Antimalarial therapy prevents Myc-induced lymphoma

Journal of Clinical Investigation

Volumn 118, Issue 1, 2008, Pages 15-17

  Dang, Chi V ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE;

AUTOPHAGY; CARCINOGENESIS; CELL CYCLE PROGRESSION; CELL METABOLISM; CELL SURVIVAL; CHEMOPROPHYLAXIS; HUMAN; LYMPHOMA; METABOLIC STRESS; NONHUMAN; NOTE; ONCOGENE MYC; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ANIMALS; ANTIMALARIALS; APOPTOSIS; ATAXIA TELANGIECTASIA; AUTOPHAGY; B-LYMPHOCYTES; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; BURKITT LYMPHOMA; CASPASES; CELL CYCLE PROTEINS; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CHLOROQUINE; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA-BINDING PROTEINS; EMBRYO, MAMMALIAN; FEMALE; FIBROBLASTS; HUMANS; LYSOSOMES; MALE; MICE; MICE, MUTANT STRAINS; NEOPLASMS, EXPERIMENTAL; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-MYC; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 38149136611     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI34503     Document Type: Note

References (20)

1. van den Bosch, C.A. 2004. Is endemic Burkitt's lymphoma an alliance between three infections and a tumour promoter? Lancet Oncol. 5:738-746.
2. Geser, A., Brubaker, G., and Draper, C.C. 1989. Effect of a malaria suppression program on the incidence of African Burkitt's lymphoma. Am. J. Epidemiol. 129:740-752.
3. Dang, C.V., O'Donnell, K.A., Zeller, K.I., Nguyen, T., Osthus, R.C., and Li, F. 2006. The c-Myc target gene network. Semin. Cancer Biol. 16:253-264.
4. Maclean, K.H., Dorsey, F.C., Cleveland, J.L., and Kastan, M.B. 2008. Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. J. Clin. Invest. 118:79-88.
5. Amaravadi, R.K., et al. 2007. Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J. Clin. Invest. 117:326-336.
6. Lum, J.J., et al. 2005. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell. 120:237-248.
7. Brahimi-Horn, M.C., Chiche, J., and Pouyssegur, J. 2007. Hypoxia signalling controls metabolic demand. Curr. Opin. Cell Biol. 19:223-229.
8. Semenza, G.L. 2007. Hypoxia-inducible factor 1 (HIF-1) pathway. Sci. STKE. 2007:cm8.
9. Zeller, K.I., et al. 2006. Global mapping of c-Myc binding sites and target gene networks in human B cells. Proc. Natl. Acad. Sci. U. S. A. 103:17834-17839.
10. Cleveland, J.L., and Sherr, C.J. 2004. Antagonism of Myc functions by Arf. Cancer Cell. 6:309-311.
11. Rubinsztein, D.C., Gestwicki, J.E., Murphy, L.O., and Klionsky, D.J. 2007. Potential therapeutic applications of autophagy. Nat. Rev. Drug Discov. 6:304-312.
12. Maiuri, M.C., Zalckvar, E., Kimchi, A., and Kroemer, G. 2007. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat. Rev. Mol. Cell Biol. 8:741-752.
13. Jin, S., and White, E. 2007. Role of autophagy in cancer: management of metabolic stress. Autophagy. 3:28-31.
14. Tracy, K., et al. 2007. BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy. Mol. Cell. Biol. 27:6229-6242.
15. Scherz-Shouval, R., et al. 2007. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J. 26:1749-1760.
16. Scherz-Shouval, R., and Elazar, Z. 2007. ROS, mitochondria and the regulation of autophagy. Trends Cell Biol. 17:422-427.
17. Colell, A., et al. 2007. GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation. Cell. 129:983-997.
18. Reef, S., et al. 2006. A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death. Mol. Cell. 22:463-475.
19. Kamada, Y., et al. 2000. Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J. Cell Biol. 150:1507-1513.
20. Gao, P., et al. 2007. HIF-dependent antitumorigenic effect of antioxidants in vivo. Cancer Cell. 12:230-238.