Identification by high-throughput screening of inhibitors of Schistosoma mansoni NAD+ catabolizing enzyme

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 22, 2010, Pages 7900-7910

  Kuhn, Isabelle ^a   Kellenberger, Esther ^b   Said Hassane, Fatouma ^a   Villa, Pascal ^c   Rognan, Didier ^b   Lobstein, Annelise ^b   Haiech, Jacques ^b,c   Hibert, Marcel ^b   Schuber, Francis ^a   Muller Steffner, Hélène ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b Faculté de Pharmacie   (France)

^c ULP Strasbourg Faculté de Pharmacie   (France)

Author keywords

Anthocyanidins; CD38; Docking; Flavonoids; Fluorescence; High throughput screening; Schistosoma mansoni; SmNACE

Indexed keywords

1,8 NAPHTHALIMIDE; CATECHIN; CD38 ANTIGEN; CURCUMIN; CYANIDIN 3 GLUCOSIDE; DELPHINIDIN; DIOSMETINIDIN; FISETINIDIN; FLAVONOID; GLYCOSIDASE INHIBITOR; LUTEOLIN; LUTEOLINIDIN; MALVIDIN CHLORIDE; MYRICETIN; N (5,6 DIHYDRO 6 OXO 2 PHENANTHRIDINYL) 2 DIMETHYLAMINOACETAMIDE; NAPHTHALIMIDE DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE; PELARGONIDIN; PEONIDIN; PETUNIDIN CHLORIDE; PICEATANNOL; PRAZIQUANTEL; QUERCETAGETIN; QUERCETAGETINIDIN; QUERCETIN; RESVERATROL; ROBINETIN; SURAMIN; TAXIFOLIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; HUMAN; NONHUMAN; SCHISTOSOMA MANSONI; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIGENS, CD38; BINDING SITES; CATALYTIC DOMAIN; COMPUTER SIMULATION; ENZYME INHIBITORS; FLAVONOIDS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; NAD+ NUCLEOSIDASE; SCHISTOSOMA MANSONI; SCHISTOSOMICIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

SCHISTOSOMA MANSONI;

EID: 78449249121     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.09.041     Document Type: Article

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