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Volumn 7, Issue 9, 2013, Pages

Schistosoma mansoni Sirtuins: Characterization and Potential as Chemotherapeutic Targets

Author keywords

[No Author keywords available]

Indexed keywords

3,5 DIMETHYLPYRAZOLE; ANTHELMINTIC AGENT; HR 103; MITOCHONDRIAL PROTEIN; MS13; SALERMIDE; SIRTINOL; SIRTUIN; SIRTUIN 1; SIRTUIN 2; SIRTUIN 5; SIRTUIN 6; SIRTUIN 7; SIRTUIN INHIBITOR; UNCLASSIFIED DRUG;

EID: 84884697264     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0002428     Document Type: Article
Times cited : (75)

References (64)
  • 1
    • 75649144986 scopus 로고    scopus 로고
    • The Schistosomiasis Control Initiative (SCI): rationale, development and implementation from 2002-2008
    • Fenwick A, Webster JP, Bosque-Oliva E, Blair L, Fleming FM, et al. (2009) The Schistosomiasis Control Initiative (SCI): rationale, development and implementation from 2002-2008. Parasitology 136: 1719-1730.
    • (2009) Parasitology , vol.136 , pp. 1719-1730
    • Fenwick, A.1    Webster, J.P.2    Bosque-Oliva, E.3    Blair, L.4    Fleming, F.M.5
  • 2
    • 0037847426 scopus 로고    scopus 로고
    • Quantification of clinical morbidity associated with schistosome infection in sub-Saharan Africa
    • Van der Werf MJ, de Vlas SJ, Brooker S, Looman CW, Nagelkerke NJ, et al. (2003) Quantification of clinical morbidity associated with schistosome infection in sub-Saharan Africa. Acta Trop 86: 125-139.
    • (2003) Acta Trop , vol.86 , pp. 125-139
    • Van der Werf, M.J.1    de Vlas, S.J.2    Brooker, S.3    Looman, C.W.4    Nagelkerke, N.J.5
  • 3
    • 57049129327 scopus 로고    scopus 로고
    • Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis
    • Doenhoff MJ, Cioli D, Utzinger J, (2008) Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis. Curr Opin Infect Dis 21: 659-67.
    • (2008) Curr Opin Infect Dis , vol.21 , pp. 659-667
    • Doenhoff, M.J.1    Cioli, D.2    Utzinger, J.3
  • 4
    • 70449510166 scopus 로고    scopus 로고
    • Reduced susceptibility to praziquantel among naturally occurring Kenya isolates of Schistosoma mansoni
    • Melman SD, Steinauer ML, Cunningham C, Kubatko LS, Mwangi IN, et al. (2009) Reduced susceptibility to praziquantel among naturally occurring Kenya isolates of Schistosoma mansoni. PLoS Negl Trop Dis 3: e504.
    • (2009) PLoS Negl Trop Dis , vol.3
    • Melman, S.D.1    Steinauer, M.L.2    Cunningham, C.3    Kubatko, L.S.4    Mwangi, I.N.5
  • 5
    • 0028025029 scopus 로고
    • Drug-resistant schistosomiasis: resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific
    • Fallon PG, Doenhoff MJ, (1994) Drug-resistant schistosomiasis: resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific. Am J Trop Med Hyg 51: 83-8.
    • (1994) Am J Trop Med Hyg , vol.51 , pp. 83-88
    • Fallon, P.G.1    Doenhoff, M.J.2
  • 6
    • 20544471104 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors in programmed cell death and cancer therapy
    • Marks PA, Jiang X, (2005) Histone deacetylase inhibitors in programmed cell death and cancer therapy. Cell Cycle 4: 549-551.
    • (2005) Cell Cycle , vol.4 , pp. 549-551
    • Marks, P.A.1    Jiang, X.2
  • 9
    • 0021203978 scopus 로고
    • Changes in glucose metabolism and cyanide sensitivity in Schistosoma mansoni during development
    • Thompson DP, Morrison DD, Pax RA, Bennett JL, (1984) Changes in glucose metabolism and cyanide sensitivity in Schistosoma mansoni during development. Mol Biochem Parasitol 13: 39-51.
    • (1984) Mol Biochem Parasitol , vol.13 , pp. 39-51
    • Thompson, D.P.1    Morrison, D.D.2    Pax, R.A.3    Bennett, J.L.4
  • 10
    • 0029258665 scopus 로고
    • A molecular genetic study of the variations in metabolic function during schistosome development
    • Skelly PJ, Shoemaker CB, (1995) A molecular genetic study of the variations in metabolic function during schistosome development. Mem Inst Oswaldo Cruz 90: 281-284.
    • (1995) Mem Inst Oswaldo Cruz , vol.90 , pp. 281-284
    • Skelly, P.J.1    Shoemaker, C.B.2
  • 11
    • 79955398591 scopus 로고    scopus 로고
    • Otto Warburg's contributions to current concepts of cancer metabolism
    • Koppenol WH, Bounds PL, Dang CV, (2011) Otto Warburg's contributions to current concepts of cancer metabolism. Nat Rev Cancer 11: 325-337.
    • (2011) Nat Rev Cancer , vol.11 , pp. 325-337
    • Koppenol, W.H.1    Bounds, P.L.2    Dang, C.V.3
  • 13
    • 84875755814 scopus 로고    scopus 로고
    • Influence of metabolism on epigenetics and disease
    • Kaelin WG Jr, McKnight SL, (2013) Influence of metabolism on epigenetics and disease. Cell 153: 56-69.
    • (2013) Cell , vol.153 , pp. 56-69
    • Kaelin Jr., W.G.1    McKnight, S.L.2
  • 15
    • 0033887456 scopus 로고    scopus 로고
    • Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
    • Frye RA, (2000) Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun 273: 793-798.
    • (2000) Biochem Biophys Res Commun , vol.273 , pp. 793-798
    • Frye, R.A.1
  • 16
    • 33748316536 scopus 로고    scopus 로고
    • SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells
    • Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, et al. (2006) SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell 126: 941-54.
    • (2006) Cell , vol.126 , pp. 941-954
    • Haigis, M.C.1    Mostoslavsky, R.2    Haigis, K.M.3    Fahie, K.4    Christodoulou, D.C.5
  • 17
    • 81055122671 scopus 로고    scopus 로고
    • Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase
    • Du J, Zhou Y, Su X, Yu JJ, Khan S, et al. (2011) Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science 334: 806-809.
    • (2011) Science , vol.334 , pp. 806-809
    • Du, J.1    Zhou, Y.2    Su, X.3    Yu, J.J.4    Khan, S.5
  • 18
    • 84875881601 scopus 로고    scopus 로고
    • Sirt6 regulates TNF- secretion through hydrolysis of long-chain fatty acyl lysine
    • Jiang H, Khan S, Wang Y, Charron G, He B, et al. (2013) Sirt6 regulates TNF- secretion through hydrolysis of long-chain fatty acyl lysine. Nature 496: 110-113.
    • (2013) Nature , vol.496 , pp. 110-113
    • Jiang, H.1    Khan, S.2    Wang, Y.3    Charron, G.4    He, B.5
  • 19
    • 72949112693 scopus 로고    scopus 로고
    • Sirtuin/Sir2 phylogeny, evolutionary considerations and structural conservation
    • Greiss S, Gartner A, (2009) Sirtuin/Sir2 phylogeny, evolutionary considerations and structural conservation. Mol Cells 28: 407-415.
    • (2009) Mol Cells , vol.28 , pp. 407-415
    • Greiss, S.1    Gartner, A.2
  • 20
    • 26244436281 scopus 로고    scopus 로고
    • Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins
    • Michishita E, Park JY, Burneskis JM, Barrett JC, Horikawa I, (2005) Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol Biol Cell 16: 4623-4635.
    • (2005) Mol Biol Cell , vol.16 , pp. 4623-4635
    • Michishita, E.1    Park, J.Y.2    Burneskis, J.M.3    Barrett, J.C.4    Horikawa, I.5
  • 21
    • 0035913903 scopus 로고    scopus 로고
    • hSIR2 (SIRT1) functions as an NAD-dependent p53 deacetylase
    • Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, et al. (2001) hSIR2 (SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107: 149-159.
    • (2001) Cell , vol.107 , pp. 149-159
    • Vaziri, H.1    Dessain, S.K.2    Ng Eaton, E.3    Imai, S.I.4    Frye, R.A.5
  • 22
    • 23844485211 scopus 로고    scopus 로고
    • Acetylation of FoxO1 alters its DNA-binding ability and sensitivity to phosphorylation
    • Matsuzaki H, Daitoku H, Hatta M, Aoyama H, Yoshimochi K, et al. (2005) Acetylation of FoxO1 alters its DNA-binding ability and sensitivity to phosphorylation. Proc Natl Acad Sci U S A 102: 11278-11283.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 11278-11283
    • Matsuzaki, H.1    Daitoku, H.2    Hatta, M.3    Aoyama, H.4    Yoshimochi, K.5
  • 24
    • 84857245894 scopus 로고    scopus 로고
    • Binding free energy calculations and biological testing of novel thiobarbiturates as inhibitors of the human NAD+ dependent histone deacetylase Sirt2
    • Uciechowska U, Schemies J, Scharfe M, Lawson M, Wichapong K, et al. (2012) Binding free energy calculations and biological testing of novel thiobarbiturates as inhibitors of the human NAD+ dependent histone deacetylase Sirt2. Med Chem Commun 3: 167-173.
    • (2012) Med Chem Commun , vol.3 , pp. 167-173
    • Uciechowska, U.1    Schemies, J.2    Scharfe, M.3    Lawson, M.4    Wichapong, K.5
  • 25
    • 84865037340 scopus 로고    scopus 로고
    • Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells
    • Wang J, Kim TH, Ahn MY, Lee J, Jung JH, et al. (2012) Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells. Int J Oncol 41: 1101-1109.
    • (2012) Int J Oncol , vol.41 , pp. 1101-1109
    • Wang, J.1    Kim, T.H.2    Ahn, M.Y.3    Lee, J.4    Jung, J.H.5
  • 26
    • 60149091562 scopus 로고    scopus 로고
    • Salermide, a sirtuin inhibitor with a strong cancer-specific proapoptotic effect
    • Lara E, Mai A, Calvanese V, Altucci L, Lopez-Nieva P, et al. (2009) Salermide, a sirtuin inhibitor with a strong cancer-specific proapoptotic effect. Oncogene 28: 781-791.
    • (2009) Oncogene , vol.28 , pp. 781-791
    • Lara, E.1    Mai, A.2    Calvanese, V.3    Altucci, L.4    Lopez-Nieva, P.5
  • 27
    • 65949120199 scopus 로고    scopus 로고
    • Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum
    • Tonkin CJ, Carret CJ, Duraisingh MT, Voss TS, Ralph SA, et al. (2009) Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum. PLoS Biol 7: e84.
    • (2009) PLoS Biol , vol.7
    • Tonkin, C.J.1    Carret, C.J.2    Duraisingh, M.T.3    Voss, T.S.4    Ralph, S.A.5
  • 28
    • 42449117061 scopus 로고    scopus 로고
    • Nicotinamide inhibits Plasmodium falciparum Sir2 activity in vitro and parasite growth
    • Prusty D, Mehra P, Srivastava S, Shivange AV, Gupta A, et al. (2008) Nicotinamide inhibits Plasmodium falciparum Sir2 activity in vitro and parasite growth. FEMS Microbiol Lett 282: 266-272.
    • (2008) FEMS Microbiol Lett , vol.282 , pp. 266-272
    • Prusty, D.1    Mehra, P.2    Srivastava, S.3    Shivange, A.V.4    Gupta, A.5
  • 29
    • 39049164295 scopus 로고    scopus 로고
    • Biochemical characterization of Plasmodium falciparum Sir2, a NAD+-dependent deacetylase
    • Chakrabarty SP, Saikumari YK, Bopanna MP, Balaram H, (2008) Biochemical characterization of Plasmodium falciparum Sir2, a NAD+-dependent deacetylase. Mol Biochem Parasitol 158: 139-151.
    • (2008) Mol Biochem Parasitol , vol.158 , pp. 139-151
    • Chakrabarty, S.P.1    Saikumari, Y.K.2    Bopanna, M.P.3    Balaram, H.4
  • 30
    • 28044445460 scopus 로고    scopus 로고
    • Targeted disruption of cytosolic SIR2 deacetylase discloses its essential role in Leishmania survival and proliferation
    • Vergnes B, Sereno D, Tavares J, Cordeiro-da-Silva A, Vanhille L, et al. (2005) Targeted disruption of cytosolic SIR2 deacetylase discloses its essential role in Leishmania survival and proliferation. Gene 363: 85-96.
    • (2005) Gene , vol.363 , pp. 85-96
    • Vergnes, B.1    Sereno, D.2    Tavares, J.3    Cordeiro-da-Silva, A.4    Vanhille, L.5
  • 31
    • 0013812695 scopus 로고
    • The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms
    • Smithers SR, Terry RJ, (1965) The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms. Parasitology 55: 695-700.
    • (1965) Parasitology , vol.55 , pp. 695-700
    • Smithers, S.R.1    Terry, R.J.2
  • 32
    • 0028840320 scopus 로고
    • Production of Schistosoma mansoni daughter sporocysts from mother sporocysts maintained in synxenic culture with Biomphalaria glabrata embryonic (Bge) cells
    • Yoshino TP, Laursen JR, (1995) Production of Schistosoma mansoni daughter sporocysts from mother sporocysts maintained in synxenic culture with Biomphalaria glabrata embryonic (Bge) cells. J Parasitol 81: 714-722.
    • (1995) J Parasitol , vol.81 , pp. 714-722
    • Yoshino, T.P.1    Laursen, J.R.2
  • 33
    • 33644822214 scopus 로고    scopus 로고
    • Schistosoma mansoni CBP/p300 has a conserved domain structure and interacts functionally with the nuclear receptor SmFtz-F1
    • Bertin B, Oger F, Cornette J, Caby S, Noël C, et al. (2006) Schistosoma mansoni CBP/p300 has a conserved domain structure and interacts functionally with the nuclear receptor SmFtz-F1. Mol Biochem Parasitol 146: 180-191.
    • (2006) Mol Biochem Parasitol , vol.146 , pp. 180-191
    • Bertin, B.1    Oger, F.2    Cornette, J.3    Caby, S.4    Noël, C.5
  • 37
    • 84876533617 scopus 로고    scopus 로고
    • Building phylogenetic trees from molecular data with MEGA
    • Hall BG, (2013) Building phylogenetic trees from molecular data with MEGA. Mol Biol Evol 30: 1229-35.
    • (2013) Mol Biol Evol , vol.30 , pp. 1229-1235
    • Hall, B.G.1
  • 38
    • 48449106792 scopus 로고    scopus 로고
    • The Jpred 3 secondary structure prediction server
    • Cole C, Barber JD, Barton GJ, (2008) The Jpred 3 secondary structure prediction server. Nucl Acids Res 36: W197-201.
    • (2008) Nucl Acids Res , vol.36
    • Cole, C.1    Barber, J.D.2    Barton, G.J.3
  • 39
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl MW, (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucl Acids Res 29: e45.
    • (2001) Nucl Acids Res , vol.29
    • Pfaffl, M.W.1
  • 40
    • 68749093790 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni
    • Dubois F, Caby S, Oger F, Cosseau C, Capron M, et al. (2009) Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni. Mol Biochem Parasitol 168: 7-15.
    • (2009) Mol Biochem Parasitol , vol.168 , pp. 7-15
    • Dubois, F.1    Caby, S.2    Oger, F.3    Cosseau, C.4    Capron, M.5
  • 41
    • 0035914304 scopus 로고    scopus 로고
    • Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening
    • Grozinger CM, Chao ED, Blackwell HE, Moazed D, Schreiber SL, (2001) Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J Biol Chem 276: 38837-38843.
    • (2001) J Biol Chem , vol.276 , pp. 38837-38843
    • Grozinger, C.M.1    Chao, E.D.2    Blackwell, H.E.3    Moazed, D.4    Schreiber, S.L.5
  • 42
    • 57549089690 scopus 로고    scopus 로고
    • Thiobarbiturates as sirtuin inhibitors: virtual screening, free-energy calculations, and biological testing
    • Uciechowska U, Schemies J, Neugebauer RC, Huda EM, Schmitt ML, et al. (2008) Thiobarbiturates as sirtuin inhibitors: virtual screening, free-energy calculations, and biological testing. ChemMedChem 3: 1965-76.
    • (2008) ChemMedChem , vol.3 , pp. 1965-1976
    • Uciechowska, U.1    Schemies, J.2    Neugebauer, R.C.3    Huda, E.M.4    Schmitt, M.L.5
  • 44
    • 41649103241 scopus 로고    scopus 로고
    • Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode
    • Neugebauer RC, Uchiechowska U, Meier R, Hruby H, Valkov V, et al. (2008) Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode. J Med Chem 51: 1203-13.
    • (2008) J Med Chem , vol.51 , pp. 1203-1213
    • Neugebauer, R.C.1    Uchiechowska, U.2    Meier, R.3    Hruby, H.4    Valkov, V.5
  • 45
    • 84878486356 scopus 로고    scopus 로고
    • Dual targeting of insulin and venus kinase receptors of Schistosoma mansoni for novel anti-schistosome therapy
    • Vanderstraete M, Gouignard N, Caillau K, Morel M, Lancelot J, et al. (2013) Dual targeting of insulin and venus kinase receptors of Schistosoma mansoni for novel anti-schistosome therapy. PLoS Negl Trop Dis 7: e2226.
    • (2013) PLoS Negl Trop Dis , vol.7
    • Vanderstraete, M.1    Gouignard, N.2    Caillau, K.3    Morel, M.4    Lancelot, J.5
  • 48
    • 0030200110 scopus 로고    scopus 로고
    • PEST sequences and regulation by proteolysis
    • Reichsteiner M, Rogers SW, (1996) PEST sequences and regulation by proteolysis. Trends Biochem Sci 21: 267-271.
    • (1996) Trends Biochem Sci , vol.21 , pp. 267-271
    • Reichsteiner, M.1    Rogers, S.W.2
  • 49
    • 0034845958 scopus 로고    scopus 로고
    • PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?
    • Lawlor MA, Alessi DR, (2001) PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? J Cell Sci 114: 2903-2910.
    • (2001) J Cell Sci , vol.114 , pp. 2903-2910
    • Lawlor, M.A.1    Alessi, D.R.2
  • 50
    • 84856579279 scopus 로고    scopus 로고
    • A systematically improved high quality genome and transcriptome of the human blood fluke Schistosoma mansoni
    • Protasio AV, Tsai IJ, Babbage A, Nichol S, Hunt M, et al. (2012) A systematically improved high quality genome and transcriptome of the human blood fluke Schistosoma mansoni. PLoS Negl Trop Dis 6: e1455.
    • (2012) PLoS Negl Trop Dis , vol.6
    • Protasio, A.V.1    Tsai, I.J.2    Babbage, A.3    Nichol, S.4    Hunt, M.5
  • 51
    • 0029143929 scopus 로고
    • RNA trans-splicing in flatworms. Analysis of trans-spliced mRNAs and genes in the human parasite, Schistosoma mansoni
    • Davis RE, Hardwick C, Tavernier P, Hodgson S, Singh H, (1995) RNA trans-splicing in flatworms. Analysis of trans-spliced mRNAs and genes in the human parasite, Schistosoma mansoni. J Biol Chem 270: 21813-21819.
    • (1995) J Biol Chem , vol.270 , pp. 21813-21819
    • Davis, R.E.1    Hardwick, C.2    Tavernier, P.3    Hodgson, S.4    Singh, H.5
  • 52
    • 33644862641 scopus 로고    scopus 로고
    • The flatworm spliced leader 3′-terminal AUG as a translation initiator methionine
    • Cheng G, Cohen L, Ndegwa D, Davis RE, (2006) The flatworm spliced leader 3′-terminal AUG as a translation initiator methionine. J Biol Chem 281: 733-743.
    • (2006) J Biol Chem , vol.281 , pp. 733-743
    • Cheng, G.1    Cohen, L.2    Ndegwa, D.3    Davis, R.E.4
  • 53
    • 0032972509 scopus 로고    scopus 로고
    • PSORT: a program for detecting the sorting signals of proteins and predicting their subcellular localization
    • Nakai K, Horton P, (1999) PSORT: a program for detecting the sorting signals of proteins and predicting their subcellular localization,. Trends Biochem Sci 24: 34-35.
    • (1999) Trends Biochem Sci , vol.24 , pp. 34-35
    • Nakai, K.1    Horton, P.2
  • 54
    • 67650786530 scopus 로고    scopus 로고
    • The Schistosoma japonicum genome reveals features of host-parasite interplay
    • Schistosoma japonicum genome sequencing and functional analysis consortium
    • Schistosoma japonicum genome sequencing and functional analysis consortium (2009) The Schistosoma japonicum genome reveals features of host-parasite interplay. Nature 460: 345-351.
    • (2009) Nature , vol.460 , pp. 345-351
  • 55
    • 84862777661 scopus 로고    scopus 로고
    • Whole-genome sequence of Schistosoma haematobium
    • Young ND, Jex AR, Li B, Liu S, Yang L, et al. (2012) Whole-genome sequence of Schistosoma haematobium. Nat Genet 44: 221-225.
    • (2012) Nat Genet , vol.44 , pp. 221-225
    • Young, N.D.1    Jex, A.R.2    Li, B.3    Liu, S.4    Yang, L.5
  • 57
    • 84876359638 scopus 로고    scopus 로고
    • SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism
    • Jeong SM, Xiao C, Finley LW, Lahusen T, Souza AL, et al. (2013) SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer Cell 23: 450-463.
    • (2013) Cancer Cell , vol.23 , pp. 450-463
    • Jeong, S.M.1    Xiao, C.2    Finley, L.W.3    Lahusen, T.4    Souza, A.L.5
  • 58
    • 0037178748 scopus 로고    scopus 로고
    • Interfaces between the detection, signaling, and repair of DNA damage
    • Rouse J, Jackson SP, (2002) Interfaces between the detection, signaling, and repair of DNA damage. Science 297: 547-551.
    • (2002) Science , vol.297 , pp. 547-551
    • Rouse, J.1    Jackson, S.P.2
  • 59
    • 79952274786 scopus 로고    scopus 로고
    • SIRT6: a master gatekeeper of glucose metabolism
    • Zhong L, Mostoslavsky R, (2010) SIRT6: a master gatekeeper of glucose metabolism. Transcription 1: 17-21.
    • (2010) Transcription , vol.1 , pp. 17-21
    • Zhong, L.1    Mostoslavsky, R.2
  • 60
    • 84863453769 scopus 로고    scopus 로고
    • Sirt7 links H3K18 deacetylation to maintenance of oncogenic transformation
    • Barber MF, Michisita-Kioi E, Xi Y, Tasselli L, Kioi M, et al. (2012) Sirt7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature 487: 114-118.
    • (2012) Nature , vol.487 , pp. 114-118
    • Barber, M.F.1    Michisita-Kioi, E.2    Xi, Y.3    Tasselli, L.4    Kioi, M.5
  • 61
    • 77950835404 scopus 로고    scopus 로고
    • SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2
    • Peck B, Chen CY, Ho KK, Di Fruscia P, Myatt SS, et al. (2010) SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2. Mol Cancer Ther 9: 844-855.
    • (2010) Mol Cancer Ther , vol.9 , pp. 844-855
    • Peck, B.1    Chen, C.Y.2    Ho, K.K.3    Di Fruscia, P.4    Myatt, S.S.5
  • 62
    • 0037086045 scopus 로고    scopus 로고
    • A microplate reader-based nonisotopic histone deacetylase activity assay
    • Heltweg B, Jung M, (2002) A microplate reader-based nonisotopic histone deacetylase activity assay. Anal Biochem 302: 175-183.
    • (2002) Anal Biochem , vol.302 , pp. 175-183
    • Heltweg, B.1    Jung, M.2
  • 64
    • 84863403463 scopus 로고    scopus 로고
    • SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice
    • Seifert EL, Caron AZ, Morin K, Coulombe J, He XH, et al. (2012) SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice. FASEB J 26: 555-566.
    • (2012) FASEB J , vol.26 , pp. 555-566
    • Seifert, E.L.1    Caron, A.Z.2    Morin, K.3    Coulombe, J.4    He, X.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.