Defects in mitochondrial clearance predispose human monocytes to interleukin-1β hypersecretion

Journal of Biological Chemistry

Volumn 289, Issue 8, 2014, Pages 5000-5012

  Van Der Burgh, Robert ^a   Nijhuis, Lotte ^a   Pervolaraki, Kalliopi ^a   Compeer, Ewoud B ^a   Jongeneel, Lieneke H ^a   Van Gijn, Marielle ^b   Coffer, Paul J ^a,b   Murphy, Michael P ^c   Mastroberardino, Pier G ^d   Frenkel, Joost ^a   Boes, Marianne ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS;

AUTOPHAGY; CYTOKINE SECRETIONS; CYTOSOLS; HUMAN MONOCYTES; HYPERSECRETION; INTERLEUKIN-1; MOLECULAR MECHANISM;

MITOCHONDRIA;

INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; ISOPRENOID; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE;

ADOLESCENT; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BIOACCUMULATION; BIOSYNTHESIS; CELL ACTIVATION; CELL DAMAGE; CELL DEGENERATION; CHILD; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOSOL; DISEASE PREDISPOSITION; HUMAN; HUMAN CELL; MEVALONATE KINASE DEFICIENCY; MITOCHONDRION; MONOCYTE; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; RESPIRATORY CHAIN; SIGNAL TRANSDUCTION;

AUTOINFLAMMATORY DISORDER; AUTOPHAGY; INTERLEUKIN; MITOCHONDRIAL DNA; MONOCYTES; PERIODIC FEVER; REDOX REGULATION;

ADOLESCENT; AUTOPHAGY; CELL LINE; CHILD; CHILD, PRESCHOOL; CYTOSOL; DISEASE SUSCEPTIBILITY; DNA, MITOCHONDRIAL; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; MEMBRANE POTENTIAL, MITOCHONDRIAL; MEVALONATE KINASE DEFICIENCY; MITOCHONDRIA; MODELS, BIOLOGICAL; MONOCYTES; OXIDATION-REDUCTION; TERPENES;

EID: 84894481149     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.536920     Document Type: Article

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