The conjugation of diphtheria toxin T domain to poly(ethylenimine) based vectors for enhanced endosomal escape during gene transfection

Biomaterials

Volumn 30, Issue 3, 2009, Pages 402-408

  Kakimoto, Shinji ^a   Hamada, Tsutomu ^b   Komatsu, Yuuki ^b   Takagi, Masahiro ^b   Tanabe, Toshizumi ^a   Azuma, Hideki ^a   Shinkai, Seiji ^c   Nagasaki, Takeshi ^a  

^a Osaka Prefecture University   (Japan)

^b JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

Controlled drug release; Gene transfer; Nanocomposite; Protein

Indexed keywords

ACIDS; GENE TRANSFER; NUCLEIC ACIDS;

CONTROLLED DRUG RELEASE; CYTOSOL; DIPHTHERIA TOXINS; DO-MAINS; ENDOCYTIC VESICLES; ENDOSOME; ENZYMATIC DEGRADATIONS; ETHYLENIMINE; EXOGENOUS GENES; GENE TRANSFECTIONS; MEMBRANE PERMEABILITIES; NON-VIRAL GENE DELIVERIES; POLYPLEX; TRANSFECTION EFFICIENCIES;

POTENTIOMETRIC SENSORS;

BIOTIN; BOVINE SERUM ALBUMIN; DIOLEOYLPHOSPHATIDYLCHOLINE; DIOLEOYLPHOSPHATIDYLSERINE; DIPHTHERIA TOXIN; FLUORESCEIN; PLASMID DNA; POLYETHYLENEIMINE; POLYMER; RECOMBINANT PROTEIN; STREPTAVIDIN;

ARTICLE; BIOTINYLATION; CANCER CELL CULTURE; CONFOCAL MICROSCOPY; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; ENDOCYTOSIS; ENDOSOME; FLUORESCENCE MICROSCOPY; GENE TRANSFER; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INTERNALIZATION; LUNG CARCINOMA; LYSOSOME; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MEMBRANE PERMEABILITY; MEMBRANE VESICLE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PHASE CONTRAST MICROSCOPY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

ANIMALS; BIOLOGICAL TRANSPORT; BIOTINYLATION; CELL MEMBRANE PERMEABILITY; CERCOPITHECUS AETHIOPS; COS CELLS; DIPHTHERIA TOXIN; ENDOCYTOSIS; ENDOSOMES; GENETIC VECTORS; HUMANS; HYDROGEN-ION CONCENTRATION; INTRACELLULAR SPACE; LIPOSOMES; POLYETHYLENEIMINE; PROTEIN STRUCTURE, TERTIARY; STREPTAVIDIN; SUBCELLULAR FRACTIONS; TRANSFECTION;

EID: 55249112680     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2008.09.042     Document Type: Article

References (39)

1. Rolland A.P. From genes to gene medicines: recent advances in nonviral gene delivery. Crit Rev Ther Drug Carrier Syst 15 (1998) 143-198
2. Boussif O., Lezoualch F., Zanta M.A., Mergny M.D., Scherman D., Demeneix B., et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci U S A 92 (1995) 7297-7301
3. Kopatz I., Remy J.S., and Behr J.P. A model for non-viral gene delivery: through syndecan adhesion molecules and powered by actin. J Gene Med 6 (2004) 769-776
4. Greenfield L., Bjorn M.J., Horn G., Fong D., Buck G.A., Collier R.J., et al. Nucleotide-sequence of the structural gene for diphtheria-toxin carried by corynebacteriophage-beta. Proc Natl Acad Sci U S A 80 (1983) 6853-6857
5. Choe S., Bennett M.J., Fujii G., Curmi P.M.G., Kantardjieff K.A., Collier R.J., et al. The crystal-structure of diphtheria-toxin. Nature 357 (1992) 216-222
6. Keen J.H., Maxfield F.R., Hardegree M.C., and Habig W.H. Receptor-mediated endocytosis of diphtheria-toxin by cells in culture. Proc Natl Acad Sci U S A 79 (1982) 2912-2916
7. Morris R.E., Gerstein A.S., Bonventre P.F., and Saelinger C.B. Receptor-mediated entry of diphtheria-toxin into monkey kidney (Vero) cells - electron-microscopic evaluation. Infect Immun 50 (1985) 721-727
8. Moya M., Dautryvarsat A., Goud B., Louvard D., and Boquet P. Inhibition of coated pit formation in Hep2 cells blocks the cyto-toxicity of diphtheria-toxin but not that of ricin toxin. J Cell Biol 101 (1985) 548-559
9. London E. How bacterial protein toxins enter cells - the role of partial unfolding in membrane translocation. Mol Microbiol 6 (1992) 3277-3282
10. Sandvig K., and Olsnes S. Diphtheria toxin entry into cells is facilitated by low pH. J Cell Biol 87 (1980) 828-832
11. Zalman L.S., and Wisnieski B.J. Mechanism of insertion of diphtheria-toxin - peptide entry and pore-size determinations. Proc Natl Acad Sci U S A 81 (1984) 3341-3345
12. Collier R.J. Diphtheria-toxin - mode of action and structure. Bacteriol Rev 39 (1975) 54-85
13. Fisher K.J., and Wilson J.M. The transmembrane domain of diphtheria toxin improves molecular conjugate gene transfer. Biochem J 321 (1997) 49-58
14. Uherek C., Fominaya J., and Wels W. A modular DNA carrier protein based on the structure of diphtheria toxin mediates target cell-specific gene delivery. J Biol Chem 273 (1998) 8835-8841
15. Box M., Parks D.A., Knight A., Hale C., Fishman P.S., and Fairweather N.F. A multi-domain protein system based on the H-C fragment of tetanus toxin for targeting DNA to neuronal cells. J Drug Target 11 (2003) 333-343
16. Green N.M. Avidin. Adv Protein Chem 29 (1975) 85-133
17. Rex S. Pore formation induced by the peptide melittin in different lipid vesicle membranes. Biophys Chem 58 (1996) 75-85
18. Schwarz G., Zong R.T., and Popescu T. Kinetics of melittin induced pore formation in the membrane of lipid vesicles. Biochim Biophys Acta 1110 (1992) 97-104
19. Hamada T., Sato Y.T., Yoshikawa K., and Nagasaki T. Reversible photoswitching in a cell-sized vesicle. Langmuir 21 (2005) 7626-7628
20. Blumenthal R., Clague M.J., Durell S.R., and Epand R.M. Membrane fusion. Chem Rev 103 (2003) 53-69
21. Cho Y.W., Kim J.D., and Park K. Polycation gene delivery systems: escape from endosomes to cytosol. J Pharm Pharmacol 55 (2003) 721-734
22. Sonawane N.D., Szoka F.C., and Verkman A.S. Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes. J Biol Chem 278 (2003) 44826-44831
23. Haensler J., and Szoka F.C. Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. Bioconjug Chem 4 (1993) 372-379
24. Simoes S., Slepushkin V., Gaspar R., de Lima M.C.P., and Duzgunes N. Gene delivery by negatively charged ternary complexes of DNA, cationic liposomes and transferrin or fusigenic peptides. Gene Ther 5 (1998) 955-964
25. Simoes S., Slepushkin V., Pires P., Gaspar R., de Lima M.C.P., and Duzgunes N. Mechanisms of gene transfer mediated by lipoplexes associated with targeting ligands or pH-sensitive peptides. Gene Ther 6 (1999) 1798-1807
26. Wagner E., Plank C., Zatloukal K., Cotton M., and Birnstiel M.L. Influenza-virus hemagglutinin-HA-2 N-terminal fusogenic peptides augment gene-transfer by transferrin polylysine DNA complexes - toward a synthetic virus-like gene-transfer vehicle. Proc Natl Acad Sci U S A 89 (1992) 7934-7938
27. Plank C., Oberhauser B., Mechtler K., Koch C., and Wagner E. The influence of endosome-disruptive peptides on gene-transfer using synthetic virus-like gene-transfer systems. J Biol Chem 269 (1994) 12918-12924
28. Schoen P., Chonn A., Cullis P.R., Wilschut J., and Scherrer P. Gene transfer mediated by fusion protein hemagglutinin reconstituted in cationic lipid vesicles. Gene Ther 6 (1999) 823-832
29. Kakimoto S., Moriyama T., Tanabe T., Shinkai S., and Nagasaki T. Dual-ligand effect of transferrin and transforming growth factor alpha on polyethyleneimine-mediated gene delivery. J Controlled Release 120 (2007) 242-249
30. Kohanski R.A., and Lane M.D. Monovalent avidin affinity columns. Methods Enzymol 184 (1990) 94-200
31. London E. Diphtheria-toxin - membrane interaction and membrane translocation. Biochem Biophys Acta 1113 (1992) 25-51
32. Blewitt M.G., Chung La E., and London E. Effect of pH on the conformation of diphtheria-toxin and its implications for membrane penetration. Biochemistry 24 (1985) 5458-5464
33. Paliwal R., and London E. Comparison of the conformation, hydrophobicity, and model membrane interactions of diphtheria toxin to those of formaldehyde-treated toxin (diphtheria toxoid): formaldehyde stabilization of the native conformation inhibits changes that allow membrane insertion. Biochemistry 35 (1996) 2374-2379
34. Collot J., Gradinaru J., Humbert N., Skander M., Zocchi A., and Ward T.R. Artificial metalloenzymes for enantioselective catalysis based on biotin-avidin. J Am Chem Soc 125 (2003) 9030-9031
35. Ellinger I., Klapper H., and Fuchs R. Fluid-phase marker transport in rat liver: free-flow electrophoresis separates distinct endosome subpopulations. Electrophoresis 19 (1998) 1154-1161
36. Shiraishi T., Pankratova S., and Nielsen P.E. Calcium ions effectively enhance the effect of antisense peptide nucleic acids conjugated to cationic tat and oligoarginine peptides. Chem Biol 12 (2005) 923-929
37. Ruponen M., Yla-Herttuala S., and Urtti A. Interactions of polymeric and liposomal gene delivery systems with extracellular glycosaminoglycans: physicochemical and transfection studies. Biochem Biophys Acta 1415 (1999) 331-341
38. Mislick K.A., and Baldeschwieler J.D. Evidence for the role of proteoglycans in cation-mediated gene transfer. Proc Natl Acad Sci U S A 93 (1996) 12349-12354
39. Duan H.W., and Nie S.M. Cell-penetrating quantum dots based on multivalent and endosome-disrupting surface coatings. J Am Chem Soc 129 (2007) 3333-3338