-
1
-
-
0037039929
-
Alkylating capacity and reaction products of antimalarial trioxanes after activation by a heme model
-
Cazelles J, Robert A, Meunier B (2002) Alkylating capacity and reaction products of antimalarial trioxanes after activation by a heme model. J Org Chem 67:609-619
-
(2002)
J Org Chem
, vol.67
, pp. 609-619
-
-
Cazelles, J.1
Robert, A.2
Meunier, B.3
-
2
-
-
0000435329
-
Studies on antischistosomal activity of qinghaosu in experimental therapy
-
Chen DJ, Fu LF, Shao PP, Wu FZ, Fan CZ, Shu H, Ren CS, Sheng XL (1980) Studies on antischistosomal activity of qinghaosu in experimental therapy (in Chinese). Zhong Hui Yi Xue Zha Zhi 80:422-428
-
(1980)
Zhong Hui Yi Xue Zha Zhi
, vol.80
, pp. 422-428
-
-
Chen, D.J.1
Fu, L.F.2
Shao, P.P.3
Wu, F.Z.4
Fan, C.Z.5
Shu, H.6
Ren, C.S.7
Sheng, X.L.8
-
3
-
-
0020097279
-
The chemistry and synthesis of qinghaosu derivatives
-
China Cooperative Research Group on Qinghaosu and its Derivatives as Antimalarials (1982) The chemistry and synthesis of qinghaosu derivatives. J Tradit Chin Med 2:9-16
-
(1982)
J Tradit Chin Med
, vol.2
, pp. 9-16
-
-
-
4
-
-
0035208051
-
Artemisinin and derivatives: The future for malaria treatment?
-
Haynes RK (2001) Artemisinin and derivatives: the future for malaria treatment? Curr Opin Infect Dis 14:719-726
-
(2001)
Curr Opin Infect Dis
, vol.14
, pp. 719-726
-
-
Haynes, R.K.1
-
5
-
-
0035207181
-
Why artemisinin and certain synthetic peroxides are potent antimalarials. Implications for the mode of action
-
Jefford CW (2001) Why artemisinin and certain synthetic peroxides are potent antimalarials. Implications for the mode of action. Curr Med Chem 8:1803-1826
-
(2001)
Curr Med Chem
, vol.8
, pp. 1803-1826
-
-
Jefford, C.W.1
-
6
-
-
0031973066
-
Plasma concentrations of artemether and its major plasma metabolite, dihydroartemisinin, following a 5-day regimen of oral artemether, in patients with uncomplicated falciparum malaria
-
Karbwang J, Na-Bangchang K, Thanvibul A, Molunto P (1998) Plasma concentrations of artemether and its major plasma metabolite, dihydroartemisinin, following a 5-day regimen of oral artemether, in patients with uncomplicated falciparum malaria. Ann Trop Med Parasitol 92:31-36
-
(1998)
Ann Trop Med Parasitol
, vol.92
, pp. 31-36
-
-
Karbwang, J.1
Na-Bangchang, K.2
Thanvibul, A.3
Molunto, P.4
-
7
-
-
0021948029
-
Qinghaosu (artemisinin): An antimalarial drug from China
-
Klayman DL (1985) Qinghaosu (artemisinin): an antimalarial drug from China. Science 228:1049-1055
-
(1985)
Science
, vol.228
, pp. 1049-1055
-
-
Klayman, D.L.1
-
8
-
-
0006981524
-
Studies on the efficacy of artemether in experimental schistosomiasis
-
Le WJ, You JQ, Yang YQ, Mei JY, Guo HF, Yang HZ, Zang CW (1982) Studies on the efficacy of artemether in experimental schistosomiasis (in Chinese). Acta Pharmaceut Sin 17:187-193
-
(1982)
Acta Pharmaceut Sin
, vol.17
, pp. 187-193
-
-
Le, W.J.1
You, J.Q.2
Yang, Y.Q.3
Mei, J.Y.4
Guo, H.F.5
Yang, H.Z.6
Zang, C.W.7
-
9
-
-
0037021405
-
Artemisinin: Mechanisms of action, resistance and toxicity
-
Meshnick SR (2002) Artemisinin: mechanisms of action, resistance and toxicity. Int J Parasitol 32:1655-1660
-
(2002)
Int J Parasitol
, vol.32
, pp. 1655-1660
-
-
Meshnick, S.R.1
-
10
-
-
0026014249
-
Artemisinin (qinghaosu): The role of intracellular hemin in its mechanism of antimalarial action
-
Meshnick SR, Thomas A, Ranz A, Xu CM, Pan HZ (1991) Artemisinin (qinghaosu): the role of intracellular hemin in its mechanism of antimalarial action. Mol Biochem Parasitol 49:181-189
-
(1991)
Mol Biochem Parasitol
, vol.49
, pp. 181-189
-
-
Meshnick, S.R.1
Thomas, A.2
Ranz, A.3
Xu, C.M.4
Pan, H.Z.5
-
11
-
-
0029894037
-
Artemisinin and the antimalarial endoperoxides: From herbal remedy to targeted chemotherapy
-
Meshnick SR, Taylor TE, Kamchonwongpaisan S (1996) Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy. Microbiol Rev 60:301-315
-
(1996)
Microbiol Rev
, vol.60
, pp. 301-315
-
-
Meshnick, S.R.1
Taylor, T.E.2
Kamchonwongpaisan, S.3
-
12
-
-
0037263883
-
Randomized, double-blind, placebo-controlled trial of oral artemether for the prevention of patent Schistosoma haematobium infections
-
N'Goran EK, Utzinger J, Gnaka HN, Yapi A, N'Guessan NA, Kigbafori SD, Lengeler C, Chollet J, Xiao SH, Tanner M (2003) Randomized, double-blind, placebo-controlled trial of oral artemether for the prevention of patent Schistosoma haematobium infections. Am J Trop Med Hyg 68:24-32
-
(2003)
Am J Trop Med Hyg
, vol.68
, pp. 24-32
-
-
N'Goran, E.K.1
Utzinger, J.2
Gnaka, H.N.3
Yapi, A.4
N'Guessan, N.A.5
Kigbafori, S.D.6
Lengeler, C.7
Chollet, J.8
Xiao, S.H.9
Tanner, M.10
-
13
-
-
0036078913
-
Combination therapy for malaria: The way forward?
-
Nosten F, Brasseur P (2002) Combination therapy for malaria: the way forward? Drugs 62:1315-1329
-
(2002)
Drugs
, vol.62
, pp. 1315-1329
-
-
Nosten, F.1
Brasseur, P.2
-
15
-
-
0034989816
-
Radical mechanism of action of the artemisinin-type compounds
-
Posner GH, Meshnick SR (2001) Radical mechanism of action of the artemisinin-type compounds. Trends Parasitol 17:266-267
-
(2001)
Trends Parasitol
, vol.17
, pp. 266-267
-
-
Posner, G.H.1
Meshnick, S.R.2
-
16
-
-
0026746574
-
A regiospecifically oxygen-18 labelled 1,2,4-trioxane: A simple chemical model system to probe the mechanism(s) for the antimalarial activity of artemisinin (qinghaosu)
-
Posner GH, Oh CH (1992) A regiospecifically oxygen-18 labelled 1,2,4-trioxane: a simple chemical model system to probe the mechanism(s) for the antimalarial activity of artemisinin (qinghaosu). J Am Chem Soc 114:8328-8329
-
(1992)
J Am Chem Soc
, vol.114
, pp. 8328-8329
-
-
Posner, G.H.1
Oh, C.H.2
-
17
-
-
0033869568
-
Artemisinin drugs: Novel antimalarial agents
-
Price RN (2000) Artemisinin drugs: novel antimalarial agents. Expert Opin Investig Drugs 9:1815-1827
-
(2000)
Expert Opin Investig Drugs
, vol.9
, pp. 1815-1827
-
-
Price, R.N.1
-
18
-
-
0035743022
-
From classical antimalarial drugs to new compounds based on the mechanism of action of artemisinin
-
Robert A, Benoit-Vical F, Dechy-Cabaret O, Meunier B (2001) From classical antimalarial drugs to new compounds based on the mechanism of action of artemisinin. Pure Appl Chem 73:1173-1188
-
(2001)
Pure Appl Chem
, vol.73
, pp. 1173-1188
-
-
Robert, A.1
Benoit-Vical, F.2
Dechy-Cabaret, O.3
Meunier, B.4
-
19
-
-
0037034905
-
Alkylation of heme by the antimalarial drug artemisinin
-
Robert A, Coppel Y, Meunier B (2002) Alkylation of heme by the antimalarial drug artemisinin. Chem Commun 2002:414-415
-
(2002)
Chem Commun
, vol.2002
, pp. 414-415
-
-
Robert, A.1
Coppel, Y.2
Meunier, B.3
-
20
-
-
0035205287
-
Redox reaction of artemisinin with ferrous and ferric ions in aqueous buffer
-
Sibmooh N, Udomsangpetch R, Kijjoa A, Chantharaksri U, Mankhetkorn S (2001) Redox reaction of artemisinin with ferrous and ferric ions in aqueous buffer. Chem Pharm Bull 49:1541-1546
-
(2001)
Chem Pharm Bull
, vol.49
, pp. 1541-1546
-
-
Sibmooh, N.1
Udomsangpetch, R.2
Kijjoa, A.3
Chantharaksri, U.4
Mankhetkorn, S.5
-
21
-
-
0034656258
-
Oral artemether for prevention of Schistosoma mansoni infection: Randomised controlled trial
-
Utzinger J, N'Goran EK, N'Dri A, Lengeler C, Xiao SH, Tanner M (2000) Oral artemether for prevention of Schistosoma mansoni infection: randomised controlled trial. Lancet 355:1320-1325
-
(2000)
Lancet
, vol.355
, pp. 1320-1325
-
-
Utzinger, J.1
N'Goran, E.K.2
N'Dri, A.3
Lengeler, C.4
Xiao, S.H.5
Tanner, M.6
-
22
-
-
0035217959
-
The potential of artemether for the control of schistosomiasis
-
Utzinger J, Xiao SH, N'Goran EK, Bergquist R, Tanner M (2001) The potential of artemether for the control of schistosomiasis. Int J Parasitol 31:1549-1562
-
(2001)
Int J Parasitol
, vol.31
, pp. 1549-1562
-
-
Utzinger, J.1
Xiao, S.H.2
N'Goran, E.K.3
Bergquist, R.4
Tanner, M.5
-
23
-
-
0034700205
-
A possible antimalarial action mode of qinghaosu (artemisinin) series compounds. Alkylation of reduced glutathione by C-centred primary radicals produced from antimalarial compound qinghaosu and 12-(2,4-dimethoixyphenyl)-deoxoqinghaosu
-
Wang DY, Wu YL (2000) A possible antimalarial action mode of qinghaosu (artemisinin) series compounds. Alkylation of reduced glutathione by C-centred primary radicals produced from antimalarial compound qinghaosu and 12-(2,4-dimethoixyphenyl)-deoxoqinghaosu. Chem Commun 2000:2193-2194
-
(2000)
Chem Commun
, vol.2000
, pp. 2193-2194
-
-
Wang, D.Y.1
Wu, Y.L.2
-
24
-
-
0001048209
-
Synthesis, iron(II)-induced cleavage and in vivo antimalarial efficacy of 10-(2-hydroxy-1-naphthyl)-deoxoqinghaosu(-deoxoartemisinin)
-
Wang DY, Wu Y, Wu YL, Shan F (1999) Synthesis, iron(II)-induced cleavage and in vivo antimalarial efficacy of 10-(2-hydroxy-1-naphthyl)-deoxoqinghaosu(-deoxoartemisinin). J Chem Soc Perkin Trans 1:1827-1831
-
(1999)
J Chem Soc Perkin Trans
, vol.1
, pp. 1827-1831
-
-
Wang, D.Y.1
Wu, Y.2
Wu, Y.L.3
Shan, F.4
-
25
-
-
0035925869
-
Further evidence for the participation of primary carbon-centred free radicals in the antimalarial action of the qinghaosu (artemisinin) series of compounds
-
Wang DY, Wu YL, Wu Y, Liang J, Li Y (2001) Further evidence for the participation of primary carbon-centred free radicals in the antimalarial action of the qinghaosu (artemisinin) series of compounds. J Chem Soc Perkin Trans 1:605-609
-
(2001)
J Chem Soc Perkin Trans
, vol.1
, pp. 605-609
-
-
Wang, D.Y.1
Wu, Y.L.2
Wu, Y.3
Liang, J.4
Li, Y.5
-
26
-
-
0032522115
-
Unified mechanistic framework for the Fe(II)-induced cleavage of qinghaosu and derivatives/analogues. The first spin-trapping evidence for the previously postulated secondary C-4 radical
-
Wu WM, Wu YK, Wu YL, Yao ZJ, Zhou CM, Li Y, Shan F (1998) Unified mechanistic framework for the Fe(II)-induced cleavage of qinghaosu and derivatives/analogues. The first spin-trapping evidence for the previously postulated secondary C-4 radical. J Am Chem Soc 120:3316-3325.
-
(1998)
J Am Chem Soc
, vol.120
, pp. 3316-3325
-
-
Wu, W.M.1
Wu, Y.K.2
Wu, Y.L.3
Yao, Z.J.4
Zhou, C.M.5
Li, Y.6
Shan, F.7
-
27
-
-
0033520282
-
Interaction of qinghaosu (artemisinin) with cysteine sulfhydryl mediated by traces of nonheme iron
-
Wu YK, Yue ZY, Wu YL (1999) Interaction of qinghaosu (artemisinin) with cysteine sulfhydryl mediated by traces of nonheme iron. Angew Chem Int Ed 38:2580-2582
-
(1999)
Angew Chem Int Ed
, vol.38
, pp. 2580-2582
-
-
Wu, Y.K.1
Yue, Z.Y.2
Wu, Y.L.3
-
28
-
-
0035047259
-
New insights into the degradation of qinghaosu (artemisinin) mediated by non-heme-iron chelates, and their relavance to the antimalarial mechanism
-
Wu YK, Yue ZY, Liu HH (2001) New insights into the degradation of qinghaosu (artemisinin) mediated by non-heme-iron chelates, and their relavance to the antimalarial mechanism. Helv Chim Acta 84:928-932
-
(2001)
Helv Chim Acta
, vol.84
, pp. 928-932
-
-
Wu, Y.K.1
Yue, Z.Y.2
Liu, H.H.3
-
29
-
-
0034161264
-
The prophylactic effects of artemether against Schistosoma japonicum infections
-
Xiao SH, Booth M, Tanner M (2000a) The prophylactic effects of artemether against Schistosoma japonicum infections. Parasitol Today 16:122-126
-
(2000)
Parasitol Today
, vol.16
, pp. 122-126
-
-
Xiao, S.H.1
Booth, M.2
Tanner, M.3
-
30
-
-
0034572416
-
Artemether, an effective new agent for chemoprophylaxis against schistosomiasis in China: Its in vivo effect on the biochemical metabolism of the asian schistosome
-
Xiao SH, Hotez PJ, Tanner M (2000b) Artemether, an effective new agent for chemoprophylaxis against schistosomiasis in China: its in vivo effect on the biochemical metabolism of the asian schistosome. Southeast Asian J Trop Med Public Health 31:724-732
-
(2000)
Southeast Asian J Trop Med Public Health
, vol.31
, pp. 724-732
-
-
Xiao, S.H.1
Hotez, P.J.2
Tanner, M.3
-
31
-
-
0035725313
-
Artemether administered together with haemin damages schistosomes in vitro
-
Xiao SH, Chollet J, Utzinger J, Matile H, Mei JY, Tanner M (2001) Artemether administered together with haemin damages schistosomes in vitro. Trans R Soc Trop Med Hyg 95:67-71
-
(2001)
Trans R Soc Trop Med Hyg
, vol.95
, pp. 67-71
-
-
Xiao, S.H.1
Chollet, J.2
Utzinger, J.3
Matile, H.4
Mei, J.Y.5
Tanner, M.6
-
32
-
-
0036103409
-
Recent investigations of artemether, a novel agent for the prevention of schistosomiasis japonica, mansoni and haematobia
-
Xiao SH, Tanner M, N'Goran EK, Utzinger J, Chollet J, Bergquist R, Chen MG, Zeng J (2002) Recent investigations of artemether, a novel agent for the prevention of schistosomiasis japonica, mansoni and haematobia. Acta Trop 82:175-181
-
(2002)
Acta Trop
, vol.82
, pp. 175-181
-
-
Xiao, S.H.1
Tanner, M.2
N'Goran, E.K.3
Utzinger, J.4
Chollet, J.5
Bergquist, R.6
Chen, M.G.7
Zeng, J.8
-
33
-
-
0035947477
-
Histopathological changes in juvenile Schistosoma haematobium harboured in hamsters treated with artemether
-
Yang YQ, Xiao SH, Tanner M, Utzinger J, Chollet J, Wu JD, Guo J (2001) Histopathological changes in juvenile Schistosoma haematobium harboured in hamsters treated with artemether. Acta Trop 79:135-141
-
(2001)
Acta Trop
, vol.79
, pp. 135-141
-
-
Yang, Y.Q.1
Xiao, S.H.2
Tanner, M.3
Utzinger, J.4
Chollet, J.5
Wu, J.D.6
Guo, J.7
-
34
-
-
0000025937
-
A technique for the perfusion of laboratory animals for the recovery of schistosomes
-
Yolles TK, Moore DV, De Giusti DL, Ripsom CA, Meleney HE (1947) A technique for the perfusion of laboratory animals for the recovery of schistosomes. J Parasitol 33:419-426
-
(1947)
J Parasitol
, vol.33
, pp. 419-426
-
-
Yolles, T.K.1
Moore, D.V.2
De Giusti, D.L.3
Ripsom, C.A.4
Meleney, H.E.5
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