Identification of thioredoxin glutathione reductase inhibitors that kill cestode and trematode parasites

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Ross, Fabiana ^a   Hernández, Paola ^a   Porcal, Williams ^a   López, Gloria V ^a   Cerecetto, Hugo ^a   González, Mercedes ^a   Basika, Tatiana ^b   Carmona, Carlos ^b   Fló, Martín ^a   Maggioli, Gabriela ^b   Bonilla, Mariana ^a   Gladyshev, Vadim N ^c   Boiani, Mariana ^a   Salinas, Gustavo ^a  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHELMINTIC AGENT; BENZOFURAXAN; OXADIAZOLE N OXIDE; QUINOXALINE; THIADIAZOLE; THIOREDOXIN REDUCTASE; UNCLASSIFIED DRUG; ANTICESTODAL AGENT; ANTIPLATYHELMINTIC AGENT; FUROXANS; HELMINTH PROTEIN; MULTIENZYME COMPLEX; OXADIAZOLE DERIVATIVE; OXIDOREDUCTASE; QUINOXALINE DERIVATIVE; THIADIAZOLE DERIVATIVE; THIOREDOXIN GLUTATHIONE REDUCTASE;

ANIMAL CELL; ANTHELMINTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING; DRUG STRUCTURE; ECHINOCOCCUS GRANULOSUS; FASCIOLA HEPATICA; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; TOXICITY TESTING; ANIMAL; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; ENZYMOLOGY; FIBROBLAST; LARVA; LYMPHOCYTE; QUANTUM THEORY;

ANIMALS; ANTICESTODAL AGENTS; ANTIPLATYHELMINTIC AGENTS; CELL LINE; DRUG EVALUATION, PRECLINICAL; ECHINOCOCCUS GRANULOSUS; FASCIOLA HEPATICA; FIBROBLASTS; HELMINTH PROTEINS; HUMANS; LARVA; LYMPHOCYTES; MICE; MODELS, MOLECULAR; MULTIENZYME COMPLEXES; NADH, NADPH OXIDOREDUCTASES; OXADIAZOLES; QUANTUM THEORY; QUINOXALINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES;

EID: 84859970281     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035033     Document Type: Article

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