-
1
-
-
62449089680
-
Microbial drug discovery: 80 years of progress
-
A.L. Demain, S. Sanchez, Microbial drug discovery: 80 years of progress, J. Antibiot. 62 (2009) 5e16
-
(2009)
J. Antibiot
, vol.62
, pp. 5e16
-
-
Demain, A.L.1
Sanchez, S.2
-
2
-
-
0004138693
-
-
last accessed 22.05.14
-
Tropical Diseases, http://www.astmh.org/Content/NavigationMenu/Education/Tropical Medicine QA/Major-Tropical-Disea.htm (last accessed 22.05.14
-
Tropical Diseases
-
-
-
4
-
-
0035871063
-
Mechanism of malarial haem detoxification inhibition by chloroquine
-
A.V. Pandey, H. Bisht, V.K. Babbarwal, J. Srivastava, K.C. Pandey, V.S. Chauhan, Mechanism of malarial haem detoxification inhibition by chloroquine, Biochem. J. 355 (2001) 333-338
-
(2001)
Biochem. J.
, vol.355
, pp. 333-333
-
-
Pandey, A.V.1
Bisht, H.2
Babbarwal, V.K.3
Srivastava, J.4
Pandey, K.C.5
Chauhan, V.S.6
-
5
-
-
84901019719
-
The rise and fall of malaria in a west african rural community dielmo senegal from 1990 to 2012: A 22 year longitudinal study
-
J.F. Trape, A. Tall, C. Sokhna, A.B. Ly, N. Diagne, O. Ndiath, C. Mazenot, V. Richard, A. Badiane, F. Dieye-Ba, J. Faye, G. Ndiaye, F.D. Sarr, C. Roucher, C. Bouganali, H. Basséne, A. Touré-Baldé, C. Roussilhon, R. Perraut, A. Spiegel, J.L. Sarthou, L.P. da Silva, O.M. Puijalon, P. Druilhe, C. Rogier, The rise and fall of malaria in a west African rural community, Dielmo, Senegal, from 1990 to 2012: a 22 year longitudinal study, Lancet Infect. Dis. 14 (2014) 476-488
-
(2014)
Lancet Infect. Dis
, vol.14
, pp. 476-476
-
-
Trape, J.F.1
Tall, A.2
Sokhna, C.3
Ly, A.B.4
Diagne, N.5
Ndiath, O.6
Mazenot, C.7
Richard, V.8
Badiane, A.9
Dieye-Ba, F.10
Faye, J.11
Ndiaye, G.12
Sarr, F.D.13
Roucher, C.14
Bouganali, C.15
Basséne, H.16
Touré-Baldé, A.17
Roussilhon, C.18
Perraut, R.19
Spiegel, A.20
Sarthou, J.L.21
Da Silva, L.P.22
Puijalon, O.M.23
Druilhe, P.24
Rogier, C.25
more..
-
6
-
-
0032144870
-
Impact of chloroquine resistance on malaria mortality
-
J.F. Trape, G. Pison, M.P. Preziosi, C. Enel, A. Desgrées du Loû, V. Delaunay, B. Samb, E. Lagarde, J.F. Molez, F. Simondon, Impact of chloroquine resistance on malaria mortality, CR Acad. Sci. Paris 321 (1998) 689-697
-
(1998)
CR Acad. Sci. Paris 321
, pp. 689-689
-
-
Trape, J.F.1
Pison, G.2
Preziosi, M.P.3
Enel, C.4
Desgrées Du Loû, A.5
Delaunay, V.6
Samb, B.7
Lagarde, E.8
Molez, J.F.9
Simondon, F.10
-
7
-
-
77957320551
-
Monitoring of malaria parasite resistance to chloroquine and sulphadoxinepyrimethamine in the solomon islands by dna microarray technology
-
M. Ballif, J. Hii, J. Marfurt, A. Crameri, A. Fafale, I. Felger, H.P. Beck, B. Genton, Monitoring of malaria parasite resistance to chloroquine and sulphadoxinepyrimethamine in the Solomon Islands by DNA microarray technology, Malar. J. 9 (2010) 270
-
(2010)
Malar. J.
, vol.9
, pp. 270
-
-
Ballif, M.1
Hii, J.2
Marfurt, J.3
Crameri, A.4
Fafale, A.5
Felger, I.6
Beck, H.P.7
Genton, B.8
-
8
-
-
0035884456
-
Chloroquine-resistant malaria
-
T.E. Wellems, C.V. Plowe, Chloroquine-resistant malaria, J. Infect. Dis. 184 (2001) 770-776
-
(2001)
J. Infect. Dis
, vol.184
, pp. 770-770
-
-
Wellems, T.E.1
Plowe, C.V.2
-
10
-
-
77952332778
-
Chloroquine and its derivatives exacerbate B19V-associated anemia by promoting viral replication
-
C. Bonsch, C. Kempf, I. Mueller, L. Manning, M. Laman, T.M. Davis, C. Ros, Chloroquine and its derivatives exacerbate B19V-associated anemia by promoting viral replication, PLoS Negl. Trop. Dis. 4 (2010) e669
-
(2010)
PLoS Negl. Trop. Dis
, vol.4
, pp. e669
-
-
Bonsch, C.1
Kempf, C.2
Mueller, I.3
Manning, L.4
Laman, M.5
Davis, T.M.6
Ros, C.7
-
11
-
-
84892582609
-
Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance
-
A.K. Lukens, L.S. Ross, R. Heidebrecht, F.J. Gamo, M.J. Lafuente-Monasterio, M.L. Booker, D.L. Hartl, R.C. Wiegand, D.F. Wirth, Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance, Proc. Natl. Acad. Sci. U. S. A. 111 (2014) 799-804
-
(2014)
Proc. Natl. Acad. Sci. U. S. A.
, vol.111
, pp. 799-799
-
-
Lukens, A.K.1
Ross, L.S.2
Heidebrecht, R.3
Gamo, F.J.4
Lafuente-Monasterio, M.J.5
Booker, M.L.6
Hartl, D.L.7
Wiegand, R.C.8
Wirth, D.F.9
-
12
-
-
0023137728
-
Reversal of chloroquine resistance in Plasmodium falciparum by verapamil
-
S.K. Martin, A.M. Oduola, W.K. Milhous, Reversal of chloroquine resistance in Plasmodium falciparum by verapamil, Science 235 (1987) 899-901
-
(1987)
Science
, vol.235
, pp. 899-899
-
-
Martin, S.K.1
Oduola, A.M.2
Milhous, W.K.3
-
13
-
-
84887622121
-
Novel phenotypic assays for the detection of artemisinin-resistant plasmodium falciparum malaria in cambodia: In-vitro and ex-vivo drug-response studies
-
B. Witkowski, C. Amaratunga, N. Khim, S. Sreng, P. Chim, Saorin Kim, P. Lim, S. Mao, C. Sopha, B. Sam, J.M. Anderson, D. Socheat, C.M. Chuor, W.R.J. Taylor, S. Seila, O. Mercereau-Puijalon, R.M. Fairhurst, D. Menard, Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies, Lancet Infect. Dis. 13 (2013) 1043-1049
-
(2013)
Lancet Infect. Dis
, vol.13
, pp. 1043-1043
-
-
Witkowski, B.1
Amaratunga, C.2
Khim, N.3
Sreng, S.4
Chim, P.5
Kim, S.6
Lim, P.7
Mao, S.8
Sopha, C.9
Sam, B.10
Anderson, J.M.11
Socheat, D.12
Chuor, C.M.13
Taylor, W.R.J.14
Seila, S.15
Mercereau-Puijalon, O.16
Fairhurst, R.M.17
Menard, D.18
-
14
-
-
0027403103
-
A review of its antimalarial activity pharmacokinetic properties and therapeutic efficacy
-
K.J. Palmer, S.M. Holliday, R.N. Brogden, Mefloquine. A review of its antimalarial activity, pharmacokinetic properties and therapeutic efficacy, Drugs 45 (1993) 430-475
-
(1993)
Drugs
, vol.45
, pp. 430-430
-
-
Palmer, K.J.1
Holliday, S.M.2
Brogden Mefloquine, R.N.3
-
15
-
-
79953199006
-
A series of structurally simple chloroquine chemosensitizing dibemethin derivatives that inhibit chloroquine transport by pfcrt
-
V.K. Zishiri, R. Hunter, P.J. Smith, D. Taylor, R. Summers, K. Kirk, R.E. Martin, T.J. Egan, A series of structurally simple chloroquine chemosensitizing dibemethin derivatives that inhibit chloroquine transport by PfCRT, Eur. J. Med. Chem. 46 (2011) 1729-1742
-
(2011)
Eur. J. Med. Chem
, vol.46
, pp. 1729-1729
-
-
Zishiri, V.K.1
Hunter, R.2
Smith, P.J.3
Taylor, D.4
Summers, R.5
Kirk, K.6
Martin, R.E.7
Egan, T.J.8
-
16
-
-
0003707898
-
-
second ed.WHO Monograph Series World Health Organization, Geneva
-
L.J. Bruce-Chwatt (Ed.), Chemotherapy of Malaria, second ed.WHO Monograph Series, vol. 27, World Health Organization, Geneva, 1981
-
(1981)
Chemotherapy of Malaria
, vol.27
-
-
Bruce-Chwatt, L.J.1
-
17
-
-
84912005192
-
-
last accessed 22.05.14
-
Chloroquine, http://www.drugbank.ca/drugs/DB00608#identification (last accessed 22.05.14
-
Chloroquine
-
-
-
18
-
-
0025696126
-
Drugs that reverse chloroquine resistance in malaria
-
S. Salomone, T. Godfraind, Drugs that reverse chloroquine resistance in malaria, Trends Pharmacol. Sci. 11 (1990) 475-476
-
(1990)
Trends Pharmacol. Sci
, vol.11
, pp. 475-475
-
-
Salomone, S.1
Godfraind, T.2
-
19
-
-
0025779428
-
The mode of action of chloroquine non-weak base properties of 4-aminoquinolines and antimalarial effects on strains of plasmodium
-
E. Veignie, S. Moreau, The mode of action of chloroquine non-weak base properties of 4-aminoquinolines and antimalarial effects on strains of Plasmodium, Ann. Trop. Med. Parasitol. 85 (1991) 229-237
-
(1991)
Ann. Trop. Med. Parasitol
, vol.85
, pp. 229-229
-
-
Veignie, E.1
Moreau, S.2
-
20
-
-
0028022062
-
Single-dose pharmacokinetics of chloroquine and its main metabolite in healthy volunteers
-
P.J. De Vries, B. Oosterhuis, C.J. Van Boxtel, Single-dose pharmacokinetics of chloroquine and its main metabolite in healthy volunteers, Drug Invest. 8 (1994) 143-149
-
(1994)
Drug Invest
, vol.8
, pp. 143-143
-
-
De Vries, P.J.1
Oosterhuis, B.2
Van Boxtel, C.J.3
-
21
-
-
0029015171
-
The pharmacokinetics of three multiple dose regimens of chloroquine: Implications for malaria chemoprophylaxis
-
J.C.F.M. Wetsteyn, P.J. De Vries, B. Oosterhuis, C.J. Van Boxtel, The pharmacokinetics of three multiple dose regimens of chloroquine: implications for malaria chemoprophylaxis, Br. J. Clin. Pharmacol. 39 (1995) 696-699
-
(1995)
Br. J. Clin. Pharmacol
, vol.39
, pp. 696-696
-
-
Wetsteyn, J.C.F.M.1
De Vries, P.J.2
Oosterhuis, B.3
Van Boxtel, C.J.4
-
22
-
-
84872870399
-
-
last accessed 22.05.14
-
Annual Report, 2011-2012, http://pharmaceuticals.gov.in/annualreport2012.pdf (last accessed 22.05.14
-
Annual Report 2011-2012
-
-
-
23
-
-
84912021776
-
-
last accessed 22.05.14
-
Chloroquine for Malaria, http://www.webmd.com/a-to-z-guides/chloroquine-for-malaria (last accessed 22.05.14
-
Chloroquine for Malaria
-
-
-
24
-
-
84912049302
-
-
Indian Council of Medical Research last accessed 22.05.14
-
Communicable Diseases, Annual Report 2012-13. Indian Council of Medical Research, http://www.icmr.nic.in/annual/2012-13/english/3.pdf (last accessed 22.05.14
-
Communicable Diseases Annual Report 2012-13
-
-
-
25
-
-
84912005191
-
-
last accessed 22.05.14
-
Choroquine Phosphate Oral, http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682318.html (last accessed 22.05.14
-
Choroquine Phosphate Oral
-
-
-
26
-
-
85028294794
-
-
Springer, Basel
-
H.M. Staines, S. Krishna, Treatment and Prevention of Malaria: Antimalarial Drug Chemistry, Action and Use, Springer, Basel, 2012
-
(2012)
Treatment and Prevention of Malaria: Antimalarial Drug Chemistry, Action and Use
-
-
Staines, H.M.1
Krishna, S.2
-
27
-
-
0030007219
-
Pharmacokinetics of quinine, chloroquine and amodiaquine
-
S. Krishna, N.J. White, Pharmacokinetics of quinine, chloroquine and amodiaquine. Clinical implications, Clin. Pharmacokinet. 30 (1996) 263-299
-
(1996)
Clinical Implications, Clin. Pharmacokinet
, vol.30
, pp. 263-263
-
-
Krishna, S.1
White, N.J.2
-
28
-
-
0015496390
-
Lysosomes pH and the anti-malarial action of chloroquine
-
C.A. Homewood, D.C. Warhurst, W. Peters, V.C. Baggaley, Lysosomes, pH and the anti-malarial action of chloroquine, Nature 235 (1972) 50-52
-
(1972)
Nature
, vol.235
, pp. 50-50
-
-
Homewood, C.A.1
Warhurst, D.C.2
Peters, W.3
Baggaley, V.C.4
-
29
-
-
16044372680
-
On the molecular mechanism of chloroquine's antimalarial action
-
D.J. Sullivan Jr., I.Y. Gluzman, D.G. Russell, D.E. Goldberg, On the molecular mechanism of chloroquine's antimalarial action, Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 11865-11870
-
(1996)
Proc. Natl. Acad. Sci. U. S. A.
, vol.93
, pp. 11865-11865
-
-
Sullivan, D.J.1
Gluzman, I.Y.2
Russell, D.G.3
Goldberg, D.E.4
-
30
-
-
42049124049
-
Recent advances in understanding the mechanism of hemozoin (malaria pigment) formation
-
T.J. Egan, Recent advances in understanding the mechanism of hemozoin (malaria pigment) formation, J. Inorg. Biochem. 102 (2008) 1288-1299
-
(2008)
J. Inorg. Biochem
, vol.102
, pp. 1288-1288
-
-
Egan, T.J.1
-
31
-
-
0025255254
-
-
D.E. Goldberg, A.F.G. Slater, A. Cerami, G.B. Henderson, Proc. Natl. Acad. Sci. U. S. A. 87 (1990) 2931-2935
-
(1990)
Proc. Natl. Acad. Sci. U. S. A.
, vol.87
, pp. 2931-2931
-
-
Goldberg, D.E.1
Slater, A.F.G.2
Cerami, A.3
Henderson, G.B.4
-
32
-
-
0001180035
-
Metal effects on metalloporphyrins and on their pep chargetransfer complexes with aromatic acceptors: Urohemin complexes
-
J.A. Shelnutt, Metal effects on metalloporphyrins and on their pep chargetransfer complexes with aromatic acceptors: Urohemin complexes, Inorg. Chem. 22 (1983) 2535-2544
-
(1983)
Inorg. Chem
, vol.22
, pp. 2535-2535
-
-
Shelnutt, J.A.1
-
33
-
-
0000668753
-
Aggregation of porphyrins and metalloporphyrins, in
-
Dolphin (Ed. Academic Press, New York
-
N.J. White, Aggregation of porphyrins and metalloporphyrins, in: Dolphin (Ed.), The Porphyrins, Academic Press, New York, 1978, pp. 303-339
-
(1978)
The Porphyrins
, pp. 303-303
-
-
White, N.J.1
-
34
-
-
33846649572
-
Hemozoin biocrystallization in Plasmodium falciparum and the antimalarial activity of crystallization inhibitors
-
E. Hempelmann, Hemozoin biocrystallization in Plasmodium falciparum and the antimalarial activity of crystallization inhibitors, Parasitol. Res. 100 (2007) 671-676
-
(2007)
Parasitol. Res
, vol.100
, pp. 671-671
-
-
Hempelmann, E.1
-
35
-
-
78649518769
-
On the mechanism of chloroquine resistance in plasmodium falciparum
-
M. Chinappi, A. Via, P. Marcatili, A. Tramontano, On the mechanism of chloroquine resistance in Plasmodium falciparum, PLoS One 5 (2010) e14064
-
(2010)
PLoS One
, vol.5
, pp. e14064
-
-
Chinappi, M.1
Via, A.2
Marcatili, P.3
Tramontano, A.4
-
36
-
-
0036681979
-
Structureeactivity relationships in 4-aminoquinoline antiplasmodials. The role of the group at the 7-position
-
C.H. Kaschula, T.J. Egan, R. Hunter, N. Basilico, S. Parapini, D. Taramelli, E. Pasini, D. Monti, Structureeactivity relationships in 4-aminoquinoline antiplasmodials. The role of the group at the 7-position, J. Med. Chem. 45 (2002) 3531-3539
-
(2002)
J. Med. Chem
, vol.45
, pp. 3531-3531
-
-
Kaschula, C.H.1
Egan, T.J.2
Hunter, R.3
Basilico, N.4
Parapini, S.5
Taramelli, D.6
Pasini, E.7
Monti, D.8
-
37
-
-
84878577436
-
Structureeactivity relationships for ferriprotoporphyrin IX association and b-hematin inhibition by 4-aminoquinolines using experimental and ab initio methods
-
S. Nsumiwa, D. Kuter, S. Wittlin, K. Chibale, T.J. Egan, Structureeactivity relationships for ferriprotoporphyrin IX association and b-hematin inhibition by 4-aminoquinolines using experimental and ab initio methods, Bioorg. Med. Chem. 21 (2013) 3738-3748
-
(2013)
Bioorg. Med. Chem
, vol.21
, pp. 3738-3738
-
-
Nsumiwa, S.1
Kuter, D.2
Wittlin, S.3
Chibale, K.4
Egan, T.J.5
-
38
-
-
0034719487
-
Structureefunction relationships in aminoquinolines: Effect of amino and chloro groups on quinoline-hematin complex formation, inhibition of bhematin formation, and antiplasmodial activity
-
T.J. Egan, R. Hunter, C.H. Kaschula, H.M. Marques, A. Misplon, J.C. Walden, Structureefunction relationships in aminoquinolines: effect of amino and chloro groups on quinoline-hematin complex formation, inhibition of bhematin formation, and antiplasmodial activity, J. Med. Chem. 43 (2000) 283-291
-
(2000)
J. Med. Chem
, vol.43
, pp. 283-283
-
-
Egan, T.J.1
Hunter, R.2
Kaschula, C.H.3
Marques, H.M.4
Misplon, A.5
Walden, J.C.6
-
39
-
-
77952067548
-
Development of a new generation of 4-aminoquinoline antimalarial compounds using predictive pharmacokinetic and toxicology models
-
S. Ray, P.B. Madrid, P. Catz, S.E. Le Valley, M.J. Furniss, L.L. Rausch, R.K. Guy, J.L. De Risi, L.V. Iyer, C.E. Green, J.C. Mirsalis, Development of a new generation of 4-aminoquinoline antimalarial compounds using predictive pharmacokinetic and toxicology models, J. Med. Chem. 53 (2010) 3685-3695
-
(2010)
J. Med. Chem
, vol.53
, pp. 3685-3685
-
-
Ray, S.1
Madrid, P.B.2
Catz, P.3
Le Valley, S.E.4
Furniss, M.J.5
Rausch, L.L.6
Guy, R.K.7
De Risi, J.L.8
Iyer, L.V.9
Green, C.E.10
Mirsalis, J.C.11
-
40
-
-
84877757930
-
-
last accessed 22.05.14
-
Treatment of Malaria, http://www.globalmalariafoundation.com/Malaria%Treatment.html (last accessed 22.05.14
-
Treatment of Malaria
-
-
-
41
-
-
84862519697
-
Sontochin as a guide to the development of drugs against chloroquine-resistant malaria antimicrob
-
S. Pou, R.W. Winter, A. Nilsen, J.X. Kelly, Y. Li, J.S. Doggett, E.W. Riscoe, K.W. Wegmann, D.J. Hinrichs, M.K. Riscoe, Sontochin as a guide to the development of drugs against chloroquine-resistant malaria, Antimicrob. Agents Chemother. 56 (2012) 3475-3480
-
(2012)
Agents Chemother
, vol.56
, pp. 3475-3475
-
-
Pou, S.1
Winter, R.W.2
Nilsen, A.3
Kelly, J.X.4
Li, Y.5
Doggett, J.S.6
Riscoe, E.W.7
Wegmann, K.W.8
Hinrichs, D.J.9
Riscoe, M.K.10
-
42
-
-
48749094725
-
In vitro activity of ferroquine is independent of polymorphisms in transport protein genes implicated in quinoline resistance in Plasmodium falciparum
-
M. Henry, S. Briolant, A. Fontaine, J. Mosnier, E. Baret, R. Amalvict, T. Fusaï, L. Fraisse, C. Rogier, B. Pradines, In vitro activity of ferroquine is independent of polymorphisms in transport protein genes implicated in quinoline resistance in Plasmodium falciparum, Antimicrob. Agents Chemother. 52 (2008) 2755-2759
-
(2008)
Antimicrob. Agents Chemother
, vol.52
, pp. 2755-2755
-
-
Henry, M.1
Briolant, S.2
Fontaine, A.3
Mosnier, J.4
Baret, E.5
Amalvict, R.6
Fusaï, T.7
Fraisse, L.8
Rogier, C.9
Pradines, B.10
-
43
-
-
33748520577
-
A chloroquine-like molecule designed to reverse resistance in plasmodium falciparum
-
S.J. Burgess, A. Selzer, J.X. Kelly, M.J. Smilkstein, M.K. Riscoe, D.H. Peyton, A chloroquine-like molecule designed to reverse resistance in Plasmodium falciparum, J. Med. Chem. 49 (2006) 5623-5625
-
(2006)
J. Med. Chem
, vol.49
, pp. 5623-5623
-
-
Burgess, S.J.1
Selzer, A.2
Kelly, J.X.3
Smilkstein, M.J.4
Riscoe, M.K.5
Peyton, D.H.6
-
44
-
-
77249090275
-
Reversal agent and linker variants of reversed chloroquines: Activities against Plasmodium falciparum
-
S. Andrews, S.J. Burgess, D. Skaalrud, J.X. Kelly, D.H. Peyton, Reversal agent and linker variants of reversed chloroquines: activities against Plasmodium falciparum, J. Med. Chem. 53 (2010) 916-919
-
(2010)
J. Med. Chem
, vol.53
, pp. 916-916
-
-
Andrews, S.1
Burgess, S.J.2
Skaalrud, D.3
Kelly, J.X.4
Peyton, D.H.5
-
45
-
-
77956319522
-
Syn thesis, structureeactivity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds
-
S.J. Burgess, J.X. Kelly, S. Shomloo, S. Wittlin, R. Brun, K. Liebmann, D.H. Peyton, Synthesis, structureeactivity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds, J. Med. Chem. 53 (2010) 6477-6489
-
(2010)
J. Med. Chem
, vol.53
, pp. 6477-6477
-
-
Burgess, S.J.1
Kelly, J.X.2
Shomloo, S.3
Wittlin, S.4
Brun, R.5
Liebmann, K.6
Peyton, D.H.7
-
46
-
-
84874602910
-
Structural characteristics of chloroquine-bridged ferrocenophane analogues of ferroquine may obviate malaria drug-resistance mechanisms
-
P.F. Salas, C. Herrmann, J.F. Cawthray, C. Nimphius, A. Kenkel, J. Chen, C. De Kock, P.J. Smith, B.O. Patrick, M.J. Adam, C. Orvig, Structural characteristics of chloroquine-bridged ferrocenophane analogues of ferroquine may obviate malaria drug-resistance mechanisms, J. Med. Chem. 56 (2013) 1596-1613
-
(2013)
J. Med. Chem
, vol.56
, pp. 1596-1596
-
-
Salas, P.F.1
Herrmann, C.2
Cawthray, J.F.3
Nimphius, C.4
Kenkel, A.5
Chen, J.6
De Kock, C.7
Smith, P.J.8
Patrick, B.O.9
Adam, M.J.10
Orvig, C.11
-
47
-
-
84866395906
-
Synthesis and comparison of antiplasmodial activity of (+), (-)and racemic 7-chloro-4-(N-lupinyl)aminoquinoline
-
C. Rusconi, N. Vaiana, M. Casagrande, N. Basilico, S. Parapini, D. Taramelli, S. Romeo, S. Paratore, Synthesis and comparison of antiplasmodial activity of (+), (-) and racemic 7-chloro-4-(N-lupinyl)aminoquinoline, Bioorg. Med. Chem. 20 (2012) 5980-5985
-
(2012)
Bioorg. Med. Chem
, vol.20
, pp. 5980-5980
-
-
Rusconi, C.1
Vaiana, N.2
Casagrande, M.3
Basilico, N.4
Parapini, S.5
Taramelli, D.6
Romeo, S.7
Paratore, S.8
-
48
-
-
77951143202
-
Antimalarial versus cytotoxic properties of dual drugs derived from 4-aminoquinolines and Mannich bases: Interaction with DNA
-
N.I. Wenzel, N. Chavain, Y. Wang, W. Friebolin, L. Maes, B. Pradines, M. Lanzer, V. Yardley, R. Brun, C. Herold-Mende, C. Biot, K. Tóth, E. Davioud- Charvet, Antimalarial versus cytotoxic properties of dual drugs derived from 4-aminoquinolines and Mannich bases: interaction with DNA, J. Med. Chem. 53 (2010) 3214-3226
-
(2010)
J. Med. Chem
, vol.53
, pp. 3214-3214
-
-
Wenzel, N.I.1
Chavain, N.2
Wang, Y.3
Friebolin, W.4
Maes, L.5
Pradines, B.6
Lanzer, M.7
Yardley, V.8
Brun, R.9
Herold-Mende, C.10
Biot, C.11
Tóth, K.12
Davioud-Charvet, E.13
-
49
-
-
84912021910
-
-
last accessed 22.05.14
-
Ruthenium Compounds as Anticancer Agents, http://www.rsc.org/images/Anticancer%20DrugséiC-January2012-tcm18-212416.pdf (last accessed 22.05.14
-
Ruthenium Compounds As Anticancer Agents
-
-
-
50
-
-
38149141767
-
Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis
-
K.H. Maclean, F.C. Dorsey, J.L. Cleveland, M.B. Kastan, Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis, J. Clin. Invest. (2008) 11879-11888
-
(2008)
J. Clin. Invest
, pp. 11879-11879
-
-
MacLean, K.H.1
Dorsey, F.C.2
Cleveland, J.L.3
Kastan, M.B.4
-
51
-
-
38149136611
-
Antimalarial therapy prevents myc-induced lymphoma
-
C.V. Dang, Antimalarial therapy prevents Myc-induced lymphoma, J. Clin. Invest. 118 (2008) 15-17
-
(2008)
J. Clin. Invest
, vol.118
, pp. 15-15
-
-
Dang, C.V.1
-
53
-
-
0003514452
-
-
World Malaria Report last accessed 22.05.14
-
World Malaria Report, World Health Organization, 2008. http://www.who. int/malaria/wmr2008/(last accessed 22.05.14
-
(2008)
World Health Organization
-
-
-
54
-
-
0037033984
-
The economic and social burden of malaria
-
J. Sachs, P. Malaney, The economic and social burden of malaria, Nature 415 (2002) 680-685
-
(2002)
Nature
, vol.415
, pp. 680-680
-
-
Sachs, J.1
Malaney, P.2
-
55
-
-
77951026407
-
Antimalarial chemotherapy: Mechanisms of action resistance and new directions in drug discovery
-
S. Croft, Antimalarial chemotherapy: mechanisms of action, resistance and new directions in drug discovery, Drug Discov. Today 6 (2001) 1151
-
(2001)
Drug Discov Today
, vol.6
, pp. 1151
-
-
Croft, S.1
-
56
-
-
84862854444
-
1,2-disubstituted ferrocenyl carbohydrate chloroquine conjugates as potential antimalarial agents
-
C. Herrmann, P.F. Salas, B.O. Patrick, C. De Kock, P.J. Smith, M.J. Adam, C. Orvig, 1,2- disubstituted ferrocenyl carbohydrate chloroquine conjugates as potential antimalarial agents, Dalton Trans. 41 (2012) 6431-6442
-
(2012)
Dalton Trans
, vol.41
, pp. 6431-6431
-
-
Herrmann, C.1
Salas, P.F.2
Patrick, B.O.3
De Kock, C.4
Smith, P.J.5
Adam, M.J.6
Orvig, C.7
-
57
-
-
84865495150
-
Modular synthesis of 1,2- and 1,10-disubstituted ferrocenyl carbohydrate chloroquine and mefloquine conjugates as potential antimalarial agents
-
C. Herrmann, P.F. Salas, B.O. Patrick, C. De Kock, P.J. Smith, M.J. Adam, C. Orvig, Modular synthesis of 1,2- and 1,10-disubstituted ferrocenyl carbohydrate chloroquine and mefloquine conjugates as potential antimalarial agents, Organometallics 31 (2012) 5748-5759
-
(2012)
Organometallics
, vol.31
, pp. 5748-5748
-
-
Herrmann, C.1
Salas, P.F.2
Patrick, B.O.3
De Kock, C.4
Smith, P.J.5
Adam, M.J.6
Orvig, C.7
-
58
-
-
33746727034
-
Probing the role of the covalent linkage of ferrocene into a chloroquine template
-
C. Biot, W. Daher, C.M. Ndiaye, P. Melnyk, B. Pradines, N. Chavain, A. Pellet, L. Fraisse, L. Pelinski, C. Jarry, J. Brocard, J. Khalife, I. Forfar-Bares, D. Dive, Probing the role of the covalent linkage of ferrocene into a chloroquine template, J. Med. Chem. 49 (2006) 4707-4714
-
(2006)
J. Med. Chem
, vol.49
, pp. 4707-4707
-
-
Biot, C.1
Daher, W.2
Ndiaye, C.M.3
Melnyk, P.4
Pradines, B.5
Chavain, N.6
Pellet, A.7
Fraisse, L.8
Pelinski, L.9
Jarry, C.10
Brocard, J.11
Khalife, J.12
Forfar-Bares, I.13
Dive, D.14
-
59
-
-
60549091778
-
Combining 4- aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials
-
S. Gemma, G. Campiani, S. Butini, B.P. Joshi, G. Kukreja, S.S. Coccone, M. Bernetti, M. Persico, V. Nacci, I. Fiorini, E. Novellino, D. Taramelli, N. Basilico, S. Parapini, V. Yardley, S. Croft, S. Keller-Maerki, M. Rottmann, R. Brun, M. Coletta, S. Marini, G. Guiso, S. Caccia, C. Fattorusso, Combining 4- aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials, J. Med. Chem. 52 (2009) 502-513
-
(2009)
J. Med. Chem
, vol.52
, pp. 502-502
-
-
Gemma, S.1
Campiani, G.2
Butini, S.3
Joshi, B.P.4
Kukreja, G.5
Coccone, S.S.6
Bernetti, M.7
Persico, M.8
Nacci, V.9
Fiorini, I.10
Novellino, E.11
Taramelli, D.12
Basilico, N.13
Parapini, S.14
Yardley, V.15
Croft, S.16
Keller-Maerki, S.17
Rottmann, M.18
Brun, R.19
Coletta, M.20
Marini, S.21
Guiso, G.22
Caccia, S.23
Fattorusso, C.24
more..
-
60
-
-
84864954364
-
Optimization of 4- aminoquinoline/clotrimazole-based hybrid antimalarials: Further structure-activity relationships, in vivo studies, and preliminary toxicity profiling
-
S. Gemma, C. Camodeca, Sanna S. Coccone, B.P. Joshi, M. Bernetti, V. Moretti, S. Brogi Bonache, M.C. De Marcos, L. Savini, D. Taramelli, N. Basilico, S. Parapini, M. Rottmann, R. Brun, S. Lamponi, S. Caccia, G. Guiso, R.L. Summers, R.E. Martin, S. Saponara, B. Gorelli, E. Novellino, G. Campiani, S. Butini, Optimization of 4- aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling, J. Med. Chem. 55 (2012) 6948-6967
-
(2012)
J. Med. Chem
, vol.55
, pp. 6948-6948
-
-
Gemma, S.1
Camodeca, C.2
Joshi Coccone, B.P.S.S.A.3
Bernetti, M.4
Moretti, V.5
Brogi Bonache, S.6
De Marcos, M.C.7
Savini, L.8
Taramelli, D.9
Basilico, N.10
Parapini, S.11
Rottmann, M.12
Brun, R.13
Lamponi, S.14
Caccia, S.15
Guiso, G.16
Summers, R.L.17
Martin, R.E.18
Saponara, S.19
Gorelli, B.20
Novellino, E.21
Campiani, G.22
Butini, S.23
more..
-
61
-
-
60549088370
-
Fragmentbased discovery of the pyrazol-4-yl urea (AT9283) a multitargeted kinase inhibitor with potent aurora kinase activity
-
S. Howard, V. Berdini, J.A. Boulstridge, M.G. Carr, D.M. Cross, J. Curry, L.A. Devine, T.R. Early, L. Fazal, A.L. Gill, M. Heathcote, S. Maman, J.A. Matthews, R.L. Mc-Menamin, E.F. Navarro, M.A. O'Brien, M. O'Reilly, D.C. Rees, M. Reule, D. Tisi, G. Williams, M. Vinkovic, P.G. Wyatt, Fragmentbased discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity, J. Med. Chem. 52 (2009) 379-388
-
(2009)
J. Med. Chem
, vol.52
, pp. 379-379
-
-
Howard, S.1
Berdini, V.2
Boulstridge, J.A.3
Carr, M.G.4
Cross, D.M.5
Curry, J.6
Devine, L.A.7
Early, T.R.8
Fazal, L.9
Gill, A.L.10
Heathcote, M.11
Maman, S.12
Matthews, J.A.13
Mc-Menamin, R.L.14
Navarro, E.F.15
O'Brien, M.A.16
O'Reilly, M.17
Rees, D.C.18
Reule, M.19
Tisi, D.20
Williams, G.21
Vinkovic, M.22
Wyatt, P.G.23
more..
-
62
-
-
1642461641
-
Design, synthesis and biological evaluation of some pyrazole derivatives as anti-inflammatory-antimicrobial agents
-
A.A. Bekhit, T. Abdel-Aziem, Design, synthesis and biological evaluation of some pyrazole derivatives as anti-inflammatory-antimicrobial agents, Bioorg. Med. Chem. 12 (2004) 1935-1945
-
(2004)
Bioorg. Med. Chem
, vol.12
, pp. 1935-1935
-
-
Bekhit, A.A.1
Abdel-Aziem, T.2
-
63
-
-
84863812396
-
Novel 4-aminoquinoline-pyrimidine based hybrids with improved in vitro and in vivo antimalarial activity
-
S. Manohar, U.C. Rajesh, S.I. Khan, B.L. Tekwani, D.S. Rawat, Novel 4- aminoquinoline-pyrimidine based hybrids with improved in vitro and in vivo antimalarial activity, ACS Med. Chem. Lett. 3 (2012) 555-559
-
(2012)
ACS Med. Chem. Lett
, vol.3
, pp. 555-555
-
-
Manohar, S.1
Rajesh, U.C.2
Khan, S.I.3
Tekwani, B.L.4
Rawat, D.S.5
-
64
-
-
84879208695
-
Synthesis and bioevaluation of novel 4-aminoquinoline- tetrazole derivatives as potent antimalarial agents
-
S. Pandey, P. Agarwal, K. Srivastava, S. Rajakumar, S.K. Puri, P. Verma, J.K. Saxena, A. Sharma, J. Lal, P.M. Chauhan, Synthesis and bioevaluation of novel 4-aminoquinoline- tetrazole derivatives as potent antimalarial agents, Eur. J. Med. Chem. 66 (2013) 69-81
-
(2013)
Eur. J. Med. Chem
, vol.66
, pp. 69-69
-
-
Pandey, S.1
Agarwal, P.2
Srivastava, K.3
Rajakumar, S.4
Puri, S.K.5
Verma, P.6
Saxena, J.K.7
Sharma, A.8
Lal, J.9
Chauhan, P.M.10
-
65
-
-
84866360704
-
Synthesis and antiplasmodial activity of new heteroaryl derivatives of 7- chloro-4 aminoquinoline
-
M. Casagrande, A. Barteselli, N. Basilico, S. Parapini, D. Taramelli, A. Sparatore, Synthesis and antiplasmodial activity of new heteroaryl derivatives of 7- chloro-4 aminoquinoline, Bioorg. Med. Chem. 20 (2012) 5965-5979
-
(2012)
Bioorg. Med. Chem
, vol.20
, pp. 5965-5965
-
-
Casagrande, M.1
Barteselli, A.2
Basilico, N.3
Parapini, S.4
Taramelli, D.5
Sparatore, A.6
-
66
-
-
84893042343
-
Quinolinepyrimidine hybrids: Syn thesis antiplasmodial activity, sar, and mode of action studies
-
K. Singh, H. Kaur, P. Smith, C. De Kock, K. Chibale, J. Balzarini, Quinolinepyrimidine hybrids: synthesis, antiplasmodial activity, SAR, and mode of action studies, J. Med. Chem. 57 (2014) 435-448
-
(2014)
J. Med. Chem
, vol.57
, pp. 435-435
-
-
Singh, K.1
Kaur, H.2
Smith, P.3
De Kock, C.4
Chibale, K.5
Balzarini, J.6
-
67
-
-
45749094225
-
4-N-, 4-S-, and 4-O-chloroquine analogues: Influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria
-
J.K. Natarajan, J.N. Alumasa, K. Yearick, K.A. Ekoue-Kovi, L.B. Casabianca, A.C. De Dios, C. Wolf, P.D. Roepe, 4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria, J. Med. Chem. 51 (2008) 3466-4347
-
(2008)
J. Med. Chem
, vol.51
, pp. 3466-3466
-
-
Natarajan, J.K.1
Alumasa, J.N.2
Yearick, K.3
Ekoue-Kovi, K.A.4
Casabianca, L.B.5
De Dios, A.C.6
Wolf, C.7
Roepe, P.D.8
-
68
-
-
84862924718
-
Synthesis of hybrid 4-anilinoquinoline triazines as potent antimalarial agents, their in silico modeling and bioevaluation as plasmodium falciparum transketolase and b-hematin inhibitors
-
M. Sharma, K. Chauhan, S.S. Chauhan, A. Kumar, S.V. Singh, J.K. Saxena, P. Agarwal, K. Srivastava, S.R. Kumar, S.K. Puri, P. Shah, M.I. Siddiqi, P.M.S. Chauhan, Synthesis of hybrid 4-anilinoquinoline triazines as potent antimalarial agents, their in silico modeling and bioevaluation as Plasmodium falciparum transketolase and b-hematin inhibitors, Med. Chem. Commun. 3 (2012) 71-79
-
(2012)
Med. Chem. Commun
, vol.3
, pp. 71-71
-
-
Sharma, M.1
Chauhan, K.2
Chauhan, S.S.3
Kumar, A.4
Singh, S.V.5
Saxena, J.K.6
Agarwal, P.7
Srivastava, K.8
Kumar, S.R.9
Puri, S.K.10
Shah, P.11
Siddiqi, M.I.12
Chauhan, P.M.S.13
-
69
-
-
0028357126
-
A comparison of amodiaquine and chloroquine in the treatment therapy of falciparum malaria in Kenya
-
C.G. Nevill, F.H. Verhoeff, C.G. Munafu, W.R. Tenhove, H.J. Van Der Kaay, J.B.O. Were, A comparison of amodiaquine and chloroquine in the treatment therapy of falciparum malaria in Kenya, East Afr. Med. J. 71 (1994) 167-170
-
(1994)
East Afr. Med. J.
, vol.71
, pp. 167-167
-
-
Nevill, C.G.1
Verhoeff, F.H.2
Munafu, C.G.3
Tenhove, W.R.4
Van Der Kaay, H.J.5
Were, J.B.O.6
-
70
-
-
9244225096
-
Randomised trial of chloroquine, amodiaquine and pyrimethamine-sulfadoxine in gambian children with uncomplicated malaria
-
O. Muller, M.B. Vanhensbroek, S. Jaffer, C. Drakeley, C. Okorie, D. Joof, M. Pinder, B.A. Greenwood, Randomised trial of chloroquine, amodiaquine and pyrimethamine-sulfadoxine in Gambian children with uncomplicated malaria, Trop. Med. Int. Health 1 (1996) 124-132
-
(1996)
Trop. Med. Int. Health 1
, pp. 124-124
-
-
Muller, O.1
Vanhensbroek, M.B.2
Jaffer, S.3
Drakeley, C.4
Okorie, C.5
Joof, D.6
Pinder, M.7
Greenwood, B.A.8
-
71
-
-
72049117615
-
Syn thesis antimalarial activity and cytotoxicity of 4-aminoquinoline-triazine conjugates
-
S. Manohar, S.I. Khan, D.S. Rawat, Synthesis, antimalarial activity and cytotoxicity of 4-aminoquinoline-triazine conjugates, Bioorg. Med. Chem. Lett. 20 (2010) 322-325
-
(2010)
Bioorg. Med. Chem. Lett
, vol.20
, pp. 322-322
-
-
Manohar, S.1
Khan, S.I.2
Rawat, D.S.3
-
72
-
-
79958808891
-
Synthesis of 4-aminoquinoline-1 2,3- triazole and 4-aminoquinoline-1,2,3-triazole-1,3,5-triazine hybrids as potential antimalarial agents
-
S. Manohar, S.I. Khan, D.S. Rawat, Synthesis of 4-aminoquinoline-1,2,3- triazole and 4-aminoquinoline-1,2,3-triazole-1,3,5-triazine hybrids as potential antimalarial agents, Chem. Biol. Drug Des. 78 (2011) 124-136
-
(2011)
Chem. Biol. Drug des
, vol.78
, pp. 124-124
-
-
Manohar, S.1
Khan, S.I.2
Rawat, D.S.3
-
73
-
-
84876884044
-
4-aminoquinoline-triazinebased hybrids with improved in vitro antimalarial activity against CQ-sensitive and CQresistant strains of Plasmodium falciparum
-
S. Manohar, S.I. Khan, D.S. Rawat, 4-aminoquinoline-triazinebased hybrids with improved in vitro antimalarial activity against CQ-sensitive and CQresistant strains of Plasmodium falciparum, Chem. Biol. Drug Des. 81 (2010) 625-630
-
(2010)
Chem. Biol. Drug Des
, vol.81
, pp. 625-625
-
-
Manohar, S.1
Khan, S.I.2
Rawat, D.S.3
-
74
-
-
84912035782
-
-
WO2013134047 A2
-
D.S. Rawat, S. Manohar, U.C. Rajesh, D. Kumar, A. Thakur, M. Tripathi, P.L. Reddy, S.K. Kandi, S. Vardhineni, K.-S. Kim, C.-H. Kim. Aminoquinoline derivatives and uses thereof, WO2013134047 A2
-
Aminoquinoline Derivatives and Uses Thereof
-
-
Rawat, D.S.1
Manohar, S.2
Rajesh, U.C.3
Kumar, D.4
Thakur, A.5
Tripathi, M.6
Reddy, P.L.7
Kandi, S.K.8
Vardhineni, S.9
Kim, K.-S.10
Kim, C.-H.11
-
75
-
-
84856226189
-
Synthesis and in vitro and in vivo antimalarial activity of novel 4-anilinoquinoline mannich base derivatives
-
B. Singh, D. Chetia, S.K. Puri, Synthesis and in vitro and in vivo antimalarial activity of novel 4-anilinoquinoline Mannich base derivatives, Med. Chem. Res. 20 (2011) 1523-1529
-
(2011)
Med. Chem. Res
, vol.20
, pp. 1523-1523
-
-
Singh, B.1
Chetia, D.2
Puri, S.K.3
-
76
-
-
64349092617
-
Candidate selection and preclinical evaluation of ntert- butyl isoquine (gsk369796) an affordable and effective 4- aminoquinoline antimalarial for the 21st century
-
P.M. O'Neill, B.K. Park, A.E. Shone, J.L. Maggs, P. Roberts, P.A. Stocks, G.A. Biagini, P.G. Bray, P. Gibbons, N. Berry, P.A. Winstanley, A. Mukhtar, R. Bonar-Law, S. Hindley, R.B. Bambal, C.B. Davis, M. Bates, T.K. Hart, S.L. Gresham, R.M. Lawrence, R.A. Brigandi, F.M. Gomez-delas-Heras, D.V. Gargallo, S.A. Ward, Candidate selection and preclinical evaluation of Ntert- butyl isoquine (GSK369796), an affordable and effective 4- aminoquinoline antimalarial for the 21st century, J. Med. Chem. 52 (2009) 1408-1415
-
(2009)
J. Med. Chem
, vol.52
, pp. 1408-1408
-
-
O'Neill, P.M.1
Park, B.K.2
Shone, A.E.3
Maggs, J.L.4
Roberts, P.5
Stocks, P.A.6
Biagini, G.A.7
Bray, P.G.8
Gibbons, P.9
Berry, N.10
Winstanley, P.A.11
Mukhtar, A.12
Bonar-Law, R.13
Hindley, S.14
Bambal, R.B.15
Davis, C.B.16
Bates, M.17
Hart, T.K.18
Gresham, S.L.19
Lawrence, R.M.20
Brigandi, R.A.21
Gomez-Delas-Heras, F.M.22
Gargallo, D.V.23
Ward, S.A.24
more..
-
77
-
-
84872319598
-
Incorporation of a 3-(2,2,2- Trifluoroethyl)-g-hydroxy-g-lactam motif in the side chain of 4- aminoquinolines syntheses and antimalarial activities
-
D. Cornut, H. Lemoine, O. Kanishchev, E. Okada, F. Albrieux, A.H. Beavogui, A.- L. Bienvenu, S. Picot, J.-P. Bouillon, M. Médebielle, Incorporation of a 3-(2,2,2- Trifluoroethyl)-g-hydroxy-g-lactam motif in the side chain of 4- aminoquinolines syntheses and antimalarial activities, J. Med. Chem. 56 (2013) 73-83
-
(2013)
J. Med. Chem
, vol.56
, pp. 73-73
-
-
Cornut, D.1
Lemoine, H.2
Kanishchev, O.3
Okada, E.4
Albrieux, F.5
Beavogui, A.H.6
Bienvenu, A.-L.7
Picot, S.8
Bouillon, J.-P.9
Médebielle, M.10
-
78
-
-
17144422120
-
Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance
-
P.G. Bray, R.E. Martin, L. Tilley, S.A. Ward, K. Kirk, D.A. Fidock, Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance, Mol. Microbiol. 56 (2005) 323-333
-
(2005)
Mol. Microbiol
, vol.56
, pp. 323-323
-
-
Bray, P.G.1
Martin, R.E.2
Tilley, L.3
Ward, S.A.4
Kirk, K.5
Fidock, D.A.6
-
79
-
-
0033636607
-
Mutations in the P. Falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance
-
D.A. Fidock, T. Nomura, A.K. Talley, R.A. Cooper, S.M. Dzekunov, M.T. Ferdig, L.M. Ursos, A.B. Sidhu, B. Naude, K.W. Deitsch, X.Z. Su, J.C. Wootton, P.D. Roepe, T.E. Wellems, Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance, Mol. Cell. 6 (2000) 861-871
-
(2000)
Mol. Cell
, vol.6
, pp. 861-861
-
-
Fidock, D.A.1
Nomura, T.2
Talley, A.K.3
Cooper, R.A.4
Dzekunov, S.M.5
Ferdig, M.T.6
Ursos, L.M.7
Sidhu, A.B.8
Naude, B.9
Deitsch, K.W.10
Su, X.Z.11
Wootton, J.C.12
Roepe, P.D.13
Wellems, T.E.14
-
80
-
-
0023666563
-
Efflux of chloroquine from plasmodium falciparum: Mechanism b of chloroquine resistance
-
D.J. Krogstad, I.Y. Gluzman, D.E. Kyle, A.M. Oduola, S.K. Martin, W.K. Milhous, P.H. Schlesinger, Efflux of chloroquine from Plasmodium falciparum: mechanism b of chloroquine resistance, Science 238 (1987) 1283-1285
-
(1987)
Science
, vol.238
, pp. 1283-1283
-
-
Krogstad, D.J.1
Gluzman, I.Y.2
Kyle, D.E.3
Oduola, A.M.4
Martin, S.K.5
Milhous, W.K.6
Schlesinger, P.H.7
-
81
-
-
84865140873
-
Synthesis and in vitro evaluation of new chloroquine-chalcone hybrids against chloroquine-resistant strain of Plasmodium falciparum
-
K.V. Sashidhara, S.R. Avula, G.R. Palnati, S.V. Singh, K. Srivastava, S.K. Puri, J.K. Saxena, Synthesis and in vitro evaluation of new chloroquine-chalcone hybrids against chloroquine-resistant strain of Plasmodium falciparum, Bioorg. Med. Chem. Lett. 22 (2012) 5455-5459
-
(2012)
Bioorg. Med. Chem. Lett
, vol.22
, pp. 5455-5455
-
-
Sashidhara, K.V.1
Avula, S.R.2
Palnati, G.R.3
Singh, S.V.4
Srivastava, K.5
Puri, S.K.6
Saxena, J.K.7
-
82
-
-
79960565312
-
Synthesis and antimalarial activity of new heterocyclic hybrids based on chloroquine and thiazolidinone scaffolds
-
F.A.R. Ruiz, R.N. García-Sánchez, S.V. Estupiñan, A. Gómez-Barrio, D.F.T. Amado, B.M. Pérez-Solórzano, J.J. Nogal-Ruiz, A.R. Martínez-Fernández, V.V. Kouznetsov, Synthesis and antimalarial activity of new heterocyclic hybrids based on chloroquine and thiazolidinone scaffolds, Bioorg. Med. Chem. 19 (2011) 4562-4573
-
(2011)
Bioorg. Med. Chem
, vol.19
, pp. 4562-4562
-
-
Ruiz, F.A.R.1
García-Sánchez, R.N.2
Estupiñan, S.V.3
Gómez-Barrio, A.4
Amado, D.F.T.5
Pérez-Solórzano, B.M.6
Nogal-Ruiz, J.J.7
Martínez-Fernández, A.R.8
Kouznetsov, V.V.9
-
84
-
-
80053895993
-
Quinoline antimalarials containing a dibemethin group are active against chloroquinone-resistant Plasmodium falciparum and inhibit chloroquine transport via the P. Falciparum chloroquine-resistance transporter (pfcrt
-
V.K. Zishiri, M.C. Joshi, R. Hunter, K. Chibale, P.J. Smith, R.L. Summers, R.E. Martin, T.J. Egan, Quinoline antimalarials containing a dibemethin group are active against chloroquinone-resistant Plasmodium falciparum and inhibit chloroquine transport via the P. falciparum chloroquine-resistance transporter (PfCRT), J. Med. Chem. 54 (2011) 6956-6968
-
(2011)
J. Med. Chem
, vol.54
, pp. 6956-6956
-
-
Zishiri, V.K.1
Joshi, M.C.2
Hunter, R.3
Chibale, K.4
Smith, P.J.5
Summers, R.L.6
Martin, R.E.7
Egan, T.J.8
-
86
-
-
84857769077
-
The activities of current antimalarial drugs on the life cycle stages of plasmodium: A comparative study with human and rodent parasites
-
M. Delves, D. Plouffe, C. Scheurer, S. Meister, S. Wittlin, E.A. Winzeler, R.E. Sinden, D. Leroy, The activities of current antimalarial drugs on the life cycle stages of plasmodium: a comparative study with human and rodent parasites, PLoS Med. 9 (2012) e1001169
-
(2012)
PLoS Med
, vol.9
, pp. e1001169
-
-
Delves, M.1
Plouffe, D.2
Scheurer, C.3
Meister, S.4
Wittlin, S.5
Winzeler, E.A.6
Sinden, R.E.7
Leroy, D.8
-
87
-
-
80053494971
-
The next opportunity in anti-malaria drug discovery: The liver stage
-
E.R. Derbyshire, M.M. Mota, J. Clardy, The next opportunity in anti-malaria drug discovery: the liver stage, PLoS Pathog. 7 (2011) e1002178
-
(2011)
PLoS Pathog
, vol.7
, pp. e1002178
-
-
Derbyshire, E.R.1
Mota, M.M.2
Clardy, J.3
-
88
-
-
84872811660
-
N-cinnamoylated chloroquine analogues as dualstage antimalarial leads
-
B.C. Pérez, C. Teixeira, I.S. Albuquerque, J. Gut, P.J. Rosenthal, J.R.B. Gomes, M. Prudencio, P. Gomes, N-cinnamoylated chloroquine analogues as dualstage antimalarial leads, J. Med. Chem. 56 (2013) 556-567
-
(2013)
J. Med. Chem
, vol.56
, pp. 556-556
-
-
Pérez, B.C.1
Teixeira, C.2
Albuquerque, I.S.3
Gut, J.4
Rosenthal, P.J.5
Gomes Prudencio, M.J.R.B.6
Gomes, P.7
-
89
-
-
84865578263
-
Cinnamic acid/chloroquinoline conjugates as potent agents against chloroquineresistant plasmodium falciparum
-
B.C. Pérez, C. Teixeira, J. Gut, P.J. Rosenthal, J.R.B. Gomes, P. Gomes, Cinnamic acid/chloroquinoline conjugates as potent agents against chloroquineresistant Plasmodium falciparum, Chem. Med. Chem. 7 (2012) 1537-1540
-
(2012)
Chem. Med. Chem
, vol.7
, pp. 1537-1537
-
-
Pérez, B.C.1
Teixeira, C.2
Gut, J.3
Rosenthal, P.J.4
Gomes, J.R.B.5
Gomes, P.6
-
90
-
-
84887614688
-
A primaquine-chloroquine hybrid with dual activity against plasmodium liver and blood stages
-
M. Lodige, M.D. Lewis, E.S. Paulsen, H.L. Esch, G. Pradel, L. Lehmann, R. Brun, G. Bringmann, A.-K. Mueller, A primaquine-chloroquine hybrid with dual activity against plasmodium liver and blood stages, Inter. J. Med. Microbiol. 303 (2013) 539-547
-
(2013)
Inter. J. Med. Microbiol
, vol.303
, pp. 539-539
-
-
Lodige, M.1
Lewis, M.D.2
Paulsen, E.S.3
Esch, H.L.4
Pradel, G.5
Lehmann, L.6
Brun, R.7
Bringmann, G.8
Mueller, A.-K.9
-
91
-
-
0014483527
-
Drug-induced hemolytic anemia
-
E. Beutler, Drug-induced hemolytic anemia, Pharmacol. Rev. 1 (1969) 73-103
-
(1969)
Pharmacol. Rev
, vol.1
, pp. 73-73
-
-
Beutler, E.1
-
93
-
-
84912037761
-
-
US 7404962 B1,US patent 7404962B1, July 29
-
F.J. Pinto, S.A. Piramal, R. Pratap, P. Bhaduri, P. Thapliyal, K. Puri, P. Dutta, K. Dwivedi, S. Singh, P. Srivastava, V.C. Pandey, S. Shrivastava, S.K. Singh, R.C. Gupta, J.S. Shrivastava, O.P. Asthana. Combination kit used in the treatment of malaria US 7404962 B1,US patent 7404962B1, July 29 2008
-
(2008)
Combination Kit Used in the Treatment of Malaria
-
-
Pinto, F.J.1
Piramal, S.A.2
Pratap, R.3
Bhaduri, P.4
Thapliyal, P.5
Puri, K.6
Dutta, P.7
Dwivedi, K.8
Singh, S.9
Srivastava, P.10
Pandey, V.C.11
Shrivastava, S.12
Singh, S.K.13
Gupta, R.C.14
Shrivastava, J.S.15
Asthana, O.P.16
-
94
-
-
84865440072
-
Novel 4- aminoquinoline analogs highly active against the blood and sexual stages of plasmodium in vivo and in vitro antimicrob
-
F.E. Sáenz, T. Mutka, K. Udenze, A.M.J. Oduola, D.E. Kyle, Novel 4- aminoquinoline analogs highly active against the blood and sexual stages of plasmodium in vivo and in vitro, Antimicrob. Agents Chemother. 56 (2012) 4685-4692
-
(2012)
Agents Chemother
, vol.56
, pp. 4685-4685
-
-
Sáenz, F.E.1
Mutka, T.2
Udenze, K.3
Oduola, A.M.J.4
Kyle, D.E.5
-
95
-
-
84876357714
-
Chemosensitization potential of P-glycoprotein inhibitors in malaria parasites
-
L.M. Alcantara, J. Kim, C.B. Moraes, C.H. Franco, K.D. Franzoi, S. Lee, L.H. Freitas-Junior, L.S. Ayong, Chemosensitization potential of P-glycoprotein inhibitors in malaria parasites, Exp. Parasitol. 134 (2013) 235-243
-
(2013)
Exp. Parasitol
, vol.134
, pp. 235-235
-
-
Alcantara, L.M.1
Kim, J.2
Moraes, C.B.3
Franco, C.H.4
Franzoi, K.D.5
Lee, S.6
Freitas-Junior, L.H.7
Ayong, L.S.8
-
96
-
-
1242318692
-
Thalassaemia major: The murky story of deferiprone
-
J. Savulescu, Thalassaemia major: the murky story of deferiprone, BMJ 328 (2004) 358-359
-
(2004)
BMJ
, vol.328
, pp. 358-358
-
-
Savulescu, J.1
-
97
-
-
84872296730
-
Conjugation to 4-aminoquinoline improves the antitrypanosomal activity of deferiprone-type iron chelator
-
S.S. Gehrke, E.G. Pinto, D. Steverding, K. Pleban, A.G. Tempone, R.C. Hider, G.K. Wagner, Conjugation to 4-aminoquinoline improves the antitrypanosomal activity of Deferiprone-type iron chelator, Bioorg. Med. Chem. 21 (2013) 805-813
-
(2013)
Bioorg. Med. Chem
, vol.21
, pp. 805-805
-
-
Gehrke, S.S.1
Pinto, E.G.2
Steverding, D.3
Pleban, K.4
Tempone, A.G.5
Hider, R.C.6
Wagner, G.K.7
-
98
-
-
79959388522
-
Docking studies on the binding of quinoline derivatives and hematin to plasmodium falciparum lactate dehydrogenase
-
W.A. Cortopassi, A.A. Oliveira, A.P. Guimarães, M.N. Rennó, A.U. Krettli, Tanos C.C. França, Docking studies on the binding of quinoline derivatives and hematin to plasmodium falciparum lactate dehydrogenase, J. Biomol. Struct. Dyn. 29 (2011) 207-218
-
(2011)
J. Biomol. Struct. Dyn
, vol.29
, pp. 207-207
-
-
Cortopassi, W.A.1
Oliveira, A.A.2
Guimarães, A.P.3
Rennó, M.N.4
Krettli Tanos, A.U.5
Franç, C.C.6
-
99
-
-
80052232955
-
Property-based design and synthesis of new chloroquine hybrids via simple incorporation of 2-imino-thiazolidin-4-one or 1H-pyrrol-2,5-dione fragments on the 4-amino-7-chloroquinoline side chain
-
F.A. Rojas, V.V. Kouznetsov, Property-based design and synthesis of new chloroquine hybrids via simple incorporation of 2-imino-thiazolidin-4-one or 1H-pyrrol-2,5-dione fragments on the 4-amino-7-chloroquinoline side chain, J. Braz. Chem. Soc. 22 (2011) 1774-1781
-
(2011)
J. Braz. Chem. Soc
, vol.22
, pp. 1774-1774
-
-
Rojas, F.A.1
Kouznetsov, V.V.2
-
100
-
-
0030483601
-
Aminoquinolines that circumvent resistance in Plasmodium falciparum in vitro
-
D. De, F.M. Krogstad, F.B. Cogswell, D.J. Krogstad, Aminoquinolines that circumvent resistance in Plasmodium falciparum in vitro, Am. J. Trop. Med. Hyg. 55 (1996) 579-583
-
(1996)
Am. J. Trop. Med. Hyg
, vol.55
, pp. 579-579
-
-
De, D.1
Krogstad, F.M.2
Cogswell, F.B.3
Krogstad, D.J.4
-
101
-
-
9444258557
-
4-Aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant plasmodium falciparum antimicrob
-
R.G. Ridley, W. Hfheinz, H. Matile, C. Jaquet, A. Dorn, R. Masciadri, S. Jolidon, W.F. Richter, A. Guenzi, M.A. Girometta, H. Urwyler, Huber, S. Thaithong, W. Peters, 4-Aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum, Antimicrob. Agents Chemother. 40 (1996) 1846-1854
-
(1996)
Agents Chemother
, vol.40
, pp. 1846-1846
-
-
Ridley, R.G.1
Hfheinz, W.2
Matile, H.3
Jaquet, C.4
Dorn, A.5
Masciadri, R.6
Jolidon, S.7
Richter, W.F.8
Guenzi, A.9
Girometta, M.A.10
Urwyler, H.11
Thaithong, H.S.12
Peters, W.13
-
102
-
-
84861362223
-
Antimalarial activity and mechanisms of action of two novel 4-aminoquinolines against chloroquineresistant parasites
-
A.C.C. Aguiar, R.D.M. Santos, F.J.B. Figueiredo, W.A. Cortopassi, A.S. Pimentel, T.C.C. França, M.R. Meneghetti, A.U. Krettli, Antimalarial activity and mechanisms of action of two novel 4-aminoquinolines against chloroquineresistant parasites, PLoS One 7 (2012) e37259
-
(2012)
PLoS One
, vol.7
, pp. e37259
-
-
Aguiar, A.C.C.1
Santos, R.D.M.2
Figueiredo, F.J.B.3
Cortopassi, W.A.4
Pimentel, A.S.5
França, T.C.C.6
Meneghetti, M.R.7
Krettli, A.U.8
-
103
-
-
0033523894
-
Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth
-
S.R. Vippagunta, A. Dorn, H. Matile, A.K. Bhattacharjee, J.M. Karle, W.Y. Ellis, R.G. Ridley, J.L. Vennerstrom, Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth, J. Med. Chem. 42 (1999) 4630-4639
-
(1999)
J. Med. Chem
, vol.42
, pp. 4630-4630
-
-
Vippagunta, S.R.1
Dorn, A.2
Matile, H.3
Bhattacharjee, A.K.4
Karle, J.M.5
Ellis, W.Y.6
Ridley, R.G.7
Vennerstrom, J.L.8
-
104
-
-
85007108669
-
Insights into activity enhancement of 4-aminoquinoline-based hybrids using atom-based and field-based qsar studies
-
K.K. Raj, S. Manohar, V.R. Talluri, D.S. Rawat, Insights into activity enhancement of 4-aminoquinoline-based hybrids using atom-based and field-based QSAR studies, Med. Chem. Res. (2014), http://dx.doi.org/10.1007/s00044-014-1195-6
-
(2014)
Med. Chem. Res
-
-
Raj, K.K.1
Manohar, S.2
Talluri, V.R.3
Rawat, D.S.4
-
105
-
-
84856025752
-
Synthesis of aminoquinoline-based aminoalcohols and oxazolidinones and their antiplasmodial activity
-
F. Kobarfard, V. Yardley, S. Little, F. Daryaee, K. Chibale, Synthesis of aminoquinoline-based aminoalcohols and oxazolidinones and their antiplasmodial activity, Chem. Biol. Drug Des. 79 (2012) 326-331
-
(2012)
Chem. Biol. Drug Des
, vol.79
, pp. 326-326
-
-
Kobarfard, F.1
Yardley, V.2
Little, S.3
Daryaee, F.4
Chibale, K.5
-
106
-
-
84901253130
-
Second generation steroidal 4-aminoquinolines are potent, dual-target inhibitors of the botulinum neurotoxin serotype a metalloprotease and p falciparum malaria
-
M. Idenovi, D.M. Opsenica, J.C. Burnett, L. Gomba, J.E. Nuss, Z. Selakovi, J. Konstantinovi, M. Krsti, S. Segan, M. Zlatovi, R.J. Sciotti, S. Bavari, B.A. Solaja, Second generation steroidal 4-aminoquinolines are potent, dual-target inhibitors of the Botulinum neurotoxin serotype A metalloprotease and P. falciparum Malaria, J. Med. Chem. 57 (2014) 4134-4153
-
(2014)
J. Med. Chem
, vol.57
, pp. 4134-4134
-
-
Idenovi, M.1
Opsenica, D.M.2
Burnett, J.C.3
Gomba, L.4
Nuss, J.E.5
Selakovi, Z.6
Konstantinovi, J.7
Krsti, M.8
Segan, S.9
Zlatovi, M.10
Sciotti, R.J.11
Bavari, S.12
Solaja, B.A.13
-
107
-
-
34247633446
-
A refined pharmacophore identifies potent 4- amino-7-chloroquinoline-based inhibitors of the botulinum neurotoxin serotype a metalloprotease
-
J.C. Burnett, D. Opsenica, K. Sriraghavan, R.G. Panchal, G. Ruthel, A.R. Hermone, T.L. Nguyen, T.A. Kenny, D.J. Lane, C.F. McGrath, J.J. Schmidt, J.L. Vennerstrom, R. Gussio, B.A. Solaja, S. Bavari, A refined pharmacophore identifies potent 4- amino-7-chloroquinoline-based inhibitors of the Botulinum neurotoxin serotype A metalloprotease, J. Med. Chem. 50 (2007) 2127-2136
-
(2007)
J. Med. Chem
, vol.50
, pp. 2127-2127
-
-
Burnett, J.C.1
Opsenica, D.2
Sriraghavan, K.3
Panchal, R.G.4
Ruthel, G.5
Hermone, A.R.6
Nguyen, T.L.7
Kenny, T.A.8
Lane, D.J.9
McGrath, C.F.10
Schmidt, J.J.11
Vennerstrom, J.L.12
Gussio, R.13
Solaja, B.A.14
Bavari, S.15
-
108
-
-
49449118829
-
Novel 4-aminoquinolines active against chloroquine-resistant and sensitive P. Falciparum strains that also inhibit Botulinum serotype
-
B.A. Solaja, D. Opsenica, K.S. Smith, W.K. Milhous, N. Terzi, I. Opsenica, J.C. Burnett, J. Nuss, R. Gussio, S. Bavari, Novel 4-aminoquinolines active against chloroquine-resistant and sensitive P. falciparum strains that also inhibit Botulinum serotype A, J. Med. Chem. 51 (2008) 4388-4391
-
(2008)
A J. Med. Chem
, vol.51
, pp. 4388-4388
-
-
Solaja, B.A.1
Opsenica, D.2
Smith, K.S.3
Milhous, W.K.4
Terzi, N.5
Opsenica, I.6
Burnett, J.C.7
Nuss, J.8
Gussio, R.9
Bavari, S.10
-
109
-
-
0001228583
-
Oncological implications of the chemistry of ruthenium
-
H. Sigel (Ed. Marcel Dekker, Basel and New York
-
M.J. Clarke, Oncological implications of the chemistry of ruthenium, in: H. Sigel (Ed.), Metal Ions in Biological Systems, Metal Complexes as Anticancer Agents, vol. 11, Marcel Dekker, Basel and New York, 1980, p. 231
-
(1980)
Metal Ions in Biological Systems, Metal Complexes As Anticancer Agents
, vol.11
, pp. 231
-
-
Clarke, M.J.1
-
110
-
-
60849083853
-
Syn thesis, characterization, and in vitro antimalarial and antitumor activity of new ruthenium II) complexes of chloroquine
-
C.S. Rajapakse, A. Martínez, B. Naoulou, A.A. Jarzecki, L. Suárez, C.n Deregnaucourt, V. Sinou, J. Schrével, E. Musi, G. Ambrosini, G.K. Schwartz, R.A. Sánchez-Delgado, Synthesis, characterization, and in vitro antimalarial and antitumor activity of new ruthenium(II) complexes of chloroquine, Inorg. Chem. 48 (2009) 1122-1131
-
(2009)
Inorg. Chem
, vol.48
, pp. 1122-1122
-
-
Rajapakse, C.S.1
Martínez, A.2
Naoulou, B.3
Jarzecki, A.A.4
Suárez, L.5
Deregnaucourt, C.N.6
Sinou, V.7
Schrével, J.8
Musi, E.9
Ambrosini, G.10
Schwartz, G.K.11
Sánchez-Delgado, R.A.12
-
111
-
-
0031006370
-
Toward a novel metal-based chemotherapy against tropical diseases 3 synthesis and antimalarial activity in vitro and in vivo of the new gold-chloroquine complex [au(pph3)(cq)]pf6
-
M. Navarro, H. Pérez, R.A. Sánchez-Delgado, Toward a novel metal-based chemotherapy against tropical diseases. 3. Synthesis and antimalarial activity in vitro and in vivo of the new gold-chloroquine complex [Au(PPh3)(CQ)]PF6, J. Med. Chem. 40 (1997) 1937-1939
-
(1997)
J. Med. Chem
, vol.40
, pp. 1937-1937
-
-
Navarro, M.1
Pérez, H.2
Sánchez-Delgado, R.A.3
-
112
-
-
84872721184
-
Syn thesis characterization, and pharmacological evaluation of silicon-containing aminoquinoline organometallic complexes as antiplasmodial antitumor, and antimycobacterial agents
-
Y. Li, C. De Kock, P.J. Smith, H. Guzgay, D.T. Hendricks, K. Naran, V. Mizrahi, D.F. Warner, K. Chibale, G.S. Smith, Synthesis, characterization, and pharmacological evaluation of silicon-containing aminoquinoline organometallic complexes as antiplasmodial, antitumor, and antimycobacterial agents, Organometallics 32 (2013) 141-150
-
(2013)
Organometallics
, vol.32
, pp. 141-141
-
-
Li, Y.1
De Kock, C.2
Smith, P.J.3
Guzgay, H.4
Hendricks, D.T.5
Naran, K.6
Mizrahi, V.7
Warner, D.F.8
Chibale, K.9
Smith, G.S.10
-
113
-
-
84900841501
-
Low-dose primaquine for falciparum malaria
-
K. Goyal, H. Kaur, R. Sehgal, Low-dose primaquine for falciparum malaria, Lancet Infect. Dis. 14 (2014) 449
-
(2014)
Lancet Infect. Dis
, vol.14
, pp. 449
-
-
Goyal, K.1
Kaur, H.2
Sehgal, R.3
-
115
-
-
0035941397
-
Anti-HIV effects of chloroquine: Mechanisms of inhibition and spectrum of activity
-
A. Savarino, L. Gennero, H.C. Chen, D. Serrano, F. Malavasi, J.R. Boelaert, K. Sperber, Anti-HIV effects of chloroquine: mechanisms of inhibition and spectrum of activity, AIDS 15 (2001) 2221-2229
-
(2001)
AIDS
, vol.15
, pp. 2221-2221
-
-
Savarino, A.1
Gennero, L.2
Chen, H.C.3
Serrano, D.4
Malavasi, F.5
Boelaert, J.R.6
Sperber, K.7
-
116
-
-
0035141602
-
The anti-HIV-1 activity of chloroquine
-
A. Savarino, L. Gennero, K. Sperber, J.R. Boelaert, The anti-HIV-1 activity of chloroquine, J. Clin. Virol. 20 (2001) 131-135
-
(2001)
J. Clin. Virol
, vol.20
, pp. 131-131
-
-
Savarino, A.1
Gennero, L.2
Sperber, K.3
Boelaert, J.R.4
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