메뉴 건너뛰기




Volumn 79, Issue 9, 2014, Pages 928-946

Use of intracellular transport processes for targeted drug delivery into a specified cellular compartment

Author keywords

cancer therapy; intracellular transport; modular nanotransporters; nuclear import; receptor mediated endocytosis; targeted drug delivery; transport of macromolecules

Indexed keywords

ANIMAL; CELL COMPARTMENTALIZATION; DRUG DELIVERY SYSTEM; HUMAN; TRANSPORT AT THE CELLULAR LEVEL;

EID: 84920264525     PISSN: 00062979     EISSN: 16083040     Source Type: Journal    
DOI: 10.1134/S0006297914090090     Document Type: Article
Times cited : (20)

References (194)
  • 1
    • 75349103697 scopus 로고    scopus 로고
    • Subcellular targeting: A new frontier for drug-loaded pharmaceutical nanocarriers and the concept of the magic bullet
    • 19708822
    • D'Souza, G. G., and Weissig, V. (2009) Subcellular targeting: a new frontier for drug-loaded pharmaceutical nanocarriers and the concept of the magic bullet, Expert. Opin. Drug Deliv., 6, 1135-1148.
    • (2009) Expert. Opin. Drug Deliv. , vol.6 , pp. 1135-1148
    • D'Souza, G.G.1    Weissig, V.2
  • 2
    • 74049133619 scopus 로고    scopus 로고
    • Subcellular targeting strategies for drug design and delivery
    • 20043027 1:CAS:528:DC%2BD1MXhs1aqtbfL
    • Rajendran, L., Knolker, H. J., and Simons, K. (2010) Subcellular targeting strategies for drug design and delivery, Nat. Rev. Drug Discov., 9, 29-42.
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 29-42
    • Rajendran, L.1    Knolker, H.J.2    Simons, K.3
  • 3
    • 34548267667 scopus 로고    scopus 로고
    • Endocytic mechanisms for targeted drug delivery
    • 17659804 1:CAS:528:DC%2BD2sXpvFWmt7w%3D 2000329
    • Bareford, L. M., and Swaan, P. W. (2007) Endocytic mechanisms for targeted drug delivery, Adv. Drug Deliv. Rev., 59, 748-758.
    • (2007) Adv. Drug Deliv. Rev. , vol.59 , pp. 748-758
    • Bareford, L.M.1    Swaan, P.W.2
  • 4
    • 70350076889 scopus 로고    scopus 로고
    • Novel modular transporters delivering anticancer drugs and foreign DNA to the nuclei of target cancer cells
    • 19785068 2834187
    • Sobolev, A. S. (2009) Novel modular transporters delivering anticancer drugs and foreign DNA to the nuclei of target cancer cells, J. BUON, 14,Suppl. 1, S33-S42.
    • (2009) J. BUON , vol.14 , pp. 33-S42
    • Sobolev, A.S.1
  • 5
    • 84878306995 scopus 로고    scopus 로고
    • Protein-protein interactions: General trends in the relationship between binding affinity and interfacial buried surface area
    • 23389845 1:CAS:528:DC%2BC3sXktFKntbw%3D 3610057
    • Chen, J., Sawyer, N., and Regan, L. (2013) Protein-protein interactions: general trends in the relationship between binding affinity and interfacial buried surface area, Protein Sci., 22, 510-515.
    • (2013) Protein Sci. , vol.22 , pp. 510-515
    • Chen, J.1    Sawyer, N.2    Regan, L.3
  • 6
    • 0003187567 scopus 로고    scopus 로고
    • The atomic structure of protein-protein recognition sites
    • 9925793
    • Lo Conte, L., Chothia, C., and Janin, J. (1999) The atomic structure of protein-protein recognition sites, J. Mol. Biol., 285, 2177-2198.
    • (1999) J. Mol. Biol. , vol.285 , pp. 2177-2198
    • Lo Conte, L.1    Chothia, C.2    Janin, J.3
  • 7
    • 84920269491 scopus 로고    scopus 로고
    • Modular nanocarriers as a multipurposed platform for delivery of anticancer drugs
    • 1:CAS:528:DC%2BC3sXhvFChtr7E
    • Sobolev, A. S. (2013) Modular nanocarriers as a multipurposed platform for delivery of anticancer drugs, Vestn. Ros. Akad. Nauk, 83, 685-697.
    • (2013) Vestn. Ros. Akad. Nauk , vol.83 , pp. 685-697
    • Sobolev, A.S.1
  • 8
    • 0032549625 scopus 로고    scopus 로고
    • Selective gene transfer into the liver of non-human primates with E1-deleted, E2A-defective, or E1-E4 deleted recombinant adenoviruses
    • 9551615 1:CAS:528:DyaK1cXit1ertr0%3D
    • Raper, S. E., Haskal, Z. J., Ye, X., Pugh, C., Furth, E. E., Gao, G. P., and Wilson, J. M. (1998) Selective gene transfer into the liver of non-human primates with E1-deleted, E2A-defective, or E1-E4 deleted recombinant adenoviruses, Hum. Gene Ther., 9, 671-679.
    • (1998) Hum. Gene Ther. , vol.9 , pp. 671-679
    • Raper, S.E.1    Haskal, Z.J.2    Ye, X.3    Pugh, C.4    Furth, E.E.5    Gao, G.P.6    Wilson, J.M.7
  • 11
    • 33750725097 scopus 로고    scopus 로고
    • Nucleic acid based therapeutics for tumor therapy
    • 17100559 1:CAS:528:DC%2BD28XhtFemtr7L
    • Ogris, M. (2006) Nucleic acid based therapeutics for tumor therapy, Anticancer Agents Med. Chem., 6, 563-570.
    • (2006) Anticancer Agents Med. Chem. , vol.6 , pp. 563-570
    • Ogris, M.1
  • 12
    • 4344605995 scopus 로고    scopus 로고
    • Approaches for targeted intracellular delivery of photosensitizers for increasing their efficiency and lending cell specificity
    • 15129633 1:CAS:528:DC%2BD2cXjsVSgu7c%3D
    • Sobolev, A. S., Rosenkranz, A. A., and Gilyazova, D. G. (2004) Approaches for targeted intracellular delivery of photosensitizers for increasing their efficiency and lending cell specificity, Biofizika, 49, 351-379.
    • (2004) Biofizika , vol.49 , pp. 351-379
    • Sobolev, A.S.1    Rosenkranz, A.A.2    Gilyazova, D.G.3
  • 14
    • 0010469247 scopus 로고
    • Nuclear recoils from 211-At decay
    • 1:CAS:528:DyaK3cXis1CltQ%3D%3D
    • Roessler, K., and Eich, G. (1989) Nuclear recoils from 211-At decay, Radiochim. Acta, 47, 87-89.
    • (1989) Radiochim. Acta , vol.47 , pp. 87-89
    • Roessler, K.1    Eich, G.2
  • 15
    • 33644874043 scopus 로고    scopus 로고
    • Auger electrons: Lethal, low energy, and coming soon to a tumor cell nucleus near you
    • 16330556
    • Boswell, C. A., and Brechbiel, M. W. (2005) Auger electrons: lethal, low energy, and coming soon to a tumor cell nucleus near you, J. Nucl. Med., 46, 1946-1947.
    • (2005) J. Nucl. Med. , vol.46 , pp. 1946-1947
    • Boswell, C.A.1    Brechbiel, M.W.2
  • 17
    • 84863951245 scopus 로고    scopus 로고
    • Peptide vectors for the nonviral delivery of nucleic acids
    • 22455499 1:CAS:528:DC%2BC38Xks1Cgs70%3D
    • Hoyer, J., and Neundorf, I. (2012) Peptide vectors for the nonviral delivery of nucleic acids, Acc. Chem. Res., 45, 1048-1056.
    • (2012) Acc. Chem. Res. , vol.45 , pp. 1048-1056
    • Hoyer, J.1    Neundorf, I.2
  • 19
    • 84858004499 scopus 로고    scopus 로고
    • Mitochondrial protein import: From transport pathways to an integrated network
    • 22178138 1:CAS:528:DC%2BC38XjsFKrtbs%3D
    • Becker, T., Bottinger, L., and Pfanner, N. (2012) Mitochondrial protein import: from transport pathways to an integrated network, Trends Biochem. Sci., 37, 85-91.
    • (2012) Trends Biochem. Sci. , vol.37 , pp. 85-91
    • Becker, T.1    Bottinger, L.2    Pfanner, N.3
  • 20
    • 84873252557 scopus 로고    scopus 로고
    • Liposomal drug delivery systems: From concept to clinical applications
    • 23036225 1:CAS:528:DC%2BC38XhsFKnsrrL
    • Allen, T. M., and Cullis, P. R. (2013) Liposomal drug delivery systems: from concept to clinical applications, Adv. Drug Deliv. Rev., 65, 36-48.
    • (2013) Adv. Drug Deliv. Rev. , vol.65 , pp. 36-48
    • Allen, T.M.1    Cullis, P.R.2
  • 21
    • 55849099605 scopus 로고    scopus 로고
    • Active targeting schemes for nanoparticle systems in cancer therapeutics
    • 18840489 1:CAS:528:DC%2BD1cXhsVSjsL%2FP
    • Byrne, J. D., Betancourt, T., and Brannon-Peppas, L. (2008) Active targeting schemes for nanoparticle systems in cancer therapeutics, Adv. Drug Deliv. Rev., 60, 1615-1626.
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , pp. 1615-1626
    • Byrne, J.D.1    Betancourt, T.2    Brannon-Peppas, L.3
  • 22
    • 84869500832 scopus 로고    scopus 로고
    • Challenges in design and characterization of ligand-targeted drug delivery systems
    • 22709588 1:CAS:528:DC%2BC38Xps1Kms7o%3D 3481020
    • Muro, S. (2012) Challenges in design and characterization of ligand-targeted drug delivery systems, J. Control Release, 164, 125-137.
    • (2012) J. Control Release , vol.164 , pp. 125-137
    • Muro, S.1
  • 23
    • 84886633919 scopus 로고    scopus 로고
    • Delivery of therapeutic nucleic acids via transferrin and transferrin receptors: Lipoplexes and other carriers
    • 24050263 1:CAS:528:DC%2BC2cXktFWktQ%3D%3D
    • Tros de Ilarduya, C., and Duzgunes, N. (2013) Delivery of therapeutic nucleic acids via transferrin and transferrin receptors: lipoplexes and other carriers, Expert Opin. Drug Deliv., 10, 1583-1591.
    • (2013) Expert Opin. Drug Deliv. , vol.10 , pp. 1583-1591
    • Tros De Ilarduya, C.1    Duzgunes, N.2
  • 24
    • 84885450082 scopus 로고    scopus 로고
    • A target-specific oral formulation of doxorubicin-protein nanoparticles: Efficacy and safety in hepatocellular cancer
    • 24155776 1:CAS:528:DC%2BC2cXitVCmt78%3D 3805992
    • Golla, K., Bhaskar, C., Ahmed, F., and Kondapi, A. K. (2013) A target-specific oral formulation of doxorubicin-protein nanoparticles: efficacy and safety in hepatocellular cancer, J. Cancer, 4, 644-652.
    • (2013) J. Cancer , vol.4 , pp. 644-652
    • Golla, K.1    Bhaskar, C.2    Ahmed, F.3    Kondapi, A.K.4
  • 25
    • 70849096524 scopus 로고    scopus 로고
    • Novel anti-tumor strategy: PEG-hydroxycamptothecin conjugate loaded transferrin-PEG-nanoparticles
    • 19735683 1:CAS:528:DC%2BD1MXhsFWls7zJ
    • Hong, M., Zhu, S., Jiang, Y., Tang, G., Sun, C., Fang, C., Shi, B., and Pei, Y. (2010) Novel anti-tumor strategy: PEG-hydroxycamptothecin conjugate loaded transferrin-PEG-nanoparticles, J. Control Release, 141, 22-29.
    • (2010) J. Control Release , vol.141 , pp. 22-29
    • Hong, M.1    Zhu, S.2    Jiang, Y.3    Tang, G.4    Sun, C.5    Fang, C.6    Shi, B.7    Pei, Y.8
  • 27
    • 84896778645 scopus 로고    scopus 로고
    • Cisplatin-alginate conjugate liposomes for targeted delivery to EGFR-positive ovarian cancer cells
    • 24565522 1:CAS:528:DC%2BC2cXivFyjsbY%3D
    • Wang, Y., Zhou, J., Qiu, L., Wang, X., Chen, L., Liu, T., and Di, W. (2014) Cisplatin-alginate conjugate liposomes for targeted delivery to EGFR-positive ovarian cancer cells, Biomaterials, 35, 4297-4309.
    • (2014) Biomaterials , vol.35 , pp. 4297-4309
    • Wang, Y.1    Zhou, J.2    Qiu, L.3    Wang, X.4    Chen, L.5    Liu, T.6    Di, W.7
  • 30
    • 84875356905 scopus 로고    scopus 로고
    • Modular nanotransporters: A versatile approach for enhancing nuclear delivery and cytotoxicity of Auger electron-emitting 125I
    • 23107475 1:CAS:528:DC%2BC3sXpsFOksw%3D%3D 3511205
    • Slastnikova, T. A., Koumarianou, E., Rosenkranz, A. A., Vaidyanathan, G., Lupanova, T. N., Sobolev, A. S., and Zalutsky, M. R. (2012) Modular nanotransporters: a versatile approach for enhancing nuclear delivery and cytotoxicity of Auger electron-emitting 125I, EJNMMI Res., 2, 59.
    • (2012) EJNMMI Res. , vol.2 , pp. 59
    • Slastnikova, T.A.1    Koumarianou, E.2    Rosenkranz, A.A.3    Vaidyanathan, G.4    Lupanova, T.N.5    Sobolev, A.S.6    Zalutsky, M.R.7
  • 31
    • 49549090470 scopus 로고    scopus 로고
    • Engineered modular recombinant transporters: Application of new platform for targeted radiotherapeutic agents to alpha-particle emitting 211At
    • 18722270 1:CAS:528:DC%2BD1cXhtVamu7zF 2834178
    • Rosenkranz, A. A., Vaidyanathan, G., Pozzi, O. R., Lunin, V. G., Zalutsky, M. R., and Sobolev, A. S. (2008) Engineered modular recombinant transporters: application of new platform for targeted radiotherapeutic agents to alpha-particle emitting 211At, Int. J. Radiat. Oncol. Biol. Phys., 72, 193-200.
    • (2008) Int. J. Radiat. Oncol. Biol. Phys. , vol.72 , pp. 193-200
    • Rosenkranz, A.A.1    Vaidyanathan, G.2    Pozzi, O.R.3    Lunin, V.G.4    Zalutsky, M.R.5    Sobolev, A.S.6
  • 32
    • 84870383721 scopus 로고    scopus 로고
    • Functional coating of liposomes using a folate-polymer conjugate to target folate receptors
    • 1:CAS:528:DC%2BC38XhtVyisrfK
    • Watanabe, K., Kaneko, M., and Maitani, Y. (2012) Functional coating of liposomes using a folate-polymer conjugate to target folate receptors, Int. J. Nanomed., 7, 3679-3688.
    • (2012) Int. J. Nanomed. , vol.7 , pp. 3679-3688
    • Watanabe, K.1    Kaneko, M.2    Maitani, Y.3
  • 33
    • 17644366858 scopus 로고    scopus 로고
    • A folate receptor-targeted lipid nanoparticle formulation for a lipophilic paclitaxel prodrug
    • 15648245 1:CAS:528:DC%2BD2MXjslOqsA%3D%3D
    • Stevens, P. J., Sekido, M., and Lee, R. J. (2004) A folate receptor-targeted lipid nanoparticle formulation for a lipophilic paclitaxel prodrug, Pharm. Res., 21, 2153-2157.
    • (2004) Pharm. Res. , vol.21 , pp. 2153-2157
    • Stevens, P.J.1    Sekido, M.2    Lee, R.J.3
  • 34
    • 84891854386 scopus 로고    scopus 로고
    • Precedent: A randomized phase II trial comparing vintafolide (EC145) and pegylated liposomal doxorubicin (PLD) in combination versus PLD alone in patients with platinum-resistant ovarian cancer
    • 24127448 1:CAS:528:DC%2BC2cXjt1Shtrc%3D
    • Naumann, R. W., Coleman, R. L., Burger, R. A., Sausville, E. A., Kutarska, E., Ghamande, S. A., Gabrail, N. Y., DePasquale, S. E., Nowara, E., and Gilbert, L. (2013) Precedent: a randomized phase II trial comparing vintafolide (EC145) and pegylated liposomal doxorubicin (PLD) in combination versus PLD alone in patients with platinum-resistant ovarian cancer, J. Clin. Oncol., 31, 4400-4406.
    • (2013) J. Clin. Oncol. , vol.31 , pp. 4400-4406
    • Naumann, R.W.1    Coleman, R.L.2    Burger, R.A.3    Sausville, E.A.4    Kutarska, E.5    Ghamande, S.A.6    Gabrail, N.Y.7    Depasquale, S.E.8    Nowara, E.9    Gilbert, L.10
  • 35
    • 84876083926 scopus 로고    scopus 로고
    • PH-responsive complexes using prefunctionalized polymers for synchronous delivery of doxorubicin and siRNA to cancer cells
    • 23541420 1:CAS:528:DC%2BC3sXkslWktLo%3D
    • Dong, D. W., Xiang, B., Gao, W., Yang, Z. Z., Li, J. Q., and Qi, X. R. (2013) pH-responsive complexes using prefunctionalized polymers for synchronous delivery of doxorubicin and siRNA to cancer cells, Biomaterials, 34, 4849-4859.
    • (2013) Biomaterials , vol.34 , pp. 4849-4859
    • Dong, D.W.1    Xiang, B.2    Gao, W.3    Yang, Z.Z.4    Li, J.Q.5    Qi, X.R.6
  • 36
    • 82955172978 scopus 로고    scopus 로고
    • Tumor specific delivery and therapy by double-targeted nanostructured lipid carriers with anti-VEGFR-2 antibody
    • 1:CAS:528:DC%2BC3MXhtlKksLvP
    • Liu, D., Liu, F., Liu, Z., Wang, L., and Zhang, N. (2011) Tumor specific delivery and therapy by double-targeted nanostructured lipid carriers with anti-VEGFR-2 antibody, Mol. Pharmaceutics, 8, 2291-2301.
    • (2011) Mol. Pharmaceutics , vol.8 , pp. 2291-2301
    • Liu, D.1    Liu, F.2    Liu, Z.3    Wang, L.4    Zhang, N.5
  • 40
    • 56949097756 scopus 로고    scopus 로고
    • Paclitaxel-octreotide conjugates in tumor growth inhibition of A549 human non-small cell lung cancer xenografted into nude mice
    • 18983839 1:CAS:528:DC%2BD1cXhsVKrsbrK
    • Shen, H., Hu, D., Du, J., Wang, X., Liu, Y., Wang, Y., Wei, J. M., Ma, D., Wang, P., and Li, L. (2008) Paclitaxel-octreotide conjugates in tumor growth inhibition of A549 human non-small cell lung cancer xenografted into nude mice, Eur. J. Pharmacol., 601, 23-29.
    • (2008) Eur. J. Pharmacol. , vol.601 , pp. 23-29
    • Shen, H.1    Hu, D.2    Du, J.3    Wang, X.4    Liu, Y.5    Wang, Y.6    Wei, J.M.7    Ma, D.8    Wang, P.9    Li, L.10
  • 41
    • 84866728365 scopus 로고    scopus 로고
    • Spatiotemporally controlled co-delivery of anti-vasculature agent and cytotoxic drug by octreotide-modified stealth liposomes
    • 1:CAS:528:DC%2BC38XovFejs7c%3D
    • Dai, W., Jin, W., Zhang, J., Wang, X., Wang, J., Zhang, X., Wan, Y., and Zhang, Q. (2012) Spatiotemporally controlled co-delivery of anti-vasculature agent and cytotoxic drug by octreotide-modified stealth liposomes, Pharmac. Res., 29, 2902-2911.
    • (2012) Pharmac. Res. , vol.29 , pp. 2902-2911
    • Dai, W.1    Jin, W.2    Zhang, J.3    Wang, X.4    Wang, J.5    Zhang, X.6    Wan, Y.7    Zhang, Q.8
  • 42
    • 84876030679 scopus 로고    scopus 로고
    • Effect of octreotide surface density on receptor-mediated endocytosis in vitro and anticancer efficacy of modified nanocarrier in vivo after optimization
    • 1:CAS:528:DC%2BC3sXjvFehu7Y%3D
    • Su, Z., Shi, Y., Xiao, Y., Sun, M., Ping, Q., Zong, L., Li, S., Niu, J., Huang, A., and You, W. (2013) Effect of octreotide surface density on receptor-mediated endocytosis in vitro and anticancer efficacy of modified nanocarrier in vivo after optimization, Int. J. Pharmaceutics, 447, 281-292.
    • (2013) Int. J. Pharmaceutics , vol.447 , pp. 281-292
    • Su, Z.1    Shi, Y.2    Xiao, Y.3    Sun, M.4    Ping, Q.5    Zong, L.6    Li, S.7    Niu, J.8    Huang, A.9    You, W.10
  • 43
    • 84856480241 scopus 로고    scopus 로고
    • Dual functional octreotide GAP modified liposomal irinotecan leads to high therapeutic efficacy for medullary thyroid carcinoma xenografts
    • 22017398 1:CAS:528:DC%2BC38Xis1OhsrY%3D
    • Iwase, Y., and Maitani, Y. (2012) Dual functional octreotide GAP modified liposomal irinotecan leads to high therapeutic efficacy for medullary thyroid carcinoma xenografts, Cancer Sci., 103, 310-316.
    • (2012) Cancer Sci. , vol.103 , pp. 310-316
    • Iwase, Y.1    Maitani, Y.2
  • 44
    • 84889102624 scopus 로고    scopus 로고
    • Improvement of pharmacokinetic and antitumor activity of PEGylated liposomal doxorubicin by targeting with Nmethylated cyclic RGD peptide in mice bearing C-26 colon carcinomas
    • 1:CAS:528:DC%2BC3sXhslCnurfF
    • Amin, M., Badiee, A., and Jaafari, M. R. (2013) Improvement of pharmacokinetic and antitumor activity of PEGylated liposomal doxorubicin by targeting with Nmethylated cyclic RGD peptide in mice bearing C-26 colon carcinomas, Int. J. Pharmaceutics, 458, 324-333.
    • (2013) Int. J. Pharmaceutics , vol.458 , pp. 324-333
    • Amin, M.1    Badiee, A.2    Jaafari, M.R.3
  • 46
    • 0034857882 scopus 로고    scopus 로고
    • An adenovirus with enhanced infectivity mediates molecular chemotherapy of ovarian cancer cells and allows imaging of gene expression
    • 11545613 1:CAS:528:DC%2BD38XhvFGqu7c%3D
    • Hemminki, A., Belousova, N., Zinn, K. R., Liu, B., Wang, M., Chaudhuri, T. R., Rogers, B. E., Buchsbaum, D. J., Siegal, G. P., and Barnes, M. N. (2001) An adenovirus with enhanced infectivity mediates molecular chemotherapy of ovarian cancer cells and allows imaging of gene expression, Mol. Ther., 4, 223-231.
    • (2001) Mol. Ther. , vol.4 , pp. 223-231
    • Hemminki, A.1    Belousova, N.2    Zinn, K.R.3    Liu, B.4    Wang, M.5    Chaudhuri, T.R.6    Rogers, B.E.7    Buchsbaum, D.J.8    Siegal, G.P.9    Barnes, M.N.10
  • 47
    • 84896719524 scopus 로고    scopus 로고
    • Nanopreparations for organelle-specific delivery in cancer
    • 24270008 1:CAS:528:DC%2BC3sXhvFGhsr3F
    • Biswas, S., and Torchilin, V. P. (2014) Nanopreparations for organelle-specific delivery in cancer, Adv. Drug Deliv. Rev., 66, 26-41.
    • (2014) Adv. Drug Deliv. Rev. , vol.66 , pp. 26-41
    • Biswas, S.1    Torchilin, V.P.2
  • 48
    • 33748126226 scopus 로고    scopus 로고
    • Recent approaches to intracellular delivery of drugs and DNA and organelle targeting
    • 16834560 1:CAS:528:DC%2BD28Xpt1CltLk%3D
    • Torchilin, V. P. (2006) Recent approaches to intracellular delivery of drugs and DNA and organelle targeting, Annu. Rev. Biomed. Eng., 8, 343-375.
    • (2006) Annu. Rev. Biomed. Eng. , vol.8 , pp. 343-375
    • Torchilin, V.P.1
  • 49
    • 80051718862 scopus 로고    scopus 로고
    • Targeting of lysosomes by liposomes modified with octadecyl-rhodamine B
    • 21275828 1:CAS:528:DC%2BC3MXhtVSmtLnF 4116792
    • Koshkaryev, A., Thekkedath, R., Pagano, C., Meerovich, I., and Torchilin, V. P. (2011) Targeting of lysosomes by liposomes modified with octadecyl-rhodamine B, J. Drug Target, 19, 606-614.
    • (2011) J. Drug Target , vol.19 , pp. 606-614
    • Koshkaryev, A.1    Thekkedath, R.2    Pagano, C.3    Meerovich, I.4    Torchilin, V.P.5
  • 50
    • 49349090381 scopus 로고    scopus 로고
    • Lysosomes and oxidative stress in aging and apoptosis
    • 18255041 1:CAS:528:DC%2BD1cXhtVarsbfK
    • Kurz, T., Terman, A., Gustafsson, B., and Brunk, U. T. (2008) Lysosomes and oxidative stress in aging and apoptosis, Biochim. Biophys. Acta, 1780, 1291-1303.
    • (2008) Biochim. Biophys. Acta , vol.1780 , pp. 1291-1303
    • Kurz, T.1    Terman, A.2    Gustafsson, B.3    Brunk, U.T.4
  • 51
    • 84856384153 scopus 로고    scopus 로고
    • Increased apoptosis in cancer cells in vitro and in vivo by ceramides in transferrin-modified liposomes
    • 22336588 1:CAS:528:DC%2BC38Xlt1OmsL0%3D 3335981
    • Koshkaryev, A., Piroyan, A., and Torchilin, V. P. (2012) Increased apoptosis in cancer cells in vitro and in vivo by ceramides in transferrin-modified liposomes, Cancer Biol. Ther., 13, 50-60.
    • (2012) Cancer Biol. Ther. , vol.13 , pp. 50-60
    • Koshkaryev, A.1    Piroyan, A.2    Torchilin, V.P.3
  • 54
    • 84885320396 scopus 로고    scopus 로고
    • Retrograde trafficking of AB(5) toxins: Mechanisms to therapeutics
    • 1:CAS:528:DC%2BC3sXhsFektrrN
    • Mukhopadhyay, S., and Linstedt, A. D. (2013) Retrograde trafficking of AB(5) toxins: mechanisms to therapeutics, J. Mol. Med. (Berl.), 91, 1131-1141.
    • (2013) J. Mol. Med. (Berl.) , vol.91 , pp. 1131-1141
    • Mukhopadhyay, S.1    Linstedt, A.D.2
  • 55
    • 0033607688 scopus 로고    scopus 로고
    • Dependence of ricin toxicity on translocation of the toxin A-chain from the endoplasmic reticulum to the cytosol
    • 10567425 1:CAS:528:DyaK1MXnslOktbk%3D
    • Wesche, J., Rapak, A., and Olsnes, S. (1999) Dependence of ricin toxicity on translocation of the toxin A-chain from the endoplasmic reticulum to the cytosol, J. Biol. Chem., 274, 34443-34449.
    • (1999) J. Biol. Chem. , vol.274 , pp. 34443-34449
    • Wesche, J.1    Rapak, A.2    Olsnes, S.3
  • 56
    • 84856074275 scopus 로고    scopus 로고
    • Manganese blocks intracellular trafficking of Shiga toxin and protects against Shiga toxicosis
    • 22267811 1:CAS:528:DC%2BC38XntlGiuw%3D%3D
    • Mukhopadhyay, S., and Linstedt, A. D. (2012) Manganese blocks intracellular trafficking of Shiga toxin and protects against Shiga toxicosis, Science, 335, 332-335.
    • (2012) Science , vol.335 , pp. 332-335
    • Mukhopadhyay, S.1    Linstedt, A.D.2
  • 57
    • 75749125021 scopus 로고    scopus 로고
    • Shiga toxins - From cell biology to biomedical applications
    • 20023663 1:CAS:528:DC%2BD1MXhsFyhsLnP
    • Johannes, L., and Romer, W. (2010) Shiga toxins - from cell biology to biomedical applications, Nat. Rev. Microbiol., 8, 105-116.
    • (2010) Nat. Rev. Microbiol. , vol.8 , pp. 105-116
    • Johannes, L.1    Romer, W.2
  • 59
    • 55949093770 scopus 로고    scopus 로고
    • Synthesis and properties of a mitochondrial peripheral benzodiazepine receptor conjugate
    • El, A. A., Schmidt, F., Sarr, M., Decaudin, D., Florent, J. C., and Johannes, L. (2008) Synthesis and properties of a mitochondrial peripheral benzodiazepine receptor conjugate, Chem. Med. Chem., 3, 1687-1695.
    • (2008) Chem. Med. Chem. , vol.3 , pp. 1687-1695
    • El, A.A.1    Schmidt, F.2    Sarr, M.3    Decaudin, D.4    Florent, J.C.5    Johannes, L.6
  • 64
    • 84866777366 scopus 로고    scopus 로고
    • Chapter two - Adenovirus strategies for tissue-specific targeting
    • 23021241 1:CAS:528:DC%2BC38XhvVWht7%2FK 3664935
    • Beatty, M. S., and Curiel, D. T. (2012) Chapter two - adenovirus strategies for tissue-specific targeting, Adv. Cancer Res., 115, 39-67.
    • (2012) Adv. Cancer Res. , vol.115 , pp. 39-67
    • Beatty, M.S.1    Curiel, D.T.2
  • 65
    • 84966315481 scopus 로고    scopus 로고
    • Endocytosis of nonenveloped DNA viruses
    • B. Ceresa (eds)
    • Boisvert, M., and Tijssen, P. (2012) Endocytosis of nonenveloped DNA viruses, in Molecular Regulation of Endocytosis, Chap. 17 (Ceresa, B., ed.) InTech; http://dx.doi.org/ 10.5772/45821.
    • (2012) Molecular Regulation of Endocytosis
    • Boisvert, M.1    Tijssen, P.2
  • 66
    • 4644298997 scopus 로고    scopus 로고
    • Adenovirus endocytosis
    • 14978758
    • Meier, O., and Greber, U. F. (2004) Adenovirus endocytosis, J. Gene Med., 6,Suppl. 1, S152-S163.
    • (2004) J. Gene Med. , vol.6 , pp. 152-S163
    • Meier, O.1    Greber, U.F.2
  • 67
    • 0020711710 scopus 로고
    • Adenovirus-induced release of epidermal growth factor and pseudomonas toxin into the cytosol of KB cells during receptor-mediated endocytosis
    • 6130853 1:CAS:528:DyaL3sXhtlyitbk%3D
    • FitzGerald, D. J., Padmanabhan, R., Pastan, I., and Willingham, M. C. (1983) Adenovirus-induced release of epidermal growth factor and pseudomonas toxin into the cytosol of KB cells during receptor-mediated endocytosis, Cell, 32, 607-617.
    • (1983) Cell , vol.32 , pp. 607-617
    • Fitzgerald, D.J.1    Padmanabhan, R.2    Pastan, I.3    Willingham, M.C.4
  • 68
    • 0028464351 scopus 로고
    • Strategies to achieve targeted gene delivery via the receptor-mediated endocytosis pathway
    • 7584085 1:CAS:528:DyaK2cXmsVCktL8%3D
    • Michael, S. I., and Curiel, D. T. (1994) Strategies to achieve targeted gene delivery via the receptor-mediated endocytosis pathway, Gene Ther., 1, 223-232.
    • (1994) Gene Ther. , vol.1 , pp. 223-232
    • Michael, S.I.1    Curiel, D.T.2
  • 69
    • 84881596511 scopus 로고    scopus 로고
    • PH-Triggered conformational switching along the membrane insertion pathway of the diphtheria toxin T-domain
    • 1:CAS:528:DC%2BC3sXht12mtLbI
    • Ladokhin, A. S. (2013) pH-Triggered conformational switching along the membrane insertion pathway of the diphtheria toxin T-domain, Toxins (Basel), 5, 1362-1380.
    • (2013) Toxins (Basel) , vol.5 , pp. 1362-1380
    • Ladokhin, A.S.1
  • 71
    • 0034081629 scopus 로고    scopus 로고
    • Topography of diphtheria toxin's T domain in the open channel state
    • 10736310 1:CAS:528:DC%2BD3cXis1emtbc%3D 2233753
    • Senzel, L., Gordon, M., Blaustein, R. O., Oh, K. J., Collier, R. J., and Finkelstein, A. (2000) Topography of diphtheria toxin's T domain in the open channel state, J. Gen. Physiol., 115, 421-434.
    • (2000) J. Gen. Physiol. , vol.115 , pp. 421-434
    • Senzel, L.1    Gordon, M.2    Blaustein, R.O.3    Oh, K.J.4    Collier, R.J.5    Finkelstein, A.6
  • 72
    • 0030886648 scopus 로고    scopus 로고
    • Probing the structure of the diphtheria toxin channel. Reactivity in planar lipid bilayer membranes of cysteine-substituted mutant channels with methanethiosulfonate derivatives
    • 9276751 1:CAS:528:DyaK2sXmt1Wlurg%3D 2229367
    • Huynh, P. D., Cui, C., Zhan, H., Oh, K. J., Collier, R. J., and Finkelstein, A. (1997) Probing the structure of the diphtheria toxin channel. Reactivity in planar lipid bilayer membranes of cysteine-substituted mutant channels with methanethiosulfonate derivatives, J. Gen. Physiol., 110, 229-242.
    • (1997) J. Gen. Physiol. , vol.110 , pp. 229-242
    • Huynh, P.D.1    Cui, C.2    Zhan, H.3    Oh, K.J.4    Collier, R.J.5    Finkelstein, A.6
  • 73
    • 84878229869 scopus 로고    scopus 로고
    • Crucial role of H322 in folding of the diphtheria toxin T-domain into the openchannel state
    • 23621842 1:CAS:528:DC%2BC3sXms1ehs7w%3D
    • Vargas-Uribe, M., Rodnin, M. V., Kienker, P., Finkelstein, A., and Ladokhin, A. S. (2013) Crucial role of H322 in folding of the diphtheria toxin T-domain into the openchannel state, Biochemistry, 52, 3457-3463.
    • (2013) Biochemistry , vol.52 , pp. 3457-3463
    • Vargas-Uribe, M.1    Rodnin, M.V.2    Kienker, P.3    Finkelstein, A.4    Ladokhin, A.S.5
  • 74
    • 79953236969 scopus 로고    scopus 로고
    • Mechanism of diphtheria toxin catalytic domain delivery to the eukaryotic cell cytosol and the cellular factors that directly participate in the process
    • 1:CAS:528:DC%2BC3MXktl2rtL0%3D
    • Murphy, J. R. (2011) Mechanism of diphtheria toxin catalytic domain delivery to the eukaryotic cell cytosol and the cellular factors that directly participate in the process, Toxins (Basel), 3, 294-308.
    • (2011) Toxins (Basel) , vol.3 , pp. 294-308
    • Murphy, J.R.1
  • 75
    • 0033215457 scopus 로고    scopus 로고
    • Diphtheria toxin forms pores of different sizes depending on its concentration in membranes: Probable relationship to oligomerization
    • 10501829 1:CAS:528:DyaK1MXmsFCntrk%3D
    • Sharpe, J. C., and London, E. (1999) Diphtheria toxin forms pores of different sizes depending on its concentration in membranes: probable relationship to oligomerization, J. Membr. Biol., 171, 209-221.
    • (1999) J. Membr. Biol. , vol.171 , pp. 209-221
    • Sharpe, J.C.1    London, E.2
  • 76
    • 44049097488 scopus 로고    scopus 로고
    • Oligomerization of membrane-bound diphtheria toxin (CRM197) facilitates a transition to the open form and deep insertion
    • 18055530 1:CAS:528:DC%2BD1cXjtlGqtLs%3D 2257914
    • Kent, M. S., Yim, H., Murton, J. K., Satija, S., Majewski, J., and Kuzmenko, I. (2008) Oligomerization of membrane-bound diphtheria toxin (CRM197) facilitates a transition to the open form and deep insertion, Biophys. J., 94, 2115-2127.
    • (2008) Biophys. J. , vol.94 , pp. 2115-2127
    • Kent, M.S.1    Yim, H.2    Murton, J.K.3    Satija, S.4    Majewski, J.5    Kuzmenko, I.6
  • 79
    • 84920275922 scopus 로고    scopus 로고
    • Studies on the pore formation in lipid layers by modular transporters containing the translocational domain of the diphtheria toxin
    • Rosenkranz, A. A., Khramtsov, Y. V., Trusov, G. A., Gnuchev, N. V., and Sobolev, A. S. (2008) Studies on the pore formation in lipid layers by modular transporters containing the translocational domain of the diphtheria toxin, Dokl. Ros. Akad. Nauk, 421, 385-387.
    • (2008) Dokl. Ros. Akad. Nauk , vol.421 , pp. 385-387
    • Rosenkranz, A.A.1    Khramtsov, Y.V.2    Trusov, G.A.3    Gnuchev, N.V.4    Sobolev, A.S.5
  • 80
    • 40349106008 scopus 로고    scopus 로고
    • Modular transporters for subcellular cell-specific targeting of anti-tumor drugs
    • 18293370 1:CAS:528:DC%2BD1cXkt1Oitrs%3D
    • Sobolev, A. S. (2008) Modular transporters for subcellular cell-specific targeting of anti-tumor drugs, Bioessays, 30, 278-287.
    • (2008) Bioessays , vol.30 , pp. 278-287
    • Sobolev, A.S.1
  • 81
    • 84869236539 scopus 로고    scopus 로고
    • Improving the endosomal escape of cell-penetrating peptides and their cargos: Strategies and challenges
    • 1:CAS:528:DC%2BC38XhvVagsrzL
    • Erazo-Oliveras, A., Muthukrishnan, N., Baker, R., Wang, T. Y., and Pellois, J. P. (2012) Improving the endosomal escape of cell-penetrating peptides and their cargos: strategies and challenges, Pharmaceuticals (Basel), 5, 1177-1209.
    • (2012) Pharmaceuticals (Basel) , vol.5 , pp. 1177-1209
    • Erazo-Oliveras, A.1    Muthukrishnan, N.2    Baker, R.3    Wang, T.Y.4    Pellois, J.P.5
  • 82
    • 0024209811 scopus 로고
    • Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein
    • 2849509 1:CAS:528:DyaL1MXhtlSksr0%3D
    • Green, M., and Loewenstein, P. M. (1988) Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein, Cell, 55, 1179-1188.
    • (1988) Cell , vol.55 , pp. 1179-1188
    • Green, M.1    Loewenstein, P.M.2
  • 83
    • 84873034419 scopus 로고    scopus 로고
    • Modeling the endosomal escape of cell-penetrating peptides using a transmembrane pH gradient
    • 23261392 1:CAS:528:DC%2BC3sXivFyit7Y%3D
    • Madani, F., Abdo, R., Lindberg, S., Hirose, H., Futaki, S., Langel, U., and Graslund, A. (2013) Modeling the endosomal escape of cell-penetrating peptides using a transmembrane pH gradient, Biochim. Biophys. Acta, 1828, 1198-1204.
    • (2013) Biochim. Biophys. Acta , vol.1828 , pp. 1198-1204
    • Madani, F.1    Abdo, R.2    Lindberg, S.3    Hirose, H.4    Futaki, S.5    Langel, U.6    Graslund, A.7
  • 84
    • 75449096829 scopus 로고    scopus 로고
    • Molecular electroporation and the transduction of oligoarginines
    • 20009189
    • Cahill, K. (2009) Molecular electroporation and the transduction of oligoarginines, Phys. Biol., 7, 16001.
    • (2009) Phys. Biol. , vol.7 , pp. 16001
    • Cahill, K.1
  • 85
    • 78650350127 scopus 로고    scopus 로고
    • Generation of endosomolytic reagents by branching of cell-penetrating peptides: Tools for the delivery of bioactive compounds to live cells in cis or trans
    • 21043514 1:CAS:528:DC%2BC3cXhtlKntb3L 3074029
    • Angeles-Boza, A. M., Erazo-Oliveras, A., Lee, Y. J., and Pellois, J. P. (2010) Generation of endosomolytic reagents by branching of cell-penetrating peptides: tools for the delivery of bioactive compounds to live cells in cis or trans, Bioconjug. Chem., 21, 2164-2167.
    • (2010) Bioconjug. Chem. , vol.21 , pp. 2164-2167
    • Angeles-Boza, A.M.1    Erazo-Oliveras, A.2    Lee, Y.J.3    Pellois, J.P.4
  • 86
    • 1942438691 scopus 로고    scopus 로고
    • Membrane-destabilizing polyanions: Interaction with lipid bilayers and endosomal escape of biomacromolecules
    • 15066757 1:CAS:528:DC%2BD2cXivVGitLc%3D
    • Yessine, M. A., and Leroux, J. C. (2004) Membrane-destabilizing polyanions: interaction with lipid bilayers and endosomal escape of biomacromolecules, Adv. Drug Deliv. Rev., 56, 999-1021.
    • (2004) Adv. Drug Deliv. Rev. , vol.56 , pp. 999-1021
    • Yessine, M.A.1    Leroux, J.C.2
  • 87
    • 1942438703 scopus 로고    scopus 로고
    • GALA: A designed synthetic pH-responsive amphipathic peptide with applications in drug and gene delivery
    • 15066755 1:CAS:528:DC%2BD2cXivVGitLk%3D
    • Li, W., Nicol, F., and Szoka, F. C., Jr. (2004) GALA: a designed synthetic pH-responsive amphipathic peptide with applications in drug and gene delivery, Adv. Drug Deliv. Rev., 56, 967-985.
    • (2004) Adv. Drug Deliv. Rev. , vol.56 , pp. 967-985
    • Li, W.1    Nicol, F.2    Szoka, Jr.F.C.3
  • 88
    • 0023805559 scopus 로고
    • Membrane fusion by peptide analogues of influenza virus haemagglutinin
    • 3404116 1:CAS:528:DyaL1cXlvVGrt7s%3D
    • Wharton, S. A., Martin, S. R., Ruigrok, R. W., Skehel, J. J., and Wiley, D. C. (1988) Membrane fusion by peptide analogues of influenza virus haemagglutinin, J. Gen. Virol., 69, 1847-1857.
    • (1988) J. Gen. Virol. , vol.69 , pp. 1847-1857
    • Wharton, S.A.1    Martin, S.R.2    Ruigrok, R.W.3    Skehel, J.J.4    Wiley, D.C.5
  • 92
    • 0029160083 scopus 로고
    • A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: Polyethylenimine
    • 7638184 1:CAS:528:DyaK2MXntlKmt7s%3D 41326
    • Boussif, O., Lezoualch, F., Zanta, M. A., Mergny, M. D., Scherman, D., Demeneix, B., and Behr, J. P. (1995) A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine, Proc. Natl. Acad. Sci. USA, 92, 7297-7301.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 7297-7301
    • Boussif, O.1    Lezoualch, F.2    Zanta, M.A.3    Mergny, M.D.4    Scherman, D.5    Demeneix, B.6    Behr, J.P.7
  • 93
    • 0242414440 scopus 로고    scopus 로고
    • Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes
    • 12944394 1:CAS:528:DC%2BD3sXoslWlsbw%3D
    • Sonawane, N. D., Szoka, F. C., Jr., and Verkman, A. S. (2003) Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes, J. Biol. Chem., 278, 44826-44831.
    • (2003) J. Biol. Chem. , vol.278 , pp. 44826-44831
    • Sonawane, N.D.1    Szoka, Jr.F.C.2    Verkman, A.S.3
  • 94
    • 84871918550 scopus 로고    scopus 로고
    • The possible "proton sponge" effect of polyethylenimine (PEI) does not include change in lysosomal pH
    • 23032976 1:CAS:528:DC%2BC38XhsVegs7%2FL 3538306
    • Benjaminsen, R. V., Mattebjerg, M. A., Henriksen, J. R., Moghimi, S. M., and Andresen, T. L. (2013) The possible "proton sponge" effect of polyethylenimine (PEI) does not include change in lysosomal pH, Mol. Ther., 21, 149-157.
    • (2013) Mol. Ther. , vol.21 , pp. 149-157
    • Benjaminsen, R.V.1    Mattebjerg, M.A.2    Henriksen, J.R.3    Moghimi, S.M.4    Andresen, T.L.5
  • 95
    • 1242292220 scopus 로고    scopus 로고
    • Partial acetylation of polyethylenimine enhances in vitro gene delivery
    • 15032320 1:CAS:528:DC%2BD2cXhtlWqsbY%3D
    • Forrest, M. L., Meister, G. E., Koerber, J. T., and Pack, D. W. (2004) Partial acetylation of polyethylenimine enhances in vitro gene delivery, Pharm. Res., 21, 365-371.
    • (2004) Pharm. Res. , vol.21 , pp. 365-371
    • Forrest, M.L.1    Meister, G.E.2    Koerber, J.T.3    Pack, D.W.4
  • 97
    • 33748374275 scopus 로고    scopus 로고
    • Acetylation of polyethylenimine enhances gene delivery via weakened polymer/DNA interactions
    • 16903692 1:CAS:528:DC%2BD28Xmt1Khs70%3D
    • Gabrielson, N. P., and Pack, D. W. (2006) Acetylation of polyethylenimine enhances gene delivery via weakened polymer/DNA interactions, Biomacromolecules, 7, 2427-2435.
    • (2006) Biomacromolecules , vol.7 , pp. 2427-2435
    • Gabrielson, N.P.1    Pack, D.W.2
  • 98
    • 76749144992 scopus 로고    scopus 로고
    • Intracellular fate of bioresponsive poly(amidoamine)s in vitro and in vivo
    • 19822175 1:CAS:528:DC%2BC3cXhs1Sgt7c%3D
    • Richardson, S. C., Pattrick, N. G., Lavignac, N., Ferruti, P., and Duncan, R. (2010) Intracellular fate of bioresponsive poly(amidoamine)s in vitro and in vivo, J. Control Release, 142, 78-88.
    • (2010) J. Control Release , vol.142 , pp. 78-88
    • Richardson, S.C.1    Pattrick, N.G.2    Lavignac, N.3    Ferruti, P.4    Duncan, R.5
  • 99
    • 0033651746 scopus 로고    scopus 로고
    • High-generation polycationic dendrimers are unusually effective at disrupting anionic vesicles: Membrane bending model
    • 11087328 1:CAS:528:DC%2BD3cXmsFeisL8%3D
    • Zhang, Z. Y., and Smith, B. D. (2000) High-generation polycationic dendrimers are unusually effective at disrupting anionic vesicles: membrane bending model, Bioconjug. Chem., 11, 805-814.
    • (2000) Bioconjug. Chem. , vol.11 , pp. 805-814
    • Zhang, Z.Y.1    Smith, B.D.2
  • 100
    • 0031782223 scopus 로고    scopus 로고
    • Effects of polyethyleneimine on endocytosis and lysosome stability
    • 9698087 1:CAS:528:DyaK1cXksFantbk%3D
    • Klemm, A. R., Young, D., and Lloyd, J. B. (1998) Effects of polyethyleneimine on endocytosis and lysosome stability, Biochem. Pharmacol., 56, 41-46.
    • (1998) Biochem. Pharmacol. , vol.56 , pp. 41-46
    • Klemm, A.R.1    Young, D.2    Lloyd, J.B.3
  • 101
    • 65849206909 scopus 로고    scopus 로고
    • Shape reconstruction of subcellular structures from live cell fluorescence microscopy images
    • 19358891 1:CAS:528:DC%2BD1MXms12gs74%3D
    • Helmuth, J. A., Burckhardt, C. J., Greber, U. F., and Sbalzarini, I. F. (2009) Shape reconstruction of subcellular structures from live cell fluorescence microscopy images, J. Struct. Biol., 167, 1-10.
    • (2009) J. Struct. Biol. , vol.167 , pp. 1-10
    • Helmuth, J.A.1    Burckhardt, C.J.2    Greber, U.F.3    Sbalzarini, I.F.4
  • 102
    • 55249112680 scopus 로고    scopus 로고
    • The conjugation of diphtheria toxin T domain to poly (ethylenimine) based vectors for enhanced endosomal escape during gene transfection
    • 18930314 1:CAS:528:DC%2BD1cXhtlCkt7bK
    • Kakimoto, S., Hamada, T., Komatsu, Y., Takagi, M., Tanabe, T., Azuma, H., Shinkai, S., and Nagasaki, T. (2009) The conjugation of diphtheria toxin T domain to poly (ethylenimine) based vectors for enhanced endosomal escape during gene transfection, Biomaterials, 30, 402-408.
    • (2009) Biomaterials , vol.30 , pp. 402-408
    • Kakimoto, S.1    Hamada, T.2    Komatsu, Y.3    Takagi, M.4    Tanabe, T.5    Azuma, H.6    Shinkai, S.7    Nagasaki, T.8
  • 103
    • 77952323111 scopus 로고    scopus 로고
    • Enhanced internalization and endosomal escape of dual-functionalized poly(ethyleneimine)s polyplex with diphtheria toxin T and R domains
    • 20347568 1:CAS:528:DC%2BC3cXltFyku7s%3D
    • Kakimoto, S., Tanabe, T., Azuma, H., and Nagasaki, T. (2010) Enhanced internalization and endosomal escape of dual-functionalized poly(ethyleneimine)s polyplex with diphtheria toxin T and R domains, Biomed. Pharmacother., 64, 296-301.
    • (2010) Biomed. Pharmacother. , vol.64 , pp. 296-301
    • Kakimoto, S.1    Tanabe, T.2    Azuma, H.3    Nagasaki, T.4
  • 104
    • 0029949266 scopus 로고    scopus 로고
    • Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection
    • 8639519 1:CAS:528:DyaK28XisV2jsbg%3D
    • Xu, Y., and Szoka, F. C., Jr. (1996) Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection, Biochemistry, 35, 5616-5623.
    • (1996) Biochemistry , vol.35 , pp. 5616-5623
    • Xu, Y.1    Szoka, Jr.F.C.2
  • 105
    • 17644419268 scopus 로고    scopus 로고
    • Nonbilayer phase of lipoplex-membrane mixture determines endosomal escape of genetic cargo and transfection efficiency
    • 15851018 1:CAS:528:DC%2BD2MXjsFGqtrw%3D
    • Zuhorn, I. S., Bakowsky, U., Polushkin, E., Visser, W. H., Stuart, M. C., Engberts, J. B., and Hoekstra, D. (2005) Nonbilayer phase of lipoplex-membrane mixture determines endosomal escape of genetic cargo and transfection efficiency, Mol. Ther., 11, 801-810.
    • (2005) Mol. Ther. , vol.11 , pp. 801-810
    • Zuhorn, I.S.1    Bakowsky, U.2    Polushkin, E.3    Visser, W.H.4    Stuart, M.C.5    Engberts, J.B.6    Hoekstra, D.7
  • 106
    • 83655184310 scopus 로고    scopus 로고
    • Modular nanotransporters of anticancer drugs attaching them cellular specificity and increased efficiency
    • Sobolev, A. S. (2009) Modular nanotransporters of anticancer drugs attaching them cellular specificity and increased efficiency, Usp. Biol. Khim., 49, 389-404.
    • (2009) Usp. Biol. Khim. , vol.49 , pp. 389-404
    • Sobolev, A.S.1
  • 109
    • 0034048924 scopus 로고    scopus 로고
    • Chromosomes are target sites for photodynamic therapy as demonstrated by subcellular laser microirradiation
    • 10836549 1:CAS:528:DC%2BD3cXjsVCqur8%3D
    • Liang, H., Do, T., Kasravi, S., Aurasteh, P., Nguyen, A., Huang, A., Wang, Z., and Berns, M. W. (2000) Chromosomes are target sites for photodynamic therapy as demonstrated by subcellular laser microirradiation, J. Photochem. Photobiol. B, 54, 175-184.
    • (2000) J. Photochem. Photobiol. B , vol.54 , pp. 175-184
    • Liang, H.1    Do, T.2    Kasravi, S.3    Aurasteh, P.4    Nguyen, A.5    Huang, A.6    Wang, Z.7    Berns, M.W.8
  • 110
    • 84860918448 scopus 로고    scopus 로고
    • Photodynamic efficacy of photosensitizers under an attenuated light dose via lipid nanocarrier-mediated nuclear targeting
    • 22560197 1:CAS:528:DC%2BC38XmsFCltL4%3D
    • Ling, D., Bae, B. C., Park, W., and Na, K. (2012) Photodynamic efficacy of photosensitizers under an attenuated light dose via lipid nanocarrier-mediated nuclear targeting, Biomaterials, 33, 5478-5486.
    • (2012) Biomaterials , vol.33 , pp. 5478-5486
    • Ling, D.1    Bae, B.C.2    Park, W.3    Na, K.4
  • 111
    • 80052242015 scopus 로고    scopus 로고
    • 223Ra in targeted alpha-particle radiotherapy
    • 22202151 1:CAS:528:DC%2BC3MXht1GnsrfO 3368371
    • 223Ra in targeted alpha-particle radiotherapy, Curr. Radiopharm., 4, 283-294.
    • (2011) Curr. Radiopharm. , vol.4 , pp. 283-294
    • Vaidyanathan, G.1    Zalutsky, M.R.2
  • 113
    • 80054108776 scopus 로고    scopus 로고
    • Nuclear drug delivery for cancer chemotherapy
    • 21846484 1:CAS:528:DC%2BC3MXhtlWmt7jM
    • Sui, M., Liu, W., and Shen, Y. (2011) Nuclear drug delivery for cancer chemotherapy, J. Control Release, 155, 227-236.
    • (2011) J. Control Release , vol.155 , pp. 227-236
    • Sui, M.1    Liu, W.2    Shen, Y.3
  • 114
    • 84874224527 scopus 로고    scopus 로고
    • The effective nuclear delivery of doxorubicin from dextran-coated gold nanoparticles larger than nuclear pores
    • 23395274 1:CAS:528:DC%2BC3sXit1els7o%3D
    • Jang, H., Ryoo, S. R., Kostarelos, K., Han, S. W., and Min, D. H. (2013) The effective nuclear delivery of doxorubicin from dextran-coated gold nanoparticles larger than nuclear pores, Biomaterials, 34, 3503-3510.
    • (2013) Biomaterials , vol.34 , pp. 3503-3510
    • Jang, H.1    Ryoo, S.R.2    Kostarelos, K.3    Han, S.W.4    Min, D.H.5
  • 115
    • 0033991590 scopus 로고    scopus 로고
    • Cytoarchitecture and physical properties of cytoplasm: Volume, viscosity, diffusion, intracellular surface area
    • 10553280 1:CAS:528:DC%2BD3cXlsVSrtA%3D%3D
    • Luby-Phelps, K. (2000) Cytoarchitecture and physical properties of cytoplasm: volume, viscosity, diffusion, intracellular surface area, Int. Rev. Cytol., 192, 189-221.
    • (2000) Int. Rev. Cytol. , vol.192 , pp. 189-221
    • Luby-Phelps, K.1
  • 116
    • 84883390305 scopus 로고    scopus 로고
    • The physical chemistry of cytoplasm and its influence on cell function: An update
    • 23989722 1:CAS:528:DC%2BC3sXhsVSgtrzJ 3756912
    • Luby-Phelps, K. (2013) The physical chemistry of cytoplasm and its influence on cell function: an update, Mol. Biol. Cell, 24, 2593-2596.
    • (2013) Mol. Biol. Cell , vol.24 , pp. 2593-2596
    • Luby-Phelps, K.1
  • 117
    • 0038699018 scopus 로고    scopus 로고
    • Role of the cytoskeleton in nuclear import
    • 12788539 1:CAS:528:DC%2BD3sXkt1yntbk%3D
    • Campbell, E. M., and Hope, T. J. (2003) Role of the cytoskeleton in nuclear import, Adv. Drug Deliv. Rev., 55, 761-771.
    • (2003) Adv. Drug Deliv. Rev. , vol.55 , pp. 761-771
    • Campbell, E.M.1    Hope, T.J.2
  • 118
    • 84855845666 scopus 로고    scopus 로고
    • Artificial viruses: Exploiting viral trafficking for therapeutics
    • 22034936 1:CAS:528:DC%2BC38XhsVKks7c%3D
    • Glover, D. J. (2012) Artificial viruses: exploiting viral trafficking for therapeutics, Infect. Disord. Drug Targets, 12, 68-80.
    • (2012) Infect. Disord. Drug Targets , vol.12 , pp. 68-80
    • Glover, D.J.1
  • 119
    • 0033960789 scopus 로고    scopus 로고
    • Membrane trafficking, organelle transport, and the cytoskeleton
    • 10679352 1:CAS:528:DC%2BD3cXhsVOjtr4%3D
    • Rogers, S. L., and Gelfand, V. I. (2000) Membrane trafficking, organelle transport, and the cytoskeleton, Curr. Opin. Cell Biol., 12, 57-62.
    • (2000) Curr. Opin. Cell Biol. , vol.12 , pp. 57-62
    • Rogers, S.L.1    Gelfand, V.I.2
  • 120
    • 84896777002 scopus 로고    scopus 로고
    • Navigating the cell: How motors overcome roadblocks and traffic jams to efficiently transport cargo
    • 24557020 1:CAS:528:DC%2BC2cXjslCqsb4%3D
    • Lakadamyali, M. (2014) Navigating the cell: how motors overcome roadblocks and traffic jams to efficiently transport cargo, Phys. Chem. Chem. Phys., 16, 5907-5916.
    • (2014) Phys. Chem. Chem. Phys. , vol.16 , pp. 5907-5916
    • Lakadamyali, M.1
  • 121
    • 0026657897 scopus 로고
    • Mitosis-specific phosphorylation of the nuclear oncoproteins Myc and Myb
    • 1500422 1:STN:280:DyaK38zmtl2hsw%3D%3D
    • Luscher, B., and Eisenman, R. N. (1992) Mitosis-specific phosphorylation of the nuclear oncoproteins Myc and Myb, J. Cell Biol., 118, 775-784.
    • (1992) J. Cell Biol. , vol.118 , pp. 775-784
    • Luscher, B.1    Eisenman, R.N.2
  • 122
    • 0033969934 scopus 로고    scopus 로고
    • Microtubule binding to Smads may regulate TGF beta activity
    • 10678166 1:CAS:528:DC%2BD3cXpvFKnsg%3D%3D
    • Dong, C., Li, Z., Alvarez, R., Jr., Feng, X. H., and Goldschmidt-Clermont, P. J. (2000) Microtubule binding to Smads may regulate TGF beta activity, Mol. Cell, 5, 27-34.
    • (2000) Mol. Cell , vol.5 , pp. 27-34
    • Dong, C.1    Li, Z.2    Alvarez, Jr.R.3    Feng, X.H.4    Goldschmidt-Clermont, P.J.5
  • 123
    • 0034306461 scopus 로고    scopus 로고
    • P53 is associated with cellular microtubules and is transported to the nucleus by dynein
    • 11025661 1:CAS:528:DC%2BD3cXnsVyntL0%3D
    • Giannakakou, P., Sackett, D. L., Ward, Y., Webster, K. R., Blagosklonny, M. V., and Fojo, T. (2000) p53 is associated with cellular microtubules and is transported to the nucleus by dynein, Nat. Cell Biol., 2, 709-717.
    • (2000) Nat. Cell Biol. , vol.2 , pp. 709-717
    • Giannakakou, P.1    Sackett, D.L.2    Ward, Y.3    Webster, K.R.4    Blagosklonny, M.V.5    Fojo, T.6
  • 124
    • 0036159923 scopus 로고    scopus 로고
    • Nuclear transport of parathyroid hormone (PTH)-related protein is dependent on microtubules
    • 11818509 1:CAS:528:DC%2BD38XhtV2iuro%3D
    • Lam, M. H., Thomas, R. J., Loveland, K. L., Schilders, S., Gu, M., Martin, T. J., Gillespie, M. T., and Jans, D. A. (2002) Nuclear transport of parathyroid hormone (PTH)-related protein is dependent on microtubules, Mol. Endocrinol., 16, 390-401.
    • (2002) Mol. Endocrinol. , vol.16 , pp. 390-401
    • Lam, M.H.1    Thomas, R.J.2    Loveland, K.L.3    Schilders, S.4    Gu, M.5    Martin, T.J.6    Gillespie, M.T.7    Jans, D.A.8
  • 125
    • 33745649610 scopus 로고    scopus 로고
    • A role for the cytoskeleton in STAT5 activation in MCF7 human breast cancer cells stimulated with EGF
    • 16765629 1:CAS:528:DC%2BD28Xms1ans7c%3D
    • Lopez-Perez, M., and Salazar, E. P. (2006) A role for the cytoskeleton in STAT5 activation in MCF7 human breast cancer cells stimulated with EGF, Int. J. Biochem. Cell Biol., 38, 1716-1728.
    • (2006) Int. J. Biochem. Cell Biol. , vol.38 , pp. 1716-1728
    • Lopez-Perez, M.1    Salazar, E.P.2
  • 126
    • 79954623914 scopus 로고    scopus 로고
    • Mechanism of microtubule-facilitated "fast track" nuclear import
    • 21339293 1:CAS:528:DC%2BC3MXkslWisrc%3D 3077634
    • Roth, D. M., Moseley, G. W., Pouton, C. W., and Jans, D. A. (2011) Mechanism of microtubule-facilitated "fast track" nuclear import, J. Biol. Chem., 286, 14335-14351.
    • (2011) J. Biol. Chem. , vol.286 , pp. 14335-14351
    • Roth, D.M.1    Moseley, G.W.2    Pouton, C.W.3    Jans, D.A.4
  • 127
    • 34249045739 scopus 로고    scopus 로고
    • A microtubule-facilitated nuclear import pathway for cancer regulatory proteins
    • 17511743 1:CAS:528:DC%2BD2sXmt1OnsL0%3D
    • Roth, D. M., Moseley, G. W., Glover, D., Pouton, C. W., and Jans, D. A. (2007) A microtubule-facilitated nuclear import pathway for cancer regulatory proteins, Traffic, 8, 673-686.
    • (2007) Traffic , vol.8 , pp. 673-686
    • Roth, D.M.1    Moseley, G.W.2    Glover, D.3    Pouton, C.W.4    Jans, D.A.5
  • 129
    • 73749084696 scopus 로고    scopus 로고
    • Enhancement of protein transduction-mediated nuclear delivery by interaction with dynein/microtubules
    • 19958802 1:CAS:528:DC%2BC3cXnt1agtg%3D%3D
    • Moseley, G. W., Leyton, D. L., Glover, D. J., Filmer, R. P., and Jans, D. A. (2010) Enhancement of protein transduction-mediated nuclear delivery by interaction with dynein/microtubules, J. Biotechnol., 145, 222-225.
    • (2010) J. Biotechnol. , vol.145 , pp. 222-225
    • Moseley, G.W.1    Leyton, D.L.2    Glover, D.J.3    Filmer, R.P.4    Jans, D.A.5
  • 130
    • 33847176295 scopus 로고    scopus 로고
    • Molecular mechanism of the nuclear protein import cycle
    • 17287812 1:CAS:528:DC%2BD2sXitVGrsr0%3D
    • Stewart, M. (2007) Molecular mechanism of the nuclear protein import cycle, Nat. Rev. Mol. Cell Biol., 8, 195-208.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 195-208
    • Stewart, M.1
  • 131
    • 79960912049 scopus 로고    scopus 로고
    • Nuclear import by karyopherin-betas: Recognition and inhibition
    • 21029754 1:CAS:528:DC%2BC3MXpsFKntbc%3D 3135726
    • Chook, Y. M., and Suel, K. E. (2011) Nuclear import by karyopherin-betas: recognition and inhibition, Biochim. Biophys. Acta, 1813, 1593-1606.
    • (2011) Biochim. Biophys. Acta , vol.1813 , pp. 1593-1606
    • Chook, Y.M.1    Suel, K.E.2
  • 132
    • 78649650714 scopus 로고    scopus 로고
    • Recognition of nuclear targeting signals by karyopherin-beta proteins
    • 20951026 1:CAS:528:DC%2BC3cXhsV2js77E 2994982
    • Xu, D., Farmer, A., and Chook, Y. M. (2010) Recognition of nuclear targeting signals by karyopherin-beta proteins, Curr. Opin. Struct. Biol., 20, 782-790.
    • (2010) Curr. Opin. Struct. Biol. , vol.20 , pp. 782-790
    • Xu, D.1    Farmer, A.2    Chook, Y.M.3
  • 133
    • 11144241881 scopus 로고    scopus 로고
    • A tumor cell-specific nuclear targeting signal within chicken anemia virus VP3/apoptin
    • 15613363 1:CAS:528:DC%2BD2MXlt12lug%3D%3D 538590
    • Poon, I. K., Oro, C., Dias, M. M., Zhang, J. P., and Jans, D. A. (2005) A tumor cell-specific nuclear targeting signal within chicken anemia virus VP3/apoptin, J. Virol., 79, 1339-1341.
    • (2005) J. Virol. , vol.79 , pp. 1339-1341
    • Poon, I.K.1    Oro, C.2    Dias, M.M.3    Zhang, J.P.4    Jans, D.A.5
  • 135
    • 84906526439 scopus 로고    scopus 로고
    • SeqNLS: Nuclear localization signal prediction based on frequent pattern mining and linear motif scoring
    • 24204689 1:CAS:528:DC%2BC3sXhslehsbnI 3812174
    • Lin, J. R., and Hu, J. (2013) SeqNLS: nuclear localization signal prediction based on frequent pattern mining and linear motif scoring, PLoS One, 8, e76864.
    • (2013) PLoS One , vol.8 , pp. 76864
    • Lin, J.R.1    Hu, J.2
  • 136
    • 79960915158 scopus 로고    scopus 로고
    • The importin beta binding domain as a master regulator of nucleocytoplasmic transport
    • 21029753 1:CAS:528:DC%2BC3MXpsFKntbY%3D 3037977
    • Lott, K., and Cingolani, G. (2011) The importin beta binding domain as a master regulator of nucleocytoplasmic transport, Biochim. Biophys. Acta, 1813, 1578-1592.
    • (2011) Biochim. Biophys. Acta , vol.1813 , pp. 1578-1592
    • Lott, K.1    Cingolani, G.2
  • 137
    • 58649104919 scopus 로고    scopus 로고
    • Six classes of nuclear localization signals specific to different binding grooves of importin alpha
    • 19001369 1:CAS:528:DC%2BD1cXhsFCjtLrE
    • Kosugi, S., Hasebe, M., Matsumura, N., Takashima, H., Miyamoto-Sato, E., Tomita, M., and Yanagawa, H. (2009) Six classes of nuclear localization signals specific to different binding grooves of importin alpha, J. Biol. Chem., 284, 478-485.
    • (2009) J. Biol. Chem. , vol.284 , pp. 478-485
    • Kosugi, S.1    Hasebe, M.2    Matsumura, N.3    Takashima, H.4    Miyamoto-Sato, E.5    Tomita, M.6    Yanagawa, H.7
  • 138
    • 84885579408 scopus 로고    scopus 로고
    • Stimulated nuclear import by beta-like importins
    • 24167722 3790567
    • Flores, K., and Seger, R. (2013) Stimulated nuclear import by beta-like importins, F1000Prime. Rep., 5, 41.
    • (2013) F1000Prime. Rep. , vol.5 , pp. 41
    • Flores, K.1    Seger, R.2
  • 139
    • 67649845784 scopus 로고    scopus 로고
    • Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs
    • 19520826 1:CAS:528:DC%2BD1MXot1Gktb0%3D 2695404
    • Kosugi, S., Hasebe, M., Tomita, M., and Yanagawa, H. (2009) Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs, Proc. Natl. Acad. Sci. USA, 106, 10171-10176.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 10171-10176
    • Kosugi, S.1    Hasebe, M.2    Tomita, M.3    Yanagawa, H.4
  • 140
    • 67650718130 scopus 로고    scopus 로고
    • NLStradamus: A simple hidden Markov model for nuclear localization signal prediction
    • 19563654 2711084
    • Nguyen Ba, A. N., Pogoutse, A., Provart, N., and Moses, A. M. (2009) NLStradamus: a simple hidden Markov model for nuclear localization signal prediction, BMC Bioinformatics, 10, 202.
    • (2009) BMC Bioinformatics , vol.10 , pp. 202
    • Nguyen Ba, A.N.1    Pogoutse, A.2    Provart, N.3    Moses, A.M.4
  • 141
    • 84857739015 scopus 로고    scopus 로고
    • Global enhancement of nuclear localization-dependent nuclear transport in transformed cells
    • 22155563 1:CAS:528:DC%2BC38Xjt12ntLk%3D
    • Kuusisto, H. V., Wagstaff, K. M., Alvisi, G., Roth, D. M., and Jans, D. A. (2012) Global enhancement of nuclear localization-dependent nuclear transport in transformed cells, FASEB J., 26, 1181-1193.
    • (2012) FASEB J. , vol.26 , pp. 1181-1193
    • Kuusisto, H.V.1    Wagstaff, K.M.2    Alvisi, G.3    Roth, D.M.4    Jans, D.A.5
  • 142
    • 84858005605 scopus 로고    scopus 로고
    • Nuclear export of proteins and drug resistance in cancer
    • 22209898 1:CAS:528:DC%2BC38XjsFKru78%3D
    • Turner, J. G., Dawson, J., and Sullivan, D. M. (2012) Nuclear export of proteins and drug resistance in cancer, Biochem. Pharmacol., 83, 1021-1032.
    • (2012) Biochem. Pharmacol. , vol.83 , pp. 1021-1032
    • Turner, J.G.1    Dawson, J.2    Sullivan, D.M.3
  • 144
    • 18344368870 scopus 로고    scopus 로고
    • HAMLET kills tumor cells by apoptosis: Structure, cellular mechanisms, and therapy
    • 15867328 1:CAS:528:DC%2BD2MXktFKiurg%3D
    • Gustafsson, L., Hallgren, O., Mossberg, A. K., Pettersson, J., Fischer, W., Aronsson, A., and Svanborg, C. (2005) HAMLET kills tumor cells by apoptosis: structure, cellular mechanisms, and therapy, J. Nutr., 135, 1299-1303.
    • (2005) J. Nutr. , vol.135 , pp. 1299-1303
    • Gustafsson, L.1    Hallgren, O.2    Mossberg, A.K.3    Pettersson, J.4    Fischer, W.5    Aronsson, A.6    Svanborg, C.7
  • 145
    • 84934444496 scopus 로고    scopus 로고
    • Apoptosis and tumor cell death in response to HAMLET (human alphalactalbumin made lethal to tumor cells)
    • 18183931 1:CAS:528:DC%2BC3cXhtleqsr3L
    • Hallgren, O., Aits, S., Brest, P., Gustafsson, L., Mossberg, A. K., Wullt, B., and Svanborg, C. (2008) Apoptosis and tumor cell death in response to HAMLET (human alphalactalbumin made lethal to tumor cells), Adv. Exp. Med. Biol., 606, 217-240.
    • (2008) Adv. Exp. Med. Biol. , vol.606 , pp. 217-240
    • Hallgren, O.1    Aits, S.2    Brest, P.3    Gustafsson, L.4    Mossberg, A.K.5    Wullt, B.6    Svanborg, C.7
  • 146
    • 32544447245 scopus 로고    scopus 로고
    • Cancer-selective therapy of the future: Apoptin and its mechanism of action
    • 16410718 1:CAS:528:DC%2BD28XkvVSntrw%3D
    • Maddika, S., Mendoza, F. J., Hauff, K., Zamzow, C. R., Paranjothy, T., and Los, M. (2006) Cancer-selective therapy of the future: apoptin and its mechanism of action, Cancer Biol. Ther., 5, 10-19.
    • (2006) Cancer Biol. Ther. , vol.5 , pp. 10-19
    • Maddika, S.1    Mendoza, F.J.2    Hauff, K.3    Zamzow, C.R.4    Paranjothy, T.5    Los, M.6
  • 147
    • 57349110738 scopus 로고    scopus 로고
    • The C-terminus of apoptin represents a unique tumor cell-enhanced nuclear targeting module
    • 18798550 1:CAS:528:DC%2BD1cXhsVKgt7%2FL
    • Kuusisto, H. V., Wagstaff, K. M., Alvisi, G., and Jans, D. A. (2008) The C-terminus of apoptin represents a unique tumor cell-enhanced nuclear targeting module, Int. J. Cancer, 123, 2965-2969.
    • (2008) Int. J. Cancer , vol.123 , pp. 2965-2969
    • Kuusisto, H.V.1    Wagstaff, K.M.2    Alvisi, G.3    Jans, D.A.4
  • 151
    • 33746215103 scopus 로고    scopus 로고
    • Apoptin nucleocytoplasmic shuttling is required for cell type-specific localization, apoptosis, and recruitment of the anaphase-promoting complex/cyclosome to PML bodies
    • 16840333 1:CAS:528:DC%2BD28XnsVWgtLg%3D 1563728
    • Heilman, D. W., Teodoro, J. G., and Green, M. R. (2006) Apoptin nucleocytoplasmic shuttling is required for cell type-specific localization, apoptosis, and recruitment of the anaphase-promoting complex/cyclosome to PML bodies, J. Virol., 80, 7535-7545.
    • (2006) J. Virol. , vol.80 , pp. 7535-7545
    • Heilman, D.W.1    Teodoro, J.G.2    Green, M.R.3
  • 152
    • 81255167458 scopus 로고    scopus 로고
    • DNA damage response signaling triggers nuclear localization of the chicken anemia virus protein Apoptin
    • 21937663 1:CAS:528:DC%2BC3MXhsFaks7bJ 3209404
    • Kucharski, T. J., Gamache, I., Gjoerup, O., and Teodoro, J. G. (2011) DNA damage response signaling triggers nuclear localization of the chicken anemia virus protein Apoptin, J. Virol., 85, 12638-12649.
    • (2011) J. Virol. , vol.85 , pp. 12638-12649
    • Kucharski, T.J.1    Gamache, I.2    Gjoerup, O.3    Teodoro, J.G.4
  • 153
    • 33846573396 scopus 로고    scopus 로고
    • Apoptin T108 phosphorylation is not required for its tumor-specific nuclear localization but partially affects its apoptotic activity
    • 17223075 1:CAS:528:DC%2BD2sXhtlOgsbc%3D
    • Lee, Y. H., Cheng, C. M., Chang, Y. F., Wang, T. Y., and Yuo, C. Y. (2007) Apoptin T108 phosphorylation is not required for its tumor-specific nuclear localization but partially affects its apoptotic activity, Biochem. Biophys. Res. Commun., 354, 391-395.
    • (2007) Biochem. Biophys. Res. Commun. , vol.354 , pp. 391-395
    • Lee, Y.H.1    Cheng, C.M.2    Chang, Y.F.3    Wang, T.Y.4    Yuo, C.Y.5
  • 154
    • 84870341677 scopus 로고    scopus 로고
    • Fabrication and characterization of nuclear localization signal-conjugated glycol chitosan micelles for improving the nuclear delivery of doxorubicin
    • 1:CAS:528:DC%2BC38XhsFylu77M
    • Yu, J., Xie, X., Zheng, M., Yu, L., Zhang, L., Zhao, J., Jiang, D., and Che, X. (2012) Fabrication and characterization of nuclear localization signal-conjugated glycol chitosan micelles for improving the nuclear delivery of doxorubicin, Int. J. Nanomed., 7, 5079-5090.
    • (2012) Int. J. Nanomed. , vol.7 , pp. 5079-5090
    • Yu, J.1    Xie, X.2    Zheng, M.3    Yu, L.4    Zhang, L.5    Zhao, J.6    Jiang, D.7    Che, X.8
  • 155
    • 0032860574 scopus 로고    scopus 로고
    • Nuclear targeting peptide scaffolds for lipofection of nondividing mammalian cells
    • 10471928 1:CAS:528:DyaK1MXlslOgtbg%3D
    • Subramanian, A., Ranganathan, P., and Diamond, S. L. (1999) Nuclear targeting peptide scaffolds for lipofection of nondividing mammalian cells, Nat. Biotechnol., 17, 873-877.
    • (1999) Nat. Biotechnol. , vol.17 , pp. 873-877
    • Subramanian, A.1    Ranganathan, P.2    Diamond, S.L.3
  • 156
    • 76949098852 scopus 로고    scopus 로고
    • 99mTc-labeled recombinant VEGF bioconjugates: In vitro evaluation of their cytotoxicity on porcine aortic endothelial cells overexpressing Flt-1 receptors
    • 20152709 1:CAS:528:DC%2BC3cXhs1ygt7s%3D
    • 99mTc-labeled recombinant VEGF bioconjugates: in vitro evaluation of their cytotoxicity on porcine aortic endothelial cells overexpressing Flt-1 receptors, Nucl. Med. Biol., 37, 105-115.
    • (2010) Nucl. Med. Biol. , vol.37 , pp. 105-115
    • Chan, C.1    Cai, Z.2    Su, R.3    Reilly, R.M.4
  • 157
    • 0033231352 scopus 로고    scopus 로고
    • Potentiation of chlorin e6 photodynamic activity in vitro with peptide-based intracellular vehicles
    • 10563767 1:CAS:528:DyaK1MXmsF2rsr0%3D
    • Bisland, S. K., Singh, D., and Gariepy, J. (1999) Potentiation of chlorin e6 photodynamic activity in vitro with peptide-based intracellular vehicles, Bioconjug. Chem., 10, 982-992.
    • (1999) Bioconjug. Chem. , vol.10 , pp. 982-992
    • Bisland, S.K.1    Singh, D.2    Gariepy, J.3
  • 158
    • 0031719662 scopus 로고    scopus 로고
    • Mutual exclusivity of DNA binding and nuclear localization signal recognition by the yeast transcription factor GAL4: Implications for nonviral DNA delivery
    • 9930321 1:CAS:528:DyaK1cXmtVOms7w%3D
    • Chan, C. K., Hubner, S., Hu, W., and Jans, D. A. (1998) Mutual exclusivity of DNA binding and nuclear localization signal recognition by the yeast transcription factor GAL4: implications for nonviral DNA delivery, Gene Ther., 5, 1204-1212.
    • (1998) Gene Ther. , vol.5 , pp. 1204-1212
    • Chan, C.K.1    Hubner, S.2    Hu, W.3    Jans, D.A.4
  • 159
    • 84865128398 scopus 로고    scopus 로고
    • Homodimeric SV40 NLS peptide formed by disulfide bond as enhancer for gene delivery
    • 22871581 1:CAS:528:DC%2BC38XhtFGht7zI
    • Kim, B. K., Kang, H., Doh, K. O., Lee, S. H., Park, J. W., Lee, S. J., and Lee, T. J. (2012) Homodimeric SV40 NLS peptide formed by disulfide bond as enhancer for gene delivery, Bioorg. Med. Chem. Lett., 22, 5415-5418.
    • (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 5415-5418
    • Kim, B.K.1    Kang, H.2    Doh, K.O.3    Lee, S.H.4    Park, J.W.5    Lee, S.J.6    Lee, T.J.7
  • 160
    • 84901290282 scopus 로고    scopus 로고
    • Radiolabeling and in vitro evaluation of Ga-NOTA-modular nanotransporter - A potential Auger electron emitting EGFR-targeted radiotherapeutic
    • 24776093 1:CAS:528:DC%2BC2cXntFGjs7c%3D
    • Koumarianou, E., Slastnikova, T. A., Pruszynski, M., Rosenkranz, A. A., Vaidyanathan, G., Sobolev, A. S., and Zalutsky, M. R. (2014) Radiolabeling and in vitro evaluation of Ga-NOTA-modular nanotransporter - a potential Auger electron emitting EGFR-targeted radiotherapeutic, Nucl. Med. Biol., 41, 441-449.
    • (2014) Nucl. Med. Biol. , vol.41 , pp. 441-449
    • Koumarianou, E.1    Slastnikova, T.A.2    Pruszynski, M.3    Rosenkranz, A.A.4    Vaidyanathan, G.5    Sobolev, A.S.6    Zalutsky, M.R.7
  • 162
    • 78650770785 scopus 로고    scopus 로고
    • Targeting the nucleus: An overview of Auger-electron radionuclide therapy
    • 21034408 1:CAS:528:DC%2BC3cXhsFGgtbfL
    • Cornelissen, B., and Vallis, K. A. (2010) Targeting the nucleus: an overview of Auger-electron radionuclide therapy, Curr. Drug Discov. Technol., 7, 263-279.
    • (2010) Curr. Drug Discov. Technol. , vol.7 , pp. 263-279
    • Cornelissen, B.1    Vallis, K.A.2
  • 163
    • 70349554208 scopus 로고    scopus 로고
    • Targeting mitochondria with organelle-specific compounds: Strategies and applications
    • 19637148 1:CAS:528:DC%2BD1MXhtVSnsr%2FO
    • Yousif, L. F., Stewart, K. M., and Kelley, S. O. (2009) Targeting mitochondria with organelle-specific compounds: strategies and applications, Chembiochem., 10, 1939-1950.
    • (2009) Chembiochem. , vol.10 , pp. 1939-1950
    • Yousif, L.F.1    Stewart, K.M.2    Kelley, S.O.3
  • 164
    • 70349554126 scopus 로고    scopus 로고
    • Mitochondria-penetrating peptides: Sequence effects and model cargo transport
    • 19670199 1:CAS:528:DC%2BD1MXhtVSnsr7M
    • Yousif, L. F., Stewart, K. M., Horton, K. L., and Kelley, S. O. (2009) Mitochondria-penetrating peptides: sequence effects and model cargo transport, Chembiochem., 10, 2081-2088.
    • (2009) Chembiochem. , vol.10 , pp. 2081-2088
    • Yousif, L.F.1    Stewart, K.M.2    Horton, K.L.3    Kelley, S.O.4
  • 165
    • 77953508445 scopus 로고    scopus 로고
    • Mitochondria as a target in treatment
    • 20175113 1:CAS:528:DC%2BC3cXnsVWgt7w%3D 2920596
    • Frantz, M. C., and Wipf, P. (2010) Mitochondria as a target in treatment, Environ. Mol. Mutagen., 51, 462-475.
    • (2010) Environ. Mol. Mutagen. , vol.51 , pp. 462-475
    • Frantz, M.C.1    Wipf, P.2
  • 167
    • 84864323386 scopus 로고    scopus 로고
    • PNPase and RNA trafficking into mitochondria
    • 22023881 1:CAS:528:DC%2BC38XhtVykt77L 3267854
    • Wang, G., Shimada, E., Koehler, C. M., and Teitell, M. A. (2012) PNPase and RNA trafficking into mitochondria, Biochim. Biophys. Acta, 1819, 998-1007.
    • (2012) Biochim. Biophys. Acta , vol.1819 , pp. 998-1007
    • Wang, G.1    Shimada, E.2    Koehler, C.M.3    Teitell, M.A.4
  • 168
    • 84880445847 scopus 로고    scopus 로고
    • Organelle targeting: Third level of drug targeting
    • 1:CAS:528:DC%2BC3sXht1ajurrI
    • Sakhrani, N. M., and Padh, H. (2013) Organelle targeting: third level of drug targeting, Drug Design Devel. Therap., 7, 585-599.
    • (2013) Drug Design Devel. Therap. , vol.7 , pp. 585-599
    • Sakhrani, N.M.1    Padh, H.2
  • 169
    • 36849049303 scopus 로고    scopus 로고
    • Mannose 6-phosphate receptor targeting and its applications in human diseases
    • 18220730 1:CAS:528:DC%2BD1cXhtlSrs74%3D 2793280
    • Gary-Bobo, M., Nirde, P., Jeanjean, A., Morere, A., and Garcia, M. (2007) Mannose 6-phosphate receptor targeting and its applications in human diseases, Curr. Med. Chem., 14, 2945-2953.
    • (2007) Curr. Med. Chem. , vol.14 , pp. 2945-2953
    • Gary-Bobo, M.1    Nirde, P.2    Jeanjean, A.3    Morere, A.4    Garcia, M.5
  • 170
    • 79954999115 scopus 로고    scopus 로고
    • Controlling subcellular delivery to optimize therapeutic effect
    • 21113240 1:CAS:528:DC%2BC3cXpvFOmt7Y%3D 2989634
    • Mossalam, M., Dixon, A. S., and Lim, C. S. (2010) Controlling subcellular delivery to optimize therapeutic effect, Ther. Deliv., 1, 169-193.
    • (2010) Ther. Deliv. , vol.1 , pp. 169-193
    • Mossalam, M.1    Dixon, A.S.2    Lim, C.S.3
  • 172
    • 74149089955 scopus 로고    scopus 로고
    • Intracellular trafficking of nuclear localization signal conjugated nanoparticles for cancer therapy
    • 19961929 1:CAS:528:DC%2BC3cXotVyntQ%3D%3D
    • Misra, R., and Sahoo, S. K. (2010) Intracellular trafficking of nuclear localization signal conjugated nanoparticles for cancer therapy, Eur. J. Pharm. Sci., 39, 152-163.
    • (2010) Eur. J. Pharm. Sci. , vol.39 , pp. 152-163
    • Misra, R.1    Sahoo, S.K.2
  • 173
    • 84859356662 scopus 로고    scopus 로고
    • A phthalocyanine-peptide conjugate with high in vitro photodynamic activity and enhanced in vivo tumor-retention property
    • 22378352 1:CAS:528:DC%2BC38XjtVyjsLk%3D
    • Ke, M. R., Yeung, S. L., Fong, W. P., Ng, D. K., and Lo, P. C. (2012) A phthalocyanine-peptide conjugate with high in vitro photodynamic activity and enhanced in vivo tumor-retention property, Chemistry, 18, 4225-4233.
    • (2012) Chemistry , vol.18 , pp. 4225-4233
    • Ke, M.R.1    Yeung, S.L.2    Fong, W.P.3    Ng, D.K.4    Lo, P.C.5
  • 175
    • 77954976593 scopus 로고    scopus 로고
    • 111In-nuclear localization sequence-trastuzumab in athymic mice bearing HER-positive human breast cancer xenografts
    • 20554744 1:CAS:528:DC%2BC3cXhtVWmu7rN
    • 111In-nuclear localization sequence-trastuzumab in athymic mice bearing HER-positive human breast cancer xenografts, J. Nucl. Med., 51, 1084-1091.
    • (2010) J. Nucl. Med. , vol.51 , pp. 1084-1091
    • Costantini, D.L.1    McLarty, K.2    Lee, H.3    Done, S.J.4    Vallis, K.A.5    Reilly, R.M.6
  • 177
    • 84863341737 scopus 로고    scopus 로고
    • Experimental radionuclide therapy of HER2-expressing xenografts using two-step targeting nuclisome particles
    • 22323773 1:CAS:528:DC%2BC38XlvVGgsr0%3D
    • Gedda, L., Fondell, A., Lundqvist, H., Park, J. W., and Edwards, K. (2012) Experimental radionuclide therapy of HER2-expressing xenografts using two-step targeting nuclisome particles, J. Nucl. Med., 53, 480-487.
    • (2012) J. Nucl. Med. , vol.53 , pp. 480-487
    • Gedda, L.1    Fondell, A.2    Lundqvist, H.3    Park, J.W.4    Edwards, K.5
  • 178
    • 27844463051 scopus 로고    scopus 로고
    • Nanotechnology for drug and gene therapy: The importance of understanding molecular mechanisms of delivery
    • 16263259 1:CAS:528:DC%2BD2MXht1GnsrbP
    • Labhasetwar, V. (2005) Nanotechnology for drug and gene therapy: the importance of understanding molecular mechanisms of delivery, Curr. Opin. Biotechnol., 16, 674-680.
    • (2005) Curr. Opin. Biotechnol. , vol.16 , pp. 674-680
    • Labhasetwar, V.1
  • 179
    • 80054108776 scopus 로고    scopus 로고
    • Nuclear drug delivery for cancer chemotherapy
    • 21846484 1:CAS:528:DC%2BC3MXhtlWmt7jM
    • Sui, M., Liu, W., and Shen, Y. (2011) Nuclear drug delivery for cancer chemotherapy, J. Control Release, 155, 227-236.
    • (2011) J. Control Release , vol.155 , pp. 227-236
    • Sui, M.1    Liu, W.2    Shen, Y.3
  • 180
    • 0036998323 scopus 로고    scopus 로고
    • Factors affecting drug and gene delivery: Effects of interaction with blood components
    • 12627613 1:CAS:528:DC%2BD3sXitVymsrc%3D
    • Opanasopit, P., Nishikawa, M., and Hashida, M. (2002) Factors affecting drug and gene delivery: effects of interaction with blood components, Crit. Rev. Ther. Drug Carrier Syst., 19, 191-233.
    • (2002) Crit. Rev. Ther. Drug Carrier Syst. , vol.19 , pp. 191-233
    • Opanasopit, P.1    Nishikawa, M.2    Hashida, M.3
  • 181
    • 0028470454 scopus 로고
    • Barriers to drug delivery in solid tumors
    • 8066425 1:STN:280:DyaK2czksFenuw%3D%3D
    • Jain, R. K. (1994) Barriers to drug delivery in solid tumors, Sci. Am., 271, 58-65.
    • (1994) Sci. Am. , vol.271 , pp. 58-65
    • Jain, R.K.1
  • 182
    • 0032781920 scopus 로고    scopus 로고
    • Understanding barriers to drug delivery: High resolution in vivo imaging is key
    • 10430057 1:STN:280:DyaK1MzlslWhtA%3D%3D
    • Jain, R. K. (1999) Understanding barriers to drug delivery: high resolution in vivo imaging is key, Clin. Cancer Res., 5, 1605-1606.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 1605-1606
    • Jain, R.K.1
  • 183
    • 84859888972 scopus 로고    scopus 로고
    • Urinary protein markers predict the severity of renal histological lesions in children with mesangial proliferative glomerulonephritis
    • 22607047 1:CAS:528:DC%2BC38XhtFeis7zL 3403987
    • Li, Y., Wang, J., Zhu, X., Feng, Q., Li, X., and Feng, X. (2012) Urinary protein markers predict the severity of renal histological lesions in children with mesangial proliferative glomerulonephritis, BMC Nephrol., 13, 29.
    • (2012) BMC Nephrol. , vol.13 , pp. 29
    • Li, Y.1    Wang, J.2    Zhu, X.3    Feng, Q.4    Li, X.5    Feng, X.6
  • 184
    • 33746491709 scopus 로고    scopus 로고
    • Drug penetration in solid tumours
    • 16862189 1:CAS:528:DC%2BD28XntFGlu7w%3D
    • Minchinton, A. I., and Tannock, I. F. (2006) Drug penetration in solid tumours, Nat. Rev. Cancer, 6, 583-592.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 583-592
    • Minchinton, A.I.1    Tannock, I.F.2
  • 185
    • 84864066561 scopus 로고    scopus 로고
    • Overall survival benefit with lapatinib in combination with trastuzumab for patients with human epidermal growth factor receptor 2-positive metastatic breast cancer: Final results from the EGF104900 study
    • 22689807 1:CAS:528:DC%2BC38Xht1ygsr7N
    • Blackwell, K. L., Burstein, H. J., Storniolo, A. M., Rugo, H. S., Sledge, G., Aktan, G., Ellis, C., Florance, A., Vukelja, S., Bischoff, J., Baselga, J., and O'Shaughnessy, J. (2012) Overall survival benefit with lapatinib in combination with trastuzumab for patients with human epidermal growth factor receptor 2-positive metastatic breast cancer: final results from the EGF104900 study, J. Clin. Oncol., 30, 2585-2592.
    • (2012) J. Clin. Oncol. , vol.30 , pp. 2585-2592
    • Blackwell, K.L.1    Burstein, H.J.2    Storniolo, A.M.3    Rugo, H.S.4    Sledge, G.5    Aktan, G.6    Ellis, C.7    Florance, A.8    Vukelja, S.9    Bischoff, J.10    Baselga, J.11    O'Shaughnessy, J.12
  • 186
    • 84869209775 scopus 로고    scopus 로고
    • Accelerating cancer therapy development: The importance of combination strategies and collaboration. Summary of an Institute of Medicine workshop
    • 23065428
    • LoRusso, P. M., Canetta, R., Wagner, J. A., Balogh, E. P., Nass, S. J., Boerner, S. A., and Hohneker, J. (2012) Accelerating cancer therapy development: the importance of combination strategies and collaboration. Summary of an Institute of Medicine workshop, Clin. Cancer Res., 18, 6101-6109.
    • (2012) Clin. Cancer Res. , vol.18 , pp. 6101-6109
    • Lorusso, P.M.1    Canetta, R.2    Wagner, J.A.3    Balogh, E.P.4    Nass, S.J.5    Boerner, S.A.6    Hohneker, J.7
  • 188
    • 0033616614 scopus 로고    scopus 로고
    • Import of DNA into mammalian nuclei by proteins originating from a plant pathogenic bacterium
    • 10097105 1:CAS:528:DyaK1MXjslCiu7o%3D 22362
    • Ziemienowicz, A., Gorlich, D., Lanka, E., Hohn, B., and Rossi, L. (1999) Import of DNA into mammalian nuclei by proteins originating from a plant pathogenic bacterium, Proc. Natl. Acad. Sci. USA, 96, 3729-3733.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 3729-3733
    • Ziemienowicz, A.1    Gorlich, D.2    Lanka, E.3    Hohn, B.4    Rossi, L.5
  • 189
    • 0038176513 scopus 로고    scopus 로고
    • Oligomers of the arginine-rich motif of the HIV-1 TAT protein are capable of transferring plasmid DNA into cells
    • 12519756 1:CAS:528:DC%2BD3sXit1Kgt78%3D
    • Rudolph, C., Plank, C., Lausier, J., Schillinger, U., Muller, R. H., and Rosenecker, J. (2003) Oligomers of the arginine-rich motif of the HIV-1 TAT protein are capable of transferring plasmid DNA into cells, J. Biol. Chem., 278, 11411-11418.
    • (2003) J. Biol. Chem. , vol.278 , pp. 11411-11418
    • Rudolph, C.1    Plank, C.2    Lausier, J.3    Schillinger, U.4    Muller, R.H.5    Rosenecker, J.6
  • 192
    • 16344382551 scopus 로고    scopus 로고
    • Evaluation of nuclear transfer and transcription of plasmid DNA condensed with protamine by microinjection: The use of a nuclear transfer score
    • 15811332 1:CAS:528:DC%2BD2MXjtlWisb4%3D
    • Masuda, T., Akita, H., and Harashima, H. (2005) Evaluation of nuclear transfer and transcription of plasmid DNA condensed with protamine by microinjection: the use of a nuclear transfer score, FEBS Lett., 579, 2143-2148.
    • (2005) FEBS Lett. , vol.579 , pp. 2143-2148
    • Masuda, T.1    Akita, H.2    Harashima, H.3
  • 193
    • 84887468746 scopus 로고    scopus 로고
    • Molecular radiotherapy using cleavable radioimmunoconjugates that target EGFR and gamma-H2AX
    • 23963362 1:CAS:528:DC%2BC3sXhslarsrnI
    • Cornelissen, B., Waller, A., Able, S., and Vallis, K. A. (2013) Molecular radiotherapy using cleavable radioimmunoconjugates that target EGFR and gamma-H2AX, Mol. Cancer Ther., 12, 2472-2482.
    • (2013) Mol. Cancer Ther. , vol.12 , pp. 2472-2482
    • Cornelissen, B.1    Waller, A.2    Able, S.3    Vallis, K.A.4
  • 194
    • 84869047365 scopus 로고    scopus 로고
    • Study of efficiency of the modular nanotransporter for targeted delivery of photosensitizers to melanoma cell nuclei in vivo
    • 23132717 1:CAS:528:DC%2BC38Xhs1ahu7vP 3646556
    • Slastnikova, T. A., Rosenkranz, A. A., Lupanova, T. N., Gulak, P. V., Gnuchev, N. V., and Sobolev, A. S. (2012) Study of efficiency of the modular nanotransporter for targeted delivery of photosensitizers to melanoma cell nuclei in vivo, Dokl. Biochem. Biophys., 446, 235-237.
    • (2012) Dokl. Biochem. Biophys. , vol.446 , pp. 235-237
    • Slastnikova, T.A.1    Rosenkranz, A.A.2    Lupanova, T.N.3    Gulak, P.V.4    Gnuchev, N.V.5    Sobolev, A.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.