Membrane-destabilizing polyanions: Interaction with lipid bilayers and endosomal escape of biomacromolecules

Advanced Drug Delivery Reviews

Volumn 56, Issue 7, 2004, Pages 999-1021

  Yessine, Marie Andrée ^a   Leroux, Jean Christophe ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Anionic polyelectrolytes; Conformational change; Drug delivery; Endosomal release; Membrane bilayers

Indexed keywords

BIOMEDICAL ENGINEERING; CONFORMATIONS; LIPIDS; PH EFFECTS; PHYSIOLOGY; POLYELECTROLYTES; POLYMERS;

ENDOSOMAL COMPARTMENTS; LIPOSOMAL FORMULATIONS; PHYSIOLOGICAL PROCESSES;

BIOLOGICAL MEMBRANES;

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; CALCEIN; COPOLYMER; CYTARABINE; DIOLEOYLPHOSPHATIDYLETHANOLAMINE; DNA; GLYCIDOL; LIPID; LIPOSOME; MACROGOL DERIVATIVE; MALEIC ACID DERIVATIVE; MALIC ACID DERIVATIVE; OLEIC ACID; PHOSPHOLIPID; POLY(BETA MALIC ACID); POLY(METHYL METHACRYLATE); POLY(N ISOPROPYLACRYLAMIDE); POLYACRYLIC ACID; POLYANION; POLYELECTROLYTE; POLYMER; POLYMETHACRYLIC ACID; PROTEIN; STYRENE DERIVATIVE; UNCLASSIFIED DRUG; WATER;

ACIDITY; AQUEOUS SOLUTION; BILAYER MEMBRANE; CARBOXYLATION; COMPLEX FORMATION; CONFORMATION; CONFORMATIONAL TRANSITION; CONJUGATION; CYTOPLASM; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; ENDOCYTOSIS; ENDOSOME; IONIZATION; LIPID BILAYER; LIPID MEMBRANE; MACROMOLECULE; MEMBRANE BINDING; MOLECULAR INTERACTION; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PH; PHOSPHOLIPID BILAYER; PRIORITY JOURNAL; REVIEW; SOLUBILITY;

EID: 1942438691     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.addr.2003.10.039     Document Type: Article

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