N-Cinnamoylated chloroquine analogues as dual-stage antimalarial leads

Journal of Medicinal Chemistry

Volumn 56, Issue 2, 2013, Pages 556-567

  Pérez, Bianca C ^a   Teixeira, Cátia ^a,b   Albuquerque, Ineîs S ^c   Gut, Jiri ^d   Rosenthal, Philip J ^d   Gomes, José R B ^b   Prudeîncio, Miguel ^c   Gomes, Paula ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF AVEIRO   (Portugal)

^c INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (N CINNAMOYLAMINOPROPYL)AMINO 7 CHLOROQUINOLINE; 4 [(7 CHLOROQUINOLIN 4 YL)AMINO]BUTAN 1 OL; 4 [N (3 FLUORO)CINNAMOYLAMINOPROPYL]AMINO 7 CHLOROQUINOLINE; 4 [N (3 NITRO)CINNAMOYLAMINOPROPYL]AMINO 7 CHLOROQUINOLINE; 4 [N (3,4 DIMETHOXY)CINNAMOYLAMINOPROPYL]AMINO 7 CHLOROQUINOLINE; 4 [N (4 [N TERT BUTOXYCARBONYL)AMINO]CINNAMOYLAMINOPROPYL]AMINO 7 CHLOROQUINOLINE; 4 [N (4 BROMO)CINNAMOYLAMINOPROPYL]AMINO 7 CHLOROQUINOLINE; 4 [N (4 CHLORO)CINNAMOYLAMINOPENTYL]AMINO 7 CHLOROQUINOLINE; 4 [N (4 CHLORO)CINNAMOYLAMINOPROPYL]AMINO 7 CHLOROQUINOLINE; 4 [N (4 DIMETHYLAMINO)CINNAMOYLAMINOBUTYL]AMINO 7 CHLOROQUINOLINE; 4 [N (4 FLUORO)CINNAMOYLAMINOPROPYL]AMINO 7 CHLOROQUINOLINE; 4 [N (4 ISOPROPYL)CINNAMOYLAMINOPENTYL]AMINO 7 CHLOROQUINOLINE; 4 [N (4 ISOPROPYL)CINNAMOYLAMINOPROPYL]AMINO 7 CHLOROQUINOLINE; 4 [N (4 ISOPROPYL)CINNAMOYLAMINOPROPYL]AMINOQUINOLINE; 4 [N (4 METHOXY)CINNAMOYLAMINOPENTYL]AMINO 7 CHLOROQUINOLINE; 4 [N (4 METHOXY)CINNAMOYLAMINOPROPYL]AMINO 7 CHLOROQUINOLINE; 4 [N (4 METHOXY)CINNAMOYLBUTYL]AMINOPYRIDINE; 4 [N (4 METHYL)CINNAMOYLAMINOPROPYL]AMINO 7 CHLOROQUINONE; 4 [N (4 NITRO)CINNAMOYLAMINOPROPYL]AMINO 7 CHLOROQUINOLINE; 4 [N(O NITRO)CINNAMOYLAMINOPROPYL]AMINO 7 CHLOROQUINOLINE; ARTEMISININ; CHLOROQUINE; N AMINOBUTYLMORPHOLINE; PRIMAQUINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ANTIMICROBIAL THERAPY; ARTICLE; CHEMICAL REACTION; CINNAMOYLATION; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PLASMODIUM BERGHEI INFECTION; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIMALARIALS; CHLOROQUINE; CINNAMATES; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84872811660     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301654b     Document Type: Article

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