Sterical hindrance promotes selectivity of the autophagy cargo receptor NDP52 for the danger receptor galectin-8 in antibacterial autophagy

Science Signaling

Volumn 6, Issue 261, 2013, Pages

  Li, Sai ^a   Wandel, Michal P ^b   Li, Fudong ^a   Liu, Zhonghua ^a   He, Chao ^a   Wu, Jihui ^a   Shi, Yunyu ^a   Randow, Felix ^b  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GALECTIN 8; NDP52 PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL GROWTH; CRYSTAL STRUCTURE; HUMAN; HUMAN CELL; MEMBRANE DAMAGE; NONHUMAN; PRIORITY JOURNAL; SALMONELLA; XENOPHAGY;

AMINO ACID SEQUENCE; AUTOPHAGY; BINDING SITES; CYTOSOL; ENDOSOMES; GALECTINS; HELA CELLS; HOST-PATHOGEN INTERACTIONS; HUMANS; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INTRACELLULAR MEMBRANES; LYSOSOMES; MICROSCOPY, CONFOCAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RNA INTERFERENCE; SALMONELLA TYPHIMURIUM; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84874274351     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2003730     Document Type: Article

References (23)

1. N. Mizushima, T. Yoshimori, Y. Ohsumi, The role of Atg proteins in autophagosome formation. Annu. Rev. Cell Dev. Biol. 27, 107-132 (2011).
2. B. Levine, N. Mizushima, H. W. Virgin, Autophagy in immunity and inflammation. Nature 469, 323-335 (2011).
3. F. Randow, C. Münz, Autophagy in the regulation of pathogen replication and adaptive immunity. Trends Immunol. 33, 475-487 (2012).
4. T. Johansen, T. Lamark, Selective autophagy mediated by autophagic adapter proteins. Autophagy 7, 279-296 (2011).
5. T. L M. Thurston, G. Ryzhakov, S. Bloor, N. von Muhlinen, F. Randow, The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria. Nat. Immunol. 10, 1215-1221 (2009).
6. Y. T. Zheng, S. Shahnazari, A. Brech, T. Lamark, T. Johansen, J. H. Brumell, The adaptor protein p62/SQSTM1 targets invading bacteria to the autophagy pathway. J. Immunol. 183, 5909-5916 (2009).
7. P. Wild, H. Farhan, D. G. McEwan, S. Wagner, V. V. Rogov, N. R. Brady, B. Richter, J. Korac, O. Waidmann, C. Choudhary, V. Dötsch, D. Bumann, I. Dikic, Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. Science 333, 228-233 (2011).
8. T. L M. Thurston, M. P. Wandel, N. von Muhlinen, A. Foeglein, F. Randow, Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion. Nature 482, 414-418 (2012).
9. D. Houzelstein, I. R. Gonçalves, A. J. Fadden, S. S. Sidhu, D. N. Cooper, K. Drickamer, H. Leffler, F. Poirier, Phylogenetic analysis of the vertebrate galectin family. Mol. Biol. Evol. 21, 1177-1187 (2004).
10. G. A. Rabinovich, M. A. Toscano, Turning "sweet" on immunity: Galectin-glycan interactions in immune tolerance and inflammation. Nat. Rev. Immunol. 9, 338-352 (2009).
11. I. Paz, M. Sachse, N. Dupont, J. Mounier, C. Cederfur, J. Enninga, H. Leffler, F. Poirier, M. C. Prevost, F. Lafont, P. Sansonetti, Galectin-3, a marker for vacuole lysis by invasive pathogens. Cell. Microbiol. 12, 530-544 (2010).
12. N. von Muhlinen, M. Akutsu, B. J. Ravenhill, Á. Foeglein, S. Bloor, T. J. Rutherford, S. M. Freund, D. Komander, F. Randow, LC3C, bound selectively by a non-canonical LIR motif in NDP52, is required for anti-bacterial autophagy. Mol. Cell 48, 329-342 (2012).
13. M. Nagae, N. Nishi, T. Murata, T. Usui, T. Nakamura, S. Wakatsuki, R. Kato, Crystal structure of the galectin-9 N-terminal carbohydrate recognition domain from Mus musculus reveals the basic mechanism of carbohydrate recognition. J. Biol. Chem. 281, 35884-35893 (2006).
14. J. Seetharaman, A. Kanigsberg, R. Slaaby, H. Leffler, S. H. Barondes, J. M. Rini, X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-Å resolution. J. Biol. Chem. 273, 13047-13052 (1998).
15. Y. Bourne, B. Bolgiano, D. I. Liao, G. Strecker, P. Cantau, O. Herzberg, T. Feizi, C. Cambillau, Crosslinking of mammalian lectin (galectin-1) by complex biantennary saccharides. Nat. Struct. Biol. 1, 863-870 (1994).
16. N. Dupont, N. Temime-Smaali, F. Lafont, How ubiquitination and autophagy participate in the regulation of the cell response to bacterial infection. Biol. Cell 102, 621-634 (2010).
17. N. Dupont, S. Lacas-Gervais, J. Bertout, I. Paz, B. Freche, G. T. Van Nhieu, F. G. van der Goot, P. J. Sansonetti, F. Lafont, Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy. Cell Host Microbe 6, 137-149 (2009).
18. F. Randow, J. E. Sale, Retroviral transduction of DT40. Subcell. Biochem. 40, 383-386 (2006).
19. M. Barrios-Rodiles, K. R. Brown, B. Ozdamar, R. Bose, Z. Liu, R. S. Donovan, F. Shinjo, Y. Liu, J. Dembowy, I. W. Taylor, V. Luga, N. Przulj, M. Robinson, H. Suzuki, Y. Hayashizaki, I. Jurisica, J. L. Wrana, High-throughput mapping of a dynamic signaling network in mammalian cells. Science 307, 1621-1625 (2005).
20. G. Ryzhakov, F. Randow, SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK. EMBO J. 26, 3180-3190 (2007).
21. A. Vagin, A. Teplyakov, Molecular replacement with MOLREP. Acta Crystallogr. D Biol. Crystallogr. 66, 22-25 (2010).
22. P. Emsley, B. Lohkamp, W. G. Scott, K. Cowtan, Features and development of Coot. Acta Crystallogr. D Biol. Crystallogr. 66, 486-501 (2010).
23. P. D. Adams, P. V. Afonine, G. Bunkóczi, V. B. Chen, I. W. Davis, N. Echols, J. J. Headd, L. W. Hung, G. J. Kapral, R. W. Grosse-Kunstleve, A. J. McCoy, N. W. Moriarty, R. Oeffner, R. J. Read, D. C. Richardson, J. S. Richardson, T. C. Terwilliger, P. H. Zwart, PHENIX: A comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr. D Biol. Crystallogr. 66, 213-221 (2010).