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Volumn 20, Issue 2, 2015, Pages 1872-1903

Natural products as leads in schistosome drug discovery

Author keywords

Chemical scaffolds; Leads; Natural products; Schistosomiasis; Virtual screening

Indexed keywords

ANTISCHISTOSOMAL AGENT; ARACHIDONIC ACID DERIVATIVE; ARTEMISININ DERIVATIVE; BIOLOGICAL PRODUCT; QUINOLINE DERIVATIVE; TERPENE;

EID: 84921653041     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules20021872     Document Type: Review
Times cited : (76)

References (198)
  • 2
    • 84949102352 scopus 로고    scopus 로고
    • Available online accessed on 10 December 2014
    • WHO Schistosomiasis. 2014, Fact Sheet. Available online: http://www.who.int/mediacentre/ factsheets/fs115/en (accessed on 10 December 2014).
    • (2014) Fact Sheet
    • WHO Schistosomiasis1
  • 5
    • 0017622884 scopus 로고
    • Praziquantel, a new board-spectrum antischistosomal agent
    • Gönnert, R.; Andrews, P. Praziquantel, a new board-spectrum antischistosomal agent. Z. Parasitenkd. 1977, 52, 129-150.
    • (1977) Z. Parasitenkd , vol.52 , pp. 129-150
    • Gönnert, R.1    Andrews, P.2
  • 7
    • 82955212953 scopus 로고    scopus 로고
    • Effect of praziquantel prolonged administration on granuloma formation around Schistosoma japonicum eggs in lung of sensitized mice
    • Huang, Y.; Xu, Y.; Yu, C.; Li, H.; Yin, X.; Wang, T.; Wang, W.; Liang, Y. Effect of praziquantel prolonged administration on granuloma formation around Schistosoma japonicum eggs in lung of sensitized mice. Parasitol. Res. 2011, 109, 1453-1459.
    • (2011) Parasitol. Res. , vol.109 , pp. 1453-1459
    • Huang, Y.1    Xu, Y.2    Yu, C.3    Li, H.4    Yin, X.5    Wang, T.6    Wang, W.7    Liang, Y.8
  • 8
    • 84866016930 scopus 로고    scopus 로고
    • Therapeutic effect of alpha lipoic acid combined with praziquantel on liver fibrosis induced by Schistosoma mansoni challenged mice
    • Abdel-Hafeez, E.H.; Ahmad, A.K.; Abdulla, A.M.; Aabdel-Wahab, S.; Mosalem, F.A. Therapeutic effect of alpha lipoic acid combined with praziquantel on liver fibrosis induced by Schistosoma mansoni challenged mice. Parasitol. Res. 2012, 111, 577-586.
    • (2012) Parasitol. Res. , vol.111 , pp. 577-586
    • Abdel-Hafeez, E.H.1    Ahmad, A.K.2    Abdulla, A.M.3    Aabdel-Wahab, S.4    Mosalem, F.A.5
  • 9
    • 0029738033 scopus 로고    scopus 로고
    • Characterization of isolates of Schistosoma mansoni from Egyptian villagers that tolerate high doses of praziquantel
    • Ismail, M.; Metwally, A.; Farghaly, A.; Bruce, J.; Tao, L.F.; Bennett, J.L. Characterization of isolates of Schistosoma mansoni from Egyptian villagers that tolerate high doses of praziquantel. Am. J. Trop. Med. Hyg. 1996, 55, 214-218.
    • (1996) Am. J. Trop. Med. Hyg. , vol.55 , pp. 214-218
    • Ismail, M.1    Metwally, A.2    Farghaly, A.3    Bruce, J.4    Tao, L.F.5    Bennett, J.L.6
  • 11
    • 0029009379 scopus 로고
    • Short report: Diminished susceptibility to praziquantel in a Senegal isolate of Schistosoma mansoni
    • Fallon, P.G.; Sturrock, R.F.; Niang, A.C.; Doenhoff, M.J. Short report: Diminished susceptibility to praziquantel in a Senegal isolate of Schistosoma mansoni. Am. J. Trop. Med. Hyg. 1995, 53, 61-62.
    • (1995) Am. J. Trop. Med. Hyg. , vol.53 , pp. 61-62
    • Fallon, P.G.1    Sturrock, R.F.2    Niang, A.C.3    Doenhoff, M.J.4
  • 13
    • 0028025029 scopus 로고
    • Drug-resistant schistosomiasis: Resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific
    • Fallon, P.G.; Doenhoff, M.J. Drug-resistant schistosomiasis: Resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific. Am. J. Trop. Med. Hyg. 1994, 51, 83-88.
    • (1994) Am. J. Trop. Med. Hyg. , vol.51 , pp. 83-88
    • Fallon, P.G.1    Doenhoff, M.J.2
  • 14
    • 0028719106 scopus 로고
    • Laboratory induced resistance to praziquantel in experimental schistosomiasis
    • Ismail, M.M.; Taha, S.A.; Farghaly, A.M.; El-Azony, A.S. Laboratory induced resistance to praziquantel in experimental schistosomiasis. J. Egypt. Soc. Parasitol. 1994, 24, 685-695.
    • (1994) J. Egypt. Soc. Parasitol. , vol.24 , pp. 685-695
    • Ismail, M.M.1    Taha, S.A.2    Farghaly, A.M.3    El-Azony, A.S.4
  • 15
    • 80052091736 scopus 로고    scopus 로고
    • Rule-based classification of chemical structures by scaffold
    • Schuffenhauer, A.; Varin, T. Rule-Based Classification of Chemical Structures by Scaffold. Mol. Inf. 2011, 47, 646-664.
    • (2011) Mol. Inf. , vol.47 , pp. 646-664
    • Schuffenhauer, A.1    Varin, T.2
  • 16
    • 84858308226 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the 30 years from 1981 to 2010
    • Newman, D.J.; Cragg, G.M. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J. Nat. Prod. 2012, 75, 311-335.
    • (2012) J. Nat. Prod. , vol.75 , pp. 311-335
    • Newman, D.J.1    Cragg, G.M.2
  • 17
    • 52049109838 scopus 로고    scopus 로고
    • Natural products in drug discovery
    • Harvey, A.L. Natural products in drug discovery. Drug Discov. Today 2008, 13, 894-901.
    • (2008) Drug Discov. Today , vol.13 , pp. 894-901
    • Harvey, A.L.1
  • 21
    • 11344292132 scopus 로고    scopus 로고
    • The role of natural product chemistry in drug discovery
    • Butler, M.S. The role of natural product chemistry in drug discovery. J. Nat. Prod. 2004, 67, 2141-2153.
    • (2004) J. Nat. Prod. , vol.67 , pp. 2141-2153
    • Butler, M.S.1
  • 22
    • 80054923170 scopus 로고    scopus 로고
    • Modern drug discovery technologies: Opportunities and challenges in lead discovery
    • Guido, R.V.C.; Oliva, G.; Andricopulo, A.D. Modern drug discovery technologies: Opportunities and challenges in lead discovery. Comb. Chem. High Throughput Screen. 2011, 14, 830-839.
    • (2011) Comb. Chem. High Throughput Screen. , vol.14 , pp. 830-839
    • Guido, R.V.C.1    Oliva, G.2    Andricopulo, A.D.3
  • 23
    • 36348987143 scopus 로고    scopus 로고
    • The value of natural products to future pharmaceutical discovery
    • Baker, D.D.; Chu, M.; Oza, U.; Rajgarhia, V. The value of natural products to future pharmaceutical discovery. Nat. Prod. Rep. 2007, 24, 1225-1244.
    • (2007) Nat. Prod. Rep. , vol.24 , pp. 1225-1244
    • Baker, D.D.1    Chu, M.2    Oza, U.3    Rajgarhia, V.4
  • 24
    • 42949149681 scopus 로고    scopus 로고
    • Modern natural products chemistry and drug discovery
    • Ojima, I. Modern natural products chemistry and drug discovery. J. Med. Chem. 2008, 51, 2587-2588.
    • (2008) J. Med. Chem. , vol.51 , pp. 2587-2588
    • Ojima, I.1
  • 25
    • 84921653624 scopus 로고    scopus 로고
    • Available online accessed on 12 December 2014
    • TimTec Natural Products Library. Available online: http://www.timtec.net/natural-compound-library.htm (accessed on 12 December 2014).
    • TimTec Natural Products Library1
  • 26
    • 84921672455 scopus 로고    scopus 로고
    • Available online accessed on 10 December 2014
    • IBScreen Natural Products. Available online: http://www.ibscreen.com/index.htm (accessed on 10 December 2014).
    • IBScreen Natural Products1
  • 27
    • 84921672454 scopus 로고    scopus 로고
    • Available online accessed on 10 December 2014
    • Specs Natural Products. Available online: http://www.specs.net/ (accessed on 10 December 2014).
    • Specs Natural Products1
  • 28
    • 78049522482 scopus 로고    scopus 로고
    • Identification of bioactive natural products by pharmacophore-based virtual screening
    • Schuster, D.; Wolber, G. Identification of bioactive natural products by pharmacophore-based virtual screening. Curr. Pharm. Des. 2010, 16, 1666-1681.
    • (2010) Curr. Pharm. Des. , vol.16 , pp. 1666-1681
    • Schuster, D.1    Wolber, G.2
  • 29
    • 84855824565 scopus 로고    scopus 로고
    • Natural products of dietary origin as lead compounds in virtual screening and drug design
    • Geldenhuys, W.J.; Bishayee, A.; Darvesh, A.S.; Carroll, R.T. Natural products of dietary origin as lead compounds in virtual screening and drug design. Curr. Pharm. Biotechnol. 2012, 13, 117-124.
    • (2012) Curr. Pharm. Biotechnol. , vol.13 , pp. 117-124
    • Geldenhuys, W.J.1    Bishayee, A.2    Darvesh, A.S.3    Carroll, R.T.4
  • 30
    • 84875084369 scopus 로고    scopus 로고
    • Natural products as a source for treating neglected parasitic diseases
    • Ndjonka, D.; Rapado, L.N.; Silber, A.M.; Liebau, E.; Wrenger, C. Natural products as a source for treating neglected parasitic diseases. Int. J. Mol. Sci. 2013, 14, 3395-3439.
    • (2013) Int. J. Mol. Sci. , vol.14 , pp. 3395-3439
    • Ndjonka, D.1    Rapado, L.N.2    Silber, A.M.3    Liebau, E.4    Wrenger, C.5
  • 31
    • 0015820846 scopus 로고
    • A comparative study of the reproductive system of mature, immature and "unisexual" female Schistosoma mansoni
    • Erasmus, D.A. A comparative study of the reproductive system of mature, immature and "unisexual" female Schistosoma mansoni. Parasitology 1973, 67, 165-183.
    • (1973) Parasitology , vol.67 , pp. 165-183
    • Erasmus, D.A.1
  • 32
    • 84893789834 scopus 로고    scopus 로고
    • Serotonin signaling in Schistosoma mansoni: A serotonin-activated G protein-coupled receptor controls parasite movement
    • Patocka, N.; Sharma, N.; Rashid, M.; Ribeiro, P. Serotonin signaling in Schistosoma mansoni: A serotonin-activated G protein-coupled receptor controls parasite movement. PLoS Pathog. 2014, 10, e1003878.
    • (2014) PLoS Pathog. , vol.10 , pp. e1003878
    • Patocka, N.1    Sharma, N.2    Rashid, M.3    Ribeiro, P.4
  • 33
    • 84885386465 scopus 로고    scopus 로고
    • Neurotransmitter transporters in schistosomes: Structure, function and prospects for drug discovery
    • Ribeiro, P.; Patocka, N. Neurotransmitter transporters in schistosomes: Structure, function and prospects for drug discovery. Parasitol. Int. 2013, 62, 629-638.
    • (2013) Parasitol. Int. , vol.62 , pp. 629-638
    • Ribeiro, P.1    Patocka, N.2
  • 34
    • 70350244564 scopus 로고    scopus 로고
    • Schistosoma genomics: New perspectives on schistosome biology and host-parasite interaction
    • Han, Z.-G.; Brindley, P.J.; Wang, S.-Y.; Chen, Z. Schistosoma genomics: New perspectives on schistosome biology and host-parasite interaction. Annu. Rev. Genomics Hum. Genet. 2009, 10, 211-240.
    • (2009) Annu. Rev. Genomics Hum. Genet. , vol.10 , pp. 211-240
    • Han, Z.-G.1    Brindley, P.J.2    Wang, S.-Y.3    Chen, Z.4
  • 35
    • 0033035094 scopus 로고    scopus 로고
    • Artemisinin drugs in the treatment of malaria: From medicinal herb to registered medication
    • Van Agtmael, M.A.; Eggelte, T.A.; van Boxtel, C.J. Artemisinin drugs in the treatment of malaria: From medicinal herb to registered medication. Trends Pharmacol. Sci. 1999, 20, 199-205.
    • (1999) Trends Pharmacol. Sci. , vol.20 , pp. 199-205
    • Van Agtmael, M.A.1    Eggelte, T.A.2    Van Boxtel, C.J.3
  • 36
    • 84896719929 scopus 로고    scopus 로고
    • Artemisinins: Pharmacological actions beyond anti-malarial
    • Ho, W.E.; Peh, H.Y.; Chan, T.K.; Wong, W.S. F. Artemisinins: Pharmacological actions beyond anti-malarial. Pharmacol. Ther. 2014, 142, 126-139.
    • (2014) Pharmacol. Ther. , vol.142 , pp. 126-139
    • Ho, W.E.1    Peh, H.Y.2    Chan, T.K.3    Wong, W.S.F.4
  • 37
    • 84865988767 scopus 로고    scopus 로고
    • Qinghaosu (artemisinin): Chemistry and pharmacology
    • Li, Y. Qinghaosu (artemisinin): Chemistry and pharmacology. Acta Pharmacol. Sin. 2012, 33, 1141-1146.
    • (2012) Acta Pharmacol. Sin. , vol.33 , pp. 1141-1146
    • Li, Y.1
  • 40
    • 84863474441 scopus 로고    scopus 로고
    • Effect of the in vivo activity of dihydroartemisinin against Schistosoma mansoni infection in mice
    • Li, H.; Wang, W.; Qu, G.; Li, Y.; Tao, Y.; Xing, Y.; Wang, X.; Dai, Y.; Wei, J.; Dai, J.; et al. Effect of the in vivo activity of dihydroartemisinin against Schistosoma mansoni infection in mice. Parasitol. Res. 2012, 110, 1727-1732.
    • (2012) Parasitol. Res. , vol.110 , pp. 1727-1732
    • Li, H.1    Wang, W.2    Qu, G.3    Li, Y.4    Tao, Y.5    Xing, Y.6    Wang, X.7    Dai, Y.8    Wei, J.9    Dai, J.10
  • 42
    • 31044454267 scopus 로고    scopus 로고
    • Evaluation of the anthelmintic effects of artesunate against experimental Schistosoma mansoni infection in mice using different treatment protocols
    • Shaohong, L.; Kumagai, T.; Qinghua, A.; Xiaolan, Y.; Ohmae, H.; Yabu, Y.; Siwen, L.; Liyong, W.; Maruyama, H.; Ohta, N. Evaluation of the anthelmintic effects of artesunate against experimental Schistosoma mansoni infection in mice using different treatment protocols. Parasitol. Int. 2006, 55, 63-68.
    • (2006) Parasitol. Int. , vol.55 , pp. 63-68
    • Shaohong, L.1    Kumagai, T.2    Qinghua, A.3    Xiaolan, Y.4    Ohmae, H.5    Yabu, Y.6    Siwen, L.7    Liyong, W.8    Maruyama, H.9    Ohta, N.10
  • 43
    • 84895510569 scopus 로고    scopus 로고
    • Efficacy of artemether and artesunate in mice infected with praziquantel non-susceptible isolate of Schistosoma japonicum
    • Wang, W.; Li, T.-Y.; Ji, Y.; Qu, G.-L.; Qian, Y.-L.; Li, H.-J.; Dai, J.-R.; Liang, Y.-S. Efficacy of artemether and artesunate in mice infected with praziquantel non-susceptible isolate of Schistosoma japonicum. Parasitol. Res. 2014, 113, 925-931.
    • (2014) Parasitol. Res. , vol.113 , pp. 925-931
    • Wang, W.1    Li, T.-Y.2    Ji, Y.3    Qu, G.-L.4    Qian, Y.-L.5    Li, H.-J.6    Dai, J.-R.7    Liang, Y.-S.8
  • 44
    • 21544479736 scopus 로고    scopus 로고
    • Effects of praziquantel and artesunate on the tegument of adult Schistosoma mekongi harboured in mice
    • Jiraungkoorskul, W.; Sahaphong, S.; Sobhon, P.; Riengrojpitak, S.; Kangwanrangsan, N. Effects of praziquantel and artesunate on the tegument of adult Schistosoma mekongi harboured in mice. Parasitol. Int. 2005, 54, 177-183.
    • (2005) Parasitol. Int. , vol.54 , pp. 177-183
    • Jiraungkoorskul, W.1    Sahaphong, S.2    Sobhon, P.3    Riengrojpitak, S.4    Kangwanrangsan, N.5
  • 45
    • 0034599096 scopus 로고    scopus 로고
    • Preventive effect of artemether in experimental animals infected with Schistosoma mansoni
    • Shuhua, X.; Chollet, J.; Weiss, N.; Bergquist, R.N.; Tanner, M. Preventive effect of artemether in experimental animals infected with Schistosoma mansoni. Parasitol. Int. 2000, 49, 19-24.
    • (2000) Parasitol. Int. , vol.49 , pp. 19-24
    • Shuhua, X.1    Chollet, J.2    Weiss, N.3    Bergquist, R.N.4    Tanner, M.5
  • 46
    • 84882239760 scopus 로고    scopus 로고
    • In vivo effect of single oral dose of artemether against early juvenile stages of Schistosoma mansoni Egyptian strain
    • El-Beshbishi, S.N.; Taman, A.; El-Malky, M.; Azab, M.S.; El-Hawary, A.K.; El-Tantawy, D. In vivo effect of single oral dose of artemether against early juvenile stages of Schistosoma mansoni Egyptian strain. Exp. Parasitol. 2013, 135, 240-245.
    • (2013) Exp. Parasitol. , vol.135 , pp. 240-245
    • El-Beshbishi, S.N.1    Taman, A.2    El-Malky, M.3    Azab, M.S.4    El-Hawary, A.K.5    El-Tantawy, D.6
  • 47
    • 0033841737 scopus 로고    scopus 로고
    • Effect of artemether against Schistosoma haematobium in experimentally infected hamsters
    • Shuhua, X.; Utzinger, J.; Chollet, J.; Endriss, Y.; N'Goran, E.K.; Tanner, M. Effect of artemether against Schistosoma haematobium in experimentally infected hamsters. Int. J. Parasitol. 2000, 30, 1001-1006.
    • (2000) Int. J. Parasitol. , vol.30 , pp. 1001-1006
    • Shuhua, X.1    Utzinger, J.2    Chollet, J.3    Endriss, Y.4    N'Goran, E.K.5    Tanner, M.6
  • 49
    • 80052313469 scopus 로고    scopus 로고
    • Effects of artemether, artesunate and dihydroartemisinin administered orally at multiple doses or combination in treatment of mice infected with Schistosoma japonicum
    • Li, H.-J.; Wang, W.; Li, Y.-Z.; Qu, G.-L.; Xing, Y.-T.; Tao, Y.-H.; Wei, J.-Y.; Dai, J.-R.; Liang, Y.-S. Effects of artemether, artesunate and dihydroartemisinin administered orally at multiple doses or combination in treatment of mice infected with Schistosoma japonicum. Parasitol. Res. 2011, 109, 515-519.
    • (2011) Parasitol. Res. , vol.109 , pp. 515-519
    • Li, H.-J.1    Wang, W.2    Li, Y.-Z.3    Qu, G.-L.4    Xing, Y.-T.5    Tao, Y.-H.6    Wei, J.-Y.7    Dai, J.-R.8    Liang, Y.-S.9
  • 50
    • 0344451208 scopus 로고    scopus 로고
    • Schistosoma japonicum: In vitro effects of artemether combined with haemin depend on cultivation media and appraisal of artemether products appearing in the media
    • Xiao, S.-H.; Wu, Y.-L.; Tanner, M.; Wu, W.-M.; Utzinger, J.; Mei, J.-Y.; Scorneaux, B.; Chollet, J.; Zhai, Z. Schistosoma japonicum: In vitro effects of artemether combined with haemin depend on cultivation media and appraisal of artemether products appearing in the media. Parasitol. Res. 2003, 89, 459-466.
    • (2003) Parasitol. Res. , vol.89 , pp. 459-466
    • Xiao, S.-H.1    Wu, Y.-L.2    Tanner, M.3    Wu, W.-M.4    Utzinger, J.5    Mei, J.-Y.6    Scorneaux, B.7    Chollet, J.8    Zhai, Z.9
  • 52
    • 0031148701 scopus 로고    scopus 로고
    • Schistosoma mansoni: The developmental regulation and immunolocalization of antioxidant enzymes
    • Mei, H.; LoVerde, P.T. Schistosoma mansoni: The developmental regulation and immunolocalization of antioxidant enzymes. Exp. Parasitol. 1997, 86, 69-78.
    • (1997) Exp. Parasitol. , vol.86 , pp. 69-78
    • Mei, H.1    LoVerde, P.T.2
  • 53
    • 84907007344 scopus 로고    scopus 로고
    • Repurposing drugs for the treatment and control of helminth infections
    • Panic, G.; Duthaler, U.; Speich, B.; Keiser, J. Repurposing drugs for the treatment and control of helminth infections. Int. J. Parasitol. 2014, 4, 185-200.
    • (2014) Int. J. Parasitol. , vol.4 , pp. 185-200
    • Panic, G.1    Duthaler, U.2    Speich, B.3    Keiser, J.4
  • 54
    • 84907916642 scopus 로고    scopus 로고
    • New uses for old drugs: The tale of artemisinin derivatives in the elimination of schistosomiasis japonica in China
    • Liu, Y.-X.; Wu, W.; Liang, Y.-J.; Jie, Z.-L.; Wang, H.; Wang, W.; Huang, Y.-X. New uses for old drugs: The tale of artemisinin derivatives in the elimination of schistosomiasis japonica in China. Molecules 2014, 19, 15058-15074.
    • (2014) Molecules , vol.19 , pp. 15058-15074
    • Liu, Y.-X.1    Wu, W.2    Liang, Y.-J.3    Jie, Z.-L.4    Wang, H.5    Wang, W.6    Huang, Y.-X.7
  • 56
    • 0034656258 scopus 로고    scopus 로고
    • Oral artemether for prevention of Schistosoma mansoni infection: Randomised controlled trial
    • Utzinger, J.; N'Goran, E.K.; N'Dri, A.; Lengeler, C.; Xiao, S.; Tanner, M. Oral artemether for prevention of Schistosoma mansoni infection: Randomised controlled trial. Lancet 2000, 355, 1320-1325.
    • (2000) Lancet , vol.355 , pp. 1320-1325
    • Utzinger, J.1    N'Goran, E.K.2    N'Dri, A.3    Lengeler, C.4    Xiao, S.5    Tanner, M.6
  • 57
    • 77950974016 scopus 로고    scopus 로고
    • Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, and praziquantel against Schistosoma haematobium: Randomized, exploratory open-label trial
    • Keiser, J.; N'Guessan, N.A.; Adoubryn, K.D.; Silué, K.D.; Vounatsou, P.; Hatz, C.; Utzinger, J.; N'Goran, E.K. Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, and praziquantel against Schistosoma haematobium: Randomized, exploratory open-label trial. Clin. Infect. Dis. 2010, 50, 1205-1213.
    • (2010) Clin. Infect. Dis. , vol.50 , pp. 1205-1213
    • Keiser, J.1    N'Guessan, N.A.2    Adoubryn, K.D.3    Silué, K.D.4    Vounatsou, P.5    Hatz, C.6    Utzinger, J.7    N'Goran, E.K.8
  • 58
    • 77955923218 scopus 로고    scopus 로고
    • Efficacy of artesunate with sulfalene plus pyrimethamine versus praziquantel for treatment of Schistosoma mansoni in Kenyan children: An open-label randomised controlled trial
    • Obonyo, C.O.; Muok, E.M.O.; Mwinzi, P.N.M. Efficacy of artesunate with sulfalene plus pyrimethamine versus praziquantel for treatment of Schistosoma mansoni in Kenyan children: An open-label randomised controlled trial. Lancet Infect. Dis. 2010, 10, 603-611.
    • (2010) Lancet Infect. Dis. , vol.10 , pp. 603-611
    • Obonyo, C.O.1    Muok, E.M.O.2    Mwinzi, P.N.M.3
  • 60
    • 80054087269 scopus 로고    scopus 로고
    • Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: A systematic review and meta-analysis
    • Liu, R.; Dong, H.-F.; Guo, Y.; Zhao, Q.-P.; Jiang, M.-S. Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: A systematic review and meta-analysis. Parasit. Vectors 2011, 4, 201.
    • (2011) Parasit. Vectors , vol.4 , pp. 201
    • Liu, R.1    Dong, H.-F.2    Guo, Y.3    Zhao, Q.-P.4    Jiang, M.-S.5
  • 61
    • 84866675899 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of artemisinin based therapies for the treatment and prevention of schistosomiasis
    • Pérez del Villar, L.; Burguillo, F.J.; López-Abán, J.; Muro, A. Systematic review and meta-analysis of artemisinin based therapies for the treatment and prevention of schistosomiasis. PLoS One 2012, 7, e45867.
    • (2012) PLoS One , vol.7 , pp. e45867
    • Pérez Del Villar, L.1    Burguillo, F.J.2    López-Abán, J.3    Muro, A.4
  • 67
    • 0035726697 scopus 로고    scopus 로고
    • African ethnobotany and healthcare: Emphasis on mozambique
    • Bandeira, S.O.; Gaspar, F.; Pagula, F.P. African ethnobotany and healthcare: Emphasis on mozambique. Pharm. Biol. 2001, 39 (Suppl. S1), 70-73.
    • (2001) Pharm. Biol. , vol.39 , pp. 70-73
    • Bandeira, S.O.1    Gaspar, F.2    Pagula, F.P.3
  • 71
    • 84867504178 scopus 로고    scopus 로고
    • Activity of compounds isolated from Baccharis dracunculifolia D.C. (Asteraceae) against Paracoccidioides brasiliensis
    • Johann, S.; Oliveira, F.B.; Siqueira, E.P.; Cisalpino, P.S.; Rosa, C.A.; Alves, T.M.A.; Zani, C.L.; Cota, B.B. Activity of compounds isolated from Baccharis dracunculifolia D.C. (Asteraceae) against Paracoccidioides brasiliensis. Med. Mycol. 2012, 50, 843-851.
    • (2012) Med. Mycol. , vol.50 , pp. 843-851
    • Johann, S.1    Oliveira, F.B.2    Siqueira, E.P.3    Cisalpino, P.S.4    Rosa, C.A.5    Alves, T.M.A.6    Zani, C.L.7    Cota, B.B.8
  • 74
    • 0026858425 scopus 로고
    • Antischistosomal activities of sesquiterpene lactones and steroid glucosides from Vernonia amygdalina, possibly used by wild chimpanzees against parasite-related diseases
    • Jisaka, M.; Kawanaka, M.; Sugiyama, H.; Takegawa, K.; Huffman, M.A.; Ohigashi, H.; Koshimizu, K. Antischistosomal activities of sesquiterpene lactones and steroid glucosides from Vernonia amygdalina, possibly used by wild chimpanzees against parasite-related diseases. Biosci. Biotechnol. Biochem. 1992, 56, 845-846.
    • (1992) Biosci. Biotechnol. Biochem. , vol.56 , pp. 845-846
    • Jisaka, M.1    Kawanaka, M.2    Sugiyama, H.3    Takegawa, K.4    Huffman, M.A.5    Ohigashi, H.6    Koshimizu, K.7
  • 76
    • 67650786530 scopus 로고    scopus 로고
    • The Schistosoma japonicum genome reveals features of host-parasite interplay
    • Consortium, F.A. The Schistosoma japonicum genome reveals features of host-parasite interplay. Nature 2009, 460, 345-351.
    • (2009) Nature , vol.460 , pp. 345-351
    • Consortium, F.A.1
  • 79
    • 79957980956 scopus 로고    scopus 로고
    • Characterization of the phytochelatin synthase of Schistosoma mansoni
    • Ray, D.; Williams, D.L. Characterization of the phytochelatin synthase of Schistosoma mansoni . PLoS Negl. Trop. Dis. 2011, 5, e1168.
    • (2011) PLoS Negl. Trop. Dis. , vol.5 , pp. e1168
    • Ray, D.1    Williams, D.L.2
  • 80
    • 84887458904 scopus 로고    scopus 로고
    • Characterization of potential drug targets farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase in Schistosoma mansoni
    • Ziniel, P.D.; Desai, J.; Cass, C.L.; Gatto, C.; Oldfield, E.; Williams, D.L. Characterization of potential drug targets farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase in Schistosoma mansoni. Antimicrob. Agents Chemother. 2013, 57, 5969-5976.
    • (2013) Antimicrob. Agents Chemother. , vol.57 , pp. 5969-5976
    • Ziniel, P.D.1    Desai, J.2    Cass, C.L.3    Gatto, C.4    Oldfield, E.5    Williams, D.L.6
  • 82
    • 84866004507 scopus 로고    scopus 로고
    • Pharmacological actions and therapeutic applications of Salvia miltiorrhiza depside salt and its active components
    • Wu, W.; Wang, Y. Pharmacological actions and therapeutic applications of Salvia miltiorrhiza depside salt and its active components. Acta Pharmacol. Sin. 2012, 33, 1119-1130.
    • (2012) Acta Pharmacol. Sin. , vol.33 , pp. 1119-1130
    • Wu, W.1    Wang, Y.2
  • 83
    • 27844511101 scopus 로고    scopus 로고
    • Danshen: An overview of its chemistry, pharmacology, pharmacokinetics, and clinical use
    • Zhou, L.; Zuo, Z.; Chow, M.S.S. Danshen: An overview of its chemistry, pharmacology, pharmacokinetics, and clinical use. J. Clin. Pharmacol. 2005, 45, 1345-1359.
    • (2005) J. Clin. Pharmacol. , vol.45 , pp. 1345-1359
    • Zhou, L.1    Zuo, Z.2    Chow, M.S.S.3
  • 85
    • 84881434938 scopus 로고    scopus 로고
    • Thioredoxin glutathione reductase-dependent redox networks in platyhelminth parasites
    • Williams, D.L.; Bonilla, M.; Gladyshev, V.N.; Salinas, G. Thioredoxin glutathione reductase-dependent redox networks in platyhelminth parasites. Antioxid. Redox Signal. 2013, 19, 735-745.
    • (2013) Antioxid. Redox Signal. , vol.19 , pp. 735-745
    • Williams, D.L.1    Bonilla, M.2    Gladyshev, V.N.3    Salinas, G.4
  • 87
    • 79953135337 scopus 로고    scopus 로고
    • Linked thioredoxin-glutathione systems in platyhelminth parasites: Alternative pathways for glutathione reduction and deglutathionylation
    • Bonilla, M.; Denicola, A.; Marino, S.M.; Gladyshev, V.N.; Salinas, G. Linked thioredoxin-glutathione systems in platyhelminth parasites: Alternative pathways for glutathione reduction and deglutathionylation. J. Biol. Chem. 2011, 286, 4959-4967.
    • (2011) J. Biol. Chem. , vol.286 , pp. 4959-4967
    • Bonilla, M.1    Denicola, A.2    Marino, S.M.3    Gladyshev, V.N.4    Salinas, G.5
  • 90
    • 84895541950 scopus 로고    scopus 로고
    • A penta-substituted pyridine alkaloid from the rhizome of Jatropha elliptica (Pohl) Muell. Arg. Is active against Schistosoma mansoni and Biomphalaria glabrata
    • Dos Santos, A.F.; Fonseca, S.A.; César, F.A.; de Azevedo Albuquerque, M.C.P.; Santana, J.V.; Santana, A.E.G. A penta-substituted pyridine alkaloid from the rhizome of Jatropha elliptica (Pohl) Muell. Arg. is active against Schistosoma mansoni and Biomphalaria glabrata. Parasitol. Res. 2014, 113, 1077-1084.
    • (2014) Parasitol. Res. , vol.113 , pp. 1077-1084
    • Dos Santos, A.F.1    Fonseca, S.A.2    César, F.A.3    De Azevedo Albuquerque, M.C.P.4    Santana, J.V.5    Santana, A.E.G.6
  • 93
    • 84872405303 scopus 로고    scopus 로고
    • Identification of plumbagin and sanguinarine as effective chemotherapeutic agents for treatment of schistosomiasis
    • Zhang, S.-M.; Coultas, K. Identification of plumbagin and sanguinarine as effective chemotherapeutic agents for treatment of schistosomiasis. Int. J. Parasitol. Drugs Drug Resist. 2013, 3, 28-34.
    • (2013) Int. J. Parasitol. Drugs Drug Resist. , vol.3 , pp. 28-34
    • Zhang, S.-M.1    Coultas, K.2
  • 98
    • 75149183510 scopus 로고    scopus 로고
    • Morphological effects and tegumental alterations induced by mefloquine on schistosomula and adult flukes of Schistosoma mansoni
    • Manneck, T.; Haggenmüller, Y.; Keiser, J. Morphological effects and tegumental alterations induced by mefloquine on schistosomula and adult flukes of Schistosoma mansoni. Parasitology 2010, 137, 85-98.
    • (2010) Parasitology , vol.137 , pp. 85-98
    • Manneck, T.1    Haggenmüller, Y.2    Keiser, J.3
  • 99
    • 78049263263 scopus 로고    scopus 로고
    • Schistosoma mansoni: Antischistosomal activity of the four optical isomers and the two racemates of mefloquine on schistosomula and adult worms in vitro and in vivo
    • Manneck, T.; Braissant, O.; Ellis, W.; Keiser, J. Schistosoma mansoni : Antischistosomal activity of the four optical isomers and the two racemates of mefloquine on schistosomula and adult worms in vitro and in vivo. Exp. Parasitol. 2011, 127, 260-269.
    • (2011) Exp. Parasitol. , vol.127 , pp. 260-269
    • Manneck, T.1    Braissant, O.2    Ellis, W.3    Keiser, J.4
  • 100
    • 84861148384 scopus 로고    scopus 로고
    • Antischistosomal activities of mefloquine-related arylmethanols
    • Ingram, K.; Ellis, W.; Keiser, J. Antischistosomal activities of mefloquine-related arylmethanols. Antimicrob. Agents Chemother. 2012, 56, 3207-3215.
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 3207-3215
    • Ingram, K.1    Ellis, W.2    Keiser, J.3
  • 101
    • 79960444155 scopus 로고    scopus 로고
    • Interactions of mefloquine with praziquantel in the Schistosoma mansoni mouse model and in vitro
    • Keiser, J.; Manneck, T.; Vargas, M. Interactions of mefloquine with praziquantel in the Schistosoma mansoni mouse model and in vitro. J. Antimicrob. Chemother. 2011, 66, 1791-1797.
    • (2011) J. Antimicrob. Chemother. , vol.66 , pp. 1791-1797
    • Keiser, J.1    Manneck, T.2    Vargas, M.3
  • 102
    • 84911869289 scopus 로고    scopus 로고
    • Flavonoids as Important Molecules of Plant Interactions with the Environment
    • Mierziak, J.; Kostyn, K.; Kulma, A. Flavonoids as Important Molecules of Plant Interactions with the Environment. Molecules 2014, 19, 16240-16265.
    • (2014) Molecules , vol.19 , pp. 16240-16265
    • Mierziak, J.1    Kostyn, K.2    Kulma, A.3
  • 105
    • 84879335548 scopus 로고    scopus 로고
    • Polyphenols: Multipotent therapeutic agents in neurodegenerative diseases
    • Bhullar, K.S.; Rupasinghe, H.P.V. Polyphenols: Multipotent therapeutic agents in neurodegenerative diseases. Oxid. Med. Cell. Longev. 2013, 2013, doi:10.1155/2013/891748.
    • (2013) Oxid. Med. Cell. Longev. , vol.2013
    • Bhullar, K.S.1    Rupasinghe, H.P.V.2
  • 106
    • 84872855976 scopus 로고    scopus 로고
    • Dietary flavonoids and the development of type 2 diabetes and cardiovascular diseases: Review of recent findings
    • Van Dam, R.M.; Naidoo, N.; Landberg, R. Dietary flavonoids and the development of type 2 diabetes and cardiovascular diseases: Review of recent findings. Curr. Opin. Lipidol. 2013, 24, 25-33.
    • (2013) Curr. Opin. Lipidol. , vol.24 , pp. 25-33
    • Van Dam, R.M.1    Naidoo, N.2    Landberg, R.3
  • 107
    • 0036194878 scopus 로고    scopus 로고
    • Antischistosomal bioactivity of isoflavonoids from Millettia thonningii (Leguminosae)
    • Lyddiard, J.R.A.; Whitfield, P.J.; Bartlett, A. Antischistosomal bioactivity of isoflavonoids from Millettia thonningii (Leguminosae). J. Parasitol. 2002, 88, 163-170.
    • (2002) J. Parasitol. , vol.88 , pp. 163-170
    • Lyddiard, J.R.A.1    Whitfield, P.J.2    Bartlett, A.3
  • 112
    • 84871760704 scopus 로고    scopus 로고
    • Development of a defined medium for arachidonic acid production by Mortierella alpina using a visualization method
    • Liu, X.; Ji, X.; Zhang, H.; Fu, N.; Yan, L.; Deng, Z.; Huang, H. Development of a defined medium for arachidonic acid production by Mortierella alpina using a visualization method. Appl. Biochem. Biotechnol. 2012, 168, 1516-527.
    • (2012) Appl. Biochem. Biotechnol. , vol.168 , pp. 1516-1527
    • Liu, X.1    Ji, X.2    Zhang, H.3    Fu, N.4    Yan, L.5    Deng, Z.6    Huang, H.7
  • 113
    • 84898545025 scopus 로고    scopus 로고
    • Fungal arachidonic acid-rich oil: Research, development and industrialization
    • Ji, X.-J.; Ren, L.-J.; Nie, Z.-K.; Huang, H.; Ouyang, P.-K. Fungal arachidonic acid-rich oil: Research, development and industrialization. Crit. Rev. Biotechnol. 2014, 34, 197-214.
    • (2014) Crit. Rev. Biotechnol. , vol.34 , pp. 197-214
    • Ji, X.-J.1    Ren, L.-J.2    Nie, Z.-K.3    Huang, H.4    Ouyang, P.-K.5
  • 115
    • 28444475157 scopus 로고    scopus 로고
    • In vitro and in vivo effects of unsaturated fatty acids on Schistosoma mansoni and S. Haematobium lung-stage larvae
    • Tallima, H.; Salah, M.; El-Ridi, R. In vitro and in vivo effects of unsaturated fatty acids on Schistosoma mansoni and S. haematobium lung-stage larvae. J. Parasitol. 2005, 91, 1094-1102.
    • (2005) J. Parasitol. , vol.91 , pp. 1094-1102
    • Tallima, H.1    Salah, M.2    El-Ridi, R.3
  • 116
    • 33748921363 scopus 로고    scopus 로고
    • Equilibrium in lung schistosomula sphingomyelin breakdown and biosynthesis allows very small molecules, but not antibody, to access proteins at the host-parasite interface
    • El Ridi, R.; Tallima, H. Equilibrium in lung schistosomula sphingomyelin breakdown and biosynthesis allows very small molecules, but not antibody, to access proteins at the host-parasite interface. J. Parasitol. 2006, 92, 730-737.
    • (2006) J. Parasitol. , vol.92 , pp. 730-737
    • El Ridi, R.1    Tallima, H.2
  • 119
    • 0014361067 scopus 로고
    • Antimicrobial substances of superior plants. XXVII. Isolation of plumbagin from Plumbago scandens L
    • De Lima, O.G.; d'Albuquerque, I.L.; Maciel, G.M.; Maciel, M.C. Antimicrobial substances of superior plants. XXVII. Isolation of plumbagin from Plumbago scandens L. Rev. Inst. Antibiot. (Recife) 1968, 8, 95-97.
    • (1968) Rev. Inst. Antibiot. (Recife) , vol.8 , pp. 95-97
    • De Lima, O.G.1    D'Albuquerque, I.L.2    Maciel, G.M.3    Maciel, M.C.4
  • 120
    • 0037078250 scopus 로고    scopus 로고
    • Kwanzoquinones A-G and other constituents of Hemerocallis fulva "Kwanzo" roots and their activity against the human pathogenic trematode Schistosoma mansoni
    • Cichewicz, R.H.; Lim, K.-C.; McKerrow, J.H.; Nair, M.G. Kwanzoquinones A-G and other constituents of Hemerocallis fulva "Kwanzo" roots and their activity against the human pathogenic trematode Schistosoma mansoni . Tetrahedron 2002, 58, 8597-8606.
    • (2002) Tetrahedron , vol.58 , pp. 8597-8606
    • Cichewicz, R.H.1    Lim, K.-C.2    McKerrow, J.H.3    Nair, M.G.4
  • 123
    • 84890130109 scopus 로고    scopus 로고
    • Evaluation of dihydroisocoumarins produced by the endophytic fungus Arthrinium state of Apiospora montagnei against Schistosoma mansoni
    • Ramos, H.P.; Simão, M.R.; de Souza, J.M.; Magalhães, L.G.; Rodrigues, V.; Ambrósio, S.R.; Said, S. Evaluation of dihydroisocoumarins produced by the endophytic fungus Arthrinium state of Apiospora montagnei against Schistosoma mansoni. Nat. Prod. Res. 2013, 27, 2240-2243.
    • (2013) Nat. Prod. Res. , vol.27 , pp. 2240-2243
    • Ramos, H.P.1    Simão, M.R.2    De Souza, J.M.3    Magalhães, L.G.4    Rodrigues, V.5    Ambrósio, S.R.6    Said, S.7
  • 125
    • 1642564603 scopus 로고    scopus 로고
    • Inhibition of proteasomal function by curcumin induces apoptosis through mitochondrial pathway
    • Jana, N.R.; Dikshit, P.; Goswami, A.; Nukina, N. Inhibition of proteasomal function by curcumin induces apoptosis through mitochondrial pathway. J. Biol. Chem. 2004, 279, 11680-11685.
    • (2004) J. Biol. Chem. , vol.279 , pp. 11680-11685
    • Jana, N.R.1    Dikshit, P.2    Goswami, A.3    Nukina, N.4
  • 127
    • 44349089757 scopus 로고    scopus 로고
    • Natural product isolation
    • Sticher, O. Natural product isolation. Nat. Prod. Rep. 2008, 25, 517-554.
    • (2008) Nat. Prod. Rep. , vol.25 , pp. 517-554
    • Sticher, O.1
  • 128
    • 84874956949 scopus 로고    scopus 로고
    • Natural product isolation-how to get from biological material to pure compounds
    • Bucar, F.; Wube, A.; Schmid, M. Natural product isolation-how to get from biological material to pure compounds. Nat. Prod. Rep. 2013, 30, 525-545.
    • (2013) Nat. Prod. Rep. , vol.30 , pp. 525-545
    • Bucar, F.1    Wube, A.2    Schmid, M.3
  • 129
    • 77949653928 scopus 로고    scopus 로고
    • In vitro and in vivo trematode models for chemotherapeutic studies
    • Keiser, J. In vitro and in vivo trematode models for chemotherapeutic studies. Parasitology 2010, 137, 589-603.
    • (2010) Parasitology , vol.137 , pp. 589-603
    • Keiser, J.1
  • 131
    • 78149266039 scopus 로고    scopus 로고
    • Comparison of microscopy and Alamar blue reduction in a larval based assay for schistosome drug screening
    • Mansour, N.R.; Bickle, Q.D. Comparison of microscopy and Alamar blue reduction in a larval based assay for schistosome drug screening. PLoS Negl. Trop. Dis. 2010, 4, e795.
    • (2010) PLoS Negl. Trop. Dis. , vol.4 , pp. e795
    • Mansour, N.R.1    Bickle, Q.D.2
  • 133
    • 84862265241 scopus 로고    scopus 로고
    • Quantification and clustering of phenotypic screening data using time-series analysis for chemotherapy of schistosomiasis
    • Lee, H.; Moody-Davis, A.; Saha, U.; Suzuki, B.M.; Asarnow, D.; Chen, S.; Arkin, M.; Caffrey, C.R.; Singh, R. Quantification and clustering of phenotypic screening data using time-series analysis for chemotherapy of schistosomiasis. BMC Genomics 2012, 13 (Suppl. 1), S4.
    • (2012) BMC Genomics , vol.13 , pp. S4
    • Lee, H.1    Moody-Davis, A.2    Saha, U.3    Suzuki, B.M.4    Asarnow, D.5    Chen, S.6    Arkin, M.7    Caffrey, C.R.8    Singh, R.9
  • 134
    • 84880299041 scopus 로고    scopus 로고
    • Automated imaging and other developments in whole-organism anthelmintic screening
    • Paveley, R.A.; Bickle, Q.D. Automated imaging and other developments in whole-organism anthelmintic screening. Parasite Immunol. 2007, 35, 302-313.
    • (2007) Parasite Immunol. , vol.35 , pp. 302-313
    • Paveley, R.A.1    Bickle, Q.D.2
  • 135
    • 84902210226 scopus 로고    scopus 로고
    • Increasing the content of high-content screening: An overview
    • Singh, S.; Carpenter, A.E.; Genovesio, A. Increasing the Content of High-Content Screening: An Overview. J. Biomol. Screen. 2014, 19, 640-650.
    • (2014) J. Biomol. Screen. , vol.19 , pp. 640-650
    • Singh, S.1    Carpenter, A.E.2    Genovesio, A.3
  • 136
    • 84878572284 scopus 로고    scopus 로고
    • Segmenting the etiological agent of schistosomiasis for high-content screening
    • Asarnow, D.E.; Singh, R. Segmenting the etiological agent of schistosomiasis for high-content screening. IEEE Trans. Med. Imaging 2013, 32, 1007-1018.
    • (2013) IEEE Trans. Med. Imaging , vol.32 , pp. 1007-1018
    • Asarnow, D.E.1    Singh, R.2
  • 137
    • 77957914128 scopus 로고    scopus 로고
    • Development and validation of a quantitative, high-throughput, fluorescent-based bioassay to detect schistosoma viability
    • Peak, E.; Chalmers, I.W.; Hoffmann, K.F. Development and validation of a quantitative, high-throughput, fluorescent-based bioassay to detect schistosoma viability. PLoS Negl. Trop. Dis. 2010, 4, e759.
    • (2010) PLoS Negl. Trop. Dis. , vol.4 , pp. e759
    • Peak, E.1    Chalmers, I.W.2    Hoffmann, K.F.3
  • 138
    • 81355161288 scopus 로고    scopus 로고
    • Molecular docking for virtual screening of natural product databases
    • Ma, D.-L.; Chan, D.S.-H.; Leung, C.-H. Molecular docking for virtual screening of natural product databases. Chem. Sci. 2011, 2, 1656-1665.
    • (2011) Chem. Sci. , vol.2 , pp. 1656-1665
    • Ma, D.-L.1    Chan, D.S.-H.2    Leung, C.-H.3
  • 140
    • 84878747400 scopus 로고    scopus 로고
    • 3-Oxoacyl-ACP reductase from Schistosoma japonicum: Integrated in silico- in vitro strategy for discovering antischistosomal lead compounds
    • Liu, J.; Dyer, D.; Wang, J.; Wang, S.; Du, X.; Xu, B.; Zhang, H.; Wang, X.; Hu, W. 3-Oxoacyl-ACP reductase from Schistosoma japonicum: Integrated in silico- in vitro strategy for discovering antischistosomal lead compounds. PLoS One 2013, 8, e64984.
    • (2013) PLoS One , vol.8 , pp. e64984
    • Liu, J.1    Dyer, D.2    Wang, J.3    Wang, S.4    Du, X.5    Xu, B.6    Zhang, H.7    Wang, X.8    Hu, W.9
  • 141
    • 84878432195 scopus 로고    scopus 로고
    • Aldose reductase from Schistosoma japonicum: Crystallization and structure-based inhibitor screening for discovering antischistosomal lead compounds
    • Liu, J.; Dyer, D.H.; Cheng, J.; Wang, J.; Wang, S.; Yang, Z.; Wang, X.; Hu, W. Aldose reductase from Schistosoma japonicum: Crystallization and structure-based inhibitor screening for discovering antischistosomal lead compounds. Parasit. Vectors 2013, 6, 162.
    • (2013) Parasit. Vectors , vol.6 , pp. 162
    • Liu, J.1    Dyer, D.H.2    Cheng, J.3    Wang, J.4    Wang, S.5    Yang, Z.6    Wang, X.7    Hu, W.8
  • 143
    • 84878798892 scopus 로고    scopus 로고
    • Assessing the performance of 3D pharmacophore models in virtual screening: How good are they?
    • Braga, R.C.; Andrade, C.H. Assessing the performance of 3D pharmacophore models in virtual screening: How good are they? Curr. Top. Med. Chem. 2013, 13, 1127-1138.
    • (2013) Curr. Top. Med. Chem. , vol.13 , pp. 1127-1138
    • Braga, R.C.1    Andrade, C.H.2
  • 145
    • 33644878571 scopus 로고    scopus 로고
    • SuperNatural: A searchable database of available natural compounds
    • Dunkel, M.; Fullbeck, M.; Neumann, S.; Preissner, R. SuperNatural: A searchable database of available natural compounds. Nucleic Acids Res. 2006, 34, D678-D683.
    • (2006) Nucleic Acids Res. , vol.34 , pp. D678-D683
    • Dunkel, M.1    Fullbeck, M.2    Neumann, S.3    Preissner, R.4
  • 146
    • 37249035096 scopus 로고    scopus 로고
    • Phytochemical informatics of traditional Chinese medicine and therapeutic relevance
    • Ehrman, T.M.; Barlow, D.J.; Hylands, P.J. Phytochemical informatics of traditional Chinese medicine and therapeutic relevance. J. Chem. Inf. Model. 2006, 47, 2316-2334.
    • (2006) J. Chem. Inf. Model. , vol.47 , pp. 2316-2334
    • Ehrman, T.M.1    Barlow, D.J.2    Hylands, P.J.3
  • 147
    • 84860634242 scopus 로고    scopus 로고
    • Seaweed metabolite database (SWMD): A database of natural compounds from marine algae
    • Davis, G.D.J.; Vasanthi, A.H.R. Seaweed metabolite database (SWMD): A database of natural compounds from marine algae. Bioinformation 2011, 5, 361-364.
    • (2011) Bioinformation , vol.5 , pp. 361-364
    • Davis, G.D.J.1    Vasanthi, A.H.R.2
  • 148
    • 84870443681 scopus 로고    scopus 로고
    • Virtual screening methods as tools for drug lead discovery from large chemical libraries
    • Ma, X.H.; Zhu, F.; Liu, X.; Shi, Z.; Zhang, J.X.; Yang, S.Y.; Wei, Y.Q.; Chen, Y.Z. Virtual screening methods as tools for drug lead discovery from large chemical libraries. Curr. Med. Chem. 2012, 19, 5562-5571.
    • (2012) Curr. Med. Chem. , vol.19 , pp. 5562-5571
    • Ma, X.H.1    Zhu, F.2    Liu, X.3    Shi, Z.4    Zhang, J.X.5    Yang, S.Y.6    Wei, Y.Q.7    Chen, Y.Z.8
  • 150
    • 84856461929 scopus 로고    scopus 로고
    • Databases aim to bridge the East-West divide of drug discovery
    • Sanderson, K. Databases aim to bridge the East-West divide of drug discovery. Nat. Med. 2011, 17, 1531.
    • (2011) Nat. Med. , vol.17 , pp. 1531
    • Sanderson, K.1
  • 151
    • 79251561193 scopus 로고    scopus 로고
    • TCM Database@Taiwan: The world's largest traditional Chinese medicine database for drug screening in silico
    • Chen, C.Y.-C. TCM Database@Taiwan: The world's largest traditional Chinese medicine database for drug screening in silico. PLoS One 2011, 6, e15939.
    • (2011) PLoS One , vol.6 , pp. e15939
    • Chen, C.Y.-C.1
  • 152
    • 84921690973 scopus 로고    scopus 로고
    • Available online accessed on 12 December 2014
    • Dictionary of Natural Products. Available online: http://www.chemnetbase.com/ (accessed on 12 December 2014).
    • Dictionary of Natural Products1
  • 154
    • 84876560772 scopus 로고    scopus 로고
    • NPACT: Naturally Occurring Plant-based Anti-cancer Compound-Activity-Target database
    • Mangal, M.; Sagar, P.; Singh, H.; Raghava, G.P.S.; Agarwal, S.M. NPACT: Naturally Occurring Plant-based Anti-cancer Compound-Activity-Target database. Nucleic Acids Res. 2013, 41, D1124-D1129.
    • (2013) Nucleic Acids Res. , vol.41 , pp. D1124-D1129
    • Mangal, M.1    Sagar, P.2    Singh, H.3    Raghava, G.P.S.4    Agarwal, S.M.5
  • 155
    • 84921653623 scopus 로고    scopus 로고
    • Available online accessed on 12 December 2014
    • Database of Indonesian Medicinal Plants. Available online: http://herbaldb.farmasi.ui.ac.id/ (accessed on 12 December 2014).
    • Database of Indonesian Medicinal Plants1
  • 156
    • 84921635428 scopus 로고    scopus 로고
    • Available online accessed on 12 December 2014
    • Greenpharma Natural Compound Library. Available online: http://www.greenpharma.com/products/ (accessed on 12 December 2014).
    • Greenpharma Natural Compound Library1
  • 158
    • 84903897661 scopus 로고    scopus 로고
    • MAPS Database: Medicinal plant activities, phytochemical and structural database
    • Ashfaq, U.A.; Mumtaz, A.; Qamar, T.U.; Fatima, T. MAPS Database: Medicinal plant Activities, Phytochemical and Structural Database. Bioinformation 2013, 9, 993-995.
    • (2013) Bioinformation , vol.9 , pp. 993-995
    • Ashfaq, U.A.1    Mumtaz, A.2    Qamar, T.U.3    Fatima, T.4
  • 159
    • 84878666771 scopus 로고    scopus 로고
    • TIPdb: A database of anticancer, antiplatelet, and antituberculosis phytochemicals from indigenous plants in Taiwan
    • Lin, Y.-C.; Wang, C.-C.; Chen, I.-S.; Jheng, J.-L.; Li, J.-H.; Tung, C.-W. TIPdb: A database of anticancer, antiplatelet, and antituberculosis phytochemicals from indigenous plants in Taiwan. Sci. World J. 2013, 2013, doi:10.1155/2013/736386.
    • (2013) Sci. World J. , vol.2013
    • Lin, Y.-C.1    Wang, C.-C.2    Chen, I.-S.3    Jheng, J.-L.4    Li, J.-H.5    Tung, C.-W.6
  • 160
    • 84987657364 scopus 로고    scopus 로고
    • TIPdb-3D: The three-dimensional structure database of phytochemicals from Taiwan indigenous plants
    • Tung, C.-W.; Lin, Y.-C.; Chang, H.-S.; Wang, C.-C.; Chen, I.-S.; Jheng, J.-L.; Li, J.-H. TIPdb-3D: the three-dimensional structure database of phytochemicals from Taiwan indigenous plants. Database (Oxford) 2014, 2014, bau055.
    • (2014) Database (Oxford) , vol.2014 , pp. bau055
    • Tung, C.-W.1    Lin, Y.-C.2    Chang, H.-S.3    Wang, C.-C.4    Chen, I.-S.5    Jheng, J.-L.6    Li, J.-H.7
  • 161
    • 84921690972 scopus 로고    scopus 로고
    • Available online accessed on 12 December 2014
    • AMRI's Natural Product Library. Available online: http://www.amriglobal.com/ (accessed on 12 December 2014).
    • AMRI's Natural Product Library1
  • 162
    • 85026053788 scopus 로고    scopus 로고
    • Glossary of terms used in medicinal chemistry (IUPAC Recommendations 1998)
    • Wermuth, C.; Ganellin, C.; Lindberg, P.; Mitscher, L. Glossary of terms used in medicinal chemistry (IUPAC Recommendations 1998). Pure Appl. Chem. 1998, 70, 1129-1143.
    • (1998) Pure Appl. Chem. , vol.70 , pp. 1129-1143
    • Wermuth, C.1    Ganellin, C.2    Lindberg, P.3    Mitscher, L.4
  • 163
    • 5644236834 scopus 로고    scopus 로고
    • Pharmacophore modeling and three dimensional database searching for drug design using catalyst: Recent advances
    • Güner, O.; Clement, O.; Kurogi, Y. Pharmacophore modeling and three dimensional database searching for drug design using catalyst: Recent advances. Curr. Med. Chem. 2004, 11, 2991-3005.
    • (2004) Curr. Med. Chem. , vol.11 , pp. 2991-3005
    • Güner, O.1    Clement, O.2    Kurogi, Y.3
  • 165
    • 0030137662 scopus 로고    scopus 로고
    • Identification of common functional configurations among molecules
    • Barnum, D.; Greene, J.; Smellie, A.; Sprague, P. Identification of common functional configurations among molecules. J. Chem. Inf. Comput. Sci. 1996, 36, 563-571.
    • (1996) J. Chem. Inf. Comput. Sci. , vol.36 , pp. 563-571
    • Barnum, D.1    Greene, J.2    Smellie, A.3    Sprague, P.4
  • 166
    • 33845868822 scopus 로고    scopus 로고
    • PHASE: A new engine for pharmacophore perception, 3D QSAR model development, and 3D database screening: 1. Methodology and preliminary results
    • Dixon, S.L.; Smondyrev, A.M.; Knoll, E.H.; Rao, S.N.; Shaw, D.E.; Friesner, R.A. PHASE: A new engine for pharmacophore perception, 3D QSAR model development, and 3D database screening: 1. Methodology and preliminary results. J. Comput. Aided. Mol. Des. 2006, 20, 647-671.
    • (2006) J. Comput. Aided. Mol. Des. , vol.20 , pp. 647-671
    • Dixon, S.L.1    Smondyrev, A.M.2    Knoll, E.H.3    Rao, S.N.4    Shaw, D.E.5    Friesner, R.A.6
  • 168
    • 84904729887 scopus 로고    scopus 로고
    • 3D-QSAR approaches in drug design: Perspectives to generate reliable CoMFA models
    • Melo-Filho, C.C.; Braga, R.C.; Andrade, C.H. 3D-QSAR Approaches in Drug Design: Perspectives to Generate Reliable CoMFA Models. Curr. Comput. Aided Drug Des. 2014, 10, 148-159.
    • (2014) Curr. Comput. Aided Drug Des. , vol.10 , pp. 148-159
    • Melo-Filho, C.C.1    Braga, R.C.2    Andrade, C.H.3
  • 169
    • 84875458244 scopus 로고    scopus 로고
    • Discovery of new potential hits of Plasmodium falciparum enoyl-ACP reductase through ligand- and structure-based drug design approaches
    • Neves, B.J.; Bueno, R.V.; Braga, R.C.; Andrade, C.H. Discovery of new potential hits of Plasmodium falciparum enoyl-ACP reductase through ligand- and structure-based drug design approaches. Bioorg. Med. Chem. Lett. 2013, 23, 2436-2441.
    • (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 2436-2441
    • Neves, B.J.1    Bueno, R.V.2    Braga, R.C.3    Andrade, C.H.4
  • 170
    • 84872327877 scopus 로고    scopus 로고
    • Structural and chemical basis for enhanced affinity to a series of mycobacterial thymidine monophosphate kinase inhibitors: Fragment-based QSAR and QM/MM docking studies
    • Bueno, R.V.; Toledo, N.R.; Neves, B.J.; Braga, R.C.; Andrade, C.H. Structural and chemical basis for enhanced affinity to a series of mycobacterial thymidine monophosphate kinase inhibitors: Fragment-based QSAR and QM/MM docking studies. J. Mol. Model. 2013, 19, 179-192.
    • (2013) J. Mol. Model. , vol.19 , pp. 179-192
    • Bueno, R.V.1    Toledo, N.R.2    Neves, B.J.3    Braga, R.C.4    Andrade, C.H.5
  • 171
    • 77956964002 scopus 로고    scopus 로고
    • Best practices for QSAR model development, validation, and exploitation
    • Tropsha, A. Best Practices for QSAR Model Development, Validation, and Exploitation. Mol. Inf. 2010, 29, 476-488.
    • (2010) Mol. Inf. , vol.29 , pp. 476-488
    • Tropsha, A.1
  • 173
    • 84857514268 scopus 로고    scopus 로고
    • Comparative studies on some metrics for external validation of QSPR models
    • Roy, K.; Mitra, I.; Kar, S.; Ojha, P.K.; Das, R.N.; Kabir, H. Comparative studies on some metrics for external validation of QSPR models. J. Chem. Inf. Model. 2012, 52, 396-408.
    • (2012) J. Chem. Inf. Model. , vol.52 , pp. 396-408
    • Roy, K.1    Mitra, I.2    Kar, S.3    Ojha, P.K.4    Das, R.N.5    Kabir, H.6
  • 174
    • 84861172684 scopus 로고    scopus 로고
    • On the use of the metric rm2 as an effective tool for validation of QSAR models in computational drug design and predictive toxicology
    • Roy, K.; Mitra, I. On the use of the metric rm2 as an effective tool for validation of QSAR models in computational drug design and predictive toxicology. Mini Rev. Med. Chem. 2012, 12, 491-504.
    • (2012) Mini Rev. Med. Chem. , vol.12 , pp. 491-504
    • Roy, K.1    Mitra, I.2
  • 175
    • 84868210651 scopus 로고    scopus 로고
    • Introduction of rm2 (rank) metric incorporating rank-order predictions as an additional tool for validation of QSAR/QSPR models
    • Roy, K.; Mitra, I.; Ojha, P.K.; Kar, S.; Das, R.N.; Kabir, H. Introduction of rm2 (rank) metric incorporating rank-order predictions as an additional tool for validation of QSAR/QSPR models. Chemom. Intell. Lab. Syst. 2012, 118, 200-210.
    • (2012) Chemom. Intell. Lab. Syst. , vol.118 , pp. 200-210
    • Roy, K.1    Mitra, I.2    Ojha, P.K.3    Kar, S.4    Das, R.N.5    Kabir, H.6
  • 176
    • 84870526047 scopus 로고    scopus 로고
    • On the development and validation of QSAR models
    • Gramatica, P. On the development and validation of QSAR models. Methods Mol. Biol. 2013, 930, 499-526.
    • (2013) Methods Mol. Biol. , vol.930 , pp. 499-526
    • Gramatica, P.1
  • 177
    • 80053295024 scopus 로고    scopus 로고
    • Real external predictivity of QSAR models: How to evaluate it? Comparison of different validation criteria and proposal of using the concordance correlation coefficient
    • Chirico, N.; Gramatica, P. Real external predictivity of QSAR models: How to evaluate it? Comparison of different validation criteria and proposal of using the concordance correlation coefficient. J. Chem. Inf. Model. 2011, 51, 2320-2335.
    • (2011) J. Chem. Inf. Model. , vol.51 , pp. 2320-2335
    • Chirico, N.1    Gramatica, P.2
  • 178
    • 84865466657 scopus 로고    scopus 로고
    • Real external predictivity of QSAR models. Part 2; New intercomparable thresholds for different validation criteria and the need for scatter plot inspection
    • Chirico, N.; Gramatica, P. Real external predictivity of QSAR models. Part 2; New intercomparable thresholds for different validation criteria and the need for scatter plot inspection. J. Chem. Inf. Model. 2012, 52, 2044-2058.
    • (2012) J. Chem. Inf. Model. , vol.52 , pp. 2044-2058
    • Chirico, N.1    Gramatica, P.2
  • 179
    • 78149410394 scopus 로고    scopus 로고
    • PKa based protonation states and microspecies for protein-ligand docking
    • Ten Brink, T.; Exner, T.E. pKa based protonation states and microspecies for protein-ligand docking. J. Comput. Aided Mol. Des. 2010, 24, 935-942.
    • (2010) J. Comput. Aided Mol. Des. , vol.24 , pp. 935-942
    • Ten Brink, T.1    Exner, T.E.2
  • 180
    • 33745199815 scopus 로고    scopus 로고
    • Virtual ligand screening: Strategies, perspectives and limitations
    • Klebe, G. Virtual ligand screening: Strategies, perspectives and limitations. Drug Discov. Today 2006, 11, 580-594.
    • (2006) Drug Discov. Today , vol.11 , pp. 580-594
    • Klebe, G.1
  • 181
    • 84911401229 scopus 로고    scopus 로고
    • Structure-based virtual screening for drug discovery: Principles, applications and recent advances
    • Lionta, E.; Spyrou, G.; Vassilatis, D.K.; Cournia, Z. Structure-based virtual screening for drug discovery: Principles, applications and recent advances. Curr. Top. Med. Chem. 2014, 14, 1923-1938.
    • (2014) Curr. Top. Med. Chem. , vol.14 , pp. 1923-1938
    • Lionta, E.1    Spyrou, G.2    Vassilatis, D.K.3    Cournia, Z.4
  • 182
    • 79952262090 scopus 로고    scopus 로고
    • FRED pose prediction and virtual screening accuracy
    • McGann, M. FRED pose prediction and virtual screening accuracy. J. Chem. Inf. Model. 2011, 51, 578-596.
    • (2011) J. Chem. Inf. Model. , vol.51 , pp. 578-596
    • McGann, M.1
  • 183
    • 84867328344 scopus 로고    scopus 로고
    • FRED and HYBRID docking performance on standardized datasets
    • McGann, M. FRED and HYBRID docking performance on standardized datasets. J. Comput. Aided Mol. Des. 2012, 26, 897-906.
    • (2012) J. Comput. Aided Mol. Des. , vol.26 , pp. 897-906
    • McGann, M.1
  • 184
    • 84921691157 scopus 로고    scopus 로고
    • OpenEye Scientific Software, Inc.: Santa Fe, NM, USA Available online accessed on 10 December 2014
    • OEDocking, version 3.0.1; OpenEye Scientific Software, Inc.: Santa Fe, NM, USA, 2014. Available online: http://www.eyesopen.com/oedocking (accessed on 10 December 2014).
    • (2014) OEDocking, Version 3.0.1
  • 185
    • 84904971603 scopus 로고    scopus 로고
    • Structure-based virtual screening approach for discovery of covalently bound ligands
    • Toledo Warshaviak, D.; Golan, G.; Borrelli, K.W.; Zhu, K.; Kalid, O. Structure-based virtual screening approach for discovery of covalently bound ligands. J. Chem. Inf. Model. 2014, 54, 1941-1950.
    • (2014) J. Chem. Inf. Model. , vol.54 , pp. 1941-1950
    • Toledo Warshaviak, D.1    Golan, G.2    Borrelli, K.W.3    Zhu, K.4    Kalid, O.5
  • 186
    • 6344294057 scopus 로고    scopus 로고
    • FlexX-Scan: Fast, structure-based virtual screening
    • Schellhammer, I.; Rarey, M. FlexX-Scan: Fast, structure-based virtual screening. Proteins 2004, 57, 504-517.
    • (2004) Proteins , vol.57 , pp. 504-517
    • Schellhammer, I.1    Rarey, M.2
  • 188
    • 84861118556 scopus 로고    scopus 로고
    • Outstanding challenges in protein-ligand docking and structure-based virtual screening
    • Waszkowycz, B.; Clark, D.E.; Gancia, E. Outstanding challenges in protein-ligand docking and structure-based virtual screening. Wiley Interdiscip. Rev. Comput. Mol. Sci. 2011, 1, 229-259.
    • (2011) Wiley Interdiscip. Rev. Comput. Mol. Sci. , vol.1 , pp. 229-259
    • Waszkowycz, B.1    Clark, D.E.2    Gancia, E.3
  • 189
    • 78649898335 scopus 로고    scopus 로고
    • Protein flexibility and ligand recognition: Challenges for molecular modeling
    • Spyrakis, F.; BidonChanal, A.; Barril, X.; Luque, F.J. Protein flexibility and ligand recognition: Challenges for molecular modeling. Curr. Top. Med. Chem. 2011, 11, 192-210.
    • (2011) Curr. Top. Med. Chem. , vol.11 , pp. 192-210
    • Spyrakis, F.1    BidonChanal, A.2    Barril, X.3    Luque, F.J.4
  • 190
    • 84891489378 scopus 로고    scopus 로고
    • Optimization of compound ranking for structure-based virtual ligand screening using an established FRED-Surflex consensus approach
    • Du, J.; Bleylevens, I.W.M.; Bitorina, A.V.; Wichapong, K.; Nicolaes, G.A.F. Optimization of compound ranking for structure-based virtual ligand screening using an established FRED-Surflex consensus approach. Chem. Biol. Drug Des. 2014, 83, 37-51.
    • (2014) Chem. Biol. Drug Des. , vol.83 , pp. 37-51
    • Du, J.1    Bleylevens, I.W.M.2    Bitorina, A.V.3    Wichapong, K.4    Nicolaes, G.A.F.5
  • 191
    • 84905020680 scopus 로고    scopus 로고
    • Consensus scoring approach to identify the inhibitors of AMPactivated protein kinase α2 with virtual screening
    • Park, H.; Eom, J.-W.; Kim, Y.-H. Consensus scoring approach to identify the inhibitors of AMPactivated protein kinase α2 with virtual screening. J. Chem. Inf. Model. 2014, 54, 2139-2146.
    • (2014) J. Chem. Inf. Model. , vol.54 , pp. 2139-2146
    • Park, H.1    Eom, J.-W.2    Kim, Y.-H.3
  • 192
    • 33748667774 scopus 로고    scopus 로고
    • Consensus scoring for protein-ligand interactions
    • Feher, M. Consensus scoring for protein-ligand interactions. Drug Discov. Today 2006, 11, 421-428.
    • (2006) Drug Discov. Today , vol.11 , pp. 421-428
    • Feher, M.1
  • 193
    • 13844320566 scopus 로고    scopus 로고
    • LigandScout: 3-D pharmacophores derived from protein-bound ligands and their use as virtual screening filters
    • Wolber, G.; Langer, T. LigandScout: 3-D pharmacophores derived from protein-bound ligands and their use as virtual screening filters. J. Chem. Inf. Model. 2005, 45, 160-169.
    • (2005) J. Chem. Inf. Model. , vol.45 , pp. 160-169
    • Wolber, G.1    Langer, T.2
  • 194
    • 33947576378 scopus 로고    scopus 로고
    • High-throughput structure-based pharmacophore modelling as a basis for successful parallel virtual screening
    • Steindl, T.M.; Schuster, D.; Wolber, G.; Laggner, C.; Langer, T. High-throughput structure-based pharmacophore modelling as a basis for successful parallel virtual screening. J. Comput. Aided Mol. Des. 2006, 20, 703-715.
    • (2006) J. Comput. Aided Mol. Des. , vol.20 , pp. 703-715
    • Steindl, T.M.1    Schuster, D.2    Wolber, G.3    Laggner, C.4    Langer, T.5
  • 195
    • 79957946803 scopus 로고    scopus 로고
    • Pharmacophore modelling: A forty year old approach and its modern synergies
    • Caporuscio, F.; Tafi, A. Pharmacophore modelling: A forty year old approach and its modern synergies. Curr. Med. Chem. 2011, 18, 2543-2553.
    • (2011) Curr. Med. Chem. , vol.18 , pp. 2543-2553
    • Caporuscio, F.1    Tafi, A.2
  • 196
    • 84861189353 scopus 로고    scopus 로고
    • Inverse virtual screening allows the discovery of the biological activity of natural compounds
    • Lauro, G.; Masullo, M.; Piacente, S.; Riccio, R.; Bifulco, G. Inverse Virtual Screening allows the discovery of the biological activity of natural compounds. Bioorg. Med. Chem. 2012, 20, 3596-3602.
    • (2012) Bioorg. Med. Chem. , vol.20 , pp. 3596-3602
    • Lauro, G.1    Masullo, M.2    Piacente, S.3    Riccio, R.4    Bifulco, G.5
  • 197
    • 79959699687 scopus 로고    scopus 로고
    • Inverse virtual screening of antitumor targets: Pilot study on a small database of natural bioactive compounds
    • Lauro, G.; Romano, A.; Riccio, R.; Bifulco, G. Inverse virtual screening of antitumor targets: Pilot study on a small database of natural bioactive compounds. J. Nat. Prod. 2011, 74, 1401-1407.
    • (2011) J. Nat. Prod. , vol.74 , pp. 1401-1407
    • Lauro, G.1    Romano, A.2    Riccio, R.3    Bifulco, G.4
  • 198


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