PH-responsive complexes using prefunctionalized polymers for synchronous delivery of doxorubicin and siRNA to cancer cells

Biomaterials

Volumn 34, Issue 20, 2013, Pages 4849-4859

  Dong, Da Wen ^a   Xiang, Bai ^a   Gao, Wei ^a   Yang, Zhen Zhen ^a   Li, Jing Quan ^a   Qi, Xian Rong ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Co delivery; One step self assembly; PH responsive; Prefunctionalized polymer; Target; Tumor microenvironment sensitive nanocarriers

Indexed keywords

CHEMOTHERAPEUTIC DRUGS; CO DELIVERIES; CONFOCAL LASER SCANNING MICROSCOPY; NANO-CARRIERS; PH-RESPONSIVE; SYNERGISTIC ACTION; TARGETED DELIVERY; THERAPEUTIC GENES;

CELLS; CYTOLOGY; FLOW CYTOMETRY; GENETIC ENGINEERING; LOADING; NORMAL DISTRIBUTION; SELF ASSEMBLY; TARGETS; TUMORS;

POLYMERS;

ACID; DOXORUBICIN; FOLIC ACID DERIVATIVE; HYDRAZONE DERIVATIVE; MACROGOL; NANOCARRIER; POLYETHYLENE GLYCOL FOLATE; POLYETHYLENEIMINE; POLYMER; PREFUNCTIONALIZED POLYMER; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER CHEMOTHERAPY; CELL DENSITY; CELL INVASION; CELL PH; CELL SURFACE; CHEMICAL BOND; COMPLEX FORMATION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG MECHANISM; DRUG RELEASE; DRUG SAFETY; ELECTRON SPIN RESONANCE; ENDOSOME; FEMALE; FLOW CYTOMETRY; GENE SILENCING; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LYSOSOME; MOUSE; NON INVASIVE PROCEDURE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UTERINE CERVIX CARCINOMA;

ANIMALS; DOXORUBICIN; DRUG DELIVERY SYSTEMS; ENDOSOMES; FEMALE; FOLIC ACID; GENE SILENCING; GENE TRANSFER TECHNIQUES; HELA CELLS; HUMANS; HYDRAZONES; HYDROGEN-ION CONCENTRATION; INTRACELLULAR SPACE; LIGANDS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASMS; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; RNA, SMALL INTERFERING; TISSUE DISTRIBUTION;

EID: 84876083926     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.03.018     Document Type: Article

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