Effect of octreotide surface density on receptor-mediated endocytosis in vitro and anticancer efficacy of modified nanocarrier in vivo after optimization

International Journal of Pharmaceutics

Volumn 447, Issue 1-2, 2013, Pages 281-292

  Su, Zhigui ^a   Shi, Yongping ^a   Xiao, Yanyu ^a   Sun, Minjie ^a   Ping, Qineng ^a   Zong, Li ^a   Li, Sai ^a   Niu, Jiangxiu ^b   Huang, Aiwen ^c   You, Weiliang ^a   Chen, Yinan ^a   Chen, Xi ^a   Fei, Jia ^a   Tian, Jia ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b HUANGSHAN UNIVERSITY   (China)

^c FUZHOU GENERAL HOSPITAL   (China)

Author keywords

Ligand surface density; Nanostructured lipid carrier; Octreotide; Tumor targeting

Indexed keywords

CAMPTOTHECIN DERIVATIVE; HYDROXYCAMPTOTHENCINE; MACROGOL STEARATE; NANOCARRIER; OCTREOTIDE; SOMATOSTATIN RECEPTOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; ATOMIC FORCE MICROSCOPY; CANCER INHIBITION; CANCER SIZE; CELL VIABILITY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG RELEASE; DRUG TARGETING; DRUG UPTAKE; ENDOCYTOSIS; FLUORESCENCE IMAGING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NANOENCAPSULATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; QUANTITATIVE STUDY; SURFACE PROPERTY; SURVIVAL TIME; SUSTAINED DRUG RELEASE; TISSUE DISTRIBUTION; ZETA POTENTIAL;

ANIMALS; ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; DRUG CARRIERS; ENDOCYTOSIS; HUMANS; LIPIDS; MICE; MICE, INBRED ICR; NANOPARTICLES; NEOPLASMS; OCTREOTIDE; POLYETHYLENE GLYCOLS; RECEPTORS, SOMATOSTATIN; SURFACE PROPERTIES; TUMOR BURDEN;

EID: 84876030679     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.01.068     Document Type: Article

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