A series of structurally simple chloroquine chemosensitizing dibemethin derivatives that inhibit chloroquine transport by PfCRT

European Journal of Medicinal Chemistry

Volumn 46, Issue 5, 2011, Pages 1729-1742

  Zishiri, Vincent K ^a   Hunter, Roger ^a   Smith, Peter J ^a   Taylor, Dale ^a   Summers, Robert ^b   Kirk, Kiaran ^b   Martin, Rowena E ^b,c   Egan, Timothy J ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Chemosensitizer; Chloroquine resistance; Dibemethin; Malaria; PfCRT; Resistance reverser

Indexed keywords

(4 CHLOROBENZYL)METHYLAMINE; (4 METHOXYBENZYL)METHYLAMINE; (4 N,N DIMETHYLAMINOBENZYL) METHYLAMINE; 2 (N BENZYL N METHYLAMINO)METHYLBENZALDEHYDE; 2 (N BENZYL N METHYLAMINO)METHYLBENZALDEHYDE OXIME; 2 [(N 4 CHLOROBENZYL N METHYL)AMINOMETHYL] BENZYLAMINE; 2 [(N 4 METHOXYBENZYL N METHYL)AMINOMETHYL] BENZYLAMINE; 2 [(N BENZYL N METHYL)AMINOMETHYL] BENZYLAMINE; 3 [(N 4 CHLOROBENZYL N METHYL)AMINOMETHYL] BENZYLAMINE; 3 [(N 4 METHOXYBENZYL N METHYL)AMINOMETHYL] BENZYLAMINE; 3 [(N BENZYL N METHYL)AMINOMETHYL] BENZYLAMINE; 4 [(N 4 CHLOROBENZYL N METHYL)AMINOMETHYL] BENZYLAMINE; 4 [(N 4 METHOXYBENZYL N METHYL)AMINOMETHYL] BENZYLAMINE; 4 [(N BENZYL N METHYL)AMINOMETHYL] BENZYLAMINE; AMINE; ANTIMALARIAL AGENT; CHLOROQUINE; CHLOROQUINE TRANSPORTER RESISTANCE; DIBEMETHIN; MEMBRANE PROTEIN; N [[2 (AZIDOMETHYL)PHENYL]METHYL] N (4 CHLOROBENZYL) METHYLAMINE; N [[2 (AZIDOMETHYL)PHENYL]METHYL] N (4 METHOXYBENZYL) METHYLAMINE; N [[3 (AZIDOMETHYL)PHENYL]METHYL] N (4 CHLOROBENZYL)METHYLAMINE; N [[3 (AZIDOMETHYL)PHENYL]METHYL] N (4 METHOXYBENZYL) METHYLAMINE; N [[3 (AZIDOMETHYL)PHENYL]METHYL] N BENZYLMETHYLAMINE; N [[4 (AZIDOMETHYL)PHENYL]ETHYL] N (4 CHLOROBENZYL) METHYLAMINE; N [[4 (AZIDOMETHYL)PHENYL]METHYL] N (4 METHOXYBENZYL) METHYLAMINE; N [[4 (AZIDOMETHYL)PHENYL]METHYL] N BENZYLMETHYLAMINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VERAPAMIL;

ARTICLE; CHEMOSENSITIZATION; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TRANSPORT; NONHUMAN; PLASMODIUM FALCIPARUM; XENOPUS LAEVIS;

ANIMALS; ANTIMALARIALS; CHLOROQUINE; DOSE-RESPONSE RELATIONSHIP, DRUG; MEMBRANE TRANSPORT PROTEINS; METHYLAMINES; MOLECULAR STRUCTURE; OOCYTES; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 79953199006     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.02.026     Document Type: Article

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