Schistosoma mansoni: Antischistosomal activity of the four optical isomers and the two racemates of mefloquine on schistosomula and adult worms in vitro and in vivo

Experimental Parasitology

Volumn 127, Issue 1, 2011, Pages 260-269

  Manneck, Theresia ^a,b   Braissant, Olivier ^c   Ellis, William ^d   Keiser, Jennifer ^a,b  

^a SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

^c UNIVERSITY OF BASEL   (Switzerland)

^d WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

In vitro; In vivo; Isomer; Mefloquine; Microcalorimetry; Racemate; Schistosoma mansoni

Indexed keywords

ERYTHRO ALPHA(2 PIPERIDINYL) 2,8 BIS(TRIFLUORMETHYL) 4 GUINOLINEMETHANOL; HEMIN; MEFLOQUINE; THREO ALPHA(2 PIPERIDINYL) 2,8 BIS(TRIFLUORMETHYL) 4 GUINOLINEMETHANOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTHELMINTIC ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PARASITE VIABILITY; PRIORITY JOURNAL; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI; SCHISTOSOMULUM; SINGLE DRUG DOSE; STEREOCHEMISTRY; THERMOGENESIS; TREMATODE LIFE CYCLE STAGE; WORM TEGUMENT;

ANIMALS; CALORIMETRY; DRUG EVALUATION, PRECLINICAL; FEMALE; MALE; MEFLOQUINE; MICE; MICROSCOPY, ELECTRON, SCANNING; PHENOTYPE; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI; SCHISTOSOMICIDES; STEREOISOMERISM;

CALLUNA VULGARIS; MUS; SCHISTOSOMA MANSONI;

EID: 78049263263     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2010.08.011     Document Type: Article

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