A primaquine-chloroquine hybrid with dual activity against Plasmodium liver and blood stages

International Journal of Medical Microbiology

Volumn 303, Issue 8, 2013, Pages 539-547

  Lödige, Melanie ^a   Lewis, Matthew D ^b   Paulsen, Eleonora S ^a,c   Esch, Harald L ^a   Pradel, Gabriele ^a   Lehmann, Leane ^a   Brun, Reto ^d,e   Bringmann, Gerhard ^b   Mueller, Ann Kristin ^b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^e UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Chloroquine; Hybrid molecules; Multistage; Plasmodium; Primaquine

Indexed keywords

[N 1 (7 CHLOROQUINOLIN 4 YL) N 4 (6 METHOXYQUINOLIN 8 YL)PENTANE 1,4 DIAMINE]; ANTIMALARIAL AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; IC 50; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PARASITE VIABILITY; PLASMODIUM (LIFE CYCLE STAGE); PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; SPOROZOITE;

CHLOROQUINE; HYBRID MOLECULES; MULTISTAGE; PLASMODIUM; PRIMAQUINE;

ANIMALS; ANTIMALARIALS; BLOOD; CHIMERA; CHLOROQUINE; DISEASE MODELS, ANIMAL; FEMALE; LIVER; MALARIA; MALE; MICE; MICE, INBRED C57BL; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PRIMAQUINE;

EID: 84887614688     PISSN: 14384221     EISSN: 16180607     Source Type: Journal    
DOI: 10.1016/j.ijmm.2013.07.005     Document Type: Article

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