Discovery of new inhibitors of schistosoma mansoni PNP by pharmacophore-based virtual screening

Journal of Chemical Information and Modeling

Volumn 50, Issue 9, 2010, Pages 1693-1705

  Postigo, Matheus P ^a   Guido, Rafael V C ^a   Oliva, Glaucius ^a   Castilho, Marcelo S ^b   Da R Pitta, Ivan ^c   De Albuquerque, Julianna F C ^c   Andricopulo, Adriano D ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF BAHIA   (Brazil)

^c FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

DIAGNOSIS; LEAD COMPOUNDS; NUCLEOTIDES; PHARMACODYNAMICS; SCAFFOLDS;

INHIBITORY ACTIVITY; PHARMACOPHORE MODELING; PURINE NUCLEOSIDE PHOSPHORYLASE; PURINE NUCLEOTIDES; SCHISTOSOMA MANSONI; SOCIO-ECONOMIC CONSEQUENCES; STRUCTURE ACTIVITY RELATIONSHIPS; VIRTUAL SCREENING;

SAMARIUM COMPOUNDS;

ENZYME INHIBITOR; PURINE NUCLEOSIDE PHOSPHORYLASE;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DEVELOPMENT; ENZYMOLOGY; MOLECULAR GENETICS; PROTEIN QUATERNARY STRUCTURE; SCHISTOSOMA MANSONI; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; DRUG DISCOVERY; ENZYME INHIBITORS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, QUATERNARY; PURINE-NUCLEOSIDE PHOSPHORYLASE; SCHISTOSOMA MANSONI; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77957235318     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci100128k     Document Type: Article

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