Incorporation of a 3-(2,2,2-Trifluoroethyl)-γ-hydroxy-γ-lactam motif in the side chain of 4-aminoquinolines. Syntheses and antimalarial activities

Journal of Medicinal Chemistry

Volumn 56, Issue 1, 2013, Pages 73-83

  Cornut, Damien ^a,b   Lemoine, Hugues ^a,b   Kanishchev, Oleksandr ^a   Okada, Etsuji ^c   Albrieux, Florian ^b   Beavogui, Abdoul Habib ^b,d   Bienvenu, Anne Lise ^b,d   Picot, Stéphane ^b,d   Bouillon, Jean Philippe ^a   Médebielle, Maurice ^b  

^a UNIVERSITÉ ET INSA DE ROUEN   (France)

^b UNIVERSITÉ LYON 1   (France)

^c KOBE UNIVERSITY   (Japan)

^d UNIVERSITÉ LYON 1   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 [(2 ((7 CHLOROQUINOLIN 4 YL)AMINO)ETHYL)AMINO]ETHYL] 5 HYDROXY 5 ((PHENYLSULFANYL)METHYL) 3 (2,2,2 TRIFLUOROETHYL) 1H PYRROL 2 (5H)ONE CITRATE; 1 [2 [(2 ((7 CHLOROQUINOLIN 4 YL)AMINO)ETHYL)METHYLAMINO]ETHYL] 3 (1 (ETHYLSULFANYL) 2,2,2 TRIFLUOROETHYL) 5 HYDROXY 5 METHYL 1H PYRROL 2(5H)ONE; 1 [2 [(2 ((7 CHLOROQUINOLIN 4 YL)AMINO)ETHYL)METHYLAMINO]ETHYL] 5 HYDROXY 5 ((PHENYLSULFANYL)METHYL) 3 (2,2,2 TRIFLUOROETHYL) 1H PYRROL 2 (5H)ONE; 1 [2 [(2 ((7 CHLOROQUINOLIN 4 YL)AMINO)ETHYL)PIPERAZIN 1 YL]ETHYL] 5 HYDROXY 5 ((PHENYSULFANYL)METHYL) 3 (2,2,2 TRIFLUOROETHYL) 1H PYRROL 2 (5H)ONE; 1 [3 [(7 CHLOROQUINOLIN 4 YL)AMINO]PROPYL] 3 (1 (ETHYLSULFANYL) 2,2,2 TRIFLUOROETHYL) 5 HYDROXY 5 METHYL 1H PYRROL 2 (5H)ONE; 1 [3 [(7 CHLOROQUINOLIN 4 YL)AMINO]PROPYL] 5 HYDROXY 5 [(PHENYLTHIO)METHYL] 3 (2,2,2 TRIFLUOROETHYL) 1H PYRROL 2 (5H)ONE; 3 (2,2,2 TRIFLUOROETHYL)GAMMA HYDROXY GAMMA LACTAM; 4 AMINOQUINOLINE; 5 (4 BROMOPHENYL) 1 [2 [(2 ((7 CHLOROQUINOLIN 4 YL)AMINO) ETHYL)METHYLAMINO]ETHYL] 3 (1 (ETHYLSULFANYL) 2,2,2 TRIFLUOROETHYL) 5 HYDROXY 1H PYRROL 2 (5H)ONE CITRATE; ANTIMALARIAL AGENT; LACTAM DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MALARIA; PLASMODIUM FALCIPARUM; UMBILICAL VEIN ENDOTHELIAL CELL;

AMINOQUINOLINES; ANTIMALARIALS; CHLOROQUINE; DRUG RESISTANCE; ENDOTHELIAL CELLS; HUMANS; LACTAMS; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP; UMBILICAL VEINS;

EID: 84872319598     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301076q     Document Type: Article

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