Improving the endosomal escape of cell-penetrating peptides and their cargos: Strategies and challenges

Pharmaceuticals

Volumn 5, Issue 11, 2012, Pages 1177-1209

  Erazo Oliveras, Alfredo ^a   Muthukrishnan, Nandhini ^a   Baker, Ryan ^a   Wang, Ting Yi ^a   Pellois, Jean Philippe ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Cell penetrating peptide; Endosomal escape; Multivalent peptides; pH dependent membrane active peptides; Photochemical internalization

Indexed keywords

CELL PENETRATING PEPTIDE; FLUOROCHROME; HYBRID PROTEIN; INFLUENZA VIRUS HEMAGGLUTININ TRANSACTIVATOR PROTEIN HYBRID PROTEIN; MELITTIN; MEMBRANE PROTEIN; MULTIVALENT CELL PENETRATING PEPTIDE; PEPTIDE NUCLEIC ACID; PH DEPENDENT MEMBRANE ACTIVE PEPTIDE; PHOSPHATIDYLSERINE; PROTEOHEPARAN SULFATE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; TRANSACTIVATOR PROTEIN CRE RECOMBINASE CONJUGATE; TRANSACTIVATOR PROTEIN PHOSPHATIDYLSERINE CONJUGATE; UNCLASSIFIED DRUG;

ACIDIFICATION; CELL DEATH; CHROMATOPHORE; CONFORMATIONAL TRANSITION; CONJUGATION; CYTOLYSIS; CYTOTOXICITY; DRUG DELIVERY SYSTEM; ENDOCYTOSIS; ENDOSOMAL ESCAPE; ENDOSOMAL LYSIS; ENDOSOME; HUMAN; LIPID BILAYER; MEMBRANE DAMAGE; MOLECULAR DYNAMICS; NONHUMAN; OLIGOMERIZATION; PEPTIDE SYNTHESIS; PH; PHOTOCHEMICAL INTERNALIZATION; PLASMA MEMBRANE TRANSLOCATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; REVIEW; SOLID PHASE PEPTIDE SYNTHESIS;

EID: 84869236539     PISSN: None     EISSN: 14248247     Source Type: Journal    
DOI: 10.3390/ph5111177     Document Type: Review

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