Microdistribution of MC1R-targeted polyplexes in murine melanoma tumor tissue

Biomaterials

Volumn 34, Issue 38, 2013, Pages 10209-10216

  Durymanov, Mikhail O ^a,b   Slastnikova, Tatiana A ^a   Kuzmich, Alexey I ^d   Khramtsov, Yuri V ^a,e   Ulasov, Alexey V ^a,e   Rosenkranz, Andrey A ^a,b,e   Egorov, Sergey Y ^b   Sverdlov, Eugene D ^c,d   Sobolev, Alexander S ^a,b  

^a INSTITUTE OF GENE BIOLOGY   (Russian Federation)

^b MOSCOW STATE UNIVERSITY   (Russian Federation)

^c INSTITUTE OF MOLECULAR GENETICS   (Russian Federation)

^d SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

^e Targeted Delivery of Pharmaceuticals Translek LLC   (Russian Federation)

Author keywords

Block copolymer; Confocal microscopy; Intratumoral distribution; Nanoparticles; Targeted gene transfer; Tumor diagnostics

Indexed keywords

DORSAL SKINFOLD CHAMBERS; INTRATUMORAL DISTRIBUTION; INTRAVENOUS INJECTIONS; INTRAVITAL MICROSCOPY; MELANOCORTIN RECEPTOR-1; MICRODISTRIBUTION; SUBCUTANEOUS TISSUES; TUMOR DIAGNOSTICS;

BLOCK COPOLYMERS; CONFOCAL MICROSCOPY; DERMATOLOGY; GENE EXPRESSION; GENE TRANSFER; NANOPARTICLES; ONCOLOGY; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES;

TUMORS;

COPOLYMER; IODINE 123; LIGAND; MACROGOL; MC1SP PEPTIDE; MELANOCORTIN 1 RECEPTOR; POLYETHYLENEIMINE; QUANTUM DOT; SODIUM IODIDE SYMPORTER; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BLOOD VESSEL WALL; CONTROLLED STUDY; EXTRAVASATION; FEMALE; GENE EXPRESSION; GENE TARGETING; GENE TRANSFER; IN VITRO STUDY; MELANOMA CELL; MICROSCOPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SKINFOLD; SUBCUTANEOUS TISSUE;

MURINAE;

BLOCK-COPOLYMER; CONFOCAL MICROSCOPY; INTRATUMORAL DISTRIBUTION; NANOPARTICLES; TARGETED GENE TRANSFER; TUMOR DIAGNOSTICS;

ANIMALS; CELL LINE; GENE TRANSFER TECHNIQUES; MELANOMA; MICE; MICROSCOPY, CONFOCAL; NANOPARTICLES; POLYMERS; RECEPTOR, MELANOCORTIN, TYPE 1;

EID: 84885383622     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.08.076     Document Type: Article

References (61)

1. Iyer A.K., Khaled G., Fang J., Maeda H. Exploiting the enhanced permeability and retention effect for tumor targeting. Drug Discov Today 2006, 11:812-818.
2. Yuan F., Dellian M., Fukumura D., Leunig M., Berk D.A., Torchilin V.P., et al. Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. Cancer Res 1995, 55:3752-3756.
3. Hashizume H., Baluk P., Morikawa S., McLean J.W., Thurston G., Roberge S., et al. Openings between defective endothelial cells explain tumor vessel leakiness. Am J Pathol 2000, 156:1363-1380.
4. Hobbs S.K., Monsky W.L., Yuan F., Roberts W.G., Griffith L., Torchilin V.P., et al. Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proc Natl Acad Sci U S A 1998, 95:4607-4612.
5. Sarin H. Physiologic upper limits of pore size of different blood capillary types and another perspective on the dual pore theory of microvascular permeability. JAngiogenes Res 2010, 2:14.
6. Mehra N.K., Mishra V., Jain N.K. Receptor-based targeting of therapeutics. Ther Deliv 2013, 4:369-394.
7. Holgado M.A., Martin-Banderas L., Alvarez-Fuentes J., Fernandez-Arevalo M., Arias J.L. Drug targeting to cancer by nanoparticles surface functionalized with special biomolecules. Curr Med Chem 2012, 19:3188-3195.
8. Larson N., Ghandehari H. Polymeric conjugates for drug delivery. Chem Mater 2012, 24:840-853.
9. Ng Q.K., Sutton M.K., Soonsawad P., Xing L., Cheng H., Segura T. Engineering clustered ligand binding into nonviral vectors: alphavbeta3 targeting as an example. Mol Ther 2009, 17:828-836.
10. de Bruin K., Ruthardt N., von Gersdorff K., Bausinger R., Wagner E., Ogris M., et al. Cellular dynamics of EGF receptor-targeted synthetic viruses. Mol Ther 2007, 15:1297-1305.
11. Kursa M., Walker G.F., Roessler V., Ogris M., Roedl W., Kircheis R., et al. Novel shielded transferrin-polyethylene glycol-polyethylenimine/DNA complexes for systemic tumor-targeted gene transfer. Bioconjug Chem 2003, 14:222-231.
12. Cheng H., Zhu J.L., Zeng X., Jing Y., Zhang X.Z., Zhuo R.X. Targeted gene delivery mediated by folate-polyethylenimine-block-poly(ethylene glycol) with receptor selectivity. Bioconjug Chem 2009, 20:481-487.
13. Danquah M.K., Zhang X.A., Mahato R.I. Extravasation of polymeric nanomedicines across tumor vasculature. Adv Drug Deliv Rev 2011, 63:623-639.
14. Maeda H., Nakamura H., Fang J. The EPR effect for macromolecular drug delivery to solid tumors: improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging invivo. Adv Drug Deliv Rev 2013, 65:71-79.
15. Nagamitsu A., Greish K., Maeda H. Elevating blood pressure as a strategy to increase tumor targeted delivery of macromolecular drug SMANCS: cases of advanced solid tumors. Jpn J Clin Oncol 2009, 39:756-766.
16. Barton K.N., Stricker H., Brown S.L., Elshaikh M., Aref I., Lu M., et al. Phase I study of noninvasive imaging of adenovirus-mediated gene expression in the human prostate. Mol Ther 2008, 16:1761-1769.
17. Hingorani M., Spitzweg C., Vassaux G., Newbold K., Melcher A., Pandha H., et al. The biology of the sodium iodide symporter and its potential for targeted gene delivery. Curr Cancer Drug Targets 2010, 10:242-267.
18. Ahn B.C. Sodium iodide symporter for nuclear molecular imaging and gene therapy: from bedside to bench and back. Theranostics 2012, 2:392-402.
19. Merron A., Peerlinck I., Martin-Duque P., Burnet J., Quintanilla M., Mather S., et al. SPECT/CT imaging of oncolytic adenovirus propagation in tumours invivo using the Na/I symporter as a reporter gene. Gene Ther 2007, 14:1731-1738.
20. Rajecki M., Sarparanta M., Hakkarainen T., Tenhunen M., Diaconu I., Kuhmonen V., et al. SPECT/CT imaging of hNIS-expression after intravenous delivery of an oncolytic adenovirus and 131I. PLoS One 2012, 7:e32871.
21. Chisholm E.J., Vassaux G., Martin-Duque P., Chevre R., Lambert O., Pitard B., et al. Cancer-specific transgene expression mediated by systemic injection of nanoparticles. Cancer Res 2009, 69:2655-2662.
22. Klutz K., Willhauck M.J., Dohmen C., Wunderlich N., Knoop K., Zach C., et al. Image-guided tumor-selective radioiodine therapy of liver cancer after systemic nonviral delivery of the sodium iodide symporter gene. Hum Gene Ther 2011, 22:1563-1574.
23. Durymanov M.O., Beletkaia E.A., Ulasov A.V., Khramtsov Y.V., Trusov G.A., Rodichenko N.S., et al. Subcellular trafficking and transfection efficacy of polyethylenimine-polyethylene glycol polyplex nanoparticles with a ligand to melanocortin receptor-1. JControl Release 2012, 163:211-219.
24. Kuzmin D.V., Vinogradova T.V., Kopantzev E.P., Sverdlov E.D. Cre-loxp mediated strong enhancement of pBIRC5 promoter driven suicide of cancer cells with CD/UPRT and fluorocytosine. Open Gene Ther J 2010, 3:31-39.
25. Ulasov A.V., Khramtsov Y.V., Trusov G.A., Rosenkranz A.A., Sverdlov E.D., Sobolev A.S. Properties of PEI-based polyplex nanoparticles that correlate with their transfection efficacy. Mol Ther 2011, 19:103-112.
26. Rothfels H., Paschen A., Schadendorf D. Evaluation of combined gene regulatory elements for transcriptional targeting of suicide gene expression to malignant melanoma. Exp Dermatol 2003, 12:799-810.
27. Erten A., Wrasidlo W., Scadeng M., Esener S., Hoffman R.M., Bouvet M., et al. Magnetic resonance and fluorescence imaging of doxorubicin-loaded nanoparticles using a novel invivo model. Nanomedicine 2010, 6:797-807.
28. Akita H., Ito R., Khalil I.A., Futaki S., Harashima H. Quantitative three-dimensional analysis of the intracellular trafficking of plasmid DNA transfected by a nonviral gene delivery system using confocal laser scanning microscopy. Mol Ther 2004, 9:443-451.
29. Nishikawa M., Huang L. Nonviral vectors in the new millennium: delivery barriers in gene transfer. Hum Gene Ther 2001, 12:861-870.
30. Laschke M.W., Vollmar B., Menger M.D. The dorsal skinfold chamber: window into the dynamic interaction of biomaterials with their surrounding host tissue. Eur Cell Mater 2011, 22:147-164.
31. Alexander S., Koehl G.E., Hirschberg M., Geissler E.K., Friedl P. Dynamic imaging of cancer growth and invasion: a modified skin-fold chamber model. Histochem Cell Biol 2008, 130:1147-1154.
32. Li L., Ten Hagen T.L., Bolkestein M., Gasselhuber A., Yatvin J., van Rhoon G.C., et al. Improved intratumoral nanoparticle extravasation and penetration by mild hyperthermia. JControl Release 2013, 167:130-137.
33. Neu M., Germershaus O., Behe M., Kissel T. Bioreversibly crosslinked polyplexes of PEI and high molecular weight PEG show extended circulation times invivo. JControl Release 2007, 124:69-80.
34. Hori K., Nishihara M., Yokoyama M. Vital microscopic analysis of polymeric micelle extravasation from tumor vessels: macromolecular delivery according to tumor vascular growth stage. JPharm Sci 2010, 99:549-562.
35. Moghimi S.M., Hunter A.C., Murray J.C. Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol Rev 2001, 53:283-318.
36. Gao F., Okunieff P., Han Z., Ding I., Wang L., Liu W., et al. Hypoxia-induced alterations in hyaluronan and hyaluronidase. Adv Exp Med Biol 2005, 566:249-256.
37. Schmitt-Sody M., Strieth S., Krasnici S., Sauer B., Schulze B., Teifel M., et al. Neovascular targeting therapy: paclitaxel encapsulated in cationic liposomes improves antitumoral efficacy. Clin Cancer Res 2003, 9:2335-2341.
38. Chang Y.S., di Tomaso E., McDonald D.M., Jones R., Jain R.K., Munn L.L. Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood. Proc Natl Acad Sci U S A 2000, 97:14608-14613.
39. Chung H., Lee J.H., Jeong D., Han I.O., Oh E.S. Melanocortin 1 receptor regulates melanoma cell migration by controlling syndecan-2 expression. JBiol Chem 2012, 287:19326-19335.
40. Zhong D., Jiao Y., Zhang Y., Zhang W., Li N., Zuo Q., et al. Effects of the gene carrier polyethyleneimines on structure and function of blood components. Biomaterials 2013, 34:294-305.
41. Owens D.E., Peppas N.A. Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Int J Pharm 2006, 307:93-102.
42. Gonçalves C., Mennesson E., Fuchs R., Gorvel J.P., Midoux P., Pichon C. Macropinocytosis of polyplexes and recycling of plasmid via the clathrin-dependent pathway impair the transfection efficiency of human hepatocarcinoma cells. Mol Ther 2004, 10:373-385.
43. Mickler F.M., Vachutinsky Y., Oba M., Nishiyama N., Kataoka K., Bräuchle C., et al. Effect of integrin targeting and PEG shielding on polyplex micelle internalization studied by live-cell imaging. JControl Release 2011, 156:364-373.
44. Barua S., Rege K. The influence of mediators of intracellular trafficking on transgene expression efficacy of polymer-plasmid DNA complexes. Biomaterials 2010, 31:5894-5902.
45. Kirpotin D.B., Drummond D.C., Shao Y., Shalaby M.R., Hong K., Nielsen U.B., et al. Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models. Cancer Res 2006, 66:6732-6740.
46. Lee H., Fonge H., Hoang B., Reilly R.M., Allen C. The effects of particle size and molecular targeting on the intratumoral and subcellular distribution of polymeric nanoparticles. Mol Pharm 2010, 7:1195-1208.
47. Kwon I.K., Lee S.C., Han B., Park K. Analysis on the current status of targeted drug delivery to tumors. JControl Release 2012, 164:108-114.
48. von Gersdorff K., Ogris M., Wagner E. Cryoconserved shielded and EGF receptor targeted DNA polyplexes: cellular mechanisms. Eur J Pharm Biopharm 2005, 60:279-285.
49. Lammers T., Kiessling F., Hennink W.E., Storm G. Drug targeting to tumors: principles, pitfalls and (pre-) clinical progress. JControl Release 2012, 161:175-187.
50. Juweid M., Neumann R., Paik C., Perez-Bacete M.J., Sato J., van Osdol W., et al. Micropharmacology of monoclonal antibodies in solid tumors: direct experimental evidence for a binding site barrier. Cancer Res 1992, 52:5144-5153.
51. Wiig H., Gyenge C., Iversen P.O., Gullberg D., Tenstad O. The role of the extracellular matrix in tissue distribution of macromolecules in normal and pathological tissues: potential therapeutic consequences. Microcirculation 2008, 15:283-296.
52. Rønnov-Jessen L., Petersen O.W., Bissell M.J. Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction. Physiol Rev 1996, 76:69-125.
53. Toole B.P. Hyaluronan: from extracellular glue to pericellular cue. Nat Rev Cancer 2004, 4:528-539.
54. Krasnici S., Werner A., Eichhorn M.E., Schmitt-Sody M., Pahernik S.A., Sauer B., et al. Effect of the surface charge of liposomes on their uptake by angiogenic tumor vessels. Int J Cancer 2003, 105:561-567.
55. Beekman F., van der Have F. The pinhole: gateway to ultra-high-resolution three-dimensional radionuclide imaging. Eur J Nucl Med Mol Imaging 2007, 34:151-161.
56. Strømhaug P.E., Berg T.O., Gjøen T., Seglen P.O. Differences between fluid-phase endocytosis (pinocytosis) and receptor-mediated endocytosis in isolated rat hepatocytes. Eur J Cell Biol 1997, 73:28-39.
57. Hanzlíková M., Ruponen M., Galli E., Raasmaja A., Aseyev V., Tenhu H., et al. Mechanisms of polyethylenimine-mediated DNA delivery: free carrier helps to overcome the barrier of cell-surface glycosaminoglycans. JGene Med 2011, 13:402-409.
58. Zhang Y., Satterlee A., Huang L. Invivo gene delivery by nonviral vectors: overcoming hurdles?. Mol Ther 2012, 20:1298-1304.
59. Noga M., Edinger D., Kläger R., Wegner S.V., Spatz J.P., Wagner E., et al. The effect of molar mass and degree of hydroxyethylation on the controlled shielding and deshielding of hydroxyethyl starch-coated polyplexes. Biomaterials 2013, 34:2530-2538.
60. Li L., Wang R., Wilcox D., Zhao X., Song J., Lin X., et al. Tumor vasculature is a key determinant for the efficiency of nanoparticle-mediated siRNA delivery. Gene Ther 2012, 19:775-780.
61. Rosenkranz A.A., Slastnikova T.A., Durymanov M.O., Sobolev A.S. Malignant melanoma and melanocortin receptor-1. Biochemistry (Moscow) 2013, 78:1564-1575. 10.1134/S0006297913110035.