Antimalarial versus cytotoxic properties of dual drugs derived from 4-aminoquinolines and mannich bases: Interaction with DNA

Journal of Medicinal Chemistry

Volumn 53, Issue 8, 2010, Pages 3214-3226

  Tóth, Katalin ^h   Wenzel, Nicole I ^a   Chavain, Natascha ^b   Wang, Yulin ^a   Friebolin, Wolfgang ^a   Maes, Louis ^c   Pradines, Bruno ^d   Lanzer, Michael ^a   Yardley, Vanessa ^e   Brun, Reto ^f,g   Herold Mende, Christel ^a   Biot, Christophe ^b   Davioud Charvet, Elisabeth ^a,i  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIV LILLE   (France)

^c UNIVERSITY OF ANTWERP   (Belgium)

^d SERVICE DE SANTÉ DES ARMÉES   (France)

^e LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^f SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^g UNIVERSITY OF BASEL   (Switzerland)

^h GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

ⁱ UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOQUINOLINE DERIVATIVE; AMODIAQUINE; ANTIMALARIAL AGENT; ANTINEOPLASTIC AGENT; BETA HEMATIN; CHLOROQUINE; CYTOSINE; DEETHYLAMODIAQUINE; FERROQUINE; GUANINE; HEMATIN; HEME; IRON DERIVATIVE; MANNICH BASE; N [(7 CHLOROQUINOLIN 4 YL)ETHYL] N' (1 HEXAZIN 1 YL 3 PIPERIDIN 1 YLPROPYL)ETHANE 1,2 DIAMINE; N1 [2 (7 CHLOROQUINOLIN 4 YLAMINO)ETHYL] N3,N3 DIMETHYL 1 PHENYLPROPANE 1,3 DIAMINE; PROTEIN INHIBITOR; QUININE; SR 97193; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIMALARIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA DENATURATION; DRUG CYTOTOXICITY; DRUG DNA INTERACTION; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; GLIOBLASTOMA; HUMAN; HUMAN CELL; IC 50; MALARIA FALCIPARUM; MOUSE; NONHUMAN; PLASMODIUM BERGHEI; PLASMODIUM BERGHEI INFECTION; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

EID: 77951143202     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm9018383     Document Type: Article

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