; PMID:14603443; DOI:10.1002/gcc.10290.
-
(2004)
Genes Chromosomes Cancer
, vol.39
, pp. 71-76
-
-
Palakodeti, A.1
Han, Y.2
Jiang, Y.3
Le Beau, M.M.4
-
15
-
-
77649290673
-
Impaired replication dynamics at the FRA3B common fragile site
-
PMID:19815620; DOI:10.1093/hmg/ ddp470
-
Palakodeti A, Lucas I, Jiang Y, Young DJ, Fernald AA, Karrison T, et al. Impaired replication dynamics at the FRA3B common fragile site. Hum Mol Genet 2010; 19:99-110; PMID:19815620; DOI:10.1093/hmg/ ddp470.
-
(2010)
Hum Mol Genet
, vol.19
, pp. 99-110
-
-
Palakodeti, A.1
Lucas, I.2
Jiang, Y.3
Young, D.J.4
Fernald, A.A.5
Karrison, T.6
-
16
-
-
0037074013
-
ATR regulates fragile site stability
-
PMID:12526805; DOI:10.1016/S0092- 8674(02)01113-3
-
Casper AM, Nghiem P, Arlt MF, Glover TW. ATR regulates fragile site stability. Cell 2002; 111:779- 89; PMID:12526805; DOI:10.1016/S0092- 8674(02)01113-3.
-
(2002)
Cell
, vol.111
, pp. 779-789
-
-
Casper, A.M.1
Nghiem, P.2
Arlt, M.F.3
Glover, T.W.4
-
17
-
-
79551661935
-
Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site
-
PMID:21258320; DOI:10.1038/nature09745
-
Letessier A, Millot GA, Koundrioukoff S, Lachages AM, Vogt N, Hansen RS, et al. Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site. Nature 2011; 470:120-3; PMID:21258320; DOI:10.1038/ nature09745.
-
(2011)
Nature
, vol.470
, pp. 120-123
-
-
Letessier, A.1
Millot, G.A.2
Koundrioukoff, S.3
Lachages, A.M.4
Vogt, N.5
Hansen, R.S.6
-
18
-
-
17244367849
-
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
-
PMID:15829956; DOI:10.1038/nature03482
-
Bartkova J, Horejsi Z, Koed K, Kramer A, Tort F, Zieger K, et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 2005; 434:864-70; PMID:15829956; DOI:10.1038/nature03482.
-
(2005)
Nature
, vol.434
, pp. 864-870
-
-
Bartkova, J.1
Horejsi, Z.2
Koed, K.3
Kramer, A.4
Tort, F.5
Zieger, K.6
-
19
-
-
17244366865
-
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
-
PMID:15829965; DOI:10.1038/nature03485
-
Gorgoulis VG, Vassiliou LV, Karakaidos P, Zacharatos P, Kotsinas A, Liloglou T, et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 2005; 434:907- 13; PMID:15829965; DOI:10.1038/nature03485.
-
(2005)
Nature
, vol.434
, pp. 907-913
-
-
Gorgoulis, V.G.1
Vassiliou, L.V.2
Karakaidos, P.3
Zacharatos, P.4
Kotsinas, A.5
Liloglou, T.6
-
20
-
-
2942659914
-
Molecular cross-talk among chromosome fragility syndromes
-
PMID:15198978; DOI:10.1101/gad.1216304
-
Surrallés J, Jackson SP, Jasin M, Kastan MB, West SC, Joenje H. Molecular cross-talk among chromosome fragility syndromes. Genes Dev 2004; 18:1359-70; PMID:15198978; DOI:10.1101/gad.1216304.
-
(2004)
Genes Dev
, vol.18
, pp. 1359-1370
-
-
Surrallés, J.1
Jackson, S.P.2
Jasin, M.3
Kastan, M.B.4
West, S.C.5
Joenje, H.6
-
21
-
-
0035449355
-
Cell cycle checkpoint signaling through the ATM and ATR kinases
-
PMID:11544175; DOI:10.1101/gad.914401
-
Abraham RT. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 2001; 15:2177- 96; PMID:11544175; DOI:10.1101/gad.914401.
-
(2001)
Genes Dev
, vol.15
, pp. 2177-2196
-
-
Abraham, R.T.1
-
22
-
-
0037567268
-
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
-
PMID:12791985; DOI:10.1126/ science.1083430
-
Zou L, Elledge SJ. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 2003; 300:1542-8; PMID:12791985; DOI:10.1126/ science.1083430.
-
(2003)
Science
, vol.300
, pp. 1542-1548
-
-
Zou, L.1
Elledge, S.J.2
-
23
-
-
0034306184
-
Temporally coordinated assembly and disassembly of replication factories in the absence of DNA synthesis
-
PMID:11025658; DOI:10.1038/35036309
-
Dimitrova DS, Gilbert DM. Temporally coordinated assembly and disassembly of replication factories in the absence of DNA synthesis. Nat Cell Biol 2000; 2:686- 94; PMID:11025658; DOI:10.1038/35036309.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 686-694
-
-
Dimitrova, D.S.1
Gilbert, D.M.2
-
24
-
-
0035797383
-
The DNA replication checkpoint response stabilizes stalled replication forks
-
PMID:11484058; DOI:10.1038/35087613
-
Lopes M, Cotta-Ramusino C, Pellicioli A, Liberi G, Plevani P, Muzi-Falconi M, et al. The DNA replication checkpoint response stabilizes stalled replication forks. Nature 2001; 412:557-61; PMID:11484058; DOI:10.1038/35087613.
-
(2001)
Nature
, vol.412
, pp. 557-561
-
-
Lopes, M.1
Cotta-Ramusino, C.2
Pellicioli, A.3
Liberi, G.4
Plevani, P.5
Muzi-Falconi, M.6
-
25
-
-
0035797444
-
Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint
-
PMID:11484057; DOI:10.1038/35087607
-
Tercero JA, Diffley JF. Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint. Nature 2001; 412:553-7; PMID:11484057; DOI:10.1038/35087607.
-
(2001)
Nature
, vol.412
, pp. 553-557
-
-
Tercero, J.A.1
Diffley, J.F.2
-
26
-
-
0034102337
-
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
-
PMID:10691732
-
Brown EJ, Baltimore D. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev 2000; 14:397-402; PMID:10691732.
-
(2000)
Genes Dev
, vol.14
, pp. 397-402
-
-
Brown, E.J.1
Baltimore, D.2
-
27
-
-
0034177408
-
Targeted disruption of the cell cycle checkpoint gene ATR leads to early embryonic lethality in mice
-
PMID:10801416; DOI:10.1016/S0960-9822(00)00447-4
-
de Klein A, Muijtjens M, van Os R, Verhoeven Y, Smit B, Carr AM, et al. Targeted disruption of the cell cycle checkpoint gene ATR leads to early embryonic lethality in mice. Curr Biol 2000; 10:479-82; PMID:10801416; DOI:10.1016/S0960-9822(00)00447-4.
-
(2000)
Curr Biol
, vol.10
, pp. 479-482
-
-
De Klein, A.1
Muijtjens, M.2
Van Os, R.3
Verhoeven, Y.4
Smit, B.5
Carr, A.M.6
-
28
-
-
4544333154
-
Chromosomal instability at common fragile sites in Seckel syndrome
-
PMID:15309689; DOI:10.1086/422701
-
Casper AM, Durkin SG, Arlt MF, Glover TW. Chromosomal instability at common fragile sites in Seckel syndrome. Am J Hum Genet 2004; 75:654-60; PMID:15309689; DOI:10.1086/422701.
-
(2004)
Am J Hum Genet
, vol.75
, pp. 654-660
-
-
Casper, A.M.1
Durkin, S.G.2
Arlt, M.F.3
Glover, T.W.4
-
29
-
-
0037178723
-
ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones
-
PMID:12142538; DOI:10.1126/science.1071398
-
Cha RS, Kleckner N. ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones. Science 2002; 297:602-6; PMID:12142538; DOI:10.1126/science.1071398.
-
(2002)
Science
, vol.297
, pp. 602-606
-
-
Cha, R.S.1
Kleckner, N.2
-
30
-
-
33947145194
-
Increased common fragile site expression, cell proliferation defects and apoptosis following conditional inactivation of mouse Hus1 in primary cultured cells
-
PMID:17215515; DOI:10.1091/mbc.E06-10-0957
-
Zhu M, Weiss RS. Increased common fragile site expression, cell proliferation defects and apoptosis following conditional inactivation of mouse Hus1 in primary cultured cells. Mol Biol Cell 2007; 18:1044-55; PMID:17215515; DOI:10.1091/mbc.E06-10-0957.
-
(2007)
Mol Biol Cell
, vol.18
, pp. 1044-1055
-
-
Zhu, M.1
Weiss, R.S.2
-
31
-
-
70350234776
-
Claspin inhibition leads to fragile site expression
-
PMID:19760606; DOI:10.1002/ gcc.20710
-
Focarelli ML, Soza S, Mannini L, Paulis M, Montecucco A, Musio A. Claspin inhibition leads to fragile site expression. Genes Chromosomes Cancer 2009; 48:1083-90; PMID:19760606; DOI:10.1002/ gcc.20710.
-
(2009)
Genes Chromosomes Cancer
, vol.48
, pp. 1083-1090
-
-
Focarelli, M.L.1
Soza, S.2
Mannini, L.3
Paulis, M.4
Montecucco, A.5
Musio, A.6
-
32
-
-
14044258550
-
SMC1 involvement in fragile site expression
-
PMID:15640246; DOI:10.1093/hmg/ddi049
-
Musio A, Montagna C, Mariani T, Tilenni M, Focarelli ML, Brait L, et al. SMC1 involvement in fragile site expression. Hum Mol Genet 2005; 14:525-33; PMID:15640246; DOI:10.1093/hmg/ddi049.
-
(2005)
Hum Mol Genet
, vol.14
, pp. 525-533
-
-
Musio, A.1
Montagna, C.2
Mariani, T.3
Tilenni, M.4
Focarelli, M.L.5
Brait, L.6
-
33
-
-
3242712112
-
BRCA1 is required for commonfragile- Site stability via its G2/M checkpoint function
-
PMID:15254237; DOI:10.1128/MCB.24.15.6701-9.2004
-
Arlt MF, Xu B, Durkin SG, Casper AM, Kastan MB, Glover TW. BRCA1 is required for commonfragile- site stability via its G2/M checkpoint function. Mol Cell Biol 2004; 24:6701-9; PMID:15254237; DOI:10.1128/MCB.24.15.6701-9.2004.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 6701-6709
-
-
Arlt, M.F.1
Xu, B.2
Durkin, S.G.3
Casper, A.M.4
Kastan, M.B.5
Glover, T.W.6
-
34
-
-
0034967556
-
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
-
PMID:11390642; DOI:10.1128/MCB.21.13.4129- 39.2001
-
Zhao H, Piwnica-Worms H. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol 2001; 21:4129-39; PMID:11390642; DOI:10.1128/MCB.21.13.4129- 39.2001.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 4129-4139
-
-
Zhao, H.1
Piwnica-Worms, H.2
-
35
-
-
17644432403
-
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
-
PMID:10859164
-
Liu Q, Guntuku S, Cui XS, Matsuoka S, Cortez D, Tamai K, et al. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev 2000; 14:1448-59; PMID:10859164.
-
(2000)
Genes Dev
, vol.14
, pp. 1448-1459
-
-
Liu, Q.1
Guntuku, S.2
Cui, X.S.3
Matsuoka, S.4
Cortez, D.5
Tamai, K.6
-
36
-
-
0035802112
-
Activation of mammalian Chk1 during DNA replication arrest: A role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing
-
PMID:11535615; DOI:10.1083/jcb.200104099
-
Feijoo C, Hall-Jackson C, Wu R, Jenkins D, Leitch J, Gilbert DM, et al. Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing. J Cell Biol 2001; 154:913-23; PMID:11535615; DOI:10.1083/jcb.200104099.
-
(2001)
J Cell Biol
, vol.154
, pp. 913-923
-
-
Feijoo, C.1
Hall-Jackson, C.2
Wu, R.3
Jenkins, D.4
Leitch, J.5
Gilbert, D.M.6
-
37
-
-
33749599776
-
Evidence that the ATR/ Chk1 pathway maintains normal replication fork progression during unperturbed S phase
-
PMID:16969104; DOI:10.4161/ cc.5.19.3256
-
Petermann E, Caldecott KW. Evidence that the ATR/ Chk1 pathway maintains normal replication fork progression during unperturbed S phase. Cell Cycle 2006; 5:2203-9; PMID:16969104; DOI:10.4161/ cc.5.19.3256.
-
(2006)
Cell Cycle
, vol.5
, pp. 2203-2209
-
-
Petermann, E.1
Caldecott, K.W.2
-
38
-
-
20244388673
-
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets and DNA breakage
-
PMID:15831461; DOI:10.1128/MCB.25.9.3553-62.2005
-
Syljuåsen RG, Sorensen CS, Hansen LT, Fugger K, Lundin C, Johansson F, et al. Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets and DNA breakage. Mol Cell Biol 2005; 25:3553-62; PMID:15831461; DOI:10.1128/MCB.25.9.3553-62.2005.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 3553-3562
-
-
Syljuåsen, R.G.1
Sorensen, C.S.2
Hansen, L.T.3
Fugger, K.4
Lundin, C.5
Johansson, F.6
-
39
-
-
34250010317
-
Chk1 regulates the density of active replication origins during the vertebrate S phase
-
PMID:17491592; DOI:10.1038/sj.emboj.7601714
-
Maya-Mendoza A, Petermann E, Gillespie DA, Caldecott KW, Jackson DA. Chk1 regulates the density of active replication origins during the vertebrate S phase. EMBO J 2007; 26:2719-31; PMID:17491592; DOI:10.1038/sj.emboj.7601714.
-
(2007)
EMBO J
, vol.26
, pp. 2719-2731
-
-
Maya-Mendoza, A.1
Petermann, E.2
Gillespie, D.A.3
Caldecott, K.W.4
Jackson, D.A.5
-
40
-
-
77953506262
-
Chk1 inhibition after replicative stress activates a double strand break response mediated by ATM and DNA-dependent protein kinase
-
PMID:20160494; DOI:10.4161/cc.9.5.10935
-
McNeely S, Conti C, Sheikh T, Patel H, Zabludoff S, Pommier Y, et al. Chk1 inhibition after replicative stress activates a double strand break response mediated by ATM and DNA-dependent protein kinase. Cell Cycle 2010; 9:995-1004; PMID:20160494; DOI:10.4161/cc.9.5.10935.
-
(2010)
Cell Cycle
, vol.9
, pp. 995-1004
-
-
McNeely, S.1
Conti, C.2
Sheikh, T.3
Patel, H.4
Zabludoff, S.5
Pommier, Y.6
-
41
-
-
33746495515
-
Depletion of CHK1, but not CHK2, induces chromosomal instability and breaks at common fragile sites
-
PMID:16732333; DOI:10.1038/sj.onc.1209466
-
Durkin SG, Arlt MF, Howlett NG, Glover TW. Depletion of CHK1, but not CHK2, induces chromosomal instability and breaks at common fragile sites. Oncogene 2006; 25:4381-8; PMID:16732333; DOI:10.1038/sj.onc.1209466.
-
(2006)
Oncogene
, vol.25
, pp. 4381-4388
-
-
Durkin, S.G.1
Arlt, M.F.2
Howlett, N.G.3
Glover, T.W.4
-
42
-
-
0043032435
-
Human claspin is required for replication checkpoint control
-
PMID:12766152; DOI:10.1074/jbc.M301136200
-
Chini CC, Chen J. Human claspin is required for replication checkpoint control. J Biol Chem 2003; 278:30057-62; PMID:12766152; DOI:10.1074/jbc. M301136200.
-
(2003)
J Biol Chem
, vol.278
, pp. 30057-30062
-
-
Chini, C.C.1
Chen, J.2
-
43
-
-
0042865938
-
S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex
-
PMID:12944972; DOI:10.1038/nature01900
-
Katou Y, Kanoh Y, Bando M, Noguchi H, Tanaka H, Ashikari T, et al. S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex. Nature 2003; 424:1078-83; PMID:12944972; DOI:10.1038/nature01900.
-
(2003)
Nature
, vol.424
, pp. 1078-1083
-
-
Katou, Y.1
Kanoh, Y.2
Bando, M.3
Noguchi, H.4
Tanaka, H.5
Ashikari, T.6
-
44
-
-
15944424299
-
Human Rad9 is required for the activation of S-phase checkpoint and the maintenance of chromosomal stability
-
PMID:15773892; DOI:10.1111/j.1365- 2443.2005.00840.x
-
Dang T, Bao S, Wang XF. Human Rad9 is required for the activation of S-phase checkpoint and the maintenance of chromosomal stability. Genes Cells 2005; 10:287-95; PMID:15773892; DOI:10.1111/j.1365- 2443.2005.00840.x.
-
(2005)
Genes Cells
, vol.10
, pp. 287-295
-
-
Dang, T.1
Bao, S.2
Wang, X.F.3
-
45
-
-
0032508506
-
Structural maintenance of chromosomes protein C-terminal domains bind preferentially to DNA with secondary structure
-
PMID:9727028; DOI:10.1074/ jbc.273.37.24088
-
Akhmedov AT, Frei C, Tsai-Pflugfelder M, Kemper B, Gasser SM, Jessberger R. Structural maintenance of chromosomes protein C-terminal domains bind preferentially to DNA with secondary structure. J Biol Chem 1998; 273:24088-94; PMID:9727028; DOI:10.1074/ jbc.273.37.24088.
-
(1998)
J Biol Chem
, vol.273
, pp. 24088-24094
-
-
Akhmedov, A.T.1
Frei, C.2
Tsai-Pflugfelder, M.3
Kemper, B.4
Gasser, S.M.5
Jessberger, R.6
-
46
-
-
0033637170
-
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress
-
PMID:11114888; DOI:10.1101/gad.851000
-
Tibbetts RS, Cortez D, Brumbaugh KM, Scully R, Livingston D, Elledge SJ, et al. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev 2000; 14:2989-3002; PMID:11114888; DOI:10.1101/gad.851000.
-
(2000)
Genes Dev
, vol.14
, pp. 2989-3002
-
-
Tibbetts, R.S.1
Cortez, D.2
Brumbaugh, K.M.3
Scully, R.4
Livingston, D.5
Elledge, S.J.6
-
47
-
-
0036510163
-
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
-
PMID:11836499; DOI:10.1038/ ng837
-
Yarden RI, Pardo-Reoyo S, Sgagias M, Cowan KH, Brody LC. BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. Nat Genet 2002; 30:285-9; PMID:11836499; DOI:10.1038/ ng837.
-
(2002)
Nat Genet
, vol.30
, pp. 285-289
-
-
Yarden, R.I.1
Pardo-Reoyo, S.2
Sgagias, M.3
Cowan, K.H.4
Brody, L.C.5
-
48
-
-
33645283603
-
Common fragile sites nested at the interfaces of early and latereplicating chromosome bands: Cis acting components of the G2/M checkpoint?
-
PMID:16582603; DOI:10.4161/cc.5.6.2574
-
Debatisse M, El Achkar E, Dutrillaux B. Common fragile sites nested at the interfaces of early and latereplicating chromosome bands: cis acting components of the G2/M checkpoint? Cell Cycle 2006; 5:578-81; PMID:16582603; DOI:10.4161/cc.5.6.2574.
-
(2006)
Cell Cycle
, vol.5
, pp. 578-581
-
-
Debatisse, M.1
El Achkar, E.2
Dutrillaux, B.3
-
49
-
-
27744496209
-
Homologous recombination and nonhomologous end-joining repair pathways regulate fragile site stability
-
PMID:16291645; DOI:10.1101/gad.340905
-
Schwartz M, Zlotorynski E, Goldberg M, Ozeri E, Rahat A, le Sage C, et al. Homologous recombination and nonhomologous end-joining repair pathways regulate fragile site stability. Genes Dev 2005; 19:2715-26; PMID:16291645; DOI:10.1101/gad.340905.
-
(2005)
Genes Dev
, vol.19
, pp. 2715-2726
-
-
Schwartz, M.1
Zlotorynski, E.2
Goldberg, M.3
Ozeri, E.4
Rahat, A.5
Le Sage, C.6
-
50
-
-
0036316015
-
Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells
-
PMID:12138197; DOI:10.1128/ MCB.22.16.5869-78.2002
-
Lundin C, Erixon K, Arnaudeau C, Schultz N, Jenssen D, Meuth M, et al. Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells. Mol Cell Biol 2002; 22:5869-78; PMID:12138197; DOI:10.1128/ MCB.22.16.5869-78.2002.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 5869-5878
-
-
Lundin, C.1
Erixon, K.2
Arnaudeau, C.3
Schultz, N.4
Jenssen, D.5
Meuth, M.6
-
51
-
-
0032999346
-
Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells
-
PMID:10373565
-
Sonoda E, Sasaki MS, Morrison C, Yamaguchi-Iwai Y, Takata M, Takeda S. Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells. Mol Cell Biol 1999; 19:5166-9; PMID:10373565.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 5166-5169
-
-
Sonoda, E.1
Sasaki, M.S.2
Morrison, C.3
Yamaguchi-Iwai, Y.4
Takata, M.5
Takeda, S.6
-
52
-
-
14644391577
-
The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability
-
PMID:15661754; DOI:10.1093/hmg/ddi065
-
Howlett NG, Taniguchi T, Durkin SG, D'Andrea AD, Glover TW. The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability. Hum Mol Genet 2005; 14:693-701; PMID:15661754; DOI:10.1093/hmg/ddi065.
-
(2005)
Hum Mol Genet
, vol.14
, pp. 693-701
-
-
Howlett, N.G.1
Taniguchi, T.2
Durkin, S.G.3
D'Andrea, A.D.4
Glover, T.W.5
-
53
-
-
70349278437
-
The FANC pathway and mitosis: A replication legacy
-
PMID:19729998; DOI:10.4161/cc.8.18.9538
-
Naim V, Rosselli F. The FANC pathway and mitosis: a replication legacy. Cell Cycle 2009; 8:2907-11; PMID:19729998; DOI:10.4161/cc.8.18.9538.
-
(2009)
Cell Cycle
, vol.8
, pp. 2907-2911
-
-
Naim, V.1
Rosselli, F.2
-
54
-
-
76749168005
-
Roles of Werner syndrome protein in protection of genome integrity
-
Amst PMID:20075015; DOI:10.1016/j.dnarep.2009.12.011
-
Rossi ML, Ghosh AK, Bohr VA. Roles of Werner syndrome protein in protection of genome integrity. DNA Repair (Amst) 2010; 9:331-44; PMID:20075015; DOI:10.1016/j.dnarep.2009.12.011.
-
(2010)
DNA Repair
, vol.9
, pp. 331-344
-
-
Rossi, M.L.1
Ghosh, A.K.2
Bohr, V.A.3
-
55
-
-
0033010781
-
Werner syndrome lymphoblastoid cells are sensitive to camptothecin- induced apoptosis in S-phase
-
PMID:10071186; DOI:10.1007/ s004390050903
-
Poot M, Gollahon KA, Rabinovitch PS. Werner syndrome lymphoblastoid cells are sensitive to camptothecin- induced apoptosis in S-phase. Hum Genet 1999; 104:10-4; PMID:10071186; DOI:10.1007/ s004390050903.
-
(1999)
Hum Genet
, vol.104
, pp. 10-14
-
-
Poot, M.1
Gollahon, K.A.2
Rabinovitch, P.S.3
-
56
-
-
0035169035
-
Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle
-
PMID:11514625
-
Pichierri P, Franchitto A, Mosesso P, Palitti F. Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle. Mol Biol Cell 2001; 12:2412-21; PMID:11514625.
-
(2001)
Mol Biol Cell
, vol.12
, pp. 2412-2421
-
-
Pichierri, P.1
Franchitto, A.2
Mosesso, P.3
Palitti, F.4
-
57
-
-
0035349905
-
Werner syndrome cells are sensitive to DNA cross-linking drugs
-
PMID:11344095
-
Poot M, Yom JS, Whang SH, Kato JT, Gollahon KA, Rabinovitch PS. Werner syndrome cells are sensitive to DNA cross-linking drugs. FASEB J 2001; 15:1224-6; PMID:11344095.
-
(2001)
FASEB J
, vol.15
, pp. 1224-1226
-
-
Poot, M.1
Yom, J.S.2
Whang, S.H.3
Kato, J.T.4
Gollahon, K.A.5
Rabinovitch, P.S.6
-
58
-
-
0141480945
-
WRN interacts physically and functionally with the recombination mediator protein RAD52. J Biol Chem
-
PMID:12750383; DOI:10.1074/jbc.M303885200
-
Baynton K, Otterlei M, Bjoras M, von Kobbe C, Bohr VA, Seeberg E. WRN interacts physically and functionally with the recombination mediator protein RAD52. J Biol Chem 2003; 278:36476-86; PMID:12750383; DOI:10.1074/jbc. M303885200.
-
(2003)
, vol.278
, pp. 36476-36486
-
-
Baynton, K.1
Otterlei, M.2
Bjoras, M.3
Von Kobbe, C.4
Bohr, V.A.5
Seeberg, E.6
-
59
-
-
0035009356
-
Werner helicase relocates into nuclear foci in response to DNA damaging agents and colocalizes with RPA and Rad51
-
PMID:11380620; DOI:10.1046/j.1365- 2443.2001.00433.x
-
Sakamoto S, Nishikawa K, Heo SJ, Goto M, Furuichi Y, Shimamoto A. Werner helicase relocates into nuclear foci in response to DNA damaging agents and colocalizes with RPA and Rad51. Genes Cells 2001; 6:421-30; PMID:11380620; DOI:10.1046/j.1365- 2443.2001.00433.x.
-
(2001)
Genes Cells
, vol.6
, pp. 421-430
-
-
Sakamoto, S.1
Nishikawa, K.2
Heo, S.J.3
Goto, M.4
Furuichi, Y.5
Shimamoto, A.6
-
60
-
-
68049106190
-
Premature aging syndrome gene WRN genetically interacts with a topoisomerase
-
PMID:19587535; DOI:10.4161/cc.8.14.9118
-
Aggarwal M, Brosh RM Jr. Premature aging syndrome gene WRN genetically interacts with a topoisomerase. Cell Cycle 2009; 8:2143; PMID:19587535; DOI:10.4161/cc.8.14.9118.
-
(2009)
Cell Cycle
, vol.8
, pp. 2143
-
-
Aggarwal, M.1
Brosh Jr., R.M.2
-
61
-
-
0041324850
-
Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein
-
PMID:12827497; DOI:10.1007/s00439-003-0972-y
-
Bai Y, Murnane JP. Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein. Hum Genet 2003; 113:337-47; PMID:12827497; DOI:10.1007/s00439-003-0972-y.
-
(2003)
Hum Genet
, vol.113
, pp. 337-347
-
-
Bai, Y.1
Murnane, J.P.2
-
62
-
-
2442660468
-
Linkage between Werner syndrome protein and the Mre11 complex via Nbs1
-
PMID:15026416; DOI:10.1074/jbc.M312770200
-
Cheng WH, von Kobbe C, Opresko PL, Arthur LM, Komatsu K, Seidman MM, et al. Linkage between Werner syndrome protein and the Mre11 complex via Nbs1. J Biol Chem 2004; 279:21169-76; PMID:15026416; DOI:10.1074/jbc.M312770200.
-
(2004)
J Biol Chem
, vol.279
, pp. 21169-21176
-
-
Cheng, W.H.1
Von Kobbe, C.2
Opresko, P.L.3
Arthur, L.M.4
Komatsu, K.5
Seidman, M.M.6
-
63
-
-
2942637828
-
The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2
-
PMID:15200954; DOI:10.1016/j.molcel.2004.05.023
-
Opresko PL, Otterlei M, Graakjaer J, Bruheim P, Dawut L, Kolvraa S, et al. The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2. Mol Cell 2004; 14:763-74; PMID:15200954; DOI:10.1016/j.molcel.2004.05.023.
-
(2004)
Mol Cell
, vol.14
, pp. 763-774
-
-
Opresko, P.L.1
Otterlei, M.2
Graakjaer, J.3
Bruheim, P.4
Dawut, L.5
Kolvraa, S.6
-
64
-
-
62849091779
-
The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradation
-
PMID:19283071; DOI:10.1371/journal. pone.0004825
-
Opresko PL, Sowd G, Wang H. The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradation. PLoS ONE 2009; 4:4825; PMID:19283071; DOI:10.1371/journal. pone.0004825.
-
(2009)
PLoS ONE
, vol.4
, pp. 4825
-
-
Opresko, P.L.1
Sowd, G.2
Wang, H.3
-
65
-
-
38749136967
-
Werner syndrome helicase activity is essential in maintaining fragile site stability
-
PMID:18209099; DOI:10.1083/jcb.200705126
-
Pirzio LM, Pichierri P, Bignami M, Franchitto A. Werner syndrome helicase activity is essential in maintaining fragile site stability. J Cell Biol 2008; 180:305- 14; PMID:18209099; DOI:10.1083/jcb.200705126.
-
(2008)
J Cell Biol
, vol.180
, pp. 305-314
-
-
Pirzio, L.M.1
Pichierri, P.2
Bignami, M.3
Franchitto, A.4
-
66
-
-
0034283889
-
Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA
-
PMID:10954593; DOI:10.1093/nar/28.17.3260
-
Shen JC, Loeb LA. Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA. Nucleic Acids Res 2000; 28:3260-8; PMID:10954593; DOI:10.1093/nar/28.17.3260.
-
(2000)
Nucleic Acids Res
, vol.28
, pp. 3260-3268
-
-
Shen, J.C.1
Loeb, L.A.2
-
67
-
-
1842685207
-
The Werner syndrome protein has separable recombination and survival functions
-
Amst PMID:15084309; DOI:10.1016/j. dnarep.2004.01.002
-
Swanson C, Saintigny Y, Emond MJ, Monnat RJ Jr. The Werner syndrome protein has separable recombination and survival functions. DNA Repair (Amst) 2004; 3:475-82; PMID:15084309; DOI:10.1016/j. dnarep.2004.01.002.
-
(2004)
DNA Repair
, vol.3
, pp. 475-482
-
-
Swanson, C.1
Saintigny, Y.2
Emond, M.J.3
Monnat Jr., R.J.4
-
68
-
-
0034626770
-
Lessons from human progeroid syndromes
-
PMID:11089984; DOI:10.1038/35041705
-
Martin GM, Oshima J. Lessons from human progeroid syndromes. Nature 2000; 408:263-6; PMID:11089984; DOI:10.1038/35041705.
-
(2000)
Nature
, vol.408
, pp. 263-266
-
-
Martin, G.M.1
Oshima, J.2
-
69
-
-
55949108120
-
Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway
-
PMID:18852298; DOI:10.1083/ jcb.200803173
-
Franchitto A, Pirzio LM, Prosperi E, Sapora O, Bignami M, Pichierri P. Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway. J Cell Biol 2008; 183:241-52; PMID:18852298; DOI:10.1083/ jcb.200803173.
-
(2008)
J Cell Biol
, vol.183
, pp. 241-252
-
-
Franchitto, A.1
Pirzio, L.M.2
Prosperi, E.3
Sapora, O.4
Bignami, M.5
Pichierri, P.6
-
70
-
-
54949154104
-
Model of human aging: Recent findings on Werner's and Hutchinson-Gilford progeria syndromes
-
PMID:18982914
-
Ding SL, Shen CY. Model of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromes. Clin Interv Aging 2008; 3:431-44; PMID:18982914.
-
(2008)
Clin Interv Aging
, vol.3
, pp. 431-444
-
-
Ding, S.L.1
Shen, C.Y.2
-
71
-
-
69949144385
-
Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A
-
Albany NY PMID:19851476
-
Musich PR, Zou Y. Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A. Aging (Albany NY) 2009; 1:28-37; PMID:19851476.
-
(2009)
Aging
, vol.1
, pp. 28-37
-
-
Musich, P.R.1
Zou, Y.2
-
72
-
-
0033119701
-
Defending genome integrity during DNA replication: A proposed role for RecQ family helicases
-
PMID:10377891; DOI:10.1002/(SICI)1521- 1878(199904)21:4<286::AID- BIES4>3.0.CO;2-Z
-
Chakraverty RK, Hickson ID. Defending genome integrity during DNA replication: a proposed role for RecQ family helicases. Bioessays 1999; 21:286- 94; PMID:10377891; DOI:10.1002/(SICI)1521- 1878(199904)21:4<286::AID- BIES4>3.0.CO;2-Z.
-
(1999)
Bioessays
, vol.21
, pp. 286-294
-
-
Chakraverty, R.K.1
Hickson, I.D.2
-
73
-
-
0032522789
-
RecQ helicase, in concert with RecA and SSB proteins, initiates and disrupts DNA recombination
-
PMID:9553043; DOI:10.1101/gad.12.8.1134
-
Harmon FG, Kowalczykowski SC. RecQ helicase, in concert with RecA and SSB proteins, initiates and disrupts DNA recombination. Genes Dev 1998; 12:1134- 44; PMID:9553043; DOI:10.1101/gad.12.8.1134.
-
(1998)
Genes Dev
, vol.12
, pp. 1134-1144
-
-
Harmon, F.G.1
Kowalczykowski, S.C.2
-
74
-
-
0034001767
-
RecQ family helicases: Roles in cancer and aging
-
PMID:10679384; DOI:10.1016/S0959- (99)00039-8
-
Karow JK, Wu L, Hickson ID. RecQ family helicases: roles in cancer and aging. Curr Opin Genet Dev 2000; 10:32-8; PMID:10679384; DOI:10.1016/S0959-(99) 00039-8.
-
(2000)
Curr Opin Genet Dev
, vol.10
, pp. 32-38
-
-
Karow, J.K.1
Wu, L.2
Hickson, I.D.3
-
75
-
-
33749136403
-
Roles of Pif1-like helicases in the maintenance of genomic stability
-
PMID:16935874; DOI:10.1093/ nar/gkl561
-
Boulé JB, Zakian VA. Roles of Pif1-like helicases in the maintenance of genomic stability. Nucleic Acids Res 2006; 34:4147-53; PMID:16935874; DOI:10.1093/ nar/gkl561.
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 4147-4153
-
-
Boulé, J.B.1
Zakian, V.A.2
-
76
-
-
33751237066
-
The S. cerevisiae Rrm3p DNA helicase moves with the replication fork and affects replication of all yeast chromosomes
-
PMID:17114583; DOI:10.1101/gad.1478906
-
Azvolinsky A, Dunaway S, Torres JZ, Bessler JB, Zakian VA. The S. cerevisiae Rrm3p DNA helicase moves with the replication fork and affects replication of all yeast chromosomes. Genes Dev 2006; 20:3104- 16; PMID:17114583; DOI:10.1101/gad.1478906.
-
(2006)
Genes Dev
, vol.20
, pp. 3104-3116
-
-
Azvolinsky, A.1
Dunaway, S.2
Torres, J.Z.3
Bessler, J.B.4
Zakian, V.A.5
-
77
-
-
0037291821
-
Characterisation of the interaction between WRN, the helicase/exonuclease defective in progeroid Werner's syndrome, and an essential replication factor, PCNA
-
PMID:12633936; DOI:10.1016/S0047- 6374(02)00131-8
-
Rodríguez-López AM, Jackson DA, Nehlin JO, Iborra F, Warren AV, Cox LS. Characterisation of the interaction between WRN, the helicase/exonuclease defective in progeroid Werner's syndrome, and an essential replication factor, PCNA. Mech Ageing Dev 2003; 124:167-74; PMID:12633936; DOI:10.1016/S0047- 6374(02)00131-8.
-
(2003)
Mech Ageing Dev
, vol.124
, pp. 167-174
-
-
Rodríguez-López, A.M.1
Jackson, D.A.2
Nehlin, J.O.3
Iborra, F.4
Warren, A.V.5
Cox, L.S.6
-
78
-
-
42049116919
-
The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest
-
PMID:18250621; DOI:10.4161/cc.7.6.5566
-
Sidorova JM, Li N, Folch A, Monnat RJ Jr. The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest. Cell Cycle 2008; 7:796-807; PMID:18250621; DOI:10.4161/cc.7.6. 5566.
-
(2008)
Cell Cycle
, vol.7
, pp. 796-807
-
-
Sidorova, J.M.1
Li, N.2
Folch, A.3
Monnat Jr., R.J.4
-
79
-
-
0034712726
-
Functional interaction between the Werner Syndrome protein and DNA polymerase d
-
PMID:10781066; DOI:10.1073/pnas.97.9.4603
-
Kamath-Loeb AS, Johansson E, Burgers PM, Loeb LA. Functional interaction between the Werner Syndrome protein and DNA polymerase d. Proc Natl Acad Sci USA 2000; 97:4603-8; PMID:10781066; DOI:10.1073/pnas.97.9.4603.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 4603-4608
-
-
Kamath-Loeb, A.S.1
Johansson, E.2
Burgers, P.M.3
Loeb, L.A.4
-
80
-
-
0035844242
-
Interactions between the Werner syndrome helicase and DNA polymerase d specifically facilitate copying of tetraplex and hairpin structures of the d(CGG)n trinucleotide repeat sequence
-
PMID:11279038; DOI:10.1074/jbc.M100253200
-
Kamath-Loeb AS, Loeb LA, Johansson E, Burgers PM, Fry M. Interactions between the Werner syndrome helicase and DNA polymerase d specifically facilitate copying of tetraplex and hairpin structures of the d(CGG)n trinucleotide repeat sequence. J Biol Chem 2001; 276:16439-46; PMID:11279038; DOI:10.1074/jbc.M100253200.
-
(2001)
J Biol Chem
, vol.276
, pp. 16439-16446
-
-
Kamath-Loeb, A.S.1
Loeb, L.A.2
Johansson, E.3
Burgers, P.M.4
Fry, M.5
-
81
-
-
33748947104
-
Accumulation of FFA-1, the Xenopus homolog of Werner helicase and DNA polymerase d on chromatin in response to replication fork arrest
-
PMID:16798775; DOI:10.1093/jb/mvj130
-
Sasakawa N, Fukui T, Waga S. Accumulation of FFA-1, the Xenopus homolog of Werner helicase and DNA polymerase d on chromatin in response to replication fork arrest. J Biochem 2006; 140:95-103; PMID:16798775; DOI:10.1093/jb/mvj130.
-
(2006)
J Biochem
, vol.140
, pp. 95-103
-
-
Sasakawa, N.1
Fukui, T.2
Waga, S.3
-
82
-
-
77950355795
-
DNA structure and the Werner protein modulate human DNA polymerase d-dependent replication dynamics within the common fragile site FRA16D
-
PMID:19969545; DOI:10.1093/nar/gkp1131
-
Shah SN, Opresko PL, Meng X, Lee MY, Eckert KA. DNA structure and the Werner protein modulate human DNA polymerase d-dependent replication dynamics within the common fragile site FRA16D. Nucleic Acids Res 2010; 38:1149-62; PMID:19969545; DOI:10.1093/nar/gkp1131.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 1149-1162
-
-
Shah, S.N.1
Opresko, P.L.2
Meng, X.3
Lee, M.Y.4
Eckert, K.A.5
-
83
-
-
80051662527
-
The Werner syndrome protein: Linking the replication checkpoint response to genome stability
-
Albany NY PMID:21389352
-
Pichierri P, Ammazzalorso F, Bignami M, Franchitto A. The Werner syndrome protein: linking the replication checkpoint response to genome stability. Aging (Albany NY) 2011; 3:311-8; PMID:21389352.
-
(2011)
Aging
, vol.3
, pp. 311-318
-
-
Pichierri, P.1
Ammazzalorso, F.2
Bignami, M.3
Franchitto, A.4
-
84
-
-
77956881105
-
ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery
-
PMID:20802463; DOI:10.1038/emboj.2010.205
-
Ammazzalorso F, Pirzio LM, Bignami M, Franchitto A, Pichierri P. ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery. EMBO J 2010; 29:3156-69; PMID:20802463; DOI:10.1038/emboj.2010.205.
-
(2010)
EMBO J
, vol.29
, pp. 3156-3169
-
-
Ammazzalorso, F.1
Pirzio, L.M.2
Bignami, M.3
Franchitto, A.4
Pichierri, P.5
-
85
-
-
33846141125
-
Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest
-
PMID:17118963; DOI:10.1242/jcs.03291
-
Otterlei M, Bruheim P, Ahn B, Bussen W, Karmakar P, Baynton K, et al. Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest. J Cell Sci 2006; 119:5137-46; PMID:17118963; DOI:10.1242/jcs.03291.
-
(2006)
J Cell Sci
, vol.119
, pp. 5137-5146
-
-
Otterlei, M.1
Bruheim, P.2
Ahn, B.3
Bussen, W.4
Karmakar, P.5
Baynton, K.6
-
86
-
-
0037435026
-
Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle
-
PMID:12629512; DOI:10.1038/ sj.onc.1206169
-
Pichierri P, Rosselli F, Franchitto A. Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle. Oncogene 2003; 22:1491-500; PMID:12629512; DOI:10.1038/ sj.onc.1206169.
-
(2003)
Oncogene
, vol.22
, pp. 1491-1500
-
-
Pichierri, P.1
Rosselli, F.2
Franchitto, A.3
-
87
-
-
78650724206
-
Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories
-
PMID:21173116; DOI:10.1083/jcb.201007074
-
Ge XQ, Blow JJ. Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories. J Cell Biol 2010; 191:1285-97; PMID:21173116; DOI:10.1083/jcb.201007074.
-
(2010)
J Cell Biol
, vol.191
, pp. 1285-1297
-
-
Ge, X.Q.1
Blow, J.J.2
-
88
-
-
3242670803
-
ATR and ATM regulate the timing of DNA replication origin firing
-
PMID:15220931; DOI:10.1038/ncb1145
-
Shechter D, Costanzo V, Gautier J. ATR and ATM regulate the timing of DNA replication origin firing. Nat Cell Biol 2004; 6:648-55; PMID:15220931; DOI:10.1038/ncb1145.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 648-655
-
-
Shechter, D.1
Costanzo, V.2
Gautier, J.3
-
89
-
-
0024465870
-
Mutator phenotype of Werner syndrome is characterized by extensive deletions
-
PMID:2762303; DOI:10.1073/pnas.86.15.5893
-
Fukuchi K, Martin GM, Monnat RJ Jr. Mutator phenotype of Werner syndrome is characterized by extensive deletions. Proc Natl Acad Sci USA 1989; 86:5893- 7; PMID:2762303; DOI:10.1073/pnas.86.15.5893.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 5893-5897
-
-
Fukuchi, K.1
Martin, G.M.2
Monnat Jr., R.J.3
-
90
-
-
33748623634
-
Common fragile sites as targets for chromosome rearrangements
-
Amst PMID:16807141; DOI:10.1016/j. dnarep.2006.05.010
-
Arlt MF, Durkin SG, Ragland RL, Glover TW. Common fragile sites as targets for chromosome rearrangements. DNA Repair (Amst) 2006; 5:1126-35; PMID:16807141; DOI:10.1016/j. dnarep.2006.05.010.
-
(2006)
DNA Repair
, vol.5
, pp. 1126-1135
-
-
Arlt, M.F.1
Durkin, S.G.2
Ragland, R.L.3
Glover, T.W.4
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