Design, synthesis and biological evaluation of some pyrazole derivatives as anti-inflammatory-antimicrobial agents

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 8, 2004, Pages 1935-1945

  Bekhit, Adnan A ^a   Abdel Aziem, Tarek ^b  

^a Alexandria University Faculty of Pharmacy   (Egypt)

^b ALEXANDRIA UNIVERSITY   (Egypt)

Author keywords

1H pyrazoles; Acute toxicity; Anti inflammatory activity; Antimicrobial activity; COX inhibitory activities; Ulcerogenic effect

Indexed keywords

3 (5 BROMO 2 THIENYL) 4 [1 (4 METHYLBENZENESULFONYL) 3 (4 METHYLPHENYL) 2 PYRAZOLIN 5 YL] 1 PHENYL 1H PYRAZOLE; 3 (5 BROMO 2 THIENYL) 4 [1 ACETYL 3 (4 METHYLPHENYL) 2 PYRAZOLIN 5 YL] 1 PHENYL 1H PYRAZOLE; 3 (5 BROMO 2 THIENYL) 4 [1 BENZOYL 3 (4 METHYLPHENYL) 2 PYRAZOLIN 5 YL] 1 PHENYL 1H PYRAZOLE; 3 (5 BROMO 2 THIENYL) 4 [1 FORMYL 3 (4 METHYLPHENYL) 2 PYRAZOLIN 5 YL] 1 PHENYL 1H PYRAZOLE; 3 (5 BROMO 2 THIENYL) 4 [1 METHANESULFONYL 3 (4 METHYLPHENYL) 2 PYRAZOLIN 5 YL] 1 PHENYL 1H PYRAZOLE; 3 (5 BROMO 2 THIENYL) 4 [1 NITROSO 3 (4 METHYLPHENYL) 2 PYRAZOLIN 5 YL] 1 PHENYL 1H PYRAZOLE; 3 (5 BROMO 2 THIENYL) 4 [1 PHENYLTHIOCARBAMOYL 3 (4 METHYLPHENYL) 2 PYRAZOLIN 5 YL] 1 PHENYL 1H PYRAZOLE; 3 (5 BROMO 2 THIENYL) 4 [3 (4 METHYLPHENYL) 1H PYRAZOL 5 YL] 1 PHENYL 1H PYRAZOLE; 3 (5 BROMO 2 THIENYL) 4 [3 (4 METHYLPHENYL) 2 PYRAZOLIN 5 YL] 1 PHENYL 1H PYRAZOLE; 3 (5 BROMO 2 THIENYL) 4 [3 (4 METHYLPHENYL) 3 OXOPROPENYL] 1 PHENYL 1H PYRAZOLE; AMPICILLIN; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; INDOMETACIN; PHENYLBUTAZONE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BIOASSAY; CANDIDA ALBICANS; CONTROLLED STUDY; COTTON; DRUG DESIGN; DRUG POTENCY; DRUG SAFETY; DRUG SCREENING; DRUG SYNTHESIS; DRUG TOLERABILITY; ENZYME INHIBITION; ESCHERICHIA COLI; FUNGUS; GASTROINTESTINAL SYMPTOM; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; GRANULOMA; LD 50; MALE; NONHUMAN; RAT; STAPHYLOCOCCUS AUREUS; ULCEROGENESIS;

ANIMALS; ANTI-INFECTIVE AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; LETHAL DOSE 50; MALE; MICE; MICROBIAL SENSITIVITY TESTS; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; STOMACH ULCER;

ANIMALIA; CANDIDA ALBICANS; ESCHERICHIA COLI; FUNGI; GOSSYPIUM HIRSUTUM; NEGIBACTERIA; POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 1642461641     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.01.037     Document Type: Article

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