Quinoline antimalarials containing a dibemethin group are active against chloroquinone-resistant plasmodium falciparum and inhibit chloroquine transport via the P. falciparum chloroquine-resistance transporter (PfCRT)

Journal of Medicinal Chemistry

Volumn 54, Issue 19, 2011, Pages 6956-6968

  Zishiri, Vincent K ^a   Joshi, Mukesh C ^a   Hunter, Roger ^a   Chibale, Kelly ^a   Smith, Peter J ^a   Summers, Robert L ^b   Martin, Rowena E ^b   Egan, Timothy J ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 7 CHLOROQUINOLINE DERIVATIVE; ANTIMALARIAL AGENT; CHLOROQUINE; DIBEMETHIN DERIVATIVE; HEMOZOIN; MULTIDRUG RESISTANCE PROTEIN; PLASMODIUM FALCIPARUM CHLOROQUINE RESISTANCE TRANSPORTER; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG RESISTANCE; ARTICLE; CELL LINE; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG TRANSPORT; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VIVO STUDY; MAMMAL CELL; MOUSE; NONHUMAN; OOCYTE; PARASITEMIA; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION; SURVIVAL; XENOPUS;

ANIMALS; ANTIMALARIALS; BIOLOGICAL TRANSPORT; CELL SURVIVAL; CHLOROQUINE; CHO CELLS; CRICETINAE; CRICETULUS; CRYSTALLOGRAPHY, X-RAY; FEMALE; MALARIA; MEMBRANE TRANSPORT PROTEINS; MICE; MOLECULAR STRUCTURE; OOCYTES; PARASITEMIA; PARASITIC SENSITIVITY TESTS; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 80053895993     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2009698     Document Type: Article

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