NPACT: Naturally occurring plant-based anti-cancer compound-activity-target database

Nucleic Acids Research

Volumn 41, Issue D1, 2013, Pages

  Mangal, Manu ^a   Sagar, Parul ^a   Singh, Harinder ^b   Raghava, Gajendra P S ^b   Agarwal, Subhash M ^a  

^a INSTITUTE OF CYTOLOGY AND PREVENTIVE ONCOLOGY   (India)

^b INSTITUTE OF MICROBIAL TECHNOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; HERBACEOUS AGENT;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL TYPE; DRUG CONCENTRATION; DRUG DATABASE; DRUG DOSE; DRUG STRUCTURE; GI 50; IC 50; INFORMATION PROCESSING; INFORMATION RETRIEVAL; MALIGNANT NEOPLASTIC DISEASE; MEDIAN EFFECTIVE CONCENTRATION; NATURALLY OCCURRING PLANT BASED ANTI CANCER COMPOUND ACTIVITY TARGET DATABASE; ONLINE ANALYSIS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN TARGETING;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; DATABASES, CHEMICAL; HUMANS; INTERNET; PROTEINS; USER-COMPUTER INTERFACE;

EID: 84876560772     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gks1047     Document Type: Article

References (12)

1. Koehn, F.E. and Carter, G.T. (2005) The evolving role of natural products in drug discovery. Nat. Rev. Drug Discov., 4, 206-220.
2. Newman, D.J. and Cragg, G.M. (2012) Natural products as sources of new drugs over the 30 years from 1981 to 2010. J. Nat. Prod., 75, 311-335.
3. Mishra, B.B. and Tiwari, V.K. (2011) Natural products: an evolving role in future drug discovery. Eur. J. Med. Chem., 46, 4769-4807.
4. Chin, Y.W., Yoon, K.D. and Kim, J. (2009) Cytotoxic anticancer candidates from terrestrial plants. Anticancer Agents Med. Chem., 9, 913-942.
5. Dunkel, M., Fullbeck, M., Neumann, S. and Preissner, R. (2006) SuperNatural: a searchable database of available natural compounds. Nucleic Acids Res., 34, D678-D683.
6. Ye, H., Ye, L., Kang, H., Zhang, D., Tao, L., Tang, K., Liu, X., Zhu, R., Liu, Q., Chen, Y.Z. et al. (2011) HIT: linking herbal active ingredients to targets. Nucleic Acids Res., 39, D1055-D1059.
7. Ahmed, J., Meinel, T., Dunkel, M., Murgueitio, M.S., Adams, R., Blasse, C., Eckert, A., Preissner, S. and Preissner, R. (2011) CancerResource: a comprehensive database of cancer-relevant proteins and compound interactions supported by experimental knowledge. Nucleic Acids Res., 39, D960-D967.
8. Csizmadia, F. (2000) JChem: Java applets and modules supporting chemical database handling from web browsers. J. Chem. Inf. Comput. Sci., 40, 323-324.
9. Dobson, P.D., Patel, Y. and Kell, D.B. (2009) 'Metabolite-likeness' as a criterion in the design and selection of pharmaceutical drug libraries. Drug Discov. Today, 14, 31-40.
10. Peironcely, J.E., Reijmers, T., Coulier, L., Bender, A. and Hankemeier, T. (2011) Understanding and classifying metabolite space and metabolite-likeness. PLoS One, 6, e28966.
11. Ertl, P., Roggo, S. and Schuffenhauer, A. (2008) Natural product-likeness score and its application for prioritization of compound libraries. J. Chem. Inf. Model., 48, 68-74.
12. Bohari, M.H., Srivastava, H.K. and Sastry, G.N. (2011) Analogue-based approaches in anti-cancer compound modelling: the relevance of QSAR models. Org. Med. Chem. Lett., 1, 3.