Vitamin D is required for IFN-γ-mediated antimicrobial activity of human macrophages

Science Translational Medicine

Volumn 3, Issue 104, 2011, Pages

  Fabri, Mario ^a,h   Stenger, Steffen ^b   Shin, Dong Min ^c   Yuk, Jae Min ^c   Liu, Philip T ^a   Realegeno, Susan ^a   Lee, Hye Mi ^c   Krutzik, Stephan R ^a   Schenk, Mirjam ^a   Sieling, Peter A ^a   Teles, Rosane ^a   Montoya, Dennis ^a   Iyer, Shankar S ^a   Bruns, Heiko ^b   Lewinsohn, David M ^d   Hollis, Bruce W ^e   Hewison, Martin ^a   Adams, John S ^a   Steinmeyer, Andreas ^f   Zügel, Ulrich ^f   Cheng, Genhong ^a   Jo, Eun Kyeong ^c   Bloom, Barry R ^g   Modlin, Robert L ^a   more..

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY HOSPITAL ULM   (Germany)

^c Chungnam National University   (South Korea)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^e MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^f BAYER PHARMA AG   (Germany)

^g HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^h UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIFEDIOL; CATHELICIDIN; GAMMA INTERFERON; POLYPEPTIDE ANTIBIOTIC AGENT; VITAMIN D;

ADAPTIVE IMMUNITY; ANTIMICROBIAL ACTIVITY; ARTICLE; AUTOPHAGY; CELL CULTURE; CELL FUNCTION; CELL FUSION; CELL MATURATION; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE PREDISPOSITION; ETHNIC GROUP; HUMAN; HUMAN CELL; IN VITRO STUDY; MACROPHAGE; MYCOBACTERIUM TUBERCULOSIS; PEPTIDE SYNTHESIS; PHAGOSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; T LYMPHOCYTE; TUBERCULOSIS; VITAMIN SUPPLEMENTATION;

EID: 80054046948     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3003045     Document Type: Article

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68. Acknowledgments: We thank R. Chun, A. Vazirnia, and J. Steiger for excellent technical assistance. Funding: This work was supported by NIH grants AI073539, AR040312, AI022553, and AI047868; Deutsche Forschungsgemeinschaft FA849/1-1 and SFB829; and Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (R13-2007-020-01000-0). Author contributions: M.F. designed and performed the experiments, analyzed the data, and wrote the paper. D.-M.S., J.-M.Y., S.R., H.-M.L., M.S., D.M., S.S.I., and R.T. designed and performed the experiments and analyzed the data. P.T.L. and J.S.A. designed the experiments, analyzed the data, and provided supervisory support. S.R.K. designed and performed the experiments and provided supervisory support. P.A.S. provided T cell clones and supervisory support. H.B. designed the experiments. D.M.L. provided T cell clones. B.W.H. measured the serum vitamin D levels. M.H. and G.C. designed the experiments and provided supervisory support. A.S. and U.Z. provided VAZ. E.-K.J. designed the experiments, analyzed the data, and provided supervisory support. B.R.B. provided supervisory support and wrote the paper. S.S. and R.L.M. designed the experiments, analyzed the data, provided supervisory support, and wrote the paper. Competing interests: B.W.H. and R.L.M. have served as academic consultants to DiaSorin Inc. The other authors declare that they have no competing interests.