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Volumn 125, Issue 1, 2015, Pages 75-84

Immunologic manifestations of autophagy

Author keywords

[No Author keywords available]

Indexed keywords

BECLIN 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERFERON;

EID: 84920463081     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI73945     Document Type: Review
Times cited : (119)

References (151)
  • 2
    • 84886797274 scopus 로고    scopus 로고
    • Autophagy in infection, inflammation and immunity
    • Deretic V, Saitoh T, Akira S. Autophagy in infection, inflammation and immunity. Nat Rev Immunol. 2013;13(10):722-737.
    • (2013) Nat Rev Immunol. , vol.13 , Issue.10 , pp. 722-737
    • Deretic, V.1    Saitoh, T.2    Akira, S.3
  • 3
    • 84882712453 scopus 로고    scopus 로고
    • Auto-phagy and cellular immune responses
    • Ma Y, Galluzzi L, Zitvogel L, Kroemer G. Auto-phagy and cellular immune responses. Immunity. 2013;39(2):211-227.
    • (2013) Immunity. , vol.39 , Issue.2 , pp. 211-227
    • Ma, Y.1    Galluzzi, L.2    Zitvogel, L.3    Kroemer, G.4
  • 4
    • 10944253145 scopus 로고    scopus 로고
    • Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages
    • Gutierrez MG, Master SS, Singh SB, Taylor GA, Colombo MI, Deretic V. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell. 2004;119(6):753-766.
    • (2004) Cell. , vol.119 , Issue.6 , pp. 753-766
    • Gutierrez, M.G.1    Master, S.S.2    Singh, S.B.3    Taylor, G.A.4    Colombo, M.I.5    Deretic, V.6
  • 5
    • 8344247016 scopus 로고    scopus 로고
    • Autophagy defends cells against invading group A Streptococcus
    • Nakagawa I, et al. Autophagy defends cells against invading group A Streptococcus. Science. 2004;306(5698):1037-1040.
    • (2004) Science. , vol.306 , Issue.5698 , pp. 1037-1040
    • Nakagawa, I.1
  • 6
    • 77956414236 scopus 로고    scopus 로고
    • The origin of the autophagosomal membrane
    • Tooze SA, Yoshimori T. The origin of the autophagosomal membrane. Nat Cell Biol. 2010;12(9):831-835.
    • (2010) Nat Cell Biol. , vol.12 , Issue.9 , pp. 831-835
    • Tooze, S.A.1    Yoshimori, T.2
  • 7
    • 84884220705 scopus 로고    scopus 로고
    • Diverse autophagosome membrane sources coalesce in recycling endosomes
    • Puri C, Renna M, Bento CF, Moreau K, Rubinsz-tein DC. Diverse autophagosome membrane sources coalesce in recycling endosomes. Cell. 2013;154(6):1285-1299.
    • (2013) Cell. , vol.154 , Issue.6 , pp. 1285-1299
    • Puri, C.1    Renna, M.2    Bento, C.F.3    Moreau, K.4    Rubinsz-Tein, D.C.5
  • 8
    • 84896542255 scopus 로고    scopus 로고
    • Neutral lipid stores and lipase PNPLA5 contribute to autophagosome biogenesis
    • Dupont N, et al. Neutral lipid stores and lipase PNPLA5 contribute to autophagosome biogenesis. Curr Biol. 2014;24(6):609-620.
    • (2014) Curr Biol. , vol.24 , Issue.6 , pp. 609-620
    • Dupont, N.1
  • 9
    • 84862301902 scopus 로고    scopus 로고
    • Amino acid starvation induced by invasive bacterial pathogens triggers an innate host defense program
    • Tattoli I, et al. Amino acid starvation induced by invasive bacterial pathogens triggers an innate host defense program. Cell Host Microbe. 2012;11(6):563-575.
    • (2012) Cell Host Microbe. , vol.11 , Issue.6 , pp. 563-575
    • Tattoli, I.1
  • 10
    • 79251587803 scopus 로고    scopus 로고
    • Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
    • Egan DF, et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science. 2011;331(6016):456-461.
    • (2011) Science. , vol.331 , Issue.6016 , pp. 456-461
    • Egan, D.F.1
  • 11
    • 79551598347 scopus 로고    scopus 로고
    • AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
    • Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol. 2011;13(2):132-141.
    • (2011) Nat Cell Biol. , vol.13 , Issue.2 , pp. 132-141
    • Kim, J.1    Kundu, M.2    Viollet, B.3    Guan, K.L.4
  • 12
    • 84880331368 scopus 로고    scopus 로고
    • ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
    • Russell RC, et al. ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat Cell Biol. 2013;15(7):741-750.
    • (2013) Nat Cell Biol. , vol.15 , Issue.7 , pp. 741-750
    • Russell, R.C.1
  • 13
    • 84872586081 scopus 로고    scopus 로고
    • Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy
    • Kim J, et al. Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell. 2013;152(1-2):290-303.
    • (2013) Cell. , vol.152 , Issue.1-2 , pp. 290-303
    • Kim, J.1
  • 14
    • 77953858790 scopus 로고    scopus 로고
    • TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy
    • Shi CS, Kehrl JH. TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy. Sci Signal. 2010;3(123):ra42.
    • (2010) Sci Signal. , vol.3 , Issue.123 , pp. ra42
    • Shi, C.S.1    Kehrl, J.H.2
  • 15
    • 84876488191 scopus 로고    scopus 로고
    • MTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6
    • Nazio F, et al. mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6. Nat Cell Biol. 2013;15(4):406-416.
    • (2013) Nat Cell Biol. , vol.15 , Issue.4 , pp. 406-416
    • Nazio, F.1
  • 16
    • 33947134377 scopus 로고    scopus 로고
    • Autophagy-dependent viral recognition by plasmacytoid dendritic cells
    • Lee HK, Lund JM, Ramanathan B, Mizushima N, Iwasaki A. Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science. 2007;315(5817):1398-1401.
    • (2007) Science. , vol.315 , Issue.5817 , pp. 1398-1401
    • Lee, H.K.1    Lund, J.M.2    Ramanathan, B.3    Mizushima, N.4    Iwasaki, A.5
  • 17
    • 82455210868 scopus 로고    scopus 로고
    • Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β
    • Dupont N, Jiang S, Pilli M, Ornatowski W, Bhat-tacharya D, Deretic V. Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β. EMBO J. 2011;30(23):4701-4711.
    • (2011) EMBO J. , vol.30 , Issue.23 , pp. 4701-4711
    • Dupont, N.1    Jiang, S.2    Pilli, M.3    Ornatowski, W.4    Bhat-Tacharya, D.5    Deretic, V.6
  • 18
    • 84902141285 scopus 로고    scopus 로고
    • Dectin-1 pathway activates robust autophagy-dependent unconventional protein secretion in human macrophages
    • Ohman T, et al. Dectin-1 pathway activates robust autophagy-dependent unconventional protein secretion in human macrophages. J Immunol. 2014;192(12):5952-5962.
    • (2014) J Immunol. , vol.192 , Issue.12 , pp. 5952-5962
    • Ohman, T.1
  • 19
    • 84870861513 scopus 로고    scopus 로고
    • Noncanonical autophagy is required for type i interferon secretion in response to DNA-immune complexes
    • Henault J, et al. Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes. Immunity. 2012;37(6):986-997.
    • (2012) Immunity. , vol.37 , Issue.6 , pp. 986-997
    • Henault, J.1
  • 20
    • 44649161194 scopus 로고    scopus 로고
    • The B cell receptor governs the subcellular location of Toll-like receptor 9 leading to hyperresponses to DNA-containing antigens
    • Chaturvedi A, Dorward D, Pierce SK. The B cell receptor governs the subcellular location of Toll-like receptor 9 leading to hyperresponses to DNA-containing antigens. Immunity. 2008;28(6):799-809.
    • (2008) Immunity. , vol.28 , Issue.6 , pp. 799-809
    • Chaturvedi, A.1    Dorward, D.2    Pierce, S.K.3
  • 21
    • 56249090667 scopus 로고    scopus 로고
    • Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
    • Saitoh T, et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production. Nature. 2008;456(7219):264-268.
    • (2008) Nature. , vol.456 , Issue.7219 , pp. 264-268
    • Saitoh, T.1
  • 22
    • 78651393239 scopus 로고    scopus 로고
    • A role for mitochondria in NLRP3 inflammasome activation
    • Zhou R, Yazdi AS, Menu P, Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature. 2011;469(7329):221-225.
    • (2011) Nature. , vol.469 , Issue.7329 , pp. 221-225
    • Zhou, R.1    Yazdi, A.S.2    Menu, P.3    Tschopp, J.4
  • 23
    • 79951642032 scopus 로고    scopus 로고
    • Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
    • Nakahira K, et al. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol. 2011;12(3):222-230.
    • (2011) Nat Immunol. , vol.12 , Issue.3 , pp. 222-230
    • Nakahira, K.1
  • 24
    • 84876685141 scopus 로고    scopus 로고
    • Receptor interacting protein kinase 2-mediated mitophagy regulates inflam-masome activation during virus infection
    • Lupfer C, et al. Receptor interacting protein kinase 2-mediated mitophagy regulates inflam-masome activation during virus infection. Nat Immunol. 2013;14(5):480-488.
    • (2013) Nat Immunol. , vol.14 , Issue.5 , pp. 480-488
    • Lupfer, C.1
  • 25
    • 84894481149 scopus 로고    scopus 로고
    • Defects in mitochon-drial clearance predispose human monocytes to interleukin-1β hypersecretion
    • van der Burgh R, et al. Defects in mitochon-drial clearance predispose human monocytes to interleukin-1β hypersecretion. J Biol Chem. 2014;289(8):5000-5012.
    • (2014) J Biol Chem. , vol.289 , Issue.8 , pp. 5000-5012
    • Van Der Burgh, R.1
  • 26
    • 84885077685 scopus 로고    scopus 로고
    • TLR-induced PAI-2 expression suppresses IL-1β processing via increasing autophagy and NLRP3 degradation
    • Chuang SY, Yang CH, Chou CC, Chiang YP, Chuang TH, Hsu LC. TLR-induced PAI-2 expression suppresses IL-1β processing via increasing autophagy and NLRP3 degradation. Proc Natl Acad Sci U S A. 2013;110(40):16079-16084.
    • (2013) Proc Natl Acad Sci U S A. , vol.110 , Issue.40 , pp. 16079-16084
    • Chuang, S.Y.1    Yang, C.H.2    Chou, C.C.3    Chiang, Y.P.4    Chuang, T.H.5    Hsu, L.C.6
  • 27
    • 84857195479 scopus 로고    scopus 로고
    • Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction
    • Shi CS, et al. Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction. Nat Immunol. 2012;13(3):255-263.
    • (2012) Nat Immunol. , vol.13 , Issue.3 , pp. 255-263
    • Shi, C.S.1
  • 28
    • 79953176280 scopus 로고    scopus 로고
    • Autophagy controls IL-1β secretion by targeting pro-IL-1β for degradation
    • Harris J, et al. Autophagy controls IL-1β secretion by targeting pro-IL-1β for degradation. J Biol Chem. 2011;286(11):9587-9597.
    • (2011) J Biol Chem. , vol.286 , Issue.11 , pp. 9587-9597
    • Harris, J.1
  • 29
    • 84865357562 scopus 로고    scopus 로고
    • TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autopha-gosome maturation
    • Pilli M, et al. TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autopha-gosome maturation. Immunity. 2012;37(2):223-234.
    • (2012) Immunity. , vol.37 , Issue.2 , pp. 223-234
    • Pilli, M.1
  • 30
    • 84893947749 scopus 로고    scopus 로고
    • Caspase-1 cleavage of the TLR adaptor TRIF inhibits autophagy and β-interferon production during Pseudomonas aeruginosa infection
    • Jabir MS, et al. Caspase-1 cleavage of the TLR adaptor TRIF inhibits autophagy and β-interferon production during Pseudomonas aeruginosa infection. Cell Host Microbe. 2014;15(2):214-227.
    • (2014) Cell Host Microbe. , vol.15 , Issue.2 , pp. 214-227
    • Jabir, M.S.1
  • 31
    • 84896691062 scopus 로고    scopus 로고
    • NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion
    • Wlodarska M, et al. NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. Cell. 2014;156(5):1045-1059.
    • (2014) Cell. , vol.156 , Issue.5 , pp. 1045-1059
    • Wlodarska, M.1
  • 32
    • 56249135538 scopus 로고    scopus 로고
    • A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
    • Cadwell K, et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature. 2008;456(7219):259-263.
    • (2008) Nature. , vol.456 , Issue.7219 , pp. 259-263
    • Cadwell, K.1
  • 33
    • 35348921764 scopus 로고    scopus 로고
    • The Atg5 Atg12 conjugate associates with innate antiviral immune responses
    • Jounai N, et al. The Atg5 Atg12 conjugate associates with innate antiviral immune responses. Proc Natl Acad Sci U S A. 2007;104(35):14050-14055.
    • (2007) Proc Natl Acad Sci U S A. , vol.104 , Issue.35 , pp. 14050-14055
    • Jounai, N.1
  • 34
    • 73949083594 scopus 로고    scopus 로고
    • Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
    • Saitoh T, et al. Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. Proc Natl Acad Sci U S A. 2009;106(49):20842-20846.
    • (2009) Proc Natl Acad Sci U S A. , vol.106 , Issue.49 , pp. 20842-20846
    • Saitoh, T.1
  • 35
    • 84879385334 scopus 로고    scopus 로고
    • CGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
    • Ablasser A, et al. cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING. Nature. 2013;498(7454):380-384.
    • (2013) Nature. , vol.498 , Issue.7454 , pp. 380-384
    • Ablasser, A.1
  • 36
    • 84879408976 scopus 로고    scopus 로고
    • Structural mechanism of cytosolic DNA sensing by cGAS
    • Civril F, et al. Structural mechanism of cytosolic DNA sensing by cGAS. Nature. 2013;498(7454):332-337.
    • (2013) Nature. , vol.498 , Issue.7454 , pp. 332-337
    • Civril, F.1
  • 37
    • 84873711885 scopus 로고    scopus 로고
    • Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type i interferon pathway
    • Sun L, Wu J, Du F, Chen X, Chen ZJ. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science. 2013;339(6121):786-791.
    • (2013) Science. , vol.339 , Issue.6121 , pp. 786-791
    • Sun, L.1    Wu, J.2    Du, F.3    Chen, X.4    Chen, Z.J.5
  • 38
    • 77954070545 scopus 로고    scopus 로고
    • C-di-AMP secreted by intracellular Listeria monocyto-genes activates a host type i interferon response
    • Woodward JJ, Iavarone AT, Portnoy DA. c-di-AMP secreted by intracellular Listeria monocyto-genes activates a host type I interferon response. Science. 2010;328(5986):1703-1705.
    • (2010) Science. , vol.328 , Issue.5986 , pp. 1703-1705
    • Woodward, J.J.1    Iavarone, A.T.2    Portnoy, D.A.3
  • 39
    • 80054966913 scopus 로고    scopus 로고
    • STING is a direct innate immune sensor of cyclic di-GMP
    • Burdette DL, et al. STING is a direct innate immune sensor of cyclic di-GMP. Nature. 2011;478(7370):515-518.
    • (2011) Nature. , vol.478 , Issue.7370 , pp. 515-518
    • Burdette, D.L.1
  • 40
    • 84886789626 scopus 로고    scopus 로고
    • Cyclic dinucle-otides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling
    • Konno H, Konno K, Barber GN. Cyclic dinucle-otides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling. Cell. 2013;155(3):688-698.
    • (2013) Cell. , vol.155 , Issue.3 , pp. 688-698
    • Konno, H.1    Konno, K.2    Barber, G.N.3
  • 41
    • 84893912159 scopus 로고    scopus 로고
    • Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses
    • Liang Q, et al. Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses. Cell Host Microbe. 2014;15(2):228-238.
    • (2014) Cell Host Microbe. , vol.15 , Issue.2 , pp. 228-238
    • Liang, Q.1
  • 42
    • 62449110463 scopus 로고    scopus 로고
    • Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling
    • Tal MC, Sasai M, Lee HK, Yordy B, Shadel GS, Iwasaki A. Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling. Proc Natl Acad Sci U S A. 2009;106(8):2770-2775.
    • (2009) Proc Natl Acad Sci U S A. , vol.106 , Issue.8 , pp. 2770-2775
    • Tal, M.C.1    Sasai, M.2    Lee, H.K.3    Yordy, B.4    Shadel, G.S.5    Iwasaki, A.6
  • 43
    • 84863354715 scopus 로고    scopus 로고
    • The autophagy regulator Rubicon is a feedback inhibitor of CARD9-medi-ated host innate immunity
    • Yang CS, et al. The autophagy regulator Rubicon is a feedback inhibitor of CARD9-medi-ated host innate immunity. Cell Host Microbe. 2012;11(3):277-289.
    • (2012) Cell Host Microbe. , vol.11 , Issue.3 , pp. 277-289
    • Yang, C.S.1
  • 44
    • 84862976890 scopus 로고    scopus 로고
    • Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB
    • Paul S, Kashyap AK, Jia W, He YW, Schaefer BC. Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB. Immunity. 2012;36(6):947-958.
    • (2012) Immunity. , vol.36 , Issue.6 , pp. 947-958
    • Paul, S.1    Kashyap, A.K.2    Jia, W.3    He, Y.W.4    Schaefer, B.C.5
  • 45
    • 84860901212 scopus 로고    scopus 로고
    • Viral mediated redirection of NEMO/IKKgamma to autophagosomes curtails the inflammatory cascade
    • Fliss PM, et al. Viral mediated redirection of NEMO/IKKgamma to autophagosomes curtails the inflammatory cascade. PLoS Pathog. 2012;8(2):e1002517.
    • (2012) PLoS Pathog. , vol.8 , Issue.2 , pp. e1002517
    • Fliss, P.M.1
  • 46
    • 77953496542 scopus 로고    scopus 로고
    • NDP52, a novel autophagy receptor for ubiquitin-decorated cytosolic bacteria
    • von Muhlinen N, Thurston T, Ryzhakov G, Bloor S, Randow F. NDP52, a novel autophagy receptor for ubiquitin-decorated cytosolic bacteria. Autophagy. 2010;6(2):288-289.
    • (2010) Autophagy. , vol.6 , Issue.2 , pp. 288-289
    • Von Muhlinen, N.1    Thurston, T.2    Ryzhakov, G.3    Bloor, S.4    Randow, F.5
  • 47
    • 84857657829 scopus 로고    scopus 로고
    • Regulation of Toll-like receptor signaling by NDP52-medi-ated selective autophagy is normally inactivated by A20
    • Inomata M, Niida S, Shibata K, Into T. Regulation of Toll-like receptor signaling by NDP52-medi-ated selective autophagy is normally inactivated by A20. Cell Mol Life Sci. 2012;69(6):963-979.
    • (2012) Cell Mol Life Sci. , vol.69 , Issue.6 , pp. 963-979
    • Inomata, M.1    Niida, S.2    Shibata, K.3    Into, T.4
  • 48
    • 84880617946 scopus 로고    scopus 로고
    • Association between variants of PRDM1 and NDP52 and Crohn's disease, based on exome sequencing and functional studies
    • Ellinghaus D, et al. Association between variants of PRDM1 and NDP52 and Crohn's disease, based on exome sequencing and functional studies. Gastroen terology. 2013;145(2):339-347.
    • (2013) Gastroen Terology. , vol.145 , Issue.2 , pp. 339-347
    • Ellinghaus, D.1
  • 49
    • 84878225041 scopus 로고    scopus 로고
    • Regulatory coordination between two major intracellular homeostatic systems: Heat shock response and autophagy
    • Dokladny K, et al. Regulatory coordination between two major intracellular homeostatic systems: heat shock response and autophagy. J Biol Chem. 2013;288(21):14959-14972.
    • (2013) J Biol Chem. , vol.288 , Issue.21 , pp. 14959-14972
    • Dokladny, K.1
  • 50
    • 33748506089 scopus 로고    scopus 로고
    • Human IRGM induces autophagy to eliminate intracellular mycobacteria
    • Singh SB, Davis AS, Taylor GA, Deretic V. Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science. 2006;313(5792):1438-1441.
    • (2006) Science. , vol.313 , Issue.5792 , pp. 1438-1441
    • Singh, S.B.1    Davis, A.S.2    Taylor, G.A.3    Deretic, V.4
  • 51
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14, 000 cases of seven common diseases and 3, 000 shared controls
    • Wellcome Trust Case Control Consortium. Genome-wide association study of 14, 000 cases of seven common diseases and 3, 000 shared controls. Nature. 2007;447(7145):661-678.
    • (2007) Nature. , vol.447 , Issue.7145 , pp. 661-678
  • 52
    • 77950405093 scopus 로고    scopus 로고
    • Genome-wide association study of CNVs in 16, 000 cases of eight common diseases and 3, 000 shared controls
    • Craddock N, et al. Genome-wide association study of CNVs in 16, 000 cases of eight common diseases and 3, 000 shared controls. Nature. 2010;464(7289):713-720.
    • (2010) Nature. , vol.464 , Issue.7289 , pp. 713-720
    • Craddock, N.1
  • 53
    • 84868336049 scopus 로고    scopus 로고
    • Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
    • Jostins L, et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature. 2012;491(7422):119-124.
    • (2012) Nature. , vol.491 , Issue.7422 , pp. 119-124
    • Jostins, L.1
  • 54
    • 84855257058 scopus 로고    scopus 로고
    • A comprehensive analysis of shared loci between systemic lupus erythema-tosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap
    • Ramos PS, et al. A comprehensive analysis of shared loci between systemic lupus erythema-tosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap. PLoS Genet. 2011;7(12):e1002406.
    • (2011) PLoS Genet. , vol.7 , Issue.12 , pp. e1002406
    • Ramos, P.S.1
  • 55
    • 79955790354 scopus 로고    scopus 로고
    • Genetic variation in the autophagy gene ULK1 and risk of Crohn's disease
    • Henckaerts L, et al. Genetic variation in the autophagy gene ULK1 and risk of Crohn's disease. Inflamm Bowel Dis. 2011;17(6):1392-1397.
    • (2011) Inflamm Bowel Dis. , vol.17 , Issue.6 , pp. 1392-1397
    • Henckaerts, L.1
  • 56
    • 84855959618 scopus 로고    scopus 로고
    • Genetic variants in autophagy-re-lated genes and granuloma formation in a cohort of surgically treated Crohn's disease patients
    • Brinar M, et al. Genetic variants in autophagy-re-lated genes and granuloma formation in a cohort of surgically treated Crohn's disease patients. J Crohns Colitis. 2012;6(1):43-50.
    • (2012) J Crohns Colitis. , vol.6 , Issue.1 , pp. 43-50
    • Brinar, M.1
  • 57
    • 38649125210 scopus 로고    scopus 로고
    • Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
    • Harley JB, et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet. 2008;40(2):204-210.
    • (2008) Nat Genet. , vol.40 , Issue.2 , pp. 204-210
    • Harley, J.B.1
  • 58
    • 70350629871 scopus 로고    scopus 로고
    • Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythemato-sus
    • Han JW, et al. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythemato-sus. Nat Genet. 2009;41(11):1234-1237.
    • (2009) Nat Genet. , vol.41 , Issue.11 , pp. 1234-1237
    • Han, J.W.1
  • 59
    • 84872328824 scopus 로고    scopus 로고
    • Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians
    • Yang W, et al. Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Am J Hum Genet. 2013;92(1):41-51.
    • (2013) Am J Hum Genet. , vol.92 , Issue.1 , pp. 41-51
    • Yang, W.1
  • 60
    • 84859951546 scopus 로고    scopus 로고
    • Functional variant in the autoph-agy-related 5 gene promotor is associated with childhood asthma
    • Martin LJ, et al. Functional variant in the autoph-agy-related 5 gene promotor is associated with childhood asthma. PLoS O ne. 2012;7(4):e33454.
    • (2012) PLoS O Ne. , vol.7 , Issue.4 , pp. e33454
    • Martin, L.J.1
  • 61
    • 70649086092 scopus 로고    scopus 로고
    • Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk
    • Raychaudhuri S, et al. Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. Nat Genet. 2009;41(12):1313-1318.
    • (2009) Nat Genet. , vol.41 , Issue.12 , pp. 1313-1318
    • Raychaudhuri, S.1
  • 62
    • 84871952426 scopus 로고    scopus 로고
    • Recessive mutations in EPG5 cause Vici syndrome, a multisystem disorder with defective autophagy
    • Cullup T, et al. Recessive mutations in EPG5 cause Vici syndrome, a multisystem disorder with defective autophagy. Nat Genet. 2013;45(1):83-87.
    • (2013) Nat Genet. , vol.45 , Issue.1 , pp. 83-87
    • Cullup, T.1
  • 63
    • 84874192375 scopus 로고    scopus 로고
    • FOXO3A directs a protective autophagy program in haematopoietic stem cells
    • Warr MR, et al. FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature. 2013;494(7437):323-327.
    • (2013) Nature. , vol.494 , Issue.7437 , pp. 323-327
    • Warr, M.R.1
  • 64
    • 79952728102 scopus 로고    scopus 로고
    • The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance
    • Mortensen M, et al. The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance. J Exp Med. 2011;208(3):455-467.
    • (2011) J Exp Med. , vol.208 , Issue.3 , pp. 455-467
    • Mortensen, M.1
  • 65
    • 76949091325 scopus 로고    scopus 로고
    • In vivo requirement for Atg5 in antigen presentation by dendritic cells
    • Lee HK, et al. In vivo requirement for Atg5 in antigen presentation by dendritic cells. Immunity. 2010;32(2):227-239.
    • (2010) Immunity. , vol.32 , Issue.2 , pp. 227-239
    • Lee, H.K.1
  • 66
    • 52149099867 scopus 로고    scopus 로고
    • Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance
    • Nedjic J, Aichinger M, Emmerich J, Mizushima N, Klein L. Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance. Nature. 2008;455(7211):396-400.
    • (2008) Nature. , vol.455 , Issue.7211 , pp. 396-400
    • Nedjic, J.1    Aichinger, M.2    Emmerich, J.3    Mizushima, N.4    Klein, L.5
  • 67
    • 81455154986 scopus 로고    scopus 로고
    • The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Rα surface expression
    • McLeod IX, Zhou X, Li QJ, Wang F, He YW. The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Rα surface expression. J Immunol. 2011;187(10):5051-5061.
    • (2011) J Immunol. , vol.187 , Issue.10 , pp. 5051-5061
    • McLeod, I.X.1    Zhou, X.2    Li, Q.J.3    Wang, F.4    He, Y.W.5
  • 68
    • 64249123646 scopus 로고    scopus 로고
    • Autoph-agy is essential for mitochondrial clearance in mature T lymphocytes
    • Pua HH, Guo J, Komatsu M, He YW. Autoph-agy is essential for mitochondrial clearance in mature T lymphocytes. J Immunol. 2009;182(7):4046-4055.
    • (2009) J Immunol. , vol.182 , Issue.7 , pp. 4046-4055
    • Pua, H.H.1    Guo, J.2    Komatsu, M.3    He, Y.W.4
  • 69
    • 79251534395 scopus 로고    scopus 로고
    • Autophagy regu-lates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes
    • Jia W, Pua HH, Li QJ, He YW. Autophagy regu-lates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes. J Immunol. 2011;186(3):1564-1574.
    • (2011) J Immunol. , vol.186 , Issue.3 , pp. 1564-1574
    • Jia, W.1    Pua, H.H.2    Li, Q.J.3    He, Y.W.4
  • 70
    • 84872308031 scopus 로고    scopus 로고
    • A role for c-FLIP(L) in the regulation of apoptosis, autophagy, and necroptosis in T lymphocytes
    • He MX, He YW. A role for c-FLIP(L) in the regulation of apoptosis, autophagy, and necroptosis in T lymphocytes. Cell Death Differ. 2013;20(2):188-197.
    • (2013) Cell Death Differ. , vol.20 , Issue.2 , pp. 188-197
    • He, M.X.1    He, Y.W.2
  • 72
    • 84869217908 scopus 로고    scopus 로고
    • Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation
    • Castillo EF, et al. Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation. Proc Natl Acad Sci U S A. 2012;109(46):E3168-E3176.
    • (2012) Proc Natl Acad Sci U S A. , vol.109 , Issue.46 , pp. E3168-E3176
    • Castillo, E.F.1
  • 73
    • 84861615385 scopus 로고    scopus 로고
    • Autophagy attenuates the adaptive immune response by destabilizing the immunologic synapse
    • Wildenberg ME, et al. Autophagy attenuates the adaptive immune response by destabilizing the immunologic synapse. Gastroenterology. 2012;142(7):1493-1503.
    • (2012) Gastroenterology. , vol.142 , Issue.7 , pp. 1493-1503
    • Wildenberg, M.E.1
  • 74
    • 84902954600 scopus 로고    scopus 로고
    • Essential role for autophagy in the maintenance of immunological memory against influenza infection
    • Chen M, et al. Essential role for autophagy in the maintenance of immunological memory against influenza infection. Nat Med. 2014;20(5):503-510.
    • (2014) Nat Med. , vol.20 , Issue.5 , pp. 503-510
    • Chen, M.1
  • 75
    • 84874097064 scopus 로고    scopus 로고
    • Plasma cells require autophagy for sustainable immunoglobulin production
    • Pengo N, et al. Plasma cells require autophagy for sustainable immunoglobulin production. Nat Immunol. 2013;14(3):298-305.
    • (2013) Nat Immunol. , vol.14 , Issue.3 , pp. 298-305
    • Pengo, N.1
  • 76
    • 33846224369 scopus 로고    scopus 로고
    • Antigen-loading compartments for major histocompatibil-ity complex class II molecules continuously receive input from autophagosomes
    • Schmid D, Pypaert M, Munz C. Antigen-loading compartments for major histocompatibil-ity complex class II molecules continuously receive input from autophagosomes. Immunity. 2007;26(1):79-92.
    • (2007) Immunity. , vol.26 , Issue.1 , pp. 79-92
    • Schmid, D.1    Pypaert, M.2    Munz, C.3
  • 77
    • 77953272740 scopus 로고    scopus 로고
    • Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses
    • Blanchet FP, et al. Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses. Immunity. 2010;32(5):654-669.
    • (2010) Immunity. , vol.32 , Issue.5 , pp. 654-669
    • Blanchet, F.P.1
  • 78
    • 84899786639 scopus 로고    scopus 로고
    • Regulation of SIV antigen-specific CD4+ T cellular immunity via autopha-gosome-mediated MHC II molecule-targeting antigen presentation in mice
    • Jin Y, et al. Regulation of SIV antigen-specific CD4+ T cellular immunity via autopha-gosome-mediated MHC II molecule-targeting antigen presentation in mice. PLoS One. 2014;9(3):e93143.
    • (2014) PLoS One. , vol.9 , Issue.3 , pp. e93143
    • Jin, Y.1
  • 79
    • 12844275079 scopus 로고    scopus 로고
    • Endogenous MHC class II processing of a viral nuclear antigen after autophagy
    • Paludan C, et al. Endogenous MHC class II processing of a viral nuclear antigen after autophagy. Science. 2005;307(5709):593-596.
    • (2005) Science. , vol.307 , Issue.5709 , pp. 593-596
    • Paludan, C.1
  • 80
    • 62049084947 scopus 로고    scopus 로고
    • Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells
    • Jagannath C, Lindsey DR, Dhandayuthapani S, Xu Y, Hunter RL Jr, Eissa NT. Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells. Nat Med. 2009;15(3):267-276.
    • (2009) Nat Med. , vol.15 , Issue.3 , pp. 267-276
    • Jagannath, C.1    Lindsey, D.R.2    Dhandayuthapani, S.3    Xu, Y.4    Hunter, Jr.R.L.5    Eissa, N.T.6
  • 81
    • 84890828734 scopus 로고    scopus 로고
    • Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing
    • Romao S, et al. Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing. J Cell Biol. 2013;203(5):757-766.
    • (2013) J Cell Biol. , vol.203 , Issue.5 , pp. 757-766
    • Romao, S.1
  • 82
    • 84892598603 scopus 로고    scopus 로고
    • Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation
    • Ravindran R, et al. Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation. Science. 2014;343(6168):313-317.
    • (2014) Science. , vol.343 , Issue.6168 , pp. 313-317
    • Ravindran, R.1
  • 83
    • 73849151394 scopus 로고    scopus 로고
    • NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation
    • Cooney R, et al. NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat Med. 2010;16(1):90-97.
    • (2010) Nat Med. , vol.16 , Issue.1 , pp. 90-97
    • Cooney, R.1
  • 84
    • 84874565064 scopus 로고    scopus 로고
    • Macroau-tophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance
    • Aichinger M, Wu C, Nedjic J, Klein L. Macroau-tophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance. J Exp Med. 2013;210(2):287-300.
    • (2013) J Exp Med. , vol.210 , Issue.2 , pp. 287-300
    • Aichinger, M.1    Wu, C.2    Nedjic, J.3    Klein, L.4
  • 85
    • 84855516226 scopus 로고    scopus 로고
    • Autophagy in antigen-presenting cells results in presentation of cit-rullinated peptides to CD4 T cells
    • Ireland JM, Unanue ER. Autophagy in antigen-presenting cells results in presentation of cit-rullinated peptides to CD4 T cells. J Exp Med. 2011;208(13):2625-2632.
    • (2011) J Exp Med. , vol.208 , Issue.13 , pp. 2625-2632
    • Ireland, J.M.1    Unanue, E.R.2
  • 86
    • 84874920602 scopus 로고    scopus 로고
    • Amphisomal route of MHC class i cross-presentation in bacteria-infected dendritic cells
    • Fiegl D, et al. Amphisomal route of MHC class I cross-presentation in bacteria-infected dendritic cells. J Immunol. 2013;190(6):2791-2806.
    • (2013) J Immunol. , vol.190 , Issue.6 , pp. 2791-2806
    • Fiegl, D.1
  • 87
    • 33947715151 scopus 로고    scopus 로고
    • HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein
    • Orvedahl A, et al. HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein. Cell Host and Microbe. 2007;1(1):23-35.
    • (2007) Cell Host and Microbe. , vol.1 , Issue.1 , pp. 23-35
    • Orvedahl, A.1
  • 88
    • 67649585835 scopus 로고    scopus 로고
    • Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages
    • Kyei GB, et al. Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages. J Cell Biol. 2009;186(2):255-268.
    • (2009) J Cell Biol. , vol.186 , Issue.2 , pp. 255-268
    • Kyei, G.B.1
  • 89
    • 72649105081 scopus 로고    scopus 로고
    • Matrix protein 2 of influenza A virus blocks autophagosome fusion with lys-osomes
    • Gannage M, et al. Matrix protein 2 of influenza A virus blocks autophagosome fusion with lys-osomes. Cell Host Microbe. 2009;6(4):367-380.
    • (2009) Cell Host Microbe. , vol.6 , Issue.4 , pp. 367-380
    • Gannage, M.1
  • 90
    • 84893969715 scopus 로고    scopus 로고
    • A LC3-interacting motif in the influenza A virus M2 protein is required to subvert autophagy and maintain virion stability
    • Beale R, Wise H, Stuart A, Ravenhill BJ, Digard P, Randow F. A LC3-interacting motif in the influenza A virus M2 protein is required to subvert autophagy and maintain virion stability. Cell Host Microbe. 2014;15(2):239-247.
    • (2014) Cell Host Microbe. , vol.15 , Issue.2 , pp. 239-247
    • Beale, R.1    Wise, H.2    Stuart, A.3    Ravenhill, B.J.4    Digard, P.5    Randow, F.6
  • 91
    • 84897440003 scopus 로고    scopus 로고
    • Host cell autophagy promotes BK virus infection
    • Bouley SJ, et al. Host cell autophagy promotes BK virus infection. Virology. 2014;456-457:87-95.
    • (2014) Virology. , vol.456-457 , pp. 87-95
    • Bouley, S.J.1
  • 92
    • 84901034931 scopus 로고    scopus 로고
    • Phosphoprotein of human parainfluenza virus type 3 blocks autophagosome-lysosome fusion to increase virus production
    • Ding B, et al. Phosphoprotein of human parainfluenza virus type 3 blocks autophagosome-lysosome fusion to increase virus production. Cell Host Microbe. 2014;15(5):564-577.
    • (2014) Cell Host Microbe. , vol.15 , Issue.5 , pp. 564-577
    • Ding, B.1
  • 94
    • 84892476191 scopus 로고    scopus 로고
    • Antiviral autophagy restricts Rift Valley fever virus infection and is conserved from flies to mammals
    • Moy RH, et al. Antiviral autophagy restricts Rift Valley fever virus infection and is conserved from flies to mammals. Immunity. 2014;40(1):51-65.
    • (2014) Immunity. , vol.40 , Issue.1 , pp. 51-65
    • Moy, R.H.1
  • 95
    • 84891666174 scopus 로고    scopus 로고
    • Autophagy and the effects of its inhibition on varicella-zoster virus glycoprotein biosynthesis and infectivity
    • Buckingham EM, Carpenter JE, Jackson W, Grose C. Autophagy and the effects of its inhibition on varicella-zoster virus glycoprotein biosynthesis and infectivity. J Virol. 2014;88(2):890-902.
    • (2014) J Virol. , vol.88 , Issue.2 , pp. 890-902
    • Buckingham, E.M.1    Carpenter, J.E.2    Jackson, W.3    Grose, C.4
  • 96
    • 84873080242 scopus 로고    scopus 로고
    • Human papil-lomavirus infection is inhibited by host autoph-agy in primary human keratinocytes
    • Griffin LM, Cicchini L, Pyeon D. Human papil-lomavirus infection is inhibited by host autoph-agy in primary human keratinocytes. Virology. 2013;437(1):12-19.
    • (2013) Virology. , vol.437 , Issue.1 , pp. 12-19
    • Griffin, L.M.1    Cicchini, L.2    Pyeon, D.3
  • 97
    • 78751672975 scopus 로고    scopus 로고
    • Autoph-agy in immunity and inflammation
    • Levine B, Mizushima N, Virgin HW. Autoph-agy in immunity and inflammation. Nature. 2011;469(7330):323-335.
    • (2011) Nature. , vol.469 , Issue.7330 , pp. 323-335
    • Levine, B.1    Mizushima, N.2    Virgin, H.W.3
  • 98
    • 37549043217 scopus 로고    scopus 로고
    • Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis
    • Sanjuan MA, et al. Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis. Nature. 2007;450(7173):1253-1257.
    • (2007) Nature. , vol.450 , Issue.7173 , pp. 1253-1257
    • Sanjuan, M.A.1
  • 101
    • 77949997805 scopus 로고    scopus 로고
    • Delivery of cytosolic compo nents by autophagic adaptor protein p62 endows autophagosomes with unique antimicrobial prop erties
    • Ponpuak M, et al. Delivery of cytosolic compo nents by autophagic adaptor protein p62 endows autophagosomes with unique antimicrobial prop erties. Immunity. 2010;32(3):329-341.
    • (2010) Immunity. , vol.32 , Issue.3 , pp. 329-341
    • Ponpuak, M.1
  • 102
    • 80054046948 scopus 로고    scopus 로고
    • Vitamin D is required for IFN-γ-mediated antimicrobial activity of human macrophages
    • Fabri M, et al. Vitamin D is required for IFN-γ-mediated antimicrobial activity of human macrophages. Sci Transl Med. 2011;3(104):104ra2.
    • (2011) Sci Transl Med. , vol.3 , Issue.104 , pp. 104ra2
    • Fabri, M.1
  • 103
    • 69949184887 scopus 로고    scopus 로고
    • Vitamin D3 induces autophagy in human monocytes/macrophages via catheli-cidin
    • Yuk JM, et al. Vitamin D3 induces autophagy in human monocytes/macrophages via catheli-cidin. Cell Host Microbe. 2009;6(3):231-243.
    • (2009) Cell Host Microbe. , vol.6 , Issue.3 , pp. 231-243
    • Yuk, J.M.1
  • 104
    • 73849121209 scopus 로고    scopus 로고
    • Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
    • Travassos LH, et al. Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol. 2010;11(1):55-62.
    • (2010) Nat Immunol. , vol.11 , Issue.1 , pp. 55-62
    • Travassos, L.H.1
  • 105
    • 79251588741 scopus 로고    scopus 로고
    • NLRP4 negatively regulates autophagic processes through an association with beclin1
    • Jounai N, Kobiyama K, Shiina M, Ogata K, Ishii KJ, Takeshita F. NLRP4 negatively regulates autophagic processes through an association with beclin1. J Immunol. 2011;186(3):1646-1655.
    • (2011) J Immunol. , vol.186 , Issue.3 , pp. 1646-1655
    • Jounai, N.1    Kobiyama, K.2    Shiina, M.3    Ogata, K.4    Ishii, K.J.5    Takeshita, F.6
  • 106
    • 27944504351 scopus 로고    scopus 로고
    • P62/SQSTM1 forms protein aggregates degraded by autophagy and has a pro-tective effect on huntingtin-induced cell death
    • Bjorkoy G, et al. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a pro-tective effect on huntingtin-induced cell death. J Cell Biol. 2005;171(4):603-614.
    • (2005) J Cell Biol. , vol.171 , Issue.4 , pp. 603-614
    • Bjorkoy, G.1
  • 107
    • 60849099049 scopus 로고    scopus 로고
    • A role for NBR1 in autophagosomal degradation of ubiquitinated substrates
    • Kirkin V, et al. A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol Cell. 2009;33(4):505-516.
    • (2009) Mol Cell. , vol.33 , Issue.4 , pp. 505-516
    • Kirkin, V.1
  • 108
    • 70350450808 scopus 로고    scopus 로고
    • The TBK1 adaptor and autoph-agy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria
    • Thurston TL, Ryzhakov G, Bloor S, von Muhlinen N, Randow F. The TBK1 adaptor and autoph-agy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria. Nat Immunol. 2009;10(11):1215-1221.
    • (2009) Nat Immunol. , vol.10 , Issue.11 , pp. 1215-1221
    • Thurston, T.L.1    Ryzhakov, G.2    Bloor, S.3    Von Muhlinen, N.4    Randow, F.5
  • 109
    • 84870527124 scopus 로고    scopus 로고
    • TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-κB sig nalling
    • Newman AC, et al. TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-κB sig nalling. PLoS One. 2012;7(11):e50672.
    • (2012) PLoS One. , vol.7 , Issue.11 , pp. e50672
    • Newman, A.C.1
  • 110
    • 79960804104 scopus 로고    scopus 로고
    • Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth
    • Wild P, et al. Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. Science. 2011;333(6039):228-233.
    • (2011) Science. , vol.333 , Issue.6039 , pp. 228-233
    • Wild, P.1
  • 111
    • 68349143052 scopus 로고    scopus 로고
    • Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autoph-agy
    • Dupont N, et al. Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autoph-agy. Cell Host Microbe. 2009;6(2):137-149.
    • (2009) Cell Host Microbe. , vol.6 , Issue.2 , pp. 137-149
    • Dupont, N.1
  • 112
    • 84857071710 scopus 로고    scopus 로고
    • Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion
    • Thurston TL, Wandel MP, von Muhlinen N, Foeglein A, Randow F. Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion. Nature. 2012;482(7385):414-418.
    • (2012) Nature. , vol.482 , Issue.7385 , pp. 414-418
    • Thurston, T.L.1    Wandel, M.P.2    Von Muhlinen, N.3    Foeglein, A.4    Randow, F.5
  • 113
    • 84874274351 scopus 로고    scopus 로고
    • Sterical hindrance promotes selectivity of the autophagy cargo receptor NDP52 for the danger receptor galectin-8 in antibacterial autophagy
    • Li S, et al. Sterical hindrance promotes selectivity of the autophagy cargo receptor NDP52 for the danger receptor galectin-8 in antibacterial autophagy. Sci Signal. 2013;6(261):ra9.
    • (2013) Sci Signal. , vol.6 , Issue.261 , pp. ra9
    • Li, S.1
  • 114
    • 79952355107 scopus 로고    scopus 로고
    • Selective autophagy mediated by autophagic adapter proteins
    • Johansen T, Lamark T. Selective autophagy mediated by autophagic adapter proteins. Autophagy. 2011;7(3):279-296.
    • (2011) Autophagy. , vol.7 , Issue.3 , pp. 279-296
    • Johansen, T.1    Lamark, T.2
  • 115
    • 84871006349 scopus 로고    scopus 로고
    • The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular Salmonella Typhimurium
    • Huett A, et al. The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular Salmonella Typhimurium. Cell Host Microbe. 2012;12(6):778-790.
    • (2012) Cell Host Microbe. , vol.12 , Issue.6 , pp. 778-790
    • Huett, A.1
  • 116
    • 84885576570 scopus 로고    scopus 로고
    • The ubiquitin ligase parkin mediates resistance to intracellular pathogens
    • Manzanillo PS, et al. The ubiquitin ligase parkin mediates resistance to intracellular pathogens. Nature. 2013;501(7468):512-516.
    • (2013) Nature. , vol.501 , Issue.7468 , pp. 512-516
    • Manzanillo, P.S.1
  • 117
    • 77955077765 scopus 로고    scopus 로고
    • Autophagy of intracellular microbes and mitochondria: Two sides of the same coin?
    • Deretic V. Autophagy of intracellular microbes and mitochondria: two sides of the same coin? F1000 Biol Rep. 2010;2:45.
    • (2010) F1000 Biol Rep. , vol.2 , pp. 45
    • Deretic, V.1
  • 118
    • 82455172117 scopus 로고    scopus 로고
    • Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins
    • Matsumoto G, Wada K, Okuno M, Kurosawa M, Nukina N. Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins. Mol Cell. 2011;44(2):279-289.
    • (2011) Mol Cell. , vol.44 , Issue.2 , pp. 279-289
    • Matsumoto, G.1    Wada, K.2    Okuno, M.3    Kurosawa, M.4    Nukina, N.5
  • 119
    • 84907599058 scopus 로고    scopus 로고
    • TRIM proteins regulate autoph-agy and can target autophagic substrates by direct recognition
    • Mandell MA, et al. TRIM proteins regulate autoph-agy and can target autophagic substrates by direct recognition. Dev Cell. 2014;30(4):394-409.
    • (2014) Dev Cell. , vol.30 , Issue.4 , pp. 394-409
    • Mandell, M.A.1
  • 120
    • 80052289447 scopus 로고    scopus 로고
    • Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins
    • Kawai T, Akira S. Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins. EMBO Mol Med. 2011;3(9):513-527.
    • (2011) EMBO Mol Med. , vol.3 , Issue.9 , pp. 513-527
    • Kawai, T.1    Akira, S.2
  • 121
    • 33645794537 scopus 로고    scopus 로고
    • Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5α restriction factor
    • Stremlau M, et al. Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5α restriction factor. Proc Natl Acad Sci U S A. 2006;103(14):5514-5519.
    • (2006) Proc Natl Acad Sci U S A. , vol.103 , Issue.14 , pp. 5514-5519
    • Stremlau, M.1
  • 122
    • 77956386515 scopus 로고    scopus 로고
    • Endogenous HMGB1 regulates autophagy
    • Tang D, et al. Endogenous HMGB1 regulates autophagy. J Cell Biol. 2010;190(5):881-892.
    • (2010) J Cell Biol. , vol.190 , Issue.5 , pp. 881-892
    • Tang, D.1
  • 123
    • 84890839101 scopus 로고    scopus 로고
    • Conditional ablation of HMGB1 in mice reveals its protective function against endo-toxemia and bacterial infection
    • Yanai H, et al. Conditional ablation of HMGB1 in mice reveals its protective function against endo-toxemia and bacterial infection. Proc Natl Acad Sci U S A. 2013;110(51):20699-20704.
    • (2013) Proc Natl Acad Sci U S A. , vol.110 , Issue.51 , pp. 20699-20704
    • Yanai, H.1
  • 124
    • 48449094878 scopus 로고    scopus 로고
    • ATP-induced autophagy is associated with rapid killing of intracellular mycobacteria within human monocytes/macro-phages
    • Biswas D, Qureshi OS, Lee WY, Croudace JE, Mura M, Lammas DA. ATP-induced autophagy is associated with rapid killing of intracellular mycobacteria within human monocytes/macro-phages. BMC Immunol. 2008;9:35.
    • (2008) BMC Immunol. , vol.9 , pp. 35
    • Biswas, D.1    Qureshi, O.S.2    Lee, W.Y.3    Croudace, J.E.4    Mura, M.5    Lammas, D.A.6
  • 125
    • 34247186472 scopus 로고    scopus 로고
    • Reactive oxygen species are essentia for autophagy and specifically regulate the activity of Atg4
    • Scherz-Shouval R, Shvets E, Fass E, Shorer H, Gil L, Elazar Z. Reactive oxygen species are essentia for autophagy and specifically regulate the activity of Atg4. EMBO J. 2007;26(7):1749-1760.
    • (2007) EMBO J. , vol.26 , Issue.7 , pp. 1749-1760
    • Scherz-Shouval, R.1    Shvets, E.2    Fass, E.3    Shorer, H.4    Gil, L.5    Elazar, Z.6
  • 126
    • 34548700401 scopus 로고    scopus 로고
    • T helper 2 cytokines inhibit autoph-agic control of intracellular Mycobacterium tuberculosis
    • Harris J, et al. T helper 2 cytokines inhibit autoph-agic control of intracellular Mycobacterium tuberculosis. Immunity. 2007;27(3):505-517.
    • (2007) Immunity. , vol.27 , Issue.3 , pp. 505-517
    • Harris, J.1
  • 127
    • 78649833818 scopus 로고    scopus 로고
    • Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria
    • Singh SB, et al. Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria. Nat Cell Biol. 2010;12(12):1154-1165.
    • (2010) Nat Cell Biol. , vol.12 , Issue.12 , pp. 1154-1165
    • Singh, S.B.1
  • 128
    • 79960670161 scopus 로고    scopus 로고
    • P62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways
    • Mostowy S, et al. p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways. J Biol Chem. 2011;286(30):26987-26995.
    • (2011) J Biol Chem. , vol.286 , Issue.30 , pp. 26987-26995
    • Mostowy, S.1
  • 129
    • 78650606698 scopus 로고    scopus 로고
    • IL-10 inhibits the starvation induced autophagy in macrophages via class i phosphatidylinositol 3-kinase (PI3K) pathway
    • Park HJ, et al. IL-10 inhibits the starvation induced autophagy in macrophages via class I phosphatidylinositol 3-kinase (PI3K) pathway. Mol Immunol. 2011;48(4):720-727.
    • (2011) Mol Immunol. , vol.48 , Issue.4 , pp. 720-727
    • Park, H.J.1
  • 130
    • 84870901484 scopus 로고    scopus 로고
    • Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity
    • Shen S, et al. Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity. Mol Cell. 2012;48(5):667-680.
    • (2012) Mol Cell. , vol.48 , Issue.5 , pp. 667-680
    • Shen, S.1
  • 131
    • 34250802980 scopus 로고    scopus 로고
    • Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy
    • Alonso S, Pethe K, Russell DG, Purdy GE. Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy. Proc Natl Acad Sci U S A. 2007;104(14):6031-6036.
    • (2007) Proc Natl Acad Sci U S A. , vol.104 , Issue.14 , pp. 6031-6036
    • Alonso, S.1    Pethe, K.2    Russell, D.G.3    Purdy, G.E.4
  • 132
    • 77649112187 scopus 로고    scopus 로고
    • Genome-wide analysis of the host intracellular network that regulates survival of Mycobacterium tuberculosis
    • Kumar D, et al. Genome-wide analysis of the host intracellular network that regulates survival of Mycobacterium tuberculosis. Cell. 2010;140(5):731-743.
    • (2010) Cell. , vol.140 , Issue.5 , pp. 731-743
    • Kumar, D.1
  • 133
    • 84861550351 scopus 로고    scopus 로고
    • Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages
    • Petruccioli E, et al. Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages. J Infect Dis. 2012;205(9):1425-1435.
    • (2012) J Infect Dis. , vol.205 , Issue.9 , pp. 1425-1435
    • Petruccioli, E.1
  • 134
    • 84860241844 scopus 로고    scopus 로고
    • NOD2 enhances the innate response of alveolar macrophages to Mycobac-terium tuberculosis in humans
    • Juarez E, et al. NOD2 enhances the innate response of alveolar macrophages to Mycobac-terium tuberculosis in humans. Eur J Immunol. l 2012;42(4):880-889.
    • (2012) Eur J Immunol. L , vol.42 , Issue.4 , pp. 880-889
    • Juarez, E.1
  • 135
    • 84859779956 scopus 로고    scopus 로고
    • Mycobacterial induction of autophagy varies by species and occurs independently of mammalian target of rapamycin inhibition
    • Zullo AJ, Lee S. Mycobacterial induction of autophagy varies by species and occurs independently of mammalian target of rapamycin inhibition. J Biol Chem. 2012;287(16):12668-12678.
    • (2012) J Biol Chem. , vol.287 , Issue.16 , pp. 12668-12678
    • Zullo, A.J.1    Lee, S.2
  • 136
    • 84863714328 scopus 로고    scopus 로고
    • Vitamin D inhibits human immunodeficiency virus type 1 and Mycobacterium tuberculosis infection in macrophages through the induction of autophagy
    • Campbell GR, Spector SA. Vitamin D inhibits human immunodeficiency virus type 1 and Mycobacterium tuberculosis infection in macrophages through the induction of autophagy. PLoS Pathog. 2012;8(5):e1002689.
    • (2012) PLoS Pathog. , vol.8 , Issue.5 , pp. e1002689
    • Campbell, G.R.1    Spector, S.A.2
  • 137
    • 84871860062 scopus 로고    scopus 로고
    • Vitamin D rescues impaired Mycobacterium tuberculosis-mediated tumor necrosis factor release in macrophages of HIV-seropositive individuals through an enhanced Toll-like receptor signaling pathway in vitro
    • Anandaiah A, et al. Vitamin D rescues impaired Mycobacterium tuberculosis-mediated tumor necrosis factor release in macrophages of HIV-seropositive individuals through an enhanced Toll-like receptor signaling pathway in vitro. Infect Immun. 2013;81(1):2-10.
    • (2013) Infect Immun. , vol.81 , Issue.1 , pp. 2-10
    • Anandaiah, A.1
  • 138
    • 84865220380 scopus 로고    scopus 로고
    • Extracellular M. Tuberculosis DNA targets bacteria for autoph-agy by activating the host DNA-sensing pathway
    • Watson RO, Manzanillo PS, Cox JS. Extracellular M. tuberculosis DNA targets bacteria for autoph-agy by activating the host DNA-sensing pathway. Cell. 2012;150(4):803-815.
    • (2012) Cell. , vol.150 , Issue.4 , pp. 803-815
    • Watson, R.O.1    Manzanillo, P.S.2    Cox, J.S.3
  • 139
    • 84893441002 scopus 로고    scopus 로고
    • Autophagy adaptor protein p62/SQSTM1 and autophagy-related gene Atg5 mediate autophagosome formation in response to Mycobacterium tuberculosis infection in dendritic cells
    • Seto S, Tsujimura K, Horii T, Koide Y. Autophagy adaptor protein p62/SQSTM1 and autophagy-related gene Atg5 mediate autophagosome formation in response to Mycobacterium tuberculosis infection in dendritic cells. PLoS One. 2013;8(12):e86017.
    • (2013) PLoS One. , vol.8 , Issue.12 , pp. e86017
    • Seto, S.1    Tsujimura, K.2    Horii, T.3    Koide, Y.4
  • 141
    • 84898611787 scopus 로고    scopus 로고
    • Autopha-gosomes, phagosomes, autolysosomes, phagoly-sosomes, autophagolysosomes wait, I'm con fused
    • Klionsky DJ, Eskelinen EL, Deretic V. Autopha-gosomes, phagosomes, autolysosomes, phagoly-sosomes, autophagolysosomes wait, I'm con fused. Autophagy. 2014;10(4):549-551.
    • (2014) Autophagy. , vol.10 , Issue.4 , pp. 549-551
    • Klionsky, D.J.1    Eskelinen, E.L.2    Deretic, V.3
  • 142
    • 34250716965 scopus 로고    scopus 로고
    • M. Tuberculosis and M. Leprae translocate from the phagolysosome to the cyto-sol in myeloid cells
    • van der Wel N, et al. M. tuberculosis and M. leprae translocate from the phagolysosome to the cyto-sol in myeloid cells. Cell. 2007;129(7):1287-1298.
    • (2007) Cell. , vol.129 , Issue.7 , pp. 1287-1298
    • Van Der Wel, N.1
  • 143
    • 38949100391 scopus 로고    scopus 로고
    • Low serum vitamin D levels and tuberculosis: A systematic review and meta-analysis
    • Nnoaham KE, Clarke A. Low serum vitamin D levels and tuberculosis: a systematic review and meta-analysis. Int J Epidemiol. 2008;37(1):113-119.
    • (2008) Int J Epidemiol. , vol.37 , Issue.1 , pp. 113-119
    • Nnoaham, K.E.1    Clarke, A.2
  • 144
    • 33846189759 scopus 로고    scopus 로고
    • Control of macro-autophagy by calcium, calmodulin-depen-dent kinase kinase-β, and Bcl-2
    • Hoyer-Hansen M, et al. Control of macro-autophagy by calcium, calmodulin-depen-dent kinase kinase-β, and Bcl-2. Mol Cell. 2007;25(2):193-205.
    • (2007) Mol Cell. , vol.25 , Issue.2 , pp. 193-205
    • Hoyer-Hansen, M.1
  • 145
    • 80052511813 scopus 로고    scopus 로고
    • The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
    • Mihaylova MM, Shaw RJ. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol. 2011;13(9):1016-1023.
    • (2011) Nat Cell Biol. , vol.13 , Issue.9 , pp. 1016-1023
    • Mihaylova, M.M.1    Shaw, R.J.2
  • 146
    • 84884340814 scopus 로고    scopus 로고
    • Autophagy regulates phagocytosis by modulating the expression of scavenger receptors
    • Bonilla DL, et al. Autophagy regulates phagocytosis by modulating the expression of scavenger receptors. Immunity. 2013;39(3):537-547.
    • (2013) Immunity. , vol.39 , Issue.3 , pp. 537-547
    • Bonilla, D.L.1
  • 147
    • 84869176200 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis-driven targeted recalibration of macrophage lipid homeo-stasis promotes the foamy phenotype
    • Singh V, Jamwal S, Jain R, Verma P, Gokhale R, Rao KV. Mycobacterium tuberculosis-driven targeted recalibration of macrophage lipid homeo-stasis promotes the foamy phenotype. Cell Host Microbe. 2012;12(5):669-681.
    • (2012) Cell Host Microbe. , vol.12 , Issue.5 , pp. 669-681
    • Singh, V.1    Jamwal, S.2    Jain, R.3    Verma, P.4    Gokhale, R.5    Rao, K.V.6
  • 148
    • 78651226124 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis eis regulates autophagy, inflammation, and cell death through redox-dependent signaling
    • Shin DM, et al. Mycobacterium tuberculosis eis regulates autophagy, inflammation, and cell death through redox-dependent signaling. PLoS Pathog. 2010;6(12):e1001230.
    • (2010) PLoS Pathog. , vol.6 , Issue.12 , pp. e1001230
    • Shin, D.M.1
  • 149
    • 79951539400 scopus 로고    scopus 로고
    • Organelle membrane proteomics reveals differential influence of mycobacterial lipoglycans on macrophage phagosome maturation and autophagosome accumulation
    • Shui W, et al. Organelle membrane proteomics reveals differential influence of mycobacterial lipoglycans on macrophage phagosome maturation and autophagosome accumulation. J Proteome Res. 2011;10(1):339-348.
    • (2011) J Proteome Res. , vol.10 , Issue.1 , pp. 339-348
    • Shui, W.1
  • 150
    • 84866554596 scopus 로고    scopus 로고
    • ESX-1 dependent impairment of autophagic flux by Mycobacterium tuberculosis in human dendritic cells
    • Romagnoli A, et al. ESX-1 dependent impairment of autophagic flux by Mycobacterium tuberculosis in human dendritic cells. Autophagy. 2012;8(9):1357-1370.
    • (2012) Autophagy. , vol.8 , Issue.9 , pp. 1357-1370
    • Romagnoli, A.1
  • 151
    • 84911103917 scopus 로고    scopus 로고
    • Autophagy is essential for effector CD8(+) T cell survival and memory formation
    • Xu X, et al. Autophagy is essential for effector CD8(+) T cell survival and memory formation. Nat Immunol. 2014;15(12):1152-1161.
    • (2014) Nat Immunol. , vol.15 , Issue.12 , pp. 1152-1161
    • Xu, X.1


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