In vitro schistosomicidal activity of balsaminol F and karavilagenin C

Planta Medica

Volumn 78, Issue 18, 2012, Pages 1912-1917

  Ramalhete, Cátia ^a   Magalhães, Lizandrag ^b   Rodrigues, Vanderlei ^c   Mulhovo, Silva ^d   Da Silva Filho, Ademar A ^e   Ferreira, Maria José U ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b UNIVERSIDADE DE FRANCA   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d Universidade Pedagógica Campus de Lhanguene   (Mozambique)

^e FEDERAL UNIVERSITY OF JUIZ DE FORA   (Brazil)

Author keywords

Cucurbitaceae; cucurbitane type triterpenoids; Momordica balsamina; Schistosoma mansoni; schistosomicidal activity

Indexed keywords

ACETIC ACID ETHYL ESTER; ANTISCHISTOSOMAL AGENT; BALSAMINOL F; BALSAMINOSIDE A; BALSAMINOSIDE B; CUCURBITA 5,24 DIENE 3BETA 23 DIOL O BETA D GLUCOPYRANOSIDE; ESTER DERIVATIVE; HYDROXYL GROUP; KARAVILAGENIN C; KARAVOATE A; KARAVOATE B; KARAVOATE C; KARAVOATE I; KARAVOATE M; METHANOL; PLANT MEDICINAL PRODUCT; PRAZIQUANTEL; TRITERPENE; UNCLASSIFIED DRUG;

ACYLATION; ANTHELMINTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ISOLATION; EGG PRODUCTION; FEMALE; IN VITRO STUDY; LC 50; MALE; MOLECULAR WEIGHT; MOMORDICA BALSAMINA; MOTOR ACTIVITY; NONHUMAN; SCHISTOSOMA MANSONI;

ANIMALS; FEMALE; LETHAL DOSE 50; MALE; MEDICINE, AFRICAN TRADITIONAL; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; MOMORDICA; PLANT COMPONENTS, AERIAL; PLANT EXTRACTS; SCHISTOSOMA MANSONI; SCHISTOSOMICIDES; TRITERPENES;

CUCURBITACEAE; MOMORDICA BALSAMINA; SCHISTOSOMA MANSONI;

EID: 84871621180     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0032-1327832     Document Type: Article

References (26)

1. Chitsulo L., Engles D., Montresor A., Savioli L. The global status of schistosomiasis and its control. Acta Trop: 2000; 77 41 51
2. WHO Schistosomiasis: number of people treated worldwide in 2009. Weekly Epidemiological record, Vol. 86. Geneva World Health Organization: 2011; 73 80
3. Doenhoff M. J., Hagan P., Cioli D., Southgate V., Pica-Mattoccia L., Botros S., Coles G., Tchuem Tchuenté L. A., Mbaye A., Engels D. Praziquantel: its use in control of schistosomiasis in sub-Saharan Africa and current research needs. Parasitology: 2009; 136 1825 1835
4. Fallon P. G., Tao L. F., Ismail M. M., Bennett J. L. Schistosome resistance to praziquantel: fact or artifact. Trends Parasitol: 1996; 12 316 320 (Pubitemid 26228577)
5. Magalhães L. G., Kapadia G. J., Tonuci L. RS, Caixeta S. CC, Parreira N. A., Rodrigues V., Da Silva Filho A. A. In vitro schistosomicidal effects of phloroglucinol derivatives from Dryopteris species against Schistosoma mansoni adult worms. Parasitol Res: 2010; 106 395 401
6. Melek F. R., Tadros M. M., Yousif F., Selim M. A., Hassan M. H. Screening of marine extracts for schistosomicidal activity in vitro. Isolation of the triterpene glycosides echinosides A and B with potential activity from the Sea Cucumbers Actinopyga echinites and Holothuria polii. Pharm Biol: 2012; 50 490 496
7. Moraes J., Nascimento C., Lopes P. O., Nakano E., Yamaguchi L. F., Kato M. J., Kawano T. Schistosoma mansoni: In vitro schistosomicidal activity of piplartine. Exp Parasitol: 2011; 127 357 364
8. Pereira A. C., Magalhães L. G., Gonçalves U. O., Luz P. P., Moraes A. C., Rodrigues V., da Matta Guedes P. M., da Silva Filho A. A., Cunha W. R., Bastos J. K., Nanayakkara N. P., de Silva M. L. Schistosomicidal and trypanocidal structure-activity relationships for (±)-licarin A and its ()- and (+)-enantiomers. Phytochemistry: 2011; 72 1424 1430
9. Miranda M. A., Magalhães L. G., Tiossi R. F., Kuehn C. C., Oliveira L. G., Rodrigues V., McChesney J. D., Bastos J. K. Evaluation of the schistosomicidal activity of the steroidal alkaloids from Solanum lycocarpum fruits. Parasitol Res: 2012; 111 257 262
10. Murthy P. K., Joseph S. K. Plant products in the treatment and control of filariasis and other helminth infections and assay systems for antifilarial/anthelmintic activity. Planta Med: 2011; 77 647 661
11. Thakur G. S., Bag M., Sanodiya B. S., Bhadauriya P., Debnath M., Prasad G., Bisen P. S. Momordica balsamina: a medicinal and neutraceutical plant for health care management. Curr Pharm Biotechnol: 2009; 10 667 682
12. Bandeira S. O., Gaspar F., Pagula F. P. African ethnobotany and healthcare: emphasis on Mozambique. Pharm Biol: 2001; 39 70 73
13. Van de Venter M., Roux S., Bungu L. C., Louw J., Crouch N. R., Grace O. M., Maharaj V., Pillay P., Sewnarian P., Bhagwandin N., Folb P. Antidiabetic screening and scoring of 11 plants traditionally used in South Africa. J Ethnopharmacol: 2008; 119 81 86
14. Ramalhete C., Lopes D., Mulhovo S., Molnár J., Rosário V. E., Ferreira M. J. New antimalarials with a triterpenic scaffold from Momordica balsamina. Bioorg Med Chem: 2010; 18 5254 5260
15. Ramalhete C., Lopes D., Molnár J., Mulhovo S., Rosário V. E., Ferreira M. J. Karavilagenin C derivatives as antimalarials. Bioorg Med Chem: 2011; 19 330 338
16. Ramalhete C., da Cruz F. P., Lopes D., Mulhovo S., Rosário V. E., Prudêncio M., Ferreira M. J. Triterpenoids as inhibitors of erythrocytic and liver stages of Plasmodium infections. Bioorg Med Chem: 2011; 19 7474 7481
17. De Tommasi N., De Simone F., De Feo V., Pizza C. Phenylpropanoid glycosides and rosmarinic acid from Momordica balsamina. Planta Med: 1991; 57 201
18. De Tommasi N., De Simone F., Piacente S., Pizza C., Mahmood N. Diterpenes from Momordica balsamina. Nat Prod Lett: 1995; 6 261 268
19. Ramalhete C., Lopes D., Mulhovo S., Molnár J., Rosário V. E., Ferreira M. J. New potent P-glycoprotein modulators with the cucurbitane scaffold and their synergistic interaction with doxorubicin on resistant cancer cells. Bioorg Med Chem: 2009; 17 6942 6951
20. Smithers S. R., Terry R. J. Infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of adult worms. Parasitology: 1965; 55 695 700
21. Manneck T., Haggenmüller Y., Keiser J. Morphological effects and tegumental alterations induced by mefloquine on schistosomula adult flukes on Schistosoma mansoni. Parasitology: 2010; 137 85 98
22. Michaels R. M., Prata A. Evolution and characteristics of Schistosoma mansoni eggs laid in vitro. J Parasitol: 1968; 54 921 930
23. de Araújo S. C., de Mattos A. C., Teixeira H. F., Coelho P. M., Nelson D. L., de Oliveira M. C. Improvement of in vitro efficacy of a novel schistosomicidal drug by incorporation into nanoemulsions. Int J Pharm: 2007; 337 307 315 (Pubitemid 46778956)
24. Comley J. CW, Rees M. J., Turner C. H., Jenkins D. C. Calorimetric quantitation of filarial viability. Int J Parasitol: 1989; 19 77 83
25. Wink M. Evolutionary advantage and molecular modes of action of multi-component mixtures used in phytomedicine. Curr Drug Metab: 2008; 9 996 1009
26. Han H. K., Amidon G. L. Targeted prodrug design to optimize drug delivery. AAPS PharmSci: 2000; 2 E6