메뉴 건너뛰기




Volumn 15, Issue 12, 2014, Pages 1152-1161

Autophagy is essential for effector CD8 + T cell survival and memory formation

Author keywords

[No Author keywords available]

Indexed keywords

THYMOCYTE ANTIBODY;

EID: 84911103917     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3025     Document Type: Article
Times cited : (358)

References (48)
  • 1
    • 34247849183 scopus 로고    scopus 로고
    • Effector and memory CTL differentiation
    • Williams, M.A. and Bevan, M.J. Effector and memory CTL differentiation. Annu. Rev. Immunol. 25, 171-192 (2007).
    • (2007) Annu. Rev. Immunol , vol.25 , pp. 171-192
    • Williams, M.A.1    Bevan, M.J.2
  • 2
    • 34548683483 scopus 로고    scopus 로고
    • Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection.
    • Kaech, S.M. and Wherry, E.J. Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection. Immunity 27, 393-405 (2007).
    • (2007) Immunity , vol.27 , pp. 393-405
    • Kaech, S.M.1    Wherry, E.J.2
  • 3
    • 0347382593 scopus 로고    scopus 로고
    • Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
    • Kaech, S.M. et al. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat. Immunol. 4, 1191-1198 (2003).
    • (2003) Nat. Immunol , vol.4 , pp. 1191-1198
    • Kaech, S.M.1
  • 4
    • 41149099559 scopus 로고    scopus 로고
    • Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates
    • Sarkar, S. et al. Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates. J. Exp. Med. 205, 625-640 (2008).
    • (2008) J. Exp. Med , vol.205 , pp. 625-640
    • Sarkar, S.1
  • 5
    • 34548027000 scopus 로고    scopus 로고
    • Inflammation directs memory precursor and short-lived effector CD8+ T cell fates via the graded expression of T-bet transcription factor.
    • Joshi, N.S. et al. Inflammation directs memory precursor and short-lived effector CD8+ T cell fates via the graded expression of T-bet transcription factor. Immunity 27, 281-295 (2007).
    • (2007) Immunity , vol.27 , pp. 281-295
    • Joshi, N.S.1
  • 6
    • 78751672975 scopus 로고    scopus 로고
    • Autophagy in immunity and inflammation.
    • Levine, B., Mizushima, N. and Virgin, H.W. Autophagy in immunity and inflammation. Nature 469, 323-335 (2011).
    • (2011) Nature , vol.469 , pp. 323-335
    • Levine, B.1    Mizushima, N.2    Virgin, H.W.3
  • 7
    • 75749122303 scopus 로고    scopus 로고
    • Methods in mammalian autophagy research.
    • Mizushima, N., Yoshimori, T. and Levine, B. Methods in mammalian autophagy research. Cell 140, 313-326 (2010).
    • (2010) Cell , vol.140 , pp. 313-326
    • Mizushima, N.1    Yoshimori, T.2    Levine, B.3
  • 8
    • 77953783023 scopus 로고    scopus 로고
    • The complex interplay between autophagy, apoptosis, and necrotic signals promotes T-cell homeostasis
    • Walsh, C.M. and Edinger, A.L. The complex interplay between autophagy, apoptosis, and necrotic signals promotes T-cell homeostasis. Immunol. Rev. 236, 95-109 (2010).
    • (2010) Immunol. Rev , vol.236 , pp. 95-109
    • Walsh, C.M.1    Edinger, A.L.2
  • 9
    • 33846461678 scopus 로고    scopus 로고
    • A critical role for the autophagy gene Atg5 in T cell survival and proliferation
    • Pua, H.H., Dzhagalov, I., Chuck, M., Mizushima, N. and He, Y.W. A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J. Exp. Med. 204, 25-31 (2007).
    • (2007) J. Exp. Med , vol.204 , pp. 25-31
    • Pua, H.H.1    Dzhagalov, I.2    Chuck, M.3    Mizushima, N.4    He, Y.W.5
  • 10
    • 67650216238 scopus 로고    scopus 로고
    • Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes.
    • Stephenson, L.M. et al. Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes. Autophagy 5, 625-635 (2009).
    • (2009) Autophagy , vol.5 , pp. 625-635
    • Stephenson, L.M.1
  • 11
    • 77950500675 scopus 로고    scopus 로고
    • Autophagy in cellular growth control.
    • Wang, R.C. and Levine, B. Autophagy in cellular growth control. FEBS Lett. 584, 1417-1426 (2010).
    • (2010) FEBS Lett , vol.584 , pp. 1417-1426
    • Wang, R.C.1    Levine, B.2
  • 12
    • 78650643194 scopus 로고    scopus 로고
    • Macroautophagy regulates energy metabolism during effector T cell activation.
    • Hubbard, V.M. et al. Macroautophagy regulates energy metabolism during effector T cell activation. J. Immunol. 185, 7349-7357 (2010).
    • (2010) J. Immunol , vol.185 , pp. 7349-7357
    • Hubbard, V.M.1
  • 13
    • 33749531942 scopus 로고    scopus 로고
    • Autophagy is induced in CD4+ T cells and important for the growth factor-withdrawal cell death.
    • Li, C. et al. Autophagy is induced in CD4+ T cells and important for the growth factor-withdrawal cell death. J. Immunol. 177, 5163-5168 (2006).
    • (2006) J. Immunol , vol.177 , pp. 5163-5168
    • Li, C.1
  • 14
    • 84866122688 scopus 로고    scopus 로고
    • Autophagy modulation as a potential therapeutic target for diverse diseases
    • Rubinsztein, D.C., Codogno, P. and Levine, B. Autophagy modulation as a potential therapeutic target for diverse diseases. Nat. Rev. Drug Discov. 11, 709-730 (2012).
    • (2012) Nat. Rev. Drug Discov , vol.11 , pp. 709-730
    • Rubinsztein, D.C.1    Codogno, P.2    Levine, B.3
  • 15
    • 64249123646 scopus 로고    scopus 로고
    • Autophagy is essential for mitochondrial clearance in mature T lymphocytes.
    • Pua, H.H., Guo, J., Komatsu, M. and He, Y.W. Autophagy is essential for mitochondrial clearance in mature T lymphocytes. J. Immunol. 182, 4046-4055 (2009).
    • (2009) J. Immunol , vol.182 , pp. 4046-4055
    • Pua, H.H.1    Guo, J.2    Komatsu, M.3    He, Y.W.4
  • 16
    • 34548259958 scopus 로고    scopus 로고
    • P62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
    • Pankiv, S. et al. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J. Biol. Chem. 282, 24131-24145 (2007).
    • (2007) J. Biol. Chem , vol.282 , pp. 24131-24145
    • Pankiv, S.1
  • 17
    • 46849121421 scopus 로고    scopus 로고
    • Utilizing flow cytometry to monitor autophagy in living mammalian cells.
    • Shvets, E., Fass, E. and Elazar, Z. Utilizing flow cytometry to monitor autophagy in living mammalian cells. Autophagy 4, 621-628 (2008).
    • (2008) Autophagy , vol.4 , pp. 621-628
    • Shvets, E.1    Fass, E.2    Elazar, Z.3
  • 18
    • 84891303438 scopus 로고    scopus 로고
    • Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1
    • Gump, J.M. et al. Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1. Nat. Cell Biol. 16, 47-54 (2014).
    • (2014) Nat. Cell Biol , vol.16 , pp. 47-54
    • Gump, J.M.1
  • 19
    • 34548077575 scopus 로고    scopus 로고
    • Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3.
    • Kimura, S., Noda, T. and Yoshimori, T. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy 3, 452-460 (2007).
    • (2007) Autophagy , vol.3 , pp. 452-460
    • Kimura, S.1    Noda, T.2    Yoshimori, T.3
  • 20
    • 11144245626 scopus 로고    scopus 로고
    • The role of autophagy during the early neonatal starvation period.
    • Kuma, A. et al. The role of autophagy during the early neonatal starvation period. Nature 432, 1032-1036 (2004).
    • (2004) Nature , vol.432 , pp. 1032-1036
    • Kuma, A.1
  • 21
    • 33745192802 scopus 로고    scopus 로고
    • Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
    • Hara, T. et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441, 885-889 (2006).
    • (2006) Nature , vol.441 , pp. 885-889
    • Hara, T.1
  • 22
    • 0033542458 scopus 로고    scopus 로고
    • Modelling T-cell memory by genetic marking of memory T cells in vivo.
    • Jacob, J. and Baltimore, D. Modelling T-cell memory by genetic marking of memory T cells in vivo. Nature 399, 593-597 (1999).
    • (1999) Nature , vol.399 , pp. 593-597
    • Jacob, J.1    Baltimore, D.2
  • 23
    • 33846784031 scopus 로고    scopus 로고
    • Quantitating the magnitude of the lymphocytic choriomeningitis virus-specific CD8 T-cell response: It is even bigger than we thought.
    • Masopust, D., Murali-Krishna, K. and Ahmed, R. Quantitating the magnitude of the lymphocytic choriomeningitis virus-specific CD8 T-cell response: it is even bigger than we thought. J. Virol. 81, 2002-2011 (2007).
    • (2007) J. Virol , vol.81 , pp. 2002-2011
    • Masopust, D.1    Murali-Krishna, K.2    Ahmed, R.3
  • 24
    • 84855999478 scopus 로고    scopus 로고
    • Natural killer cells act as rheostats modulating antiviral T cells.
    • Waggoner, S.N., Cornberg, M., Selin, L.K. and Welsh, R.M. Natural killer cells act as rheostats modulating antiviral T cells. Nature 481, 394-398 (2012).
    • (2012) Nature , vol.481 , pp. 394-398
    • Waggoner, S.N.1    Cornberg, M.2    Selin, L.K.3    Welsh, R.M.4
  • 25
    • 84863011076 scopus 로고    scopus 로고
    • Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity
    • Lang, P.A. et al. Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity. Proc. Natl. Acad. Sci. USA 109, 1210-1215 (2012).
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 1210-1215
    • Lang, P.A.1
  • 26
    • 84856183120 scopus 로고    scopus 로고
    • Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development.
    • van der Windt, G.J. et al. Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. Immunity 36, 68-78 (2012).
    • (2012) Immunity , vol.36 , pp. 68-78
    • Van Der Windt, G.J.1
  • 27
    • 67650096912 scopus 로고    scopus 로고
    • Enhancing CD8 T-cell memory by modulating fatty acid metabolism.
    • Pearce, E.L. et al. Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature 460, 103-107 (2009).
    • (2009) Nature , vol.460 , pp. 103-107
    • Pearce, E.L.1
  • 28
    • 84904392273 scopus 로고    scopus 로고
    • Memory CD8+ T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development.
    • OSullivan, D. et al. Memory CD8+ T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development. Immunity 41, 75-88 (2014).
    • (2014) Immunity , vol.41 , pp. 75-88
    • Osullivan, D.1
  • 29
    • 78650181190 scopus 로고    scopus 로고
    • The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism.
    • Wellen, K.E. et al. The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism. Genes Dev. 24, 2784-2799 (2010).
    • (2010) Genes Dev , vol.24 , pp. 2784-2799
    • Wellen, K.E.1
  • 30
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. USA 102, 15545-15550 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 15545-15550
    • Subramanian, A.1
  • 31
    • 0037383592 scopus 로고    scopus 로고
    • Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment.
    • Wherry, E.J., Blattman, J.N., Murali-Krishna, K., van der Most, R. and Ahmed, R. Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J. Virol. 77, 4911-4927 (2003).
    • (2003) J. Virol , vol.77 , pp. 4911-4927
    • Wherry, E.J.1    Blattman, J.N.2    Murali-Krishna, K.3    Van Der Most, R.4    Ahmed, R.5
  • 32
    • 0032416085 scopus 로고    scopus 로고
    • Viral immune evasion due to persistence of activated T cells without effector function
    • Zajac, A.J. et al. Viral immune evasion due to persistence of activated T cells without effector function. J. Exp. Med. 188, 2205-2213 (1998).
    • (1998) J. Exp. Med , vol.188 , pp. 2205-2213
    • Zajac, A.J.1
  • 33
    • 79251534395 scopus 로고    scopus 로고
    • Autophagy regulates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes.
    • Jia, W., Pua, H.H., Li, Q.J. and He, Y.W. Autophagy regulates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes. J. Immunol. 186, 1564-1574 (2011).
    • (2011) J. Immunol , vol.186 , pp. 1564-1574
    • Jia, W.1    Pua, H.H.2    Li, Q.J.3    He, Y.W.4
  • 34
    • 0037074012 scopus 로고    scopus 로고
    • Molecular and functional profiling of memory CD8 T cell differentiation.
    • Kaech, S.M., Hemby, S., Kersh, E. and Ahmed, R. Molecular and functional profiling of memory CD8 T cell differentiation. Cell 111, 837-851 (2002).
    • (2002) Cell , vol.111 , pp. 837-851
    • Kaech, S.M.1    Hemby, S.2    Kersh, E.3    Ahmed, R.4
  • 35
    • 0035892899 scopus 로고    scopus 로고
    • IL-7 enhances the survival and maintains the size of naive T cells.
    • Rathmell, J.C., Farkash, E.A., Gao, W. and Thompson, C.B. IL-7 enhances the survival and maintains the size of naive T cells. J. Immunol. 167, 6869-6876 (2001).
    • (2001) J. Immunol , vol.167 , pp. 6869-6876
    • Rathmell, J.C.1    Farkash, E.A.2    Gao, W.3    Thompson, C.B.4
  • 36
    • 33646186619 scopus 로고    scopus 로고
    • Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis
    • Ma, A., Koka, R. and Burkett, P. Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis. Annu. Rev. Immunol. 24, 657-679 (2006).
    • (2006) Annu. Rev. Immunol , vol.24 , pp. 657-679
    • Ma, A.1    Koka, R.2    Burkett, P.3
  • 37
    • 34548014737 scopus 로고    scopus 로고
    • Revving the engine: Signal transduction fuels T cell activation.
    • Jones, R.G. and Thompson, C.B. Revving the engine: signal transduction fuels T cell activation. Immunity 27, 173-178 (2007).
    • (2007) Immunity , vol.27 , pp. 173-178
    • Jones, R.G.1    Thompson, C.B.2
  • 38
    • 0037408512 scopus 로고    scopus 로고
    • Mitochondrial potential and reactive oxygen intermediates in antigen-specific CD8+ T cells during viral infection.
    • Grayson, J.M., Laniewski, N.G., Lanier, J.G. and Ahmed, R. Mitochondrial potential and reactive oxygen intermediates in antigen-specific CD8+ T cells during viral infection. J. Immunol. 170, 4745-4751 (2003).
    • (2003) J. Immunol , vol.170 , pp. 4745-4751
    • Grayson, J.M.1    Laniewski, N.G.2    Lanier, J.G.3    Ahmed, R.4
  • 39
    • 84862976890 scopus 로고    scopus 로고
    • Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB.
    • Paul, S., Kashyap, A.K., Jia, W., He, Y.W. and Schaefer, B.C. Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB. Immunity 36, 947-958 (2012).
    • (2012) Immunity , vol.36 , pp. 947-958
    • Paul, S.1    Kashyap, A.K.2    Jia, W.3    He, Y.W.4    Schaefer, B.C.5
  • 40
    • 77649265091 scopus 로고    scopus 로고
    • The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
    • Komatsu, M. et al. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat. Cell Biol. 12, 213-223 (2010).
    • (2010) Nat. Cell Biol , vol.12 , pp. 213-223
    • Komatsu, M.1
  • 41
    • 67650074206 scopus 로고    scopus 로고
    • MTOR regulates memory CD8 T-cell differentiation.
    • Araki, K. et al. mTOR regulates memory CD8 T-cell differentiation. Nature 460, 108-112 (2009).
    • (2009) Nature , vol.460 , pp. 108-112
    • Araki, K.1
  • 42
    • 79551598347 scopus 로고    scopus 로고
    • AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
    • Kim, J., Kundu, M., Viollet, B. and Guan, K.L. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat. Cell Biol. 13, 132-141 (2011).
    • (2011) Nat. Cell Biol , vol.13 , pp. 132-141
    • Kim, J.1    Kundu, M.2    Viollet, B.3    Guan, K.L.4
  • 43
    • 84879777723 scopus 로고    scopus 로고
    • Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis.
    • Guo, J.Y. et al. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev. 27, 1447-1461 (2013).
    • (2013) Genes Dev , vol.27 , pp. 1447-1461
    • Guo, J.Y.1
  • 44
    • 65949095803 scopus 로고    scopus 로고
    • Autophagy regulates lipid metabolism.
    • Singh, R. et al. Autophagy regulates lipid metabolism. Nature 458, 1131-1135 (2009).
    • (2009) Nature , vol.458 , pp. 1131-1135
    • Singh, R.1
  • 45
    • 33747430476 scopus 로고    scopus 로고
    • Genetic reconstitution of bone marrow for the study of signal transduction ex vivo
    • Jordan, M.S. Genetic reconstitution of bone marrow for the study of signal transduction ex vivo. Methods Mol. Biol. 332, 331-342 (2006).
    • (2006) Methods Mol. Biol , vol.332 , pp. 331-342
    • Jordan, M.S.1
  • 46
    • 0032005477 scopus 로고    scopus 로고
    • Counting antigen-specific CD8 T cells: A reevaluation of bystander activation during viral infection.
    • Murali-Krishna, K. et al. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 8, 177-187 (1998).
    • (1998) Immunity , vol.8 , pp. 177-187
    • Murali-Krishna, K.1
  • 47
    • 67650733222 scopus 로고    scopus 로고
    • ApLCMS-adaptive processing of high-resolution LC/MS data
    • Yu, T., Park, Y., Johnson, J.M. and Jones, D.P. apLCMS-adaptive processing of high-resolution LC/MS data. Bioinformatics 25, 1930-1936 (2009).
    • (2009) Bioinformatics , vol.25 , pp. 1930-1936
    • Yu, T.1    Park, Y.2    Johnson, J.M.3    Jones, D.P.4
  • 48
    • 84880851838 scopus 로고    scopus 로고
    • Predicting network activity from high throughput metabolomics
    • Li, S. et al. Predicting network activity from high throughput metabolomics. PLoS Comput. Biol. 9, e1003123 (2013).
    • (2013) PLoS Comput. Biol , vol.9 , pp. e1003123
    • Li, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.