IL-10 inhibits the starvation induced autophagy in macrophages via class I phosphatidylinositol 3-kinase (PI3K) pathway

Molecular Immunology

Volumn 48, Issue 4, 2011, Pages 720-727

  Park, Hun Jung ^a   Lee, Suk Jun ^a   Kim, Sang Hoon ^a   Han, Jihye ^a   Bae, Joonbeom ^a   Kim, Sang Joon ^b   Park, Chung Gyu ^c   Chun, Taehoon ^a  

^a Korea University   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Akt; Autophagy; IL 10; Mammalian target of rapamycin; P70S6K; Phosphatidylinositol 3 kinase

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 10 RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANIMAL CELL; ARTICLE; AUTOPHAGY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; FLOW CYTOMETRY; MACROPHAGE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; AUTOPHAGY; CELL LINE; CLASS I PHOSPHATIDYLINOSITOL 3-KINASES; GENE EXPRESSION REGULATION; INTERLEUKIN-10; MACROPHAGES; MICE; MODELS, IMMUNOLOGICAL; PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, INTERLEUKIN-10; SIGNAL TRANSDUCTION;

MAMMALIA; MURINAE;

EID: 78650606698     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2010.10.020     Document Type: Article

References (33)

1. Abraham R.T., Wiederrecht G.J. Immunopharmacology of rapamycin. Ann. Rev. Immunol. 1996, 14:483-510.
2. Akdis C.A., Akdis M. Mechanisms and treatment of allergic disease in the big picture of regulatory T cells. J. Allergy Clin. Immunol. 2009, 123:735-746.
3. Arico S., Petiot A., Bauvy C., Dubbelhuis P.F., Meijer A.J., Codogno P., Ogier-Denis E. The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. J. Biol. Chem. 2001, 276:35243-35246.
4. Baehrecke E.H. Autophagy: dual roles in life and death?. Nat. Rev. Mol. Cell Biol. 2005, 6:505-510.
5. Crawley J.B., Williams L.M., Mander T., Brennan F.M., Foxwell B.M. Interleukin-10 stimulation of phosphatidylinositol 3-kinase and p70 S6 kinase is required for the proliferative but not the antiinflammatory effects of the cytokine. J. Biol. Chem. 1996, 271:16357-21362.
6. Deretic V. Autophagy as an immune defense mechanism. Curr. Opin. Immunol. 2006, 18:375-382.
7. Gutierrez M.G., Master S.S., Singh S.B., Taylor G.A., Colombo M.I., Deretic V. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell 2004, 119:753-766.
8. Harris J., De Haro S.A., Master S.S., Keane J., Roberts E.A., Delgado M., Deretic V. T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuberculosis. Immunity 2007, 27:505-517.
9. Herrera-Velit P., Reiner N.E. Bacterial lipopolysaccharide induces the association and coordinate activation of p53/56lyn and phophatidylinositol 3-kinase in human monocytes. J. Immunol. 1996, 156:1157-1165.
10. Hoover D.L., Nacy C.A. Macrophage activation to kill Leishmania tropica: defective intracellular killing of amastigotes by macrophages elicited with sterile inflammatory agents. J. Immunol. 1984, 132:1487-1491.
11. Inbal B., Bialik S., Sabanay I., Shani G., Kimchi A. DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death. J. Cell Biol. 2002, 157:455-468.
12. Jung C.H., Ro S.H., Cao J., Otto N.M., Kim D.H. mTOR regulation of autophagy. FEBS Lett. 2010, 584:1287-1295.
13. Kabeya Y., Mizushima N., Ueno T., Yamamoto A., Kirisako T., Noda T., Kominami E., Ohsumi Y., Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 2000, 19:5720-5728.
14. Kihara A., Kabeya Y., Ohsumi Y., Yoshimori T. Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep. 2001, 2:330-335.
15. Liang X.H., Jackson S., Seaman M., Brown K., Kempkes B., Hibshoosh H., Levine B. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999, 402:672-676.
16. Martelli A.M., Evangelisti C., Chiarini F., Grimaldi C., Cappellini A., Ognibene A., McCubrey J.A. The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in normal myelopoiesis and leukemogenesis. Biochim. Biophys. Acta 2010, 1803:991-1002.
17. Mosmann T.R., Cherwinski H., Bond M.W., Giedlin M.A., Coffman R.L. Two types of murine helper T cell clone I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 1986, 136:2348-2357.
18. O'Connell P.J., Yi S., Carrington E.M., Lew A.M. Role of regulatory T cells in xenotransplantation. Curr. Opin. Organ Transplant. 2010, 15:224-229.
19. O'Garra A., Murphy K.M. From IL-10 to IL-12: how pathogens and their products stimulate APCs to induce T(H)1 development. Nat. Immunol. 2009, 10:929-932.
20. O'Garra A., Barrat F.J., Castro A.G., Vicari A., Hawrylowicz C. Strategies for use of IL-10 or its antagonists in human disease. Immunol. Rev. 2008, 223:114-131.
21. Petiot A., Ogier-Denis E., Blommaart E.F., Meijer A.J., Codogno P. Distinct classes of phosphatidylinositol 30-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J. Biol. Chem. 2000, 275:992-998.
22. Pyo J.O., Jang M.H., Kwon Y.K., Lee H.J., Jun J.I., Woo H.N., Cho D.H., Choi B., Lee H., Kim J.H., Mizushima N., Oshumi Y., Jung Y.K. Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. J. Biol. Chem. 2005, 280:20722-20729.
23. Rusten T.E., Lindmo K., Juhász G., Sass M., Seglen P.O., brech A., Stenmark H. Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway. Dev. Cell 2004, 7:179-192.
24. Sanchez-Margálet V., Goldfine I.D., Vlahos C.J., Sung C.K. Role of phosphatidylinositol-3-kinase in insulin receptor signaling: studies with inhibitor, LY294002. Biochem. Biophys. Res. Commun. 1994, 204:446-452.
25. Scott R.C., Schuldiner O., Neufeld T.P. Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev. Cell 2004, 7:167-178.
26. Shinojima N., Yokoyama T., Kondo Y., Kondo S. Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy. Autophagy 2007, 3:635-637.
27. Takahashi Y., Coppola D., Matsushita N., Cualing H.D., Sun M., Sato Y., Liang C., Jung J.U., Cheng J.Q., Mulé J.J., Pledger W.J., Wang H.G. Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat. Cell Biol. 2007, 9:1142-1151.
28. Tallóczy Z., Jiang W., Virgin H.W., Leib D.A., Scheuner D., Kaufman R.J., Eskelinen E.L., Levine B. Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:190-195.
29. Van Grol J., Subauste C., Andrade R.M., Fujinaga K., Nelson J., Subauste C.S. HIV-1 inhibits autophagy in bystander macrophage/monocytic cells through Src-Akt and STAT3. PLoS ONE 2010, 22:e11733.
30. Wright K., Ward S.G., Kolios G., Westwick J. Activation of phophatidylinositol 3-kinase by interleukin-13. An inhibitory signal for inducible nitric-oxide synthases expression in epithelial cell line HT-29. J. Biol. Chem. 1997, 272:12626-12633.
31. Yamamoto A., Cremona M.L., Rothman J.E. Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin signaling pathway. J. Cell Biol. 2006, 172:719-731.
32. Yang Z., Klionsky D.J. An overview of the molecular mechanism of autophagy. Curr. Top. Microbiol. Immunol. 2009, 335:1-32.
33. Zhou J.H., Broussard S.R., Strle K., Freund G.G., Johnson R.W., Dantzer R., Kelley K.W. IL-10 inhibits apoptosis of promyeloid cells by activating insulin receptor substrate-2 and phosphatidylinositol 3'-kinase. J. Immunol. 2001, 167:4436-4442.