C-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response

Science

Volumn 328, Issue 5986, 2010, Pages 1703-1705

  Woodward, Joshua J ^a   Lavarone, Anthony T ^b   Portnoy, Daniel A ^a,c  

^a University of California Berkeley   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE PHOSPHATE; ADENYLATE CYCLASE; ANTIBIOTIC AGENT; BETA INTERFERON; CYCLIC DIADENOSINE MONOPHOSPHATE; DIADENYLATE CYCLASE; MULTIDRUG RESISTANCE PROTEIN; UNCLASSIFIED DRUG;

BACTERIUM; ENZYME ACTIVITY; GENE EXPRESSION; IMMUNITY; MICROBIAL ACTIVITY; PATHOGEN; SECRETION;

ARTICLE; BACTERIAL STRAIN; CYTOSOL; GENE OVEREXPRESSION; HOST CELL; LISTERIA MONOCYTOGENES; LISTERIOSIS; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; BACTERIAL PROTEINS; CYTOSOL; DINUCLEOSIDE PHOSPHATES; FEMALE; GENES, BACTERIAL; IMMUNITY, INNATE; INTERFERON-BETA; LIGANDS; LISTERIA MONOCYTOGENES; MACROPHAGES; MASS SPECTROMETRY; MEMBRANE TRANSPORT PROTEINS; MICE; OPERON; PHOSPHORUS-OXYGEN LYASES;

BACTERIA (MICROORGANISMS); LISTERIA MONOCYTOGENES;

EID: 77954070545     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1189801     Document Type: Article

References (28)

1. K. J. Ishii, S. Koyama, A. Nakagawa, C. Coban, S. Akira, Cell Host Microbe 3, 352 (2008).
2. R. E. Vance, R. R. Isberg, D. A. Portnoy, Cell Host Microbe 6, 10 (2009).
3. M. Lamkanfi, V. M. Dixit, Immunol. Rev. 227, 95 (2009).
4. M. O'Riordan, C. H. Yi, R. Gonzales, K. D. Lee, D. A. Portnoy, Proc. Natl. Acad. Sci. USA 99, 13861 (2002).
5. D. B. Stetson, R. Medzhitov, Immunity 24, 93 (2006).
6. T. Henry, A. Brotcke, D. S. Weiss, L. J. Thompson, D. M. Monack, J. Exp. Med. 204, 987 (2007).
7. C. M. Roux et al, Cell. Microbiol. 9, 1851 (2007).
8. S. A. Stanley, J. E. Johndrow, P. Manzanillo, J. S. Cox, J. Immunol. 178, 3143 (2007).
9. S. Vaena de Avalos, I. J. Blader, M. Fisher, J. C. Boothroyd, B. A. Burleigh, J. Biol. Chem. 277, 639 (2002).
10. G. T. Crimmins et al., Proc. Natl Acad. Sci. U.S.A 105, 10191 (2008).
11. Materials and methods are available as supporting material on Science Online.
12. S. E. Girardin et al., Science 300, 1584 (2003).
13. G. Witte, S. Hartung, K. Büttner, K. P. Hopfner, Mol. Cell 30, 167 (2008).
14. M. Bejerano-Sagie et al., Cell 125, 679 (2006).
15. U. Römling, Sci. Signal. 1, pe39 (2008).
16. C. T. French et al., Mol. Microbiol. 69, 67 (2008).
17. J. H. Song et al., Mol. Cells 19, 365 (2005).
18. J. I. Glass et al., Proc. Natl. Acad. Sci. USA. 103, 425 (2006).
19. D. P. Woolridge et al., J. Biol. Chem. 272, 8864 (1997).
20. A. van Helvoort et al., Cell 87, 507 (1996).
21. S. Yang, C. R. Lopez, E. L. Zechiedrich, Proc. Natl. Acad. Sci. U.S.A 103, 2386 (2006).
22. A. A. Neyfakh, Trends Microbiol. 5, 309 (1997).
23. J. Viala et al., Nat. Immunol. 5, 1166 (2004).
24. Y. H. Sun, H. G. Rolán, R. M. Tsolis, J. Biol. Chem. 282, 33897 (2007).
25. A. B. Molofsky et al., J. Exp. Med. 203, 1093 (2006).
26. T. Ren, D. S. Zamboni, C. R. Roy, W. F. Dietrich, R. E. Vance, PLoS Pathog. 2, e18 (2006).
27. S. M. McWhirter et al., J. Exp. Med. 206, 1899 (2009).
28. -/- BMDMs and Portnoy laboratory members J. D. Sauer and C. Rae for BMDMs. This work was supported by NIH grant P01 AI063302 (D.A.P.) and NIH training grant T32 CA 009179 (J.J.W.). D. A. Portnoy has a consulting relationship with and a financial interest in Aduro BioTech, which stands to benefit from commercialization of the results of this research. A patent covering the use of Listeria monocytogenes strains that express enhanced or diminished levels of c-di-AMP for use as vaccine vectors has been applied for.