메뉴 건너뛰기




Volumn 165, Issue 1, 2015, Pages 74-90

Epigenetics of lung cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; MICRORNA; TUMOR MARKER;

EID: 84919847817     PISSN: 19315244     EISSN: 18781810     Source Type: Journal    
DOI: 10.1016/j.trsl.2014.03.001     Document Type: Review
Times cited : (142)

References (279)
  • 2
    • 80455129249 scopus 로고    scopus 로고
    • Lung cancer: Epidemiology, etiology, and prevention
    • C.S. Dela Cruz, L.T. Tanoue, and R.A. Matthay Lung cancer: epidemiology, etiology, and prevention Clin Chest Med 32 2011 605 644
    • (2011) Clin Chest Med , vol.32 , pp. 605-644
    • Dela Cruz, C.S.1    Tanoue, L.T.2    Matthay, R.A.3
  • 3
    • 80054111424 scopus 로고    scopus 로고
    • DNA methylation and nonsmall cell lung cancer
    • F. Lu, and H.T. Zhang DNA methylation and nonsmall cell lung cancer Anat Rec 294 2011 1787 1795
    • (2011) Anat Rec , vol.294 , pp. 1787-1795
    • Lu, F.1    Zhang, H.T.2
  • 4
    • 3042831843 scopus 로고    scopus 로고
    • The molecular basis of lung cancer: Molecular abnormalities and therapeutic implications
    • P.P. Massion, and D.P. Carbone The molecular basis of lung cancer: molecular abnormalities and therapeutic implications Respir Res 4 2003 12
    • (2003) Respir Res , vol.4 , pp. 12
    • Massion, P.P.1    Carbone, D.P.2
  • 5
    • 79959568138 scopus 로고    scopus 로고
    • DNA methylation changes in atypical adenomatous hyperplasia, adenocarcinoma in situ, and lung adenocarcinoma
    • S.A. Selamat, J.S. Galler, and A.D. Joshi DNA methylation changes in atypical adenomatous hyperplasia, adenocarcinoma in situ, and lung adenocarcinoma PLoS One 6 2011 e21443
    • (2011) PLoS One , vol.6 , pp. 21443
    • Selamat, S.A.1    Galler, J.S.2    Joshi, A.D.3
  • 6
    • 79960123768 scopus 로고    scopus 로고
    • Epigenetic mechanisms and cancer: An interface between the environment and the genome
    • Z. Herceg, and T. Vaissiere Epigenetic mechanisms and cancer: an interface between the environment and the genome Epigenetics 6 2011 804 819
    • (2011) Epigenetics , vol.6 , pp. 804-819
    • Herceg, Z.1    Vaissiere, T.2
  • 7
    • 84882276110 scopus 로고    scopus 로고
    • The fate is not always written in the genes: Epigenomics in epidemiologic studies
    • S.M. Langevin, and K.T. Kelsey The fate is not always written in the genes: epigenomics in epidemiologic studies Environ Mol Mutagenesis 54 2013 533 541
    • (2013) Environ Mol Mutagenesis , vol.54 , pp. 533-541
    • Langevin, S.M.1    Kelsey, K.T.2
  • 8
    • 84859971624 scopus 로고    scopus 로고
    • Epigenetic markers of early tumor development
    • R.G. Dumitrescu Epigenetic markers of early tumor development Methods Mol Biol 863 2012 3 14
    • (2012) Methods Mol Biol , vol.863 , pp. 3-14
    • Dumitrescu, R.G.1
  • 9
    • 84871282536 scopus 로고    scopus 로고
    • The significance of epigenetic alterations in lung carcinogenesis
    • E. Brzezianska, A. Dutkowska, and A. Antczak The significance of epigenetic alterations in lung carcinogenesis Mol Biol Rep 40 2013 309 325
    • (2013) Mol Biol Rep , vol.40 , pp. 309-325
    • Brzezianska, E.1    Dutkowska, A.2    Antczak, A.3
  • 10
    • 25144438960 scopus 로고    scopus 로고
    • Gene promoter methylation in plasma and sputum increases with lung cancer risk
    • S.A. Belinsky, D.M. Klinge, and J.D. Dekker Gene promoter methylation in plasma and sputum increases with lung cancer risk Clin Cancer Res 11 2005 6505 6511
    • (2005) Clin Cancer Res , vol.11 , pp. 6505-6511
    • Belinsky, S.A.1    Klinge, D.M.2    Dekker, J.D.3
  • 11
    • 0036411838 scopus 로고    scopus 로고
    • Aberrant DNA methylation in lung cancer: Biological and clinical implications
    • S. Zochbauer-Muller, J.D. Minna, and A.F. Gazdar Aberrant DNA methylation in lung cancer: biological and clinical implications Oncologist 7 2002 451 457
    • (2002) Oncologist , vol.7 , pp. 451-457
    • Zochbauer-Muller, S.1    Minna, J.D.2    Gazdar, A.F.3
  • 12
    • 80052424755 scopus 로고    scopus 로고
    • DNA methylation profile during multistage progression of pulmonary adenocarcinomas
    • J.H. Chung, H.J. Lee, B.H. Kim, N.Y. Cho, and G.H. Kang DNA methylation profile during multistage progression of pulmonary adenocarcinomas Virchow Arch 459 2011 201 211
    • (2011) Virchow Arch , vol.459 , pp. 201-211
    • Chung, J.H.1    Lee, H.J.2    Kim, B.H.3    Cho, N.Y.4    Kang, G.H.5
  • 13
    • 47949123984 scopus 로고    scopus 로고
    • Promoter hypermethylation of hallmark cancer genes in atypical adenomatous hyperplasia of the lung
    • J.D. Licchesi, W.H. Westra, C.M. Hooker, and J.G. Herman Promoter hypermethylation of hallmark cancer genes in atypical adenomatous hyperplasia of the lung Clin Cancer Res 14 2008 2570 2578
    • (2008) Clin Cancer Res , vol.14 , pp. 2570-2578
    • Licchesi, J.D.1    Westra, W.H.2    Hooker, C.M.3    Herman, J.G.4
  • 14
    • 80051680291 scopus 로고    scopus 로고
    • A continuum model for tumour suppression
    • A.H. Berger, A.G. Knudson, and P.P. Pandolfi A continuum model for tumour suppression Nature 476 2011 163 169
    • (2011) Nature , vol.476 , pp. 163-169
    • Berger, A.H.1    Knudson, A.G.2    Pandolfi, P.P.3
  • 16
    • 33847704518 scopus 로고    scopus 로고
    • Prognostic significance of RASSF1A promoter methylation on survival of non-small cell patients with lung cancer treated with gemcitabine
    • J.R. Fischer, U. Ohnmacht, and N. Rieger Prognostic significance of RASSF1A promoter methylation on survival of non-small cell patients with lung cancer treated with gemcitabine Lung Cancer 56 2007 115 123
    • (2007) Lung Cancer , vol.56 , pp. 115-123
    • Fischer, J.R.1    Ohnmacht, U.2    Rieger, N.3
  • 17
    • 1842426642 scopus 로고    scopus 로고
    • Detection of promoter hypermethylation of multiple genes in the tumor and bronchoalveolar lavage of patients with lung cancer
    • O. Topaloglu, M.O. Hoque, and Y. Tokumaru Detection of promoter hypermethylation of multiple genes in the tumor and bronchoalveolar lavage of patients with lung cancer Clin Cancer Res 10 2004 2284 2288
    • (2004) Clin Cancer Res , vol.10 , pp. 2284-2288
    • Topaloglu, O.1    Hoque, M.O.2    Tokumaru, Y.3
  • 18
    • 0032578509 scopus 로고    scopus 로고
    • Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis
    • S.A. Belinsky, K.J. Nikula, and W.A. Palmisano Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis Proc Natl Acad Sci U S A 95 1998 11891 11896
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 11891-11896
    • Belinsky, S.A.1    Nikula, K.J.2    Palmisano, W.A.3
  • 19
    • 0033607147 scopus 로고    scopus 로고
    • In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis
    • G.J. Nuovo, T.W. Plaia, S.A. Belinsky, S.B. Baylin, and J.G. Herman In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis Proc Natl Acad Sci U S A 96 1999 12754 12759
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 12754-12759
    • Nuovo, G.J.1    Plaia, T.W.2    Belinsky, S.A.3    Baylin, S.B.4    Herman, J.G.5
  • 20
    • 0034326238 scopus 로고    scopus 로고
    • Predicting lung cancer by detecting aberrant promoter methylation in sputum
    • W.A. Palmisano, K.K. Divine, and G. Saccomanno Predicting lung cancer by detecting aberrant promoter methylation in sputum Cancer Res 60 2000 5954 5958
    • (2000) Cancer Res , vol.60 , pp. 5954-5958
    • Palmisano, W.A.1    Divine, K.K.2    Saccomanno, G.3
  • 21
    • 0035870282 scopus 로고    scopus 로고
    • P16(INK4a) and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer
    • D.H. Kim, H.H. Nelson, and J.K. Wiencke p16(INK4a) and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer Cancer Res 61 2001 3419 3424
    • (2001) Cancer Res , vol.61 , pp. 3419-3424
    • Kim, D.H.1    Nelson, H.H.2    Wiencke, J.K.3
  • 22
    • 77449124527 scopus 로고    scopus 로고
    • PTEN, RASSF1 and DAPK site-specific hypermethylation and outcome in surgically treated stage i and II nonsmall cell patients with lung cancer
    • L. Buckingham, L. Penfield Faber, and A. Kim PTEN, RASSF1 and DAPK site-specific hypermethylation and outcome in surgically treated stage I and II nonsmall cell patients with lung cancer Int J Cancer 126 2010 1630 1639
    • (2010) Int J Cancer , vol.126 , pp. 1630-1639
    • Buckingham, L.1    Penfield Faber, L.2    Kim, A.3
  • 23
    • 33646343483 scopus 로고    scopus 로고
    • The methylation status and protein expression of CDH1, p16(INK4A), and fragile histidine triad in nonsmall cell lung carcinoma: Epigenetic silencing, clinical features, and prognostic significance
    • S. Nakata, K. Sugio, and H. Uramoto The methylation status and protein expression of CDH1, p16(INK4A), and fragile histidine triad in nonsmall cell lung carcinoma: epigenetic silencing, clinical features, and prognostic significance Cancer 106 2006 2190 2199
    • (2006) Cancer , vol.106 , pp. 2190-2199
    • Nakata, S.1    Sugio, K.2    Uramoto, H.3
  • 24
    • 80052960976 scopus 로고    scopus 로고
    • A comprehensive analysis of p16 expression, gene status, and promoter hypermethylation in surgically resected non-small cell lung carcinomas
    • W. Sterlacci, A. Tzankov, and L. Veits A comprehensive analysis of p16 expression, gene status, and promoter hypermethylation in surgically resected non-small cell lung carcinomas J Thorac Oncol 6 2011 1649 1657
    • (2011) J Thorac Oncol , vol.6 , pp. 1649-1657
    • Sterlacci, W.1    Tzankov, A.2    Veits, L.3
  • 25
    • 38349173162 scopus 로고    scopus 로고
    • Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma
    • J.A. Tsou, J.S. Galler, and K.D. Siegmund Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma Mol Cancer 6 2007 70
    • (2007) Mol Cancer , vol.6 , pp. 70
    • Tsou, J.A.1    Galler, J.S.2    Siegmund, K.D.3
  • 26
    • 17444448913 scopus 로고    scopus 로고
    • Epigenetic inactivation of 14-3-3 sigma in oral carcinoma: Association with p16(INK4a) silencing and human papillomavirus negativity
    • M. Gasco, A.K. Bell, and V. Heath Epigenetic inactivation of 14-3-3 sigma in oral carcinoma: association with p16(INK4a) silencing and human papillomavirus negativity Cancer Res 62 2002 2072 2076
    • (2002) Cancer Res , vol.62 , pp. 2072-2076
    • Gasco, M.1    Bell, A.K.2    Heath, V.3
  • 27
    • 34548510399 scopus 로고    scopus 로고
    • Aberrant DNA methylation profiles of non-small cell lung cancers in a Korean population
    • D.S. Kim, S.I. Cha, and J.H. Lee Aberrant DNA methylation profiles of non-small cell lung cancers in a Korean population Lung Cancer 58 2007 1 6
    • (2007) Lung Cancer , vol.58 , pp. 1-6
    • Kim, D.S.1    Cha, S.I.2    Lee, J.H.3
  • 28
    • 33845662751 scopus 로고    scopus 로고
    • Application of a methylation gene panel by quantitative PCR for lung cancers
    • N. Shivapurkar, V. Stastny, and M. Suzuki Application of a methylation gene panel by quantitative PCR for lung cancers Cancer Lett 247 2007 56 71
    • (2007) Cancer Lett , vol.247 , pp. 56-71
    • Shivapurkar, N.1    Stastny, V.2    Suzuki, M.3
  • 29
    • 0034692447 scopus 로고    scopus 로고
    • Hypermethylation of the death-associated protein (DAP) kinase promoter and aggressiveness in stage i non-small-cell lung cancer
    • X. Tang, F.R. Khuri, and J.J. Lee Hypermethylation of the death-associated protein (DAP) kinase promoter and aggressiveness in stage I non-small-cell lung cancer J Natl Cancer Inst 92 2000 1511 1516
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1511-1516
    • Tang, X.1    Khuri, F.R.2    Lee, J.J.3
  • 30
    • 21144453099 scopus 로고    scopus 로고
    • CpG island methylation and expression of tumour-associated genes in lung carcinoma
    • R. Dammann, M. Strunnikova, and U. Schagdarsurengin CpG island methylation and expression of tumour-associated genes in lung carcinoma Eur J Cancer 41 2005 1223 1236
    • (2005) Eur J Cancer , vol.41 , pp. 1223-1236
    • Dammann, R.1    Strunnikova, M.2    Schagdarsurengin, U.3
  • 31
    • 84861947321 scopus 로고    scopus 로고
    • Key epigenetic changes associated with lung cancer development: Results from dense methylation array profiling
    • H.H. Nelson, C.J. Marsit, and B.C. Christensen Key epigenetic changes associated with lung cancer development: results from dense methylation array profiling Epigenetics 7 2012 559 566
    • (2012) Epigenetics , vol.7 , pp. 559-566
    • Nelson, H.H.1    Marsit, C.J.2    Christensen, B.C.3
  • 32
    • 78650583380 scopus 로고    scopus 로고
    • DNA methylation in thoracic neoplasms
    • C. Chen, N. Yin, B. Yin, and Q. Lu DNA methylation in thoracic neoplasms Cancer Lett 301 2011 7 16
    • (2011) Cancer Lett , vol.301 , pp. 7-16
    • Chen, C.1    Yin, N.2    Yin, B.3    Lu, Q.4
  • 34
    • 78549260768 scopus 로고    scopus 로고
    • Association of 5′-CpG island hypermethylation of the FHIT gene with lung cancer in southern-central Chinese population
    • W. Li, J. Deng, P. Jiang, and J. Tang Association of 5′-CpG island hypermethylation of the FHIT gene with lung cancer in southern-central Chinese population Cancer Biol Ther 10 2010 997 1000
    • (2010) Cancer Biol Ther , vol.10 , pp. 997-1000
    • Li, W.1    Deng, J.2    Jiang, P.3    Tang, J.4
  • 35
    • 63349103961 scopus 로고    scopus 로고
    • Fragile histidine triad gene inactivation in lung cancer: The European Early Lung Cancer project
    • C. Verri, L. Roz, and D. Conte Fragile histidine triad gene inactivation in lung cancer: the European Early Lung Cancer project Am J Respir Crit Care Med 179 2009 396 401
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 396-401
    • Verri, C.1    Roz, L.2    Conte, D.3
  • 36
    • 34548513807 scopus 로고    scopus 로고
    • Promoter hypermethylation of RASSF1A and RUNX3 genes as an independent prognostic prediction marker in surgically resected non-small cell lung cancers
    • N. Yanagawa, G. Tamura, and H. Oizumi Promoter hypermethylation of RASSF1A and RUNX3 genes as an independent prognostic prediction marker in surgically resected non-small cell lung cancers Lung Cancer 58 2007 131 138
    • (2007) Lung Cancer , vol.58 , pp. 131-138
    • Yanagawa, N.1    Tamura, G.2    Oizumi, H.3
  • 37
    • 8444238560 scopus 로고    scopus 로고
    • Clinicopathological significance of aberrant methylation of RARbeta2 at 3p24, RASSF1A at 3p21.3, and FHIT at 3p14.2 in patients with non-small cell lung cancer
    • Y. Tomizawa, H. Iijima, and T. Nomoto Clinicopathological significance of aberrant methylation of RARbeta2 at 3p24, RASSF1A at 3p21.3, and FHIT at 3p14.2 in patients with non-small cell lung cancer Lung Cancer 46 2004 305 312
    • (2004) Lung Cancer , vol.46 , pp. 305-312
    • Tomizawa, Y.1    Iijima, H.2    Nomoto, T.3
  • 38
    • 79960311742 scopus 로고    scopus 로고
    • An epigenetic marker panel for detection of lung cancer using cell-free serum DNA
    • S. Begum, M. Brait, and S. Dasgupta An epigenetic marker panel for detection of lung cancer using cell-free serum DNA Clin Cancer Res 17 2011 4494 4503
    • (2011) Clin Cancer Res , vol.17 , pp. 4494-4503
    • Begum, S.1    Brait, M.2    Dasgupta, S.3
  • 39
    • 2942548985 scopus 로고    scopus 로고
    • Aberrant methylation of the adenomatous polyposis coli promoter 1A in bronchial aspirates from patients with suspected lung cancer
    • H.J. Grote, V. Schmiemann, and S. Kiel Aberrant methylation of the adenomatous polyposis coli promoter 1A in bronchial aspirates from patients with suspected lung cancer Int J Cancer 110 2004 751 755
    • (2004) Int J Cancer , vol.110 , pp. 751-755
    • Grote, H.J.1    Schmiemann, V.2    Kiel, S.3
  • 40
    • 0037427808 scopus 로고    scopus 로고
    • Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer
    • S. Toyooka, R. Maruyama, and K.O. Toyooka Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer Int J Cancer 103 2003 153 160
    • (2003) Int J Cancer , vol.103 , pp. 153-160
    • Toyooka, S.1    Maruyama, R.2    Toyooka, K.O.3
  • 41
    • 0035858994 scopus 로고    scopus 로고
    • Adenomatous polyposis coli gene promoter hypermethylation in non-small cell lung cancer is associated with survival
    • J. Brabender, H. Usadel, and K.D. Danenberg Adenomatous polyposis coli gene promoter hypermethylation in non-small cell lung cancer is associated with survival Oncogene 20 2001 3528 3532
    • (2001) Oncogene , vol.20 , pp. 3528-3532
    • Brabender, J.1    Usadel, H.2    Danenberg, K.D.3
  • 42
    • 79954610853 scopus 로고    scopus 로고
    • Highly frequent promoter methylation and PIK3CA amplification in non-small cell lung cancer (NSCLC)
    • M. Ji, H. Guan, C. Gao, B. Shi, and P. Hou Highly frequent promoter methylation and PIK3CA amplification in non-small cell lung cancer (NSCLC) BMC Cancer 11 2011 147
    • (2011) BMC Cancer , vol.11 , pp. 147
    • Ji, M.1    Guan, H.2    Gao, C.3    Shi, B.4    Hou, P.5
  • 43
    • 84855221091 scopus 로고    scopus 로고
    • Quantitative promoter hypermethylation analysis of RASSF1A in lung cancer: Comparison with methylation-specific PCR technique and clinical significance
    • S.M. Lee, W.K. Lee, D.S. Kim, and J.Y. Park Quantitative promoter hypermethylation analysis of RASSF1A in lung cancer: comparison with methylation-specific PCR technique and clinical significance Mol Med Rep 5 2012 239 244
    • (2012) Mol Med Rep , vol.5 , pp. 239-244
    • Lee, S.M.1    Lee, W.K.2    Kim, D.S.3    Park, J.Y.4
  • 45
    • 0035858992 scopus 로고    scopus 로고
    • The CpG island of the novel tumor suppressor gene RASSF1A is intensely methylated in primary small cell lung carcinomas
    • R. Dammann, T. Takahashi, and G.P. Pfeifer The CpG island of the novel tumor suppressor gene RASSF1A is intensely methylated in primary small cell lung carcinomas Oncogene 20 2001 3563 3567
    • (2001) Oncogene , vol.20 , pp. 3563-3567
    • Dammann, R.1    Takahashi, T.2    Pfeifer, G.P.3
  • 46
    • 0035967107 scopus 로고    scopus 로고
    • Promoter methylation of DAP-kinase: Association with advanced stage in non-small cell lung cancer
    • D.H. Kim, H.H. Nelson, and J.K. Wiencke Promoter methylation of DAP-kinase: association with advanced stage in non-small cell lung cancer Oncogene 20 2001 1765 1770
    • (2001) Oncogene , vol.20 , pp. 1765-1770
    • Kim, D.H.1    Nelson, H.H.2    Wiencke, J.K.3
  • 47
    • 0034674916 scopus 로고    scopus 로고
    • Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas
    • A.K. Virmani, A. Rathi, and S. Zochbauer-Muller Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas J Natl Cancer Inst 92 2000 1303 1307
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1303-1307
    • Virmani, A.K.1    Rathi, A.2    Zochbauer-Muller, S.3
  • 48
    • 79956110885 scopus 로고    scopus 로고
    • Determination of O(6)-methylguanine DNA methyltransferase promoter methylation in non-small cell lung cancer
    • M. Ekim, V. Caner, N. Buyukpinarbasili, E. Tepeli, L. Elmas, and G. Bagci Determination of O(6)-methylguanine DNA methyltransferase promoter methylation in non-small cell lung cancer Genet Test Mol Biomarkers 15 2011 357 360
    • (2011) Genet Test Mol Biomarkers , vol.15 , pp. 357-360
    • Ekim, M.1    Caner, V.2    Buyukpinarbasili, N.3    Tepeli, E.4    Elmas, L.5    Bagci, G.6
  • 49
    • 46649117841 scopus 로고    scopus 로고
    • Promoter methylation of O(6)-methylguanine-DNA-methyltransferase in lung cancer is regulated by p53
    • J.C. Lai, Y.W. Cheng, and Y.G. Goan Promoter methylation of O(6)-methylguanine-DNA-methyltransferase in lung cancer is regulated by p53 DNA Repair 7 2008 1352 1363
    • (2008) DNA Repair , vol.7 , pp. 1352-1363
    • Lai, J.C.1    Cheng, Y.W.2    Goan, Y.G.3
  • 50
    • 12244297095 scopus 로고    scopus 로고
    • Quantitative O(6)-methylguanine DNA methyltransferase methylation analysis in curatively resected non-small cell lung cancer: Associations with clinical outcome
    • J. Brabender, H. Usadel, and R. Metzger Quantitative O(6)-methylguanine DNA methyltransferase methylation analysis in curatively resected non-small cell lung cancer: associations with clinical outcome Clin Cancer Res 9 2003 223 227
    • (2003) Clin Cancer Res , vol.9 , pp. 223-227
    • Brabender, J.1    Usadel, H.2    Metzger, R.3
  • 51
    • 78049345913 scopus 로고    scopus 로고
    • SHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer based on bronchial aspirates
    • B. Schmidt, V. Liebenberg, and D. Dietrich SHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer based on bronchial aspirates BMC Cancer 10 2010 600
    • (2010) BMC Cancer , vol.10 , pp. 600
    • Schmidt, B.1    Liebenberg, V.2    Dietrich, D.3
  • 52
    • 79953072405 scopus 로고    scopus 로고
    • Correlation of SHOX2 gene amplification and DNA methylation in lung cancer tumors
    • K.U. Schneider, D. Dietrich, and M. Fleischhacker Correlation of SHOX2 gene amplification and DNA methylation in lung cancer tumors BMC Cancer 11 2011 102
    • (2011) BMC Cancer , vol.11 , pp. 102
    • Schneider, K.U.1    Dietrich, D.2    Fleischhacker, M.3
  • 53
    • 84855217232 scopus 로고    scopus 로고
    • Application of RUNX3 gene promoter methylation in the diagnosis of non-small cell lung cancer
    • G.P. Yu, Y. Ji, and G.Q. Chen Application of RUNX3 gene promoter methylation in the diagnosis of non-small cell lung cancer Oncol Lett 3 2012 159 162
    • (2012) Oncol Lett , vol.3 , pp. 159-162
    • Yu, G.P.1    Ji, Y.2    Chen, G.Q.3
  • 54
    • 84868487326 scopus 로고    scopus 로고
    • RUNX3 downregulation in human lung adenocarcinoma is independent of p53, EGFR or KRAS status
    • M.F. Omar, K. Ito, and M.E. Nga RUNX3 downregulation in human lung adenocarcinoma is independent of p53, EGFR or KRAS status Pathol Oncol Res 18 2012 783 792
    • (2012) Pathol Oncol Res , vol.18 , pp. 783-792
    • Omar, M.F.1    Ito, K.2    Nga, M.E.3
  • 55
    • 33644876855 scopus 로고    scopus 로고
    • Epigenetic inactivation of the RUNX3 gene in lung cancer
    • K. Sato, Y. Tomizawa, and H. Iijima Epigenetic inactivation of the RUNX3 gene in lung cancer Oncol Rep 15 2006 129 135
    • (2006) Oncol Rep , vol.15 , pp. 129-135
    • Sato, K.1    Tomizawa, Y.2    Iijima, H.3
  • 56
    • 2342641616 scopus 로고    scopus 로고
    • Methylation of RUNX3 in various types of human cancers and premalignant stages of gastric carcinoma
    • T.Y. Kim, H.J. Lee, and K.S. Hwang Methylation of RUNX3 in various types of human cancers and premalignant stages of gastric carcinoma Lab Invest 84 2004 479 484
    • (2004) Lab Invest , vol.84 , pp. 479-484
    • Kim, T.Y.1    Lee, H.J.2    Hwang, K.S.3
  • 57
    • 9144223364 scopus 로고    scopus 로고
    • Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer
    • Q.L. Li, H.R. Kim, and W.J. Kim Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer Biochem Biophys Res Commun 314 2004 223 228
    • (2004) Biochem Biophys Res Commun , vol.314 , pp. 223-228
    • Li, Q.L.1    Kim, H.R.2    Kim, W.J.3
  • 58
    • 37049001894 scopus 로고    scopus 로고
    • Aberrant methylation of E-cadherin and H-cadherin genes in nonsmall cell lung cancer and its relation to clinicopathologic features
    • D.S. Kim, M.J. Kim, J.Y. Lee, Y.Z. Kim, E.J. Kim, and J.Y. Park Aberrant methylation of E-cadherin and H-cadherin genes in nonsmall cell lung cancer and its relation to clinicopathologic features Cancer 110 2007 2785 2792
    • (2007) Cancer , vol.110 , pp. 2785-2792
    • Kim, D.S.1    Kim, M.J.2    Lee, J.Y.3    Kim, Y.Z.4    Kim, E.J.5    Park, J.Y.6
  • 59
    • 32544443054 scopus 로고    scopus 로고
    • Expression and methylation pattern of TSLC1 cascade genes in lung carcinomas
    • G. Heller, K.M. Fong, and L. Girard Expression and methylation pattern of TSLC1 cascade genes in lung carcinomas Oncogene 25 2006 959 968
    • (2006) Oncogene , vol.25 , pp. 959-968
    • Heller, G.1    Fong, K.M.2    Girard, L.3
  • 60
    • 33646021646 scopus 로고    scopus 로고
    • Hypermethylation of the TSLC1/IGSF4 promoter is associated with tobacco smoking and a poor prognosis in primary nonsmall cell lung carcinoma
    • S. Kikuchi, D. Yamada, and T. Fukami Hypermethylation of the TSLC1/IGSF4 promoter is associated with tobacco smoking and a poor prognosis in primary nonsmall cell lung carcinoma Cancer 106 2006 1751 1758
    • (2006) Cancer , vol.106 , pp. 1751-1758
    • Kikuchi, S.1    Yamada, D.2    Fukami, T.3
  • 61
    • 0042916159 scopus 로고    scopus 로고
    • Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines
    • T. Fukami, H. Fukuhara, and M. Kuramochi Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines Int J Cancer 107 2003 53 59
    • (2003) Int J Cancer , vol.107 , pp. 53-59
    • Fukami, T.1    Fukuhara, H.2    Kuramochi, M.3
  • 62
    • 0037466380 scopus 로고    scopus 로고
    • Methylation patterns and K-ras mutations in tumor and paired serum of resected non-small-cell patients with lung cancer
    • J.L. Ramirez, C. Sarries, and P.L. de Castro Methylation patterns and K-ras mutations in tumor and paired serum of resected non-small-cell patients with lung cancer Cancer Lett 193 2003 207 216
    • (2003) Cancer Lett , vol.193 , pp. 207-216
    • Ramirez, J.L.1    Sarries, C.2    De Castro, P.L.3
  • 63
    • 0037817414 scopus 로고    scopus 로고
    • Aberrant methylation of TMS1 in small cell, non small cell lung cancer and breast cancer
    • A. Virmani, A. Rathi, and K. Sugio Aberrant methylation of TMS1 in small cell, non small cell lung cancer and breast cancer Int J Cancer 106 2003 198 204
    • (2003) Int J Cancer , vol.106 , pp. 198-204
    • Virmani, A.1    Rathi, A.2    Sugio, K.3
  • 64
    • 20244390458 scopus 로고    scopus 로고
    • Promoter methylation of DAL-1/4.1B predicts poor prognosis in non-small cell lung cancer
    • S. Kikuchi, D. Yamada, and T. Fukami Promoter methylation of DAL-1/4.1B predicts poor prognosis in non-small cell lung cancer Clin Cancer Res 11 2005 2954 2961
    • (2005) Clin Cancer Res , vol.11 , pp. 2954-2961
    • Kikuchi, S.1    Yamada, D.2    Fukami, T.3
  • 65
    • 23444461754 scopus 로고    scopus 로고
    • PTEN expression in non-small-cell lung cancer: Evaluating its relation to tumor characteristics, allelic loss, and epigenetic alteration
    • C.J. Marsit, S. Zheng, and K. Aldape PTEN expression in non-small-cell lung cancer: evaluating its relation to tumor characteristics, allelic loss, and epigenetic alteration Hum Pathol 36 2005 768 776
    • (2005) Hum Pathol , vol.36 , pp. 768-776
    • Marsit, C.J.1    Zheng, S.2    Aldape, K.3
  • 66
    • 0036094196 scopus 로고    scopus 로고
    • Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation
    • J.C. Soria, H.Y. Lee, and J.I. Lee Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation Clin Cancer Res 8 2002 1178 1184
    • (2002) Clin Cancer Res , vol.8 , pp. 1178-1184
    • Soria, J.C.1    Lee, H.Y.2    Lee, J.I.3
  • 67
    • 84866166176 scopus 로고    scopus 로고
    • Glutathione S-transferase PI (GST-PI) mRNA expression and DNA methylation is involved in the pathogenesis and prognosis of NSCLC
    • P.P. Grimminger, M.K. Maus, and P.M. Schneider Glutathione S-transferase PI (GST-PI) mRNA expression and DNA methylation is involved in the pathogenesis and prognosis of NSCLC Lung Cancer 78 2012 87 91
    • (2012) Lung Cancer , vol.78 , pp. 87-91
    • Grimminger, P.P.1    Maus, M.K.2    Schneider, P.M.3
  • 68
    • 33748373149 scopus 로고    scopus 로고
    • DNA methyltransferases messenger RNA expression and aberrant methylation of CpG islands in non-small-cell lung cancer: Association and prognostic value
    • D. Vallbohmer, J. Brabender, and D. Yang DNA methyltransferases messenger RNA expression and aberrant methylation of CpG islands in non-small-cell lung cancer: association and prognostic value Clin Lung Cancer 8 2006 39 44
    • (2006) Clin Lung Cancer , vol.8 , pp. 39-44
    • Vallbohmer, D.1    Brabender, J.2    Yang, D.3
  • 69
    • 24144437770 scopus 로고    scopus 로고
    • Silencing of genes by promoter hypermethylation: Key event in rodent and human lung cancer
    • S.A. Belinsky Silencing of genes by promoter hypermethylation: key event in rodent and human lung cancer Carcinogenesis 26 2005 1481 1487
    • (2005) Carcinogenesis , vol.26 , pp. 1481-1487
    • Belinsky, S.A.1
  • 70
    • 70349774795 scopus 로고    scopus 로고
    • RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4A, DAPK1, PTEN and MT1G genes were frequently methylated in the stage i non-small cell lung cancer in China
    • Q. Lin, J. Geng, and K. Ma RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4A, DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-small cell lung cancer in China J Cancer Res Clin Oncol 135 2009 1675 1684
    • (2009) J Cancer Res Clin Oncol , vol.135 , pp. 1675-1684
    • Lin, Q.1    Geng, J.2    Ma, K.3
  • 71
    • 34248361968 scopus 로고    scopus 로고
    • Homeobox gene methylation in lung cancer studied by genome-wide analysis with a microarray-based methylated CpG island recovery assay
    • T. Rauch, Z. Wang, and X. Zhang Homeobox gene methylation in lung cancer studied by genome-wide analysis with a microarray-based methylated CpG island recovery assay Proc Natl Acad Sci U S A 104 2007 5527 5532
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 5527-5532
    • Rauch, T.1    Wang, Z.2    Zhang, X.3
  • 72
    • 8644278076 scopus 로고    scopus 로고
    • Aberrant promoter methylation of human DAB2 interactive protein (hDAB2IP) gene in lung cancers
    • M. Yano, S. Toyooka, and K. Tsukuda Aberrant promoter methylation of human DAB2 interactive protein (hDAB2IP) gene in lung cancers Int J Cancer 113 2005 59 66
    • (2005) Int J Cancer , vol.113 , pp. 59-66
    • Yano, M.1    Toyooka, S.2    Tsukuda, K.3
  • 73
    • 24744466279 scopus 로고    scopus 로고
    • Aberrant methylation of FBN2 in human non-small cell lung cancer
    • H. Chen, M. Suzuki, and Y. Nakamura Aberrant methylation of FBN2 in human non-small cell lung cancer Lung Cancer 50 2005 43 49
    • (2005) Lung Cancer , vol.50 , pp. 43-49
    • Chen, H.1    Suzuki, M.2    Nakamura, Y.3
  • 74
    • 77953146788 scopus 로고    scopus 로고
    • CpG island methylator phenotype involving chromosome 3p confers an increased risk of non-small cell lung cancer
    • Z. Liu, W. Li, and Z. Lei CpG island methylator phenotype involving chromosome 3p confers an increased risk of non-small cell lung cancer J Thorac Oncol 5 2010 790 797
    • (2010) J Thorac Oncol , vol.5 , pp. 790-797
    • Liu, Z.1    Li, W.2    Lei, Z.3
  • 75
    • 52149091635 scopus 로고    scopus 로고
    • CpG island methylator phenotype involving tumor suppressor genes located on chromosome 3p in non-small cell lung cancer
    • Z. Liu, J. Zhao, and X.F. Chen CpG island methylator phenotype involving tumor suppressor genes located on chromosome 3p in non-small cell lung cancer Lung Cancer 62 2008 15 22
    • (2008) Lung Cancer , vol.62 , pp. 15-22
    • Liu, Z.1    Zhao, J.2    Chen, X.F.3
  • 76
    • 33751275546 scopus 로고    scopus 로고
    • Examination of a CpG island methylator phenotype and implications of methylation profiles in solid tumors
    • C.J. Marsit, E.A. Houseman, and B.C. Christensen Examination of a CpG island methylator phenotype and implications of methylation profiles in solid tumors Cancer Res 66 2006 10621 10629
    • (2006) Cancer Res , vol.66 , pp. 10621-10629
    • Marsit, C.J.1    Houseman, E.A.2    Christensen, B.C.3
  • 77
    • 84865160485 scopus 로고    scopus 로고
    • Integrated analysis of genetic and epigenetic alterations reveals CpG island methylator phenotype associated with distinct clinical characters of lung adenocarcinoma
    • K. Shinjo, Y. Okamoto, and B. An Integrated analysis of genetic and epigenetic alterations reveals CpG island methylator phenotype associated with distinct clinical characters of lung adenocarcinoma Carcinogenesis 33 2012 1277 1285
    • (2012) Carcinogenesis , vol.33 , pp. 1277-1285
    • Shinjo, K.1    Okamoto, Y.2    An, B.3
  • 78
    • 33747891190 scopus 로고    scopus 로고
    • Elevated mRNA levels of DNA methyltransferase-1 as an independent prognostic factor in primary nonsmall cell lung cancer
    • H. Kim, Y.M. Kwon, and J.S. Kim Elevated mRNA levels of DNA methyltransferase-1 as an independent prognostic factor in primary nonsmall cell lung cancer Cancer 107 2006 1042 1049
    • (2006) Cancer , vol.107 , pp. 1042-1049
    • Kim, H.1    Kwon, Y.M.2    Kim, J.S.3
  • 79
    • 33846111256 scopus 로고    scopus 로고
    • Alteration of DNA methyltransferases contributes to 5'CpG methylation and poor prognosis in lung cancer
    • R.K. Lin, H.S. Hsu, J.W. Chang, C.Y. Chen, J.T. Chen, and Y.C. Wang Alteration of DNA methyltransferases contributes to 5'CpG methylation and poor prognosis in lung cancer Lung Cancer 55 2007 205 213
    • (2007) Lung Cancer , vol.55 , pp. 205-213
    • Lin, R.K.1    Hsu, H.S.2    Chang, J.W.3    Chen, C.Y.4    Chen, J.T.5    Wang, Y.C.6
  • 80
    • 52749093727 scopus 로고    scopus 로고
    • A high-throughput and sensitive method to measure global DNA methylation: Application in lung cancer
    • A. Anisowicz, H. Huang, and K.I. Braunschweiger A high-throughput and sensitive method to measure global DNA methylation: application in lung cancer BMC Cancer 8 2008 222
    • (2008) BMC Cancer , vol.8 , pp. 222
    • Anisowicz, A.1    Huang, H.2    Braunschweiger, K.I.3
  • 81
    • 78549270385 scopus 로고    scopus 로고
    • Global DNA hypomethylation-induced deltaNp73 transcriptional activation in non-small cell lung cancer
    • A. Daskalos, S. Logotheti, and S. Markopoulou Global DNA hypomethylation-induced deltaNp73 transcriptional activation in non-small cell lung cancer Cancer Lett 300 2011 79 86
    • (2011) Cancer Lett , vol.300 , pp. 79-86
    • Daskalos, A.1    Logotheti, S.2    Markopoulou, S.3
  • 82
    • 0020627846 scopus 로고
    • Hypomethylation of ras oncogenes in primary human cancers
    • A.P. Feinberg, and B. Vogelstein Hypomethylation of ras oncogenes in primary human cancers Biochem Biophys Res Commun 111 1983 47 54
    • (1983) Biochem Biophys Res Commun , vol.111 , pp. 47-54
    • Feinberg, A.P.1    Vogelstein, B.2
  • 83
    • 0020699979 scopus 로고
    • Hypomethylation distinguishes genes of some human cancers from their normal counterparts
    • A.P. Feinberg, and B. Vogelstein Hypomethylation distinguishes genes of some human cancers from their normal counterparts Nature 301 1983 89 92
    • (1983) Nature , vol.301 , pp. 89-92
    • Feinberg, A.P.1    Vogelstein, B.2
  • 84
    • 0028905376 scopus 로고
    • Frequent loss of imprinting of the H19 gene is often associated with its overexpression in human lung cancers
    • M. Kondo, H. Suzuki, and R. Ueda Frequent loss of imprinting of the H19 gene is often associated with its overexpression in human lung cancers Oncogene 10 1995 1193 1198
    • (1995) Oncogene , vol.10 , pp. 1193-1198
    • Kondo, M.1    Suzuki, H.2    Ueda, R.3
  • 85
    • 38349135680 scopus 로고    scopus 로고
    • High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancer
    • T.A. Rauch, X. Zhong, and X. Wu High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancer Proc Natl Acad Sci U S A 105 2008 252 257
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 252-257
    • Rauch, T.A.1    Zhong, X.2    Wu, X.3
  • 86
    • 77949515989 scopus 로고    scopus 로고
    • Integrative discovery of epigenetically derepressed cancer testis antigens in NSCLC
    • C.A. Glazer, I.M. Smith, and M.F. Ochs Integrative discovery of epigenetically derepressed cancer testis antigens in NSCLC PLoS One 4 2009 e8189
    • (2009) PLoS One , vol.4 , pp. 8189
    • Glazer, C.A.1    Smith, I.M.2    Ochs, M.F.3
  • 87
    • 71549139437 scopus 로고    scopus 로고
    • Expression of cancer-testis antigens MAGE-A3/6 and NY-ESO-1 in non-small-cell lung carcinomas and their relationship with immune cell infiltration
    • S.H. Kim, S. Lee, and C.H. Lee Expression of cancer-testis antigens MAGE-A3/6 and NY-ESO-1 in non-small-cell lung carcinomas and their relationship with immune cell infiltration Lung 187 2009 401 411
    • (2009) Lung , vol.187 , pp. 401-411
    • Kim, S.H.1    Lee, S.2    Lee, C.H.3
  • 88
    • 84858208795 scopus 로고    scopus 로고
    • Poor outcome in primary non-small cell lung cancers is predicted by transketolase TKTL1 expression
    • G. Kayser, W. Sienel, and B. Kubitz Poor outcome in primary non-small cell lung cancers is predicted by transketolase TKTL1 expression Pathology 43 2011 719 724
    • (2011) Pathology , vol.43 , pp. 719-724
    • Kayser, G.1    Sienel, W.2    Kubitz, B.3
  • 89
    • 37549004361 scopus 로고    scopus 로고
    • Expression of the CTCF-paralogous cancer-testis gene, brother of the regulator of imprinted sites (BORIS), is regulated by three alternative promoters modulated by CpG methylation and by CTCF and p53 transcription factors
    • S. Renaud, E.M. Pugacheva, and M.D. Delgado Expression of the CTCF-paralogous cancer-testis gene, brother of the regulator of imprinted sites (BORIS), is regulated by three alternative promoters modulated by CpG methylation and by CTCF and p53 transcription factors Nucl Acid Res 35 2007 7372 7388
    • (2007) Nucl Acid Res , vol.35 , pp. 7372-7388
    • Renaud, S.1    Pugacheva, E.M.2    Delgado, M.D.3
  • 90
    • 24744448032 scopus 로고    scopus 로고
    • Reciprocal binding of CTCF and BORIS to the NY-ESO-1 promoter coincides with derepression of this cancer-testis gene in lung cancer cells
    • J.A. Hong, Y. Kang, and Z. Abdullaev Reciprocal binding of CTCF and BORIS to the NY-ESO-1 promoter coincides with derepression of this cancer-testis gene in lung cancer cells Cancer Res 65 2005 7763 7774
    • (2005) Cancer Res , vol.65 , pp. 7763-7774
    • Hong, J.A.1    Kang, Y.2    Abdullaev, Z.3
  • 91
    • 80051572927 scopus 로고    scopus 로고
    • Hypomethylation of the 14-3-3sigma promoter leads to increased expression in non-small cell lung cancer
    • V.M. Radhakrishnan, T.J. Jensen, H. Cui, B.W. Futscher, and J.D. Martinez Hypomethylation of the 14-3-3sigma promoter leads to increased expression in non-small cell lung cancer Genes Chromosom Cancer 50 2011 830 836
    • (2011) Genes Chromosom Cancer , vol.50 , pp. 830-836
    • Radhakrishnan, V.M.1    Jensen, T.J.2    Cui, H.3    Futscher, B.W.4    Martinez, J.D.5
  • 92
    • 84859106601 scopus 로고    scopus 로고
    • Aberrant stratifin overexpression is regulated by tumor-associated CpG demethylation in lung adenocarcinoma
    • A. Shiba-Ishii, and M. Noguchi Aberrant stratifin overexpression is regulated by tumor-associated CpG demethylation in lung adenocarcinoma Am J Pathol 180 2012 1653 1662
    • (2012) Am J Pathol , vol.180 , pp. 1653-1662
    • Shiba-Ishii, A.1    Noguchi, M.2
  • 93
    • 56249127097 scopus 로고    scopus 로고
    • Expression of thymosin beta10 and its role in non-small cell lung cancer
    • Y. Gu, C. Wang, Y. Wang, X. Qiu, and E. Wang Expression of thymosin beta10 and its role in non-small cell lung cancer Hum Pathol 40 2009 117 124
    • (2009) Hum Pathol , vol.40 , pp. 117-124
    • Gu, Y.1    Wang, C.2    Wang, Y.3    Qiu, X.4    Wang, E.5
  • 94
    • 0035503239 scopus 로고    scopus 로고
    • Activation of melanoma antigen tumor antigens occurs early in lung carcinogenesis
    • S.J. Jang, J.C. Soria, and L. Wang Activation of melanoma antigen tumor antigens occurs early in lung carcinogenesis Cancer Res 61 2001 7959 7963
    • (2001) Cancer Res , vol.61 , pp. 7959-7963
    • Jang, S.J.1    Soria, J.C.2    Wang, L.3
  • 95
    • 36549056015 scopus 로고    scopus 로고
    • Epigenetic changes in cancer
    • K. Gronbaek, C. Hother, and P.A. Jones Epigenetic changes in cancer APMIS 115 2007 1039 1059
    • (2007) APMIS , vol.115 , pp. 1039-1059
    • Gronbaek, K.1    Hother, C.2    Jones, P.A.3
  • 96
    • 0025145277 scopus 로고
    • 5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes
    • W.M. Rideout 3rd, G.A. Coetzee, A.F. Olumi, and P.A. Jones 5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes Science 249 1990 1288 1290
    • (1990) Science , vol.249 , pp. 1288-1290
    • Rideout, W.M.1    Coetzee, G.A.2    Olumi, A.F.3    Jones, P.A.4
  • 97
    • 0032523812 scopus 로고    scopus 로고
    • Carcinogens preferentially bind at methylated CpG in the p53 mutational hot spots
    • J.X. Chen, Y. Zheng, M. West, and M.S. Tang Carcinogens preferentially bind at methylated CpG in the p53 mutational hot spots Cancer Res 58 1998 2070 2075
    • (1998) Cancer Res , vol.58 , pp. 2070-2075
    • Chen, J.X.1    Zheng, Y.2    West, M.3    Tang, M.S.4
  • 98
    • 0029806936 scopus 로고    scopus 로고
    • Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53
    • M.F. Denissenko, A. Pao, M. Tang, and G.P. Pfeifer Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53 Science 274 1996 430 432
    • (1996) Science , vol.274 , pp. 430-432
    • Denissenko, M.F.1    Pao, A.2    Tang, M.3    Pfeifer, G.P.4
  • 99
    • 0035477426 scopus 로고    scopus 로고
    • Methylated CpG dinucleotides are the preferential targets for G-to-T transversion mutations induced by benzo[a]pyrene diol epoxide in mammalian cells: Similarities with the p53 mutation spectrum in smoking-associated lung cancers
    • J.H. Yoon, L.E. Smith, Z. Feng, M. Tang, C.S. Lee, and G.P. Pfeifer Methylated CpG dinucleotides are the preferential targets for G-to-T transversion mutations induced by benzo[a]pyrene diol epoxide in mammalian cells: similarities with the p53 mutation spectrum in smoking-associated lung cancers Cancer Res 61 2001 7110 7117
    • (2001) Cancer Res , vol.61 , pp. 7110-7117
    • Yoon, J.H.1    Smith, L.E.2    Feng, Z.3    Tang, M.4    Lee, C.S.5    Pfeifer, G.P.6
  • 100
    • 33750282261 scopus 로고    scopus 로고
    • Acrolein is a major cigarette-related lung cancer agent: Preferential binding at p53 mutational hotspots and inhibition of DNA repair
    • Z. Feng, W. Hu, Y. Hu, and M.S. Tang Acrolein is a major cigarette-related lung cancer agent: preferential binding at p53 mutational hotspots and inhibition of DNA repair Proc Natl Acad Sci U S A 103 2006 15404 15409
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 15404-15409
    • Feng, Z.1    Hu, W.2    Hu, Y.3    Tang, M.S.4
  • 101
    • 4944223370 scopus 로고    scopus 로고
    • Histone deacetylase 1 mRNA expression in lung cancer
    • H. Sasaki, S. Moriyama, and Y. Nakashima Histone deacetylase 1 mRNA expression in lung cancer Lung Cancer 46 2004 171 178
    • (2004) Lung Cancer , vol.46 , pp. 171-178
    • Sasaki, H.1    Moriyama, S.2    Nakashima, Y.3
  • 102
    • 38449100788 scopus 로고    scopus 로고
    • Expression profile of class i histone deacetylases in human cancer tissues
    • M. Nakagawa, Y. Oda, and T. Eguchi Expression profile of class I histone deacetylases in human cancer tissues Oncol Rep 18 2007 769 774
    • (2007) Oncol Rep , vol.18 , pp. 769-774
    • Nakagawa, M.1    Oda, Y.2    Eguchi, T.3
  • 103
    • 22044434278 scopus 로고    scopus 로고
    • Comparative application of antibody and gene array for expression profiling in human squamous cell lung carcinoma
    • B. Bartling, H.S. Hofmann, and T. Boettger Comparative application of antibody and gene array for expression profiling in human squamous cell lung carcinoma Lung Cancer 49 2005 145 154
    • (2005) Lung Cancer , vol.49 , pp. 145-154
    • Bartling, B.1    Hofmann, H.S.2    Boettger, T.3
  • 104
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • M. Esteller Epigenetics in cancer N Engl J Med 358 2008 1148 1159
    • (2008) N Engl J Med , vol.358 , pp. 1148-1159
    • Esteller, M.1
  • 105
    • 37549006745 scopus 로고    scopus 로고
    • Decreased expression of the SIN3A gene, a candidate tumor suppressor located at the prevalent allelic loss region 15q23 in non-small cell lung cancer
    • H. Suzuki, M. Ouchida, and H. Yamamoto Decreased expression of the SIN3A gene, a candidate tumor suppressor located at the prevalent allelic loss region 15q23 in non-small cell lung cancer Lung Cancer 59 2008 24 31
    • (2008) Lung Cancer , vol.59 , pp. 24-31
    • Suzuki, H.1    Ouchida, M.2    Yamamoto, H.3
  • 106
    • 58149329023 scopus 로고    scopus 로고
    • Loss of histone H4K20 trimethylation occurs in preneoplasia and influences prognosis of non-small cell lung cancer
    • A. Van Den Broeck, E. Brambilla, and D. Moro-Sibilot Loss of histone H4K20 trimethylation occurs in preneoplasia and influences prognosis of non-small cell lung cancer Clin Cancer Res 14 2008 7237 7245
    • (2008) Clin Cancer Res , vol.14 , pp. 7237-7245
    • Van Den Broeck, A.1    Brambilla, E.2    Moro-Sibilot, D.3
  • 107
    • 84865264616 scopus 로고    scopus 로고
    • Expression patterns of USP22 and potential targets BMI-1, PTEN, p-AKT in non-small-cell lung cancer
    • J. Hu, Y.L. Liu, S.L. Piao, D.D. Yang, Y.M. Yang, and L. Cai Expression patterns of USP22 and potential targets BMI-1, PTEN, p-AKT in non-small-cell lung cancer Lung Cancer 77 2012 593 599
    • (2012) Lung Cancer , vol.77 , pp. 593-599
    • Hu, J.1    Liu, Y.L.2    Piao, S.L.3    Yang, D.D.4    Yang, Y.M.5    Cai, L.6
  • 108
    • 84872825428 scopus 로고    scopus 로고
    • The relationship between BMI-1 and the epithelial-mesenchymal transition in lung squamous cell carcinoma
    • J. Huang, Y. Qiu, G. Chen, L. Huang, and J. He The relationship between BMI-1 and the epithelial-mesenchymal transition in lung squamous cell carcinoma Med Oncol 29 2012 1606 1613
    • (2012) Med Oncol , vol.29 , pp. 1606-1613
    • Huang, J.1    Qiu, Y.2    Chen, G.3    Huang, L.4    He, J.5
  • 109
    • 79954745805 scopus 로고    scopus 로고
    • BMI1 regulates cell fate via tumor suppressor WWOX repression in small-cell lung cancer cells
    • M. Kimura, H. Takenobu, and N. Akita BMI1 regulates cell fate via tumor suppressor WWOX repression in small-cell lung cancer cells Cancer Sci 102 2011 983 990
    • (2011) Cancer Sci , vol.102 , pp. 983-990
    • Kimura, M.1    Takenobu, H.2    Akita, N.3
  • 110
    • 0035906853 scopus 로고    scopus 로고
    • The BMI-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression
    • S. Vonlanthen, J. Heighway, and H.J. Altermatt The BMI-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression Br J Cancer 84 2001 1372 1376
    • (2001) Br J Cancer , vol.84 , pp. 1372-1376
    • Vonlanthen, S.1    Heighway, J.2    Altermatt, H.J.3
  • 111
    • 19944403215 scopus 로고    scopus 로고
    • Increased expression of the EZH2 polycomb group gene in BMI-1-positive neoplastic cells during bronchial carcinogenesis
    • R.H. Breuer, P.J. Snijders, and E.F. Smit Increased expression of the EZH2 polycomb group gene in BMI-1-positive neoplastic cells during bronchial carcinogenesis Neoplasia 6 2004 736 743
    • (2004) Neoplasia , vol.6 , pp. 736-743
    • Breuer, R.H.1    Snijders, P.J.2    Smit, E.F.3
  • 112
    • 84871748742 scopus 로고    scopus 로고
    • EZH2 promotes malignant behaviors via cell cycle dysregulation and its mRNA level associates with prognosis of patient with non-small cell lung cancer
    • W. Cao, O. Ribeiro Rde, and D. Liu EZH2 promotes malignant behaviors via cell cycle dysregulation and its mRNA level associates with prognosis of patient with non-small cell lung cancer PLoS One 7 2012 e52984
    • (2012) PLoS One , vol.7 , pp. 52984
    • Cao, W.1    Ribeiro Rde, O.2    Liu, D.3
  • 113
    • 79959267832 scopus 로고    scopus 로고
    • Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker
    • M. Takawa, K. Masuda, and M. Kunizaki Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker Cancer Sci 102 2011 1298 1305
    • (2011) Cancer Sci , vol.102 , pp. 1298-1305
    • Takawa, M.1    Masuda, K.2    Kunizaki, M.3
  • 114
    • 84878548632 scopus 로고    scopus 로고
    • Quantitative analysis of EZH2 expression and its correlations with patients with lung cancer: Clinical pathological characteristics
    • L. Wan, X. Li, H. Shen, and X. Bai Quantitative analysis of EZH2 expression and its correlations with patients with lung cancer: clinical pathological characteristics Clin Transl Oncol 15 2013 132 138
    • (2013) Clin Transl Oncol , vol.15 , pp. 132-138
    • Wan, L.1    Li, X.2    Shen, H.3    Bai, X.4
  • 115
    • 84904112983 scopus 로고    scopus 로고
    • Polycomb group oncogene RING1 is over-expressed in non-small cell lung cancer
    • Y. Zhou, C. Wan, and Y. Liu Polycomb group oncogene RING1 is over-expressed in non-small cell lung cancer Pathol Oncol Res 20 2014 549 556
    • (2014) Pathol Oncol Res , vol.20 , pp. 549-556
    • Zhou, Y.1    Wan, C.2    Liu, Y.3
  • 116
    • 84878741641 scopus 로고    scopus 로고
    • PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer
    • T. Sato, A. Kaneda, and S. Tsuji PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer Sci Rep 3 2013 1911
    • (2013) Sci Rep , vol.3 , pp. 1911
    • Sato, T.1    Kaneda, A.2    Tsuji, S.3
  • 117
    • 84861557861 scopus 로고    scopus 로고
    • The expression and significance of the enhancer of zeste homolog 2 in lung adenocarcinoma
    • Y. Lv, C. Yuan, and X. Xiao The expression and significance of the enhancer of zeste homolog 2 in lung adenocarcinoma Oncol Rep 28 2012 147 154
    • (2012) Oncol Rep , vol.28 , pp. 147-154
    • Lv, Y.1    Yuan, C.2    Xiao, X.3
  • 118
    • 84857998198 scopus 로고    scopus 로고
    • Enhancer of zeste homolog 2 is a novel prognostic biomarker in nonsmall cell lung cancer
    • Huqun, R. Ishikawa, and J. Zhang Enhancer of zeste homolog 2 is a novel prognostic biomarker in nonsmall cell lung cancer Cancer 118 2012 1599 1606
    • (2012) Cancer , vol.118 , pp. 1599-1606
    • Huqun1    Ishikawa, R.2    Zhang, J.3
  • 120
    • 53849121588 scopus 로고    scopus 로고
    • Stem cell marker expression in small cell lung carcinoma and developing lung tissue
    • L.K. Koch, H. Zhou, and J. Ellinger Stem cell marker expression in small cell lung carcinoma and developing lung tissue Hum Pathol 39 2008 1597 1605
    • (2008) Hum Pathol , vol.39 , pp. 1597-1605
    • Koch, L.K.1    Zhou, H.2    Ellinger, J.3
  • 121
    • 49649083394 scopus 로고    scopus 로고
    • Prognostic value of BMI-1 oncoprotein expression in patients with NSCLC: A tissue microarray study
    • K. Vrzalikova, J. Skarda, and J. Ehrmann Prognostic value of BMI-1 oncoprotein expression in patients with NSCLC: a tissue microarray study J Cancer Res Clin Oncol 134 2008 1037 1042
    • (2008) J Cancer Res Clin Oncol , vol.134 , pp. 1037-1042
    • Vrzalikova, K.1    Skarda, J.2    Ehrmann, J.3
  • 122
    • 50149092414 scopus 로고    scopus 로고
    • BMI1 is critical for lung tumorigenesis and bronchoalveolar stem cell expansion
    • J.S. Dovey, S.J. Zacharek, C.F. Kim, and J.A. Lees BMI1 is critical for lung tumorigenesis and bronchoalveolar stem cell expansion Proc Natl Acad Sci U S A 105 2008 11857 11862
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 11857-11862
    • Dovey, J.S.1    Zacharek, S.J.2    Kim, C.F.3    Lees, J.A.4
  • 123
    • 33746218202 scopus 로고    scopus 로고
    • Loss of the human polycomb group protein BMI1 promotes cancer-specific cell death
    • L. Liu, L.G. Andrews, and T.O. Tollefsbol Loss of the human polycomb group protein BMI1 promotes cancer-specific cell death Oncogene 25 2006 4370 4375
    • (2006) Oncogene , vol.25 , pp. 4370-4375
    • Liu, L.1    Andrews, L.G.2    Tollefsbol, T.O.3
  • 124
    • 84861798830 scopus 로고    scopus 로고
    • Meta-analysis of human lung cancer microRNA expression profiling studies comparing cancer tissues with normal tissues
    • P. Guan, Z. Yin, X. Li, W. Wu, and B. Zhou Meta-analysis of human lung cancer microRNA expression profiling studies comparing cancer tissues with normal tissues J Exp Clin Cancer Res 31 2012 54
    • (2012) J Exp Clin Cancer Res , vol.31 , pp. 54
    • Guan, P.1    Yin, Z.2    Li, X.3    Wu, W.4    Zhou, B.5
  • 126
    • 84883755139 scopus 로고    scopus 로고
    • Long non-coding RNAs: A new frontier in the study of human diseases
    • X. Shi, M. Sun, H. Liu, Y. Yao, and Y. Song Long non-coding RNAs: a new frontier in the study of human diseases Cancer Lett 339 2013 159 166
    • (2013) Cancer Lett , vol.339 , pp. 159-166
    • Shi, X.1    Sun, M.2    Liu, H.3    Yao, Y.4    Song, Y.5
  • 127
    • 84879837310 scopus 로고    scopus 로고
    • MALAT1: A paradigm for long noncoding RNA function in cancer
    • T. Gutschner, M. Hammerle, and S. Diederichs MALAT1: a paradigm for long noncoding RNA function in cancer J Mol Med 91 2013 791 801
    • (2013) J Mol Med , vol.91 , pp. 791-801
    • Gutschner, T.1    Hammerle, M.2    Diederichs, S.3
  • 128
    • 0344429906 scopus 로고    scopus 로고
    • MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer
    • P. Ji, S. Diederichs, and W. Wang MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer Oncogene 22 2003 8031 8041
    • (2003) Oncogene , vol.22 , pp. 8031-8041
    • Ji, P.1    Diederichs, S.2    Wang, W.3
  • 129
    • 81755161347 scopus 로고    scopus 로고
    • The long noncoding MALAT-1 RNA indicates a poor prognosis in non-small cell lung cancer and induces migration and tumor growth
    • L.H. Schmidt, T. Spieker, and S. Koschmieder The long noncoding MALAT-1 RNA indicates a poor prognosis in non-small cell lung cancer and induces migration and tumor growth J Thorac Oncol 6 2011 1984 1992
    • (2011) J Thorac Oncol , vol.6 , pp. 1984-1992
    • Schmidt, L.H.1    Spieker, T.2    Koschmieder, S.3
  • 130
    • 84873451950 scopus 로고    scopus 로고
    • The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells
    • T. Gutschner, M. Hammerle, and M. Eissmann The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells Cancer Res 73 2013 1180 1189
    • (2013) Cancer Res , vol.73 , pp. 1180-1189
    • Gutschner, T.1    Hammerle, M.2    Eissmann, M.3
  • 131
    • 78249258719 scopus 로고    scopus 로고
    • MALAT-1 enhances cell motility of lung adenocarcinoma cells by influencing the expression of motility-related genes
    • K. Tano, R. Mizuno, and T. Okada MALAT-1 enhances cell motility of lung adenocarcinoma cells by influencing the expression of motility-related genes FEBS Lett 584 2010 4575 4580
    • (2010) FEBS Lett , vol.584 , pp. 4575-4580
    • Tano, K.1    Mizuno, R.2    Okada, T.3
  • 132
    • 80555157531 scopus 로고    scopus 로고
    • Noncoding RNA gene silencing through genomic integration of RNA destabilizing elements using zinc finger nucleases
    • T. Gutschner, M. Baas, and S. Diederichs Noncoding RNA gene silencing through genomic integration of RNA destabilizing elements using zinc finger nucleases Genome Res 21 2011 1944 1954
    • (2011) Genome Res , vol.21 , pp. 1944-1954
    • Gutschner, T.1    Baas, M.2    Diederichs, S.3
  • 133
    • 84885037105 scopus 로고    scopus 로고
    • The long non-coding RNA HOTAIR indicates a poor prognosis and promotes metastasis in non-small cell lung cancer
    • X.H. Liu, Z.L. Liu, M. Sun, J. Liu, Z.X. Wang, and W. De The long non-coding RNA HOTAIR indicates a poor prognosis and promotes metastasis in non-small cell lung cancer BMC Cancer 13 2013 464
    • (2013) BMC Cancer , vol.13 , pp. 464
    • Liu, X.H.1    Liu, Z.L.2    Sun, M.3    Liu, J.4    Wang, Z.X.5    De, W.6
  • 134
    • 84879605330 scopus 로고    scopus 로고
    • Large noncoding RNA HOTAIR enhances aggressive biological behavior and is associated with short disease-free survival in human non-small cell lung cancer
    • T. Nakagawa, H. Endo, and M. Yokoyama Large noncoding RNA HOTAIR enhances aggressive biological behavior and is associated with short disease-free survival in human non-small cell lung cancer Biochem Biophys Res Commun 436 2013 319 324
    • (2013) Biochem Biophys Res Commun , vol.436 , pp. 319-324
    • Nakagawa, T.1    Endo, H.2    Yokoyama, M.3
  • 135
    • 84877609777 scopus 로고    scopus 로고
    • Induction of long intergenic non-coding RNA HOTAIR in lung cancer cells by type i collagen
    • Y. Zhuang, X. Wang, and H.T. Nguyen Induction of long intergenic non-coding RNA HOTAIR in lung cancer cells by type I collagen J Hematol Oncol 6 2013 35
    • (2013) J Hematol Oncol , vol.6 , pp. 35
    • Zhuang, Y.1    Wang, X.2    Nguyen, H.T.3
  • 136
    • 33847763576 scopus 로고    scopus 로고
    • Genetic unmasking of an epigenetically silenced microRNA in human cancer cells
    • A. Lujambio, S. Ropero, and E. Ballestar Genetic unmasking of an epigenetically silenced microRNA in human cancer cells Cancer Res 67 2007 1424 1429
    • (2007) Cancer Res , vol.67 , pp. 1424-1429
    • Lujambio, A.1    Ropero, S.2    Ballestar, E.3
  • 137
    • 79952331586 scopus 로고    scopus 로고
    • DNA hypermethylation of microRNA-34b/c has prognostic value for stage non-small cell lung cancer
    • Z. Wang, Z. Chen, and Y. Gao DNA hypermethylation of microRNA-34b/c has prognostic value for stage non-small cell lung cancer Cancer Biol Ther 11 2011 490 496
    • (2011) Cancer Biol Ther , vol.11 , pp. 490-496
    • Wang, Z.1    Chen, Z.2    Gao, Y.3
  • 138
    • 84890710331 scopus 로고    scopus 로고
    • Epigenetic inactivation of microRNA-34b/c predicts poor disease-free survival in early-stage lung adenocarcinoma
    • E. Nadal, G. Chen, and M. Gallegos Epigenetic inactivation of microRNA-34b/c predicts poor disease-free survival in early-stage lung adenocarcinoma Clin Cancer Res 19 2013 6842 6852
    • (2013) Clin Cancer Res , vol.19 , pp. 6842-6852
    • Nadal, E.1    Chen, G.2    Gallegos, M.3
  • 139
    • 84878614756 scopus 로고    scopus 로고
    • DNA methylation-mediated repression of miR-886-3p predicts poor outcome of human small cell lung cancer
    • J. Cao, Y. Song, and N. Bi DNA methylation-mediated repression of miR-886-3p predicts poor outcome of human small cell lung cancer Cancer Res 73 2013 3326 3335
    • (2013) Cancer Res , vol.73 , pp. 3326-3335
    • Cao, J.1    Song, Y.2    Bi, N.3
  • 140
    • 84858239830 scopus 로고    scopus 로고
    • Genome-wide miRNA expression profiling identifies miR-9-3 and miR-193a as targets for DNA methylation in non-small cell lung cancers
    • G. Heller, M. Weinzierl, and C. Noll Genome-wide miRNA expression profiling identifies miR-9-3 and miR-193a as targets for DNA methylation in non-small cell lung cancers Clin Cancer Res 18 2012 1619 1629
    • (2012) Clin Cancer Res , vol.18 , pp. 1619-1629
    • Heller, G.1    Weinzierl, M.2    Noll, C.3
  • 141
    • 33847748913 scopus 로고    scopus 로고
    • The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function
    • B. Brueckner, C. Stresemann, and R. Kuner The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function Cancer Res 67 2007 1419 1423
    • (2007) Cancer Res , vol.67 , pp. 1419-1423
    • Brueckner, B.1    Stresemann, C.2    Kuner, R.3
  • 142
    • 35649020283 scopus 로고    scopus 로고
    • MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B
    • M. Fabbri, R. Garzon, and A. Cimmino MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B Proc Natl Acad Sci U S A 104 2007 15805 15810
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 15805-15810
    • Fabbri, M.1    Garzon, R.2    Cimmino, A.3
  • 143
    • 41549108332 scopus 로고    scopus 로고
    • DNA methylation in tumor and matched normal tissues from non-small cell patients with lung cancer
    • Q. Feng, S.E. Hawes, and J.E. Stern DNA methylation in tumor and matched normal tissues from non-small cell patients with lung cancer Cancer Epidemiol Biomarkers Prevent 17 2008 645 654
    • (2008) Cancer Epidemiol Biomarkers Prevent , vol.17 , pp. 645-654
    • Feng, Q.1    Hawes, S.E.2    Stern, J.E.3
  • 144
    • 2442462112 scopus 로고    scopus 로고
    • Dose effect of smoking on aberrant methylation in non-small cell lung cancers
    • S. Toyooka, M. Suzuki, and T. Tsuda Dose effect of smoking on aberrant methylation in non-small cell lung cancers Int J Cancer 110 2004 462 464
    • (2004) Int J Cancer , vol.110 , pp. 462-464
    • Toyooka, S.1    Suzuki, M.2    Tsuda, T.3
  • 145
    • 2942737264 scopus 로고    scopus 로고
    • Tumor-specific methylation in bronchial lavage for the early detection of non-small-cell lung cancer
    • H. Kim, Y.M. Kwon, and J.S. Kim Tumor-specific methylation in bronchial lavage for the early detection of non-small-cell lung cancer J Clin Oncol 22 2004 2363 2370
    • (2004) J Clin Oncol , vol.22 , pp. 2363-2370
    • Kim, H.1    Kwon, Y.M.2    Kim, J.S.3
  • 146
    • 33646427172 scopus 로고    scopus 로고
    • Aberrant promoter methylation of p16 and MGMT genes in lung tumors from smoking and never-smoking patients with lung cancer
    • Y. Liu, Q. Lan, J.M. Siegfried, J.D. Luketich, and P. Keohavong Aberrant promoter methylation of p16 and MGMT genes in lung tumors from smoking and never-smoking patients with lung cancer Neoplasia 8 2006 46 51
    • (2006) Neoplasia , vol.8 , pp. 46-51
    • Liu, Y.1    Lan, Q.2    Siegfried, J.M.3    Luketich, J.D.4    Keohavong, P.5
  • 147
    • 58249098396 scopus 로고    scopus 로고
    • Quantitative analysis of DNA methylation profiles in lung cancer identifies aberrant DNA methylation of specific genes and its association with gender and cancer risk factors
    • T. Vaissiere, R.J. Hung, and D. Zaridze Quantitative analysis of DNA methylation profiles in lung cancer identifies aberrant DNA methylation of specific genes and its association with gender and cancer risk factors Cancer Res 69 2009 243 252
    • (2009) Cancer Res , vol.69 , pp. 243-252
    • Vaissiere, T.1    Hung, R.J.2    Zaridze, D.3
  • 148
    • 79956115427 scopus 로고    scopus 로고
    • Inverse correlation between EGFR mutation and FHIT, RASSF1A and RUNX3 methylation in lung adenocarcinoma: Relation with smoking status
    • N. Yanagawa, G. Tamura, H. Oizumi, M. Endoh, M. Sadahiro, and T. Motoyama Inverse correlation between EGFR mutation and FHIT, RASSF1A and RUNX3 methylation in lung adenocarcinoma: relation with smoking status Anticancer Res 31 2011 1211 1214
    • (2011) Anticancer Res , vol.31 , pp. 1211-1214
    • Yanagawa, N.1    Tamura, G.2    Oizumi, H.3    Endoh, M.4    Sadahiro, M.5    Motoyama, T.6
  • 149
    • 36148990637 scopus 로고    scopus 로고
    • Hypermethylation of p16INK4a in Korean non-small cell patients with lung cancer
    • Y.S. Hong, M.S. Roh, and N.Y. Kim Hypermethylation of p16INK4a in Korean non-small cell patients with lung cancer J Korean Med Sci 22 2007 S32 S37
    • (2007) J Korean Med Sci , vol.22 , pp. 32-S37
    • Hong, Y.S.1    Roh, M.S.2    Kim, N.Y.3
  • 150
    • 71849104873 scopus 로고    scopus 로고
    • P16INK4A inactivation mechanisms in non-small-cell patients with lung cancer occupationally exposed to asbestos
    • P. Andujar, J. Wang, and A. Descatha p16INK4A inactivation mechanisms in non-small-cell patients with lung cancer occupationally exposed to asbestos Lung Cancer 67 2010 23 30
    • (2010) Lung Cancer , vol.67 , pp. 23-30
    • Andujar, P.1    Wang, J.2    Descatha, A.3
  • 151
    • 77954086478 scopus 로고    scopus 로고
    • Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate
    • F. Liu, J.K. Killian, and M. Yang Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate Oncogene 29 2010 3650 3664
    • (2010) Oncogene , vol.29 , pp. 3650-3664
    • Liu, F.1    Killian, J.K.2    Yang, M.3
  • 152
    • 9744220302 scopus 로고    scopus 로고
    • Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs
    • J.A. Marwick, P.A. Kirkham, and C.S. Stevenson Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs Am J Respir Cell Mol Biol 31 2004 633 642
    • (2004) Am J Respir Cell Mol Biol , vol.31 , pp. 633-642
    • Marwick, J.A.1    Kirkham, P.A.2    Stevenson, C.S.3
  • 153
    • 34548277011 scopus 로고    scopus 로고
    • Epigenetic inactivation of the RAS-effector gene RASSF2 in lung cancers
    • K. Kaira, N. Sunaga, and Y. Tomizawa Epigenetic inactivation of the RAS-effector gene RASSF2 in lung cancers Int J Oncol 31 2007 169 173
    • (2007) Int J Oncol , vol.31 , pp. 169-173
    • Kaira, K.1    Sunaga, N.2    Tomizawa, Y.3
  • 154
    • 67650164499 scopus 로고    scopus 로고
    • Concomitant promoter methylation of multiple genes in lung adenocarcinomas from current, former and never smokers
    • M. Tessema, Y.Y. Yu, and C.A. Stidley Concomitant promoter methylation of multiple genes in lung adenocarcinomas from current, former and never smokers Carcinogenesis 30 2009 1132 1138
    • (2009) Carcinogenesis , vol.30 , pp. 1132-1138
    • Tessema, M.1    Yu, Y.Y.2    Stidley, C.A.3
  • 155
    • 76649112380 scopus 로고    scopus 로고
    • The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and patients with lung cancer
    • R.K. Lin, Y.S. Hsieh, and P. Lin The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and patients with lung cancer J Clin Invest 120 2010 521 532
    • (2010) J Clin Invest , vol.120 , pp. 521-532
    • Lin, R.K.1    Hsieh, Y.S.2    Lin, P.3
  • 156
    • 55349109940 scopus 로고    scopus 로고
    • Carcinogen-induced gene promoter hypermethylation is mediated by DNMT1 and causal for transformation of immortalized bronchial epithelial cells
    • L.A. Damiani, C.M. Yingling, S. Leng, P.E. Romo, J. Nakamura, and S.A. Belinsky Carcinogen-induced gene promoter hypermethylation is mediated by DNMT1 and causal for transformation of immortalized bronchial epithelial cells Cancer Res 68 2008 9005 9014
    • (2008) Cancer Res , vol.68 , pp. 9005-9014
    • Damiani, L.A.1    Yingling, C.M.2    Leng, S.3    Romo, P.E.4    Nakamura, J.5    Belinsky, S.A.6
  • 157
    • 84862783953 scopus 로고    scopus 로고
    • The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation in laryngeal carcinoma
    • J. Wang, Y. Xu, J. Li, X. Sun, L.P. Wang, and W.Y. Ji The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation in laryngeal carcinoma Oral Oncol 48 2012 541 546
    • (2012) Oral Oncol , vol.48 , pp. 541-546
    • Wang, J.1    Xu, Y.2    Li, J.3    Sun, X.4    Wang, L.P.5    Ji, W.Y.6
  • 158
    • 84872676633 scopus 로고    scopus 로고
    • 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone induces retinoic acid receptor beta hypermethylation through DNA methyltransferase 1 accumulation in esophageal squamous epithelial cells
    • J. Wang, S.L. Zhao, Y. Li, M. Meng, and C.Y. Qin 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone induces retinoic acid receptor beta hypermethylation through DNA methyltransferase 1 accumulation in esophageal squamous epithelial cells Asian Pacific J Cancer Prevent 13 2012 2207 2212
    • (2012) Asian Pacific J Cancer Prevent , vol.13 , pp. 2207-2212
    • Wang, J.1    Zhao, S.L.2    Li, Y.3    Meng, M.4    Qin, C.Y.5
  • 159
    • 24144503182 scopus 로고    scopus 로고
    • Life-span inhalation exposure to mainstream cigarette smoke induces lung cancer in B6C3F1 mice through genetic and epigenetic pathways
    • J.A. Hutt, B.R. Vuillemenot, and E.B. Barr Life-span inhalation exposure to mainstream cigarette smoke induces lung cancer in B6C3F1 mice through genetic and epigenetic pathways Carcinogenesis 26 2005 1999 2009
    • (2005) Carcinogenesis , vol.26 , pp. 1999-2009
    • Hutt, J.A.1    Vuillemenot, B.R.2    Barr, E.B.3
  • 160
    • 2542547258 scopus 로고    scopus 로고
    • Aberrant promoter hypermethylation of the death-associated protein kinase gene is early and frequent in murine lung tumors induced by cigarette smoke and tobacco carcinogens
    • L.C. Pulling, B.R. Vuillemenot, J.A. Hutt, T.R. Devereux, and S.A. Belinsky Aberrant promoter hypermethylation of the death-associated protein kinase gene is early and frequent in murine lung tumors induced by cigarette smoke and tobacco carcinogens Cancer Res 64 2004 3844 3848
    • (2004) Cancer Res , vol.64 , pp. 3844-3848
    • Pulling, L.C.1    Vuillemenot, B.R.2    Hutt, J.A.3    Devereux, T.R.4    Belinsky, S.A.5
  • 161
    • 33646123093 scopus 로고    scopus 로고
    • Gene promoter hypermethylation in mouse lung tumors
    • B.R. Vuillemenot, J.A. Hutt, and S.A. Belinsky Gene promoter hypermethylation in mouse lung tumors Mol Cancer Res 4 2006 267 273
    • (2006) Mol Cancer Res , vol.4 , pp. 267-273
    • Vuillemenot, B.R.1    Hutt, J.A.2    Belinsky, S.A.3
  • 162
    • 4644335311 scopus 로고    scopus 로고
    • Cancer: An inflammatory link
    • F. Balkwill, and L.M. Coussens Cancer: an inflammatory link Nature 431 2004 405 406
    • (2004) Nature , vol.431 , pp. 405-406
    • Balkwill, F.1    Coussens, L.M.2
  • 163
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • L.M. Coussens, and Z. Werb Inflammation and cancer Nature 420 2002 860 867
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 164
    • 30344479916 scopus 로고    scopus 로고
    • Cancer is a functional repair tissue
    • X. Meng, and N.H. Riordan Cancer is a functional repair tissue Med Hypotheses 66 2006 486 490
    • (2006) Med Hypotheses , vol.66 , pp. 486-490
    • Meng, X.1    Riordan, N.H.2
  • 165
    • 81255162523 scopus 로고    scopus 로고
    • Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands
    • H.M. O'Hagan, W. Wang, and S. Sen Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands Cancer Cell 20 2011 606 619
    • (2011) Cancer Cell , vol.20 , pp. 606-619
    • O'Hagan, H.M.1    Wang, W.2    Sen, S.3
  • 166
    • 33845484237 scopus 로고    scopus 로고
    • Monitoring micronutrients in cigarette smokers
    • C.A. Northrop-Clewes, and D.I. Thurnham Monitoring micronutrients in cigarette smokers Clin Chim Acta 377 2007 14 38
    • (2007) Clin Chim Acta , vol.377 , pp. 14-38
    • Northrop-Clewes, C.A.1    Thurnham, D.I.2
  • 167
    • 0022202656 scopus 로고
    • Association of folate molecules as determined by proton NMR: Implications on enzyme binding
    • M.A. Khaled, and C.L. Krumdieck Association of folate molecules as determined by proton NMR: implications on enzyme binding Biochem Biophys Res Commun 130 1985 1273 1280
    • (1985) Biochem Biophys Res Commun , vol.130 , pp. 1273-1280
    • Khaled, M.A.1    Krumdieck, C.L.2
  • 168
    • 0022558665 scopus 로고
    • Inactivation of B12 and folate coenzymes by butyl nitrite as observed by NMR: Implications on one-carbon transfer mechanism
    • M. Abu Khaled, C.L. Watkins, and C.L. Krumdieck Inactivation of B12 and folate coenzymes by butyl nitrite as observed by NMR: implications on one-carbon transfer mechanism Biochem Biophys Res Commun 135 1986 201 207
    • (1986) Biochem Biophys Res Commun , vol.135 , pp. 201-207
    • Abu Khaled, M.1    Watkins, C.L.2    Krumdieck, C.L.3
  • 169
    • 0027982978 scopus 로고
    • Influence of smoking on folate intake and blood folate concentrations in a group of elderly Spanish men
    • R.M. Ortega, A.M. Lopez-Sobaler, and M.M. Gonzalez-Gross Influence of smoking on folate intake and blood folate concentrations in a group of elderly Spanish men J Am Coll Nutr 13 1994 68 72
    • (1994) J Am Coll Nutr , vol.13 , pp. 68-72
    • Ortega, R.M.1    Lopez-Sobaler, A.M.2    Gonzalez-Gross, M.M.3
  • 171
    • 0030979178 scopus 로고    scopus 로고
    • Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage
    • B.C. Blount, M.M. Mack, and C.M. Wehr Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage Proc Natl Acad Sci U S A 94 1997 3290 3295
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 3290-3295
    • Blount, B.C.1    MacK, M.M.2    Wehr, C.M.3
  • 172
    • 0142180147 scopus 로고    scopus 로고
    • Folic acid, polymorphism of methyl-group metabolism genes, and DNA methylation in relation to GI carcinogenesis
    • J.Y. Fang, and S.D. Xiao Folic acid, polymorphism of methyl-group metabolism genes, and DNA methylation in relation to GI carcinogenesis J Gastroenterol 38 2003 821 829
    • (2003) J Gastroenterol , vol.38 , pp. 821-829
    • Fang, J.Y.1    Xiao, S.D.2
  • 173
    • 84872452959 scopus 로고    scopus 로고
    • Radon-induced alterations in micro-RNA expression profiles in transformed BEAS2B cells
    • F.M. Cui, J.X. Li, and Q. Chen Radon-induced alterations in micro-RNA expression profiles in transformed BEAS2B cells J Toxicol Environ Health A 76 2013 107 119
    • (2013) J Toxicol Environ Health A , vol.76 , pp. 107-119
    • Cui, F.M.1    Li, J.X.2    Chen, Q.3
  • 174
    • 33750520162 scopus 로고    scopus 로고
    • Aberrant promoter methylation of p16(INK4a) and O(6)-methylguanine-DNA methyltransferase genes in workers at a Chinese uranium mine
    • S. Su, Y. Jin, and W. Zhang Aberrant promoter methylation of p16(INK4a) and O(6)-methylguanine-DNA methyltransferase genes in workers at a Chinese uranium mine J Occup Health 48 2006 261 266
    • (2006) J Occup Health , vol.48 , pp. 261-266
    • Su, S.1    Jin, Y.2    Zhang, W.3
  • 175
    • 0041438629 scopus 로고    scopus 로고
    • Promoter hypermethylation of the O6-methylguanine-DNA methyltransferase gene: More common in lung adenocarcinomas from never-smokers than smokers and associated with tumor progression
    • L.C. Pulling, K.K. Divine, and D.M. Klinge Promoter hypermethylation of the O6-methylguanine-DNA methyltransferase gene: more common in lung adenocarcinomas from never-smokers than smokers and associated with tumor progression Cancer Res 63 2003 4842 4848
    • (2003) Cancer Res , vol.63 , pp. 4842-4848
    • Pulling, L.C.1    Divine, K.K.2    Klinge, D.M.3
  • 176
    • 2942657615 scopus 로고    scopus 로고
    • Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
    • D.H. Johnson, L. Fehrenbacher, and W.F. Novotny Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer J Clin Oncol 22 2004 2184 2191
    • (2004) J Clin Oncol , vol.22 , pp. 2184-2191
    • Johnson, D.H.1    Fehrenbacher, L.2    Novotny, W.F.3
  • 177
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • A. Sandler, R. Gray, and M.C. Perry Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer N Engl J Med 355 2006 2542 2550
    • (2006) N Engl J Med , vol.355 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 178
    • 62449124416 scopus 로고    scopus 로고
    • Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil
    • M. Reck, J. von Pawel, and P. Zatloukal Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil J Clin Oncol 27 2009 1227 1234
    • (2009) J Clin Oncol , vol.27 , pp. 1227-1234
    • Reck, M.1    Von Pawel, J.2    Zatloukal, P.3
  • 179
    • 78651066494 scopus 로고    scopus 로고
    • Treatment-by-histology interaction analyses in three phase III trials show superiority of pemetrexed in nonsquamous non-small cell lung cancer
    • G. Scagliotti, T. Brodowicz, and F.A. Shepherd Treatment-by-histology interaction analyses in three phase III trials show superiority of pemetrexed in nonsquamous non-small cell lung cancer J Thorac Oncol 6 2011 64 70
    • (2011) J Thorac Oncol , vol.6 , pp. 64-70
    • Scagliotti, G.1    Brodowicz, T.2    Shepherd, F.A.3
  • 180
    • 84655166524 scopus 로고    scopus 로고
    • Genome-wide analysis of DNA methylation and the gene expression change in lung cancer
    • Y.J. Kwon, S.J. Lee, and J.S. Koh Genome-wide analysis of DNA methylation and the gene expression change in lung cancer J Thorac Oncol 7 2012 20 33
    • (2012) J Thorac Oncol , vol.7 , pp. 20-33
    • Kwon, Y.J.1    Lee, S.J.2    Koh, J.S.3
  • 181
    • 77957896015 scopus 로고    scopus 로고
    • Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in lung cancer
    • M. Castro, L. Grau, and P. Puerta Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in lung cancer J Transl Med 8 2010 86
    • (2010) J Transl Med , vol.8 , pp. 86
    • Castro, M.1    Grau, L.2    Puerta, P.3
  • 182
    • 77954143943 scopus 로고    scopus 로고
    • DNA hypermethylation of tumors from non-small cell lung cancer (NSCLC) patients is associated with gender and histologic type
    • S.E. Hawes, J.E. Stern, and Q. Feng DNA hypermethylation of tumors from non-small cell lung cancer (NSCLC) patients is associated with gender and histologic type Lung Cancer 69 2010 172 179
    • (2010) Lung Cancer , vol.69 , pp. 172-179
    • Hawes, S.E.1    Stern, J.E.2    Feng, Q.3
  • 183
    • 84861324338 scopus 로고    scopus 로고
    • Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor development
    • W.W. Lockwood, I.M. Wilson, and B.P. Coe Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor development PLoS One 7 2012 e37775
    • (2012) PLoS One , vol.7 , pp. 37775
    • Lockwood, W.W.1    Wilson, I.M.2    Coe, B.P.3
  • 184
    • 68049147571 scopus 로고    scopus 로고
    • Differentiation of lung adenocarcinoma, pleural mesothelioma, and nonmalignant pulmonary tissues using DNA methylation profiles
    • B.C. Christensen, C.J. Marsit, and E.A. Houseman Differentiation of lung adenocarcinoma, pleural mesothelioma, and nonmalignant pulmonary tissues using DNA methylation profiles Cancer Res 69 2009 6315 6321
    • (2009) Cancer Res , vol.69 , pp. 6315-6321
    • Christensen, B.C.1    Marsit, C.J.2    Houseman, E.A.3
  • 185
    • 74549118209 scopus 로고    scopus 로고
    • Accurate classification of non-small cell lung carcinoma using a novel microRNA-based approach
    • J.A. Bishop, H. Benjamin, H. Cholakh, A. Chajut, D.P. Clark, and W.H. Westra Accurate classification of non-small cell lung carcinoma using a novel microRNA-based approach Clin Cancer Res 16 2010 610 619
    • (2010) Clin Cancer Res , vol.16 , pp. 610-619
    • Bishop, J.A.1    Benjamin, H.2    Cholakh, H.3    Chajut, A.4    Clark, D.P.5    Westra, W.H.6
  • 186
    • 65349166324 scopus 로고    scopus 로고
    • Diagnostic assay based on hsa-miR-205 expression distinguishes squamous from nonsquamous non-small-cell lung carcinoma
    • D. Lebanony, H. Benjamin, and S. Gilad Diagnostic assay based on hsa-miR-205 expression distinguishes squamous from nonsquamous non-small-cell lung carcinoma J Clin Oncol 27 2009 2030 2037
    • (2009) J Clin Oncol , vol.27 , pp. 2030-2037
    • Lebanony, D.1    Benjamin, H.2    Gilad, S.3
  • 188
    • 79960589913 scopus 로고    scopus 로고
    • CT screening for lung cancer in the UK: Position statement by UKLS investigators following the NLST report
    • J.K. Field, D. Baldwin, and K. Brain CT screening for lung cancer in the UK: position statement by UKLS investigators following the NLST report Thorax 66 2011 736 737
    • (2011) Thorax , vol.66 , pp. 736-737
    • Field, J.K.1    Baldwin, D.2    Brain, K.3
  • 189
    • 78650449590 scopus 로고    scopus 로고
    • Existing general population models inaccurately predict lung cancer risk in patients referred for surgical evaluation
    • discussion 233
    • J.M. Isbell, S. Deppen, and J.B. Putnam Jr. Existing general population models inaccurately predict lung cancer risk in patients referred for surgical evaluation Ann Thorac Surg 91 2011 227 233 discussion 233
    • (2011) Ann Thorac Surg , vol.91 , pp. 227-233
    • Isbell, J.M.1    Deppen, S.2    Putnam, J.B.3
  • 190
    • 33745700196 scopus 로고    scopus 로고
    • Hypermethylation of ASC/TMS1 is a sputum marker for late-stage lung cancer
    • E.O. Machida, M.V. Brock, and C.M. Hooker Hypermethylation of ASC/TMS1 is a sputum marker for late-stage lung cancer Cancer Res 66 2006 6210 6218
    • (2006) Cancer Res , vol.66 , pp. 6210-6218
    • Machida, E.O.1    Brock, M.V.2    Hooker, C.M.3
  • 191
    • 84862572356 scopus 로고    scopus 로고
    • Defining a gene promoter methylation signature in sputum for lung cancer risk assessment
    • S. Leng, K. Do, and C.M. Yingling Defining a gene promoter methylation signature in sputum for lung cancer risk assessment Clin Cancer Res 18 2012 3387 3395
    • (2012) Clin Cancer Res , vol.18 , pp. 3387-3395
    • Leng, S.1    Do, K.2    Yingling, C.M.3
  • 192
    • 26444431818 scopus 로고    scopus 로고
    • Promoter methylation of genes in bronchial lavages: A marker for early diagnosis of primary and relapsing non-small cell lung cancer?
    • F. de Fraipont, D. Moro-Sibilot, S. Michelland, E. Brambilla, C. Brambilla, and M.C. Favrot Promoter methylation of genes in bronchial lavages: a marker for early diagnosis of primary and relapsing non-small cell lung cancer? Lung Cancer 50 2005 199 209
    • (2005) Lung Cancer , vol.50 , pp. 199-209
    • De Fraipont, F.1    Moro-Sibilot, D.2    Michelland, S.3    Brambilla, E.4    Brambilla, C.5    Favrot, M.C.6
  • 193
    • 84857159930 scopus 로고    scopus 로고
    • Performance evaluation of the DNA methylation biomarker SHOX2 for the aid in diagnosis of lung cancer based on the analysis of bronchial aspirates
    • D. Dietrich, C. Kneip, and O. Raji Performance evaluation of the DNA methylation biomarker SHOX2 for the aid in diagnosis of lung cancer based on the analysis of bronchial aspirates Int J Oncol 40 2012 825 832
    • (2012) Int J Oncol , vol.40 , pp. 825-832
    • Dietrich, D.1    Kneip, C.2    Raji, O.3
  • 194
    • 27744434546 scopus 로고    scopus 로고
    • Methylation assay for the diagnosis of lung cancer on bronchial aspirates: A cohort study
    • V. Schmiemann, A. Bocking, and M. Kazimirek Methylation assay for the diagnosis of lung cancer on bronchial aspirates: a cohort study Clin Cancer Res 11 2005 7728 7734
    • (2005) Clin Cancer Res , vol.11 , pp. 7728-7734
    • Schmiemann, V.1    Bocking, A.2    Kazimirek, M.3
  • 195
    • 0037152653 scopus 로고    scopus 로고
    • Molecular detection approaches for smoking associated tumors
    • Y.C. Hu, D. Sidransky, and S.A. Ahrendt Molecular detection approaches for smoking associated tumors Oncogene 21 2002 7289 7297
    • (2002) Oncogene , vol.21 , pp. 7289-7297
    • Hu, Y.C.1    Sidransky, D.2    Ahrendt, S.A.3
  • 196
    • 84862256325 scopus 로고    scopus 로고
    • Differences in the quantity of DNA found in the urine and saliva of smokers versus nonsmokers: Implications for the timing of epigenetic events
    • M. Simkin, M. Abdalla, M. El-Mogy, and Y. Haj-Ahmad Differences in the quantity of DNA found in the urine and saliva of smokers versus nonsmokers: implications for the timing of epigenetic events Epigenomics 4 2012 343 352
    • (2012) Epigenomics , vol.4 , pp. 343-352
    • Simkin, M.1    Abdalla, M.2    El-Mogy, M.3    Haj-Ahmad, Y.4
  • 197
    • 33645521023 scopus 로고    scopus 로고
    • Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort
    • S.A. Belinsky, K.C. Liechty, and F.D. Gentry Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort Cancer Res 66 2006 3338 3344
    • (2006) Cancer Res , vol.66 , pp. 3338-3344
    • Belinsky, S.A.1    Liechty, K.C.2    Gentry, F.D.3
  • 198
    • 35449006303 scopus 로고    scopus 로고
    • S-adenosylmethionine as a biomarker for the early detection of lung cancer
    • A.K. Greenberg, B. Rimal, and K. Felner S-adenosylmethionine as a biomarker for the early detection of lung cancer Chest 132 2007 1247 1252
    • (2007) Chest , vol.132 , pp. 1247-1252
    • Greenberg, A.K.1    Rimal, B.2    Felner, K.3
  • 199
    • 79953178293 scopus 로고    scopus 로고
    • Plasma microRNAs as potential biomarkers for non-small-cell lung cancer
    • J. Shen, N.W. Todd, and H. Zhang Plasma microRNAs as potential biomarkers for non-small-cell lung cancer Lab Invest 91 2011 579 587
    • (2011) Lab Invest , vol.91 , pp. 579-587
    • Shen, J.1    Todd, N.W.2    Zhang, H.3
  • 200
    • 84887629698 scopus 로고    scopus 로고
    • Quantification of plasma miRNAs by digital PCR for cancer diagnosis
    • J. Ma, N. Li, M. Guarnera, and F. Jiang Quantification of plasma miRNAs by digital PCR for cancer diagnosis Biomarker Insight 8 2013 127 136
    • (2013) Biomarker Insight , vol.8 , pp. 127-136
    • Ma, J.1    Li, N.2    Guarnera, M.3    Jiang, F.4
  • 201
    • 84889022338 scopus 로고    scopus 로고
    • Evaluation of long noncoding RNA MALAT1 as a candidate blood-based biomarker for the diagnosis of non-small cell lung cancer
    • D.G. Weber, G. Johnen, and S. Casjens Evaluation of long noncoding RNA MALAT1 as a candidate blood-based biomarker for the diagnosis of non-small cell lung cancer BMC Res Notes 6 2013 518
    • (2013) BMC Res Notes , vol.6 , pp. 518
    • Weber, D.G.1    Johnen, G.2    Casjens, S.3
  • 202
    • 84876914224 scopus 로고    scopus 로고
    • Diagnostic value of circulating microRNAs for lung cancer: A meta-analysis
    • Y. Shen, T. Wang, and T. Yang Diagnostic value of circulating microRNAs for lung cancer: a meta-analysis Genet Test Mol Biomarkers 17 2013 359 366
    • (2013) Genet Test Mol Biomarkers , vol.17 , pp. 359-366
    • Shen, Y.1    Wang, T.2    Yang, T.3
  • 203
    • 16544395214 scopus 로고    scopus 로고
    • Value of p16INK4a and RASSF1A promoter hypermethylation in prognosis of patients with resectable non-small cell lung cancer
    • J. Wang, J.J. Lee, and L. Wang Value of p16INK4a and RASSF1A promoter hypermethylation in prognosis of patients with resectable non-small cell lung cancer Clin Cancer Res 10 2004 6119 6125
    • (2004) Clin Cancer Res , vol.10 , pp. 6119-6125
    • Wang, J.1    Lee, J.J.2    Wang, L.3
  • 204
    • 33846187641 scopus 로고    scopus 로고
    • Aberrant promoter methylation profile and association with survival in patients with non-small cell lung cancer
    • J. Gu, D. Berman, and C. Lu Aberrant promoter methylation profile and association with survival in patients with non-small cell lung cancer Clin Cancer Res 12 2006 7329 7338
    • (2006) Clin Cancer Res , vol.12 , pp. 7329-7338
    • Gu, J.1    Berman, D.2    Lu, C.3
  • 205
    • 33646230046 scopus 로고    scopus 로고
    • Cohypermethylation of p16 and FHIT promoters as a prognostic factor of recurrence in surgically resected stage i non-small cell lung cancer
    • J.S. Kim, J.W. Kim, J. Han, Y.M. Shim, J. Park, and D.H. Kim Cohypermethylation of p16 and FHIT promoters as a prognostic factor of recurrence in surgically resected stage I non-small cell lung cancer Cancer Res 66 2006 4049 4054
    • (2006) Cancer Res , vol.66 , pp. 4049-4054
    • Kim, J.S.1    Kim, J.W.2    Han, J.3    Shim, Y.M.4    Park, J.5    Kim, D.H.6
  • 206
    • 33750724417 scopus 로고    scopus 로고
    • Prognostic significance of p16(INK4a) hypermethylation in non-small cell lung cancer is evident by quantitative DNA methylation analysis
    • N. Ota, K. Kawakami, and T. Okuda Prognostic significance of p16(INK4a) hypermethylation in non-small cell lung cancer is evident by quantitative DNA methylation analysis Anticancer Res 26 2006 3729 3732
    • (2006) Anticancer Res , vol.26 , pp. 3729-3732
    • Ota, N.1    Kawakami, K.2    Okuda, T.3
  • 207
    • 51049091703 scopus 로고    scopus 로고
    • Aberrant methylation of CXCL12 in non-small cell lung cancer is associated with an unfavorable prognosis
    • M. Suzuki, S. Mohamed, and T. Nakajima Aberrant methylation of CXCL12 in non-small cell lung cancer is associated with an unfavorable prognosis Int J Oncol 33 2008 113 119
    • (2008) Int J Oncol , vol.33 , pp. 113-119
    • Suzuki, M.1    Mohamed, S.2    Nakajima, T.3
  • 208
    • 48249117114 scopus 로고    scopus 로고
    • DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell lung carcinoma
    • T.J. Seng, N. Currey, and W.A. Cooper DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell lung carcinoma Br J Cancer 99 2008 375 382
    • (2008) Br J Cancer , vol.99 , pp. 375-382
    • Seng, T.J.1    Currey, N.2    Cooper, W.A.3
  • 209
    • 0037081085 scopus 로고    scopus 로고
    • Quantitative adenomatous polyposis coli promoter methylation analysis in tumor tissue, serum, and plasma DNA of patients with lung cancer
    • H. Usadel, J. Brabender, and K.D. Danenberg Quantitative adenomatous polyposis coli promoter methylation analysis in tumor tissue, serum, and plasma DNA of patients with lung cancer Cancer Res 62 2002 371 375
    • (2002) Cancer Res , vol.62 , pp. 371-375
    • Usadel, H.1    Brabender, J.2    Danenberg, K.D.3
  • 210
    • 40849124009 scopus 로고    scopus 로고
    • DNA methylation markers and early recurrence in stage i lung cancer
    • M.V. Brock, C.M. Hooker, and E. Ota-Machida DNA methylation markers and early recurrence in stage I lung cancer N Engl J Med 358 2008 1118 1128
    • (2008) N Engl J Med , vol.358 , pp. 1118-1128
    • Brock, M.V.1    Hooker, C.M.2    Ota-Machida, E.3
  • 211
    • 20144387935 scopus 로고    scopus 로고
    • Aberrant methylation of SPARC in human lung cancers
    • M. Suzuki, C. Hao, and T. Takahashi Aberrant methylation of SPARC in human lung cancers Br J Cancer 92 2005 942 948
    • (2005) Br J Cancer , vol.92 , pp. 942-948
    • Suzuki, M.1    Hao, C.2    Takahashi, T.3
  • 212
    • 70449592216 scopus 로고    scopus 로고
    • Promoter hypermethylation of the p16 and Wif-1 genes as an independent prognostic marker in stage IA non-small cell lung cancers
    • M. Yoshino, M. Suzuki, and L. Tian Promoter hypermethylation of the p16 and Wif-1 genes as an independent prognostic marker in stage IA non-small cell lung cancers Int J Oncol 35 2009 1201 1209
    • (2009) Int J Oncol , vol.35 , pp. 1201-1209
    • Yoshino, M.1    Suzuki, M.2    Tian, L.3
  • 213
    • 43649106748 scopus 로고    scopus 로고
    • Expression of methylation-related genes is associated with overall survival in patients with non-small cell lung cancer
    • J. Xing, D.J. Stewart, J. Gu, C. Lu, M.R. Spitz, and X. Wu Expression of methylation-related genes is associated with overall survival in patients with non-small cell lung cancer Br J Cancer 98 2008 1716 1722
    • (2008) Br J Cancer , vol.98 , pp. 1716-1722
    • Xing, J.1    Stewart, D.J.2    Gu, J.3    Lu, C.4    Spitz, M.R.5    Wu, X.6
  • 214
    • 55549138045 scopus 로고    scopus 로고
    • Adjuvant paclitaxel plus carboplatin compared with observation in stage IB non-small-cell lung cancer: CALGB 9633 with the Cancer and Leukemia Group B, Radiation Therapy Oncology Group, and North Central Cancer Treatment Group study groups
    • G.M. Strauss, J.E. Herndon 2nd, and M.A. Maddaus Adjuvant paclitaxel plus carboplatin compared with observation in stage IB non-small-cell lung cancer: CALGB 9633 with the Cancer and Leukemia Group B, Radiation Therapy Oncology Group, and North Central Cancer Treatment Group study groups J Clin Oncol 26 2008 5043 5051
    • (2008) J Clin Oncol , vol.26 , pp. 5043-5051
    • Strauss, G.M.1    Herndon, J.E.2    Maddaus, M.A.3
  • 215
    • 70449380233 scopus 로고    scopus 로고
    • Local recurrence after surgery for early stage lung cancer: An 11-year experience with 975 patients
    • C.R. Kelsey, L.B. Marks, and D. Hollis Local recurrence after surgery for early stage lung cancer: an 11-year experience with 975 patients Cancer 115 2009 5218 5227
    • (2009) Cancer , vol.115 , pp. 5218-5227
    • Kelsey, C.R.1    Marks, L.B.2    Hollis, D.3
  • 216
    • 76749116630 scopus 로고    scopus 로고
    • Prognostic significance of intratumoral blood vessel invasion in pathologic stage IA non-small cell lung cancer
    • F. Shoji, A. Haro, and T. Yoshida Prognostic significance of intratumoral blood vessel invasion in pathologic stage IA non-small cell lung cancer Ann Thorac Surg 89 2010 864 869
    • (2010) Ann Thorac Surg , vol.89 , pp. 864-869
    • Shoji, F.1    Haro, A.2    Yoshida, T.3
  • 217
    • 35348862421 scopus 로고    scopus 로고
    • Global histone modifications predict prognosis of resected non small-cell lung cancer
    • F. Barlesi, G. Giaccone, and M.I. Gallegos-Ruiz Global histone modifications predict prognosis of resected non small-cell lung cancer J Clin Oncol 25 2007 4358 4364
    • (2007) J Clin Oncol , vol.25 , pp. 4358-4364
    • Barlesi, F.1    Giaccone, G.2    Gallegos-Ruiz, M.I.3
  • 218
    • 65649142216 scopus 로고    scopus 로고
    • Global levels of histone modifications predict prognosis in different cancers
    • D.B. Seligson, S. Horvath, and M.A. McBrian Global levels of histone modifications predict prognosis in different cancers Am J Pathol 174 2009 1619 1628
    • (2009) Am J Pathol , vol.174 , pp. 1619-1628
    • Seligson, D.B.1    Horvath, S.2    McBrian, M.A.3
  • 219
    • 77953978709 scopus 로고    scopus 로고
    • Distinctive expression of the polycomb group proteins BMI1 polycomb ring finger oncogene and enhancer of zeste homolog 2 in nonsmall cell lung cancers and their clinical and clinicopathologic significance
    • J. Kikuchi, I. Kinoshita, and Y. Shimizu Distinctive expression of the polycomb group proteins BMI1 polycomb ring finger oncogene and enhancer of zeste homolog 2 in nonsmall cell lung cancers and their clinical and clinicopathologic significance Cancer 116 2010 3015 3024
    • (2010) Cancer , vol.116 , pp. 3015-3024
    • Kikuchi, J.1    Kinoshita, I.2    Shimizu, Y.3
  • 220
    • 78649637532 scopus 로고    scopus 로고
    • The expression of stem cell-related indicators as a prognostic factor in human lung adenocarcinoma
    • X.Y. Zhang, Q.G. Dong, and J.S. Huang The expression of stem cell-related indicators as a prognostic factor in human lung adenocarcinoma J Surg Oncol 102 2010 856 862
    • (2010) J Surg Oncol , vol.102 , pp. 856-862
    • Zhang, X.Y.1    Dong, Q.G.2    Huang, J.S.3
  • 221
    • 84884587354 scopus 로고    scopus 로고
    • Mutational analysis of Polycomb genes in solid tumours identifies PHC3 amplification as a possible cancer-driving genetic alteration
    • F. Crea, L. Sun, L. Pikor, P. Frumento, W.L. Lam, and C.D. Helgason Mutational analysis of Polycomb genes in solid tumours identifies PHC3 amplification as a possible cancer-driving genetic alteration Br J Cancer 109 2013 1699 1702
    • (2013) Br J Cancer , vol.109 , pp. 1699-1702
    • Crea, F.1    Sun, L.2    Pikor, L.3    Frumento, P.4    Lam, W.L.5    Helgason, C.D.6
  • 222
    • 84872674726 scopus 로고    scopus 로고
    • High expression of miR-21 and miR-155 predicts recurrence and unfavourable survival in non-small cell lung cancer
    • M. Yang, H. Shen, and C. Qiu High expression of miR-21 and miR-155 predicts recurrence and unfavourable survival in non-small cell lung cancer Eur J Cancer 49 2013 604 615
    • (2013) Eur J Cancer , vol.49 , pp. 604-615
    • Yang, M.1    Shen, H.2    Qiu, C.3
  • 223
    • 84885403598 scopus 로고    scopus 로고
    • The long noncoding RNA HOTAIR contributes to cisplatin resistance of human lung adenocarcinoma cells via downregulation of p21(WAF1/CIP1) expression
    • Z. Liu, M. Sun, and K. Lu The long noncoding RNA HOTAIR contributes to cisplatin resistance of human lung adenocarcinoma cells via downregulation of p21(WAF1/CIP1) expression PLoS One 8 2013 e77293
    • (2013) PLoS One , vol.8 , pp. 77293
    • Liu, Z.1    Sun, M.2    Lu, K.3
  • 225
    • 84881670319 scopus 로고    scopus 로고
    • Clinical evaluation of microRNA expression profiling in non small cell lung cancer
    • A. Markou, I. Sourvinou, P.A. Vorkas, G.M. Yousef, and E. Lianidou Clinical evaluation of microRNA expression profiling in non small cell lung cancer Lung Cancer 81 2013 388 396
    • (2013) Lung Cancer , vol.81 , pp. 388-396
    • Markou, A.1    Sourvinou, I.2    Vorkas, P.A.3    Yousef, G.M.4    Lianidou, E.5
  • 226
    • 84872464917 scopus 로고    scopus 로고
    • Two panels of plasma microRNAs as non-invasive biomarkers for prediction of recurrence in resectable NSCLC
    • C. Sanfiorenzo, M.I. Ilie, and A. Belaid Two panels of plasma microRNAs as non-invasive biomarkers for prediction of recurrence in resectable NSCLC PLoS One 8 2013 e54596
    • (2013) PLoS One , vol.8 , pp. 54596
    • Sanfiorenzo, C.1    Ilie, M.I.2    Belaid, A.3
  • 227
    • 84977478146 scopus 로고    scopus 로고
    • MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer
    • M. Boeri, C. Verri, and D. Conte MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer Proc Natl Acad Sci U S A 108 2011 3713 3718
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 3713-3718
    • Boeri, M.1    Verri, C.2    Conte, D.3
  • 228
    • 77950498821 scopus 로고    scopus 로고
    • Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer
    • Z. Hu, X. Chen, and Y. Zhao Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer J Clin Oncol 28 2010 1721 1726
    • (2010) J Clin Oncol , vol.28 , pp. 1721-1726
    • Hu, Z.1    Chen, X.2    Zhao, Y.3
  • 229
    • 84860261087 scopus 로고    scopus 로고
    • High expression of serum miR-21 and tumor miR-200c associated with poor prognosis in patients with lung cancer
    • X.G. Liu, W.Y. Zhu, and Y.Y. Huang High expression of serum miR-21 and tumor miR-200c associated with poor prognosis in patients with lung cancer Med Oncol 29 2012 618 626
    • (2012) Med Oncol , vol.29 , pp. 618-626
    • Liu, X.G.1    Zhu, W.Y.2    Huang, Y.Y.3
  • 230
    • 79953712598 scopus 로고    scopus 로고
    • Vesicle-related microRNAs in plasma of nonsmall cell patients with lung cancer and correlation with survival
    • J. Silva, V. Garcia, and A. Zaballos Vesicle-related microRNAs in plasma of nonsmall cell patients with lung cancer and correlation with survival Eur Respir J 37 2011 617 623
    • (2011) Eur Respir J , vol.37 , pp. 617-623
    • Silva, J.1    Garcia, V.2    Zaballos, A.3
  • 231
    • 80255133210 scopus 로고    scopus 로고
    • Prognostic significance of serum miRNA-21 expression in human non-small cell lung cancer
    • Z.X. Wang, H.B. Bian, J.R. Wang, Z.X. Cheng, K.M. Wang, and W. De Prognostic significance of serum miRNA-21 expression in human non-small cell lung cancer J Surg Oncol 104 2011 847 851
    • (2011) J Surg Oncol , vol.104 , pp. 847-851
    • Wang, Z.X.1    Bian, H.B.2    Wang, J.R.3    Cheng, Z.X.4    Wang, K.M.5    De, W.6
  • 232
    • 79959298372 scopus 로고    scopus 로고
    • Identification of plasma microRNA-21 as a biomarker for early detection and chemosensitivity of non-small cell lung cancer
    • J. Wei, W. Gao, and C.J. Zhu Identification of plasma microRNA-21 as a biomarker for early detection and chemosensitivity of non-small cell lung cancer Chinese J Cancer 30 2011 407 414
    • (2011) Chinese J Cancer , vol.30 , pp. 407-414
    • Wei, J.1    Gao, W.2    Zhu, C.J.3
  • 233
    • 84860637797 scopus 로고    scopus 로고
    • DNA methylation arrays as surrogate measures of cell mixture distribution
    • E.A. Houseman, W.P. Accomando, and D.C. Koestler DNA methylation arrays as surrogate measures of cell mixture distribution BMC Bioinformatics 13 2012 86
    • (2012) BMC Bioinformatics , vol.13 , pp. 86
    • Houseman, E.A.1    Accomando, W.P.2    Koestler, D.C.3
  • 234
    • 33644824212 scopus 로고    scopus 로고
    • 14-3-3sigma Methylation in pretreatment serum circulating DNA of cisplatin-plus-gemcitabine-treated advanced non-small-cell patients with lung cancer predicts survival: The Spanish Lung Cancer Group
    • J.L. Ramirez, R. Rosell, and M. Taron 14-3-3sigma Methylation in pretreatment serum circulating DNA of cisplatin-plus-gemcitabine-treated advanced non-small-cell patients with lung cancer predicts survival: the Spanish Lung Cancer Group J Clin Oncol 23 2005 9105 9112
    • (2005) J Clin Oncol , vol.23 , pp. 9105-9112
    • Ramirez, J.L.1    Rosell, R.2    Taron, M.3
  • 235
    • 80053645522 scopus 로고    scopus 로고
    • RARbeta2 gene methylation level in the circulating DNA from blood of patients with lung cancer
    • A.A. Ponomaryova, E.Y. Rykova, and N.V. Cherdyntseva RARbeta2 gene methylation level in the circulating DNA from blood of patients with lung cancer Eur J Cancer Prevent 20 2011 453 455
    • (2011) Eur J Cancer Prevent , vol.20 , pp. 453-455
    • Ponomaryova, A.A.1    Rykova, E.Y.2    Cherdyntseva, N.V.3
  • 236
    • 84892888388 scopus 로고    scopus 로고
    • MiR-21 Overexpression is associated with acquired resistance of EGFR-TKI in non-small cell lung cancer
    • B. Li, S. Ren, and X. Li miR-21 Overexpression is associated with acquired resistance of EGFR-TKI in non-small cell lung cancer Lung Cancer 83 2014 146 153
    • (2014) Lung Cancer , vol.83 , pp. 146-153
    • Li, B.1    Ren, S.2    Li, X.3
  • 237
    • 84864865233 scopus 로고    scopus 로고
    • MicroRNA-214 regulates the acquired resistance to gefitinib via the PTEN/AKT pathway in EGFR-mutant cell lines
    • Y.S. Wang, Y.H. Wang, H.P. Xia, S.W. Zhou, G. Schmid-Bindert, and C.C. Zhou MicroRNA-214 regulates the acquired resistance to gefitinib via the PTEN/AKT pathway in EGFR-mutant cell lines Asian Pacific J Cancer Prevent 13 2012 255 260
    • (2012) Asian Pacific J Cancer Prevent , vol.13 , pp. 255-260
    • Wang, Y.S.1    Wang, Y.H.2    Xia, H.P.3    Zhou, S.W.4    Schmid-Bindert, G.5    Zhou, C.C.6
  • 238
    • 84855543629 scopus 로고    scopus 로고
    • EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers
    • M. Garofalo, G. Romano, and G. Di Leva EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers Nat Med 18 2012 74 82
    • (2012) Nat Med , vol.18 , pp. 74-82
    • Garofalo, M.1    Romano, G.2    Di Leva, G.3
  • 239
    • 77949912309 scopus 로고    scopus 로고
    • MicroRNAs reduce tumor growth and contribute to enhance cytotoxicity induced by gefitinib in non-small cell lung cancer
    • M. Zhong, X. Ma, C. Sun, and L. Chen MicroRNAs reduce tumor growth and contribute to enhance cytotoxicity induced by gefitinib in non-small cell lung cancer Chem Biol Interact 184 2010 431 438
    • (2010) Chem Biol Interact , vol.184 , pp. 431-438
    • Zhong, M.1    Ma, X.2    Sun, C.3    Chen, L.4
  • 240
    • 84894206438 scopus 로고    scopus 로고
    • MiR-134/487b/655 Cluster regulates TGF-beta-induced epithelial-mesenchymal transition and drug resistance to gefitinib by targeting MAGI2 in lung adenocarcinoma cells
    • K. Kitamura, M. Seike, and T. Okano miR-134/487b/655 Cluster regulates TGF-beta-induced epithelial-mesenchymal transition and drug resistance to gefitinib by targeting MAGI2 in lung adenocarcinoma cells Mol Cancer Ther 13 2014 444 453
    • (2014) Mol Cancer Ther , vol.13 , pp. 444-453
    • Kitamura, K.1    Seike, M.2    Okano, T.3
  • 241
    • 84864976790 scopus 로고    scopus 로고
    • MiR-23a Regulates TGF-beta-induced epithelial-mesenchymal transition by targeting E-cadherin in lung cancer cells
    • M. Cao, M. Seike, and C. Soeno miR-23a Regulates TGF-beta-induced epithelial-mesenchymal transition by targeting E-cadherin in lung cancer cells Int J Oncol 41 2012 869 875
    • (2012) Int J Oncol , vol.41 , pp. 869-875
    • Cao, M.1    Seike, M.2    Soeno, C.3
  • 242
    • 84883202669 scopus 로고    scopus 로고
    • Silibinin suppresses EMT-driven erlotinib resistance by reversing the high miR-21/low miR-200c signature in vivo
    • S. Cufi, R. Bonavia, and A. Vazquez-Martin Silibinin suppresses EMT-driven erlotinib resistance by reversing the high miR-21/low miR-200c signature in vivo Sci Rep 3 2013 2459
    • (2013) Sci Rep , vol.3 , pp. 2459
    • Cufi, S.1    Bonavia, R.2    Vazquez-Martin, A.3
  • 243
    • 84855359334 scopus 로고    scopus 로고
    • A microRNA gene expression signature predicts response to erlotinib in epithelial cancer cell lines and targets EMT
    • J.L. Bryant, J. Britson, and J.M. Balko A microRNA gene expression signature predicts response to erlotinib in epithelial cancer cell lines and targets EMT Br J Cancer 106 2012 148 156
    • (2012) Br J Cancer , vol.106 , pp. 148-156
    • Bryant, J.L.1    Britson, J.2    Balko, J.M.3
  • 244
    • 84892685662 scopus 로고    scopus 로고
    • Let-7c Sensitizes acquired cisplatin-resistant A549 cells by targeting ABCC2 and Bcl-XL
    • M. Zhan, Q. Qu, G. Wang, and H. Zhou let-7c Sensitizes acquired cisplatin-resistant A549 cells by targeting ABCC2 and Bcl-XL Pharmazie 68 2013 955 961
    • (2013) Pharmazie , vol.68 , pp. 955-961
    • Zhan, M.1    Qu, Q.2    Wang, G.3    Zhou, H.4
  • 245
    • 84891829677 scopus 로고    scopus 로고
    • MicroRNA-31 inhibits cisplatin-induced apoptosis in non-small cell lung cancer cells by regulating the drug transporter ABCB9
    • Z. Dong, Z. Zhong, L. Yang, S. Wang, and Z. Gong MicroRNA-31 inhibits cisplatin-induced apoptosis in non-small cell lung cancer cells by regulating the drug transporter ABCB9 Cancer Lett 343 2014 249 257
    • (2014) Cancer Lett , vol.343 , pp. 249-257
    • Dong, Z.1    Zhong, Z.2    Yang, L.3    Wang, S.4    Gong, Z.5
  • 246
    • 84887110965 scopus 로고    scopus 로고
    • MiR-92b Regulates the cell growth, cisplatin chemosensitivity of A549 non small cell lung cancer cell line and target PTEN
    • Y. Li, L. Li, Y. Guan, X. Liu, Q. Meng, and Q. Guo miR-92b Regulates the cell growth, cisplatin chemosensitivity of A549 non small cell lung cancer cell line and target PTEN Biochem Biophys Res Commun 440 2013 604 610
    • (2013) Biochem Biophys Res Commun , vol.440 , pp. 604-610
    • Li, Y.1    Li, L.2    Guan, Y.3    Liu, X.4    Meng, Q.5    Guo, Q.6
  • 247
    • 84899995519 scopus 로고    scopus 로고
    • MiR-495 Enhances the sensitivity of non-small cell lung cancer cells to platinum by modulation of copper-transporting P-type adenosine triphosphatase A (ATP7A)
    • L. Song, Y. Li, W. Li, S. Wu, and Z. Li miR-495 Enhances the sensitivity of non-small cell lung cancer cells to platinum by modulation of copper-transporting P-type adenosine triphosphatase A (ATP7A) J Cell Biochem 115 2014 1234 1242
    • (2014) J Cell Biochem , vol.115 , pp. 1234-1242
    • Song, L.1    Li, Y.2    Li, W.3    Wu, S.4    Li, Z.5
  • 248
    • 84880416262 scopus 로고    scopus 로고
    • MiR-503 Regulates the resistance of non-small cell lung cancer cells to cisplatin by targeting Bcl-2
    • T. Qiu, L. Zhou, and T. Wang miR-503 Regulates the resistance of non-small cell lung cancer cells to cisplatin by targeting Bcl-2 Int J Mol Med 32 2013 593 598
    • (2013) Int J Mol Med , vol.32 , pp. 593-598
    • Qiu, T.1    Zhou, L.2    Wang, T.3
  • 249
    • 84876229388 scopus 로고    scopus 로고
    • MicroRNA-98 sensitizes cisplatin-resistant human lung adenocarcinoma cells by up-regulation of HMGA2
    • Q. Xiang, H. Tang, J. Yu, J. Yin, X. Yang, and X. Lei MicroRNA-98 sensitizes cisplatin-resistant human lung adenocarcinoma cells by up-regulation of HMGA2 Pharmazie 68 2013 274 281
    • (2013) Pharmazie , vol.68 , pp. 274-281
    • Xiang, Q.1    Tang, H.2    Yu, J.3    Yin, J.4    Yang, X.5    Lei, X.6
  • 250
    • 84885180721 scopus 로고    scopus 로고
    • MiR-135a/b Modulate cisplatin resistance of human lung cancer cell line by targeting MCL1
    • L. Zhou, T. Qiu, and J. Xu miR-135a/b Modulate cisplatin resistance of human lung cancer cell line by targeting MCL1 Pathol Oncol Res 19 2013 677 683
    • (2013) Pathol Oncol Res , vol.19 , pp. 677-683
    • Zhou, L.1    Qiu, T.2    Xu, J.3
  • 251
    • 84875548414 scopus 로고    scopus 로고
    • Contributions of microRNA dysregulation to cisplatin resistance in adenocarcinoma cells
    • L.M. Pouliot, D.W. Shen, T. Suzuki, M.D. Hall, and M.M. Gottesman Contributions of microRNA dysregulation to cisplatin resistance in adenocarcinoma cells Exp Cell Res 319 2013 566 574
    • (2013) Exp Cell Res , vol.319 , pp. 566-574
    • Pouliot, L.M.1    Shen, D.W.2    Suzuki, T.3    Hall, M.D.4    Gottesman, M.M.5
  • 252
    • 84867745041 scopus 로고    scopus 로고
    • MiR-155 Inhibits the sensitivity of lung cancer cells to cisplatin via negative regulation of APAF-1 expression
    • Y.S. Zang, Y.F. Zhong, Z. Fang, B. Li, and J. An miR-155 Inhibits the sensitivity of lung cancer cells to cisplatin via negative regulation of APAF-1 expression Cancer Gene Ther 19 2012 773 778
    • (2012) Cancer Gene Ther , vol.19 , pp. 773-778
    • Zang, Y.S.1    Zhong, Y.F.2    Fang, Z.3    Li, B.4    An, J.5
  • 253
    • 84870469858 scopus 로고    scopus 로고
    • MicroRNA-21 (miR-21) expression promotes growth, metastasis, and chemo- or radioresistance in non-small cell lung cancer cells by targeting PTEN
    • Z.L. Liu, H. Wang, J. Liu, and Z.X. Wang MicroRNA-21 (miR-21) expression promotes growth, metastasis, and chemo- or radioresistance in non-small cell lung cancer cells by targeting PTEN Mol Cell Biochem 372 2013 35 45
    • (2013) Mol Cell Biochem , vol.372 , pp. 35-45
    • Liu, Z.L.1    Wang, H.2    Liu, J.3    Wang, Z.X.4
  • 254
    • 84859779031 scopus 로고    scopus 로고
    • MiR-200bc/429 Cluster modulates multidrug resistance of human cancer cell lines by targeting BCL2 and XIAP
    • W. Zhu, H. Xu, and D. Zhu miR-200bc/429 Cluster modulates multidrug resistance of human cancer cell lines by targeting BCL2 and XIAP Cancer Chemother Pharmacol 69 2012 723 731
    • (2012) Cancer Chemother Pharmacol , vol.69 , pp. 723-731
    • Zhu, W.1    Xu, H.2    Zhu, D.3
  • 255
    • 77957280345 scopus 로고    scopus 로고
    • Loss of miR-200c expression induces an aggressive, invasive, and chemoresistant phenotype in non-small cell lung cancer
    • P. Ceppi, G. Mudduluru, and R. Kumarswamy Loss of miR-200c expression induces an aggressive, invasive, and chemoresistant phenotype in non-small cell lung cancer Mol Cancer Res 8 2010 1207 1216
    • (2010) Mol Cancer Res , vol.8 , pp. 1207-1216
    • Ceppi, P.1    Mudduluru, G.2    Kumarswamy, R.3
  • 256
    • 80051761550 scopus 로고    scopus 로고
    • Alterations of microRNAs in cisplatin-resistant human non-small cell lung cancer cells (A549/DDP)
    • Q. Wang, M. Zhong, W. Liu, J. Li, J. Huang, and L. Zheng Alterations of microRNAs in cisplatin-resistant human non-small cell lung cancer cells (A549/DDP) Exp Lung Res 37 2011 427 434
    • (2011) Exp Lung Res , vol.37 , pp. 427-434
    • Wang, Q.1    Zhong, M.2    Liu, W.3    Li, J.4    Huang, J.5    Zheng, L.6
  • 257
    • 79952539094 scopus 로고    scopus 로고
    • Upregulation of microRNA-451 increases cisplatin sensitivity of non-small cell lung cancer cell line (A549)
    • H.B. Bian, X. Pan, J.S. Yang, Z.X. Wang, and W. De Upregulation of microRNA-451 increases cisplatin sensitivity of non-small cell lung cancer cell line (A549) J Exp Clin Cancer Res 30 2011 20
    • (2011) J Exp Clin Cancer Res , vol.30 , pp. 20
    • Bian, H.B.1    Pan, X.2    Yang, J.S.3    Wang, Z.X.4    De, W.5
  • 258
    • 84862888913 scopus 로고    scopus 로고
    • MiR-497 Modulates multidrug resistance of human cancer cell lines by targeting BCL2
    • W. Zhu, D. Zhu, and S. Lu miR-497 Modulates multidrug resistance of human cancer cell lines by targeting BCL2 Med Oncol 29 2012 384 391
    • (2012) Med Oncol , vol.29 , pp. 384-391
    • Zhu, W.1    Zhu, D.2    Lu, S.3
  • 259
    • 77955619456 scopus 로고    scopus 로고
    • MiR-181b Modulates multidrug resistance by targeting BCL2 in human cancer cell lines
    • W. Zhu, X. Shan, T. Wang, Y. Shu, and P. Liu miR-181b Modulates multidrug resistance by targeting BCL2 in human cancer cell lines Int J Cancer 127 2010 2520 2529
    • (2010) Int J Cancer , vol.127 , pp. 2520-2529
    • Zhu, W.1    Shan, X.2    Wang, T.3    Shu, Y.4    Liu, P.5
  • 260
    • 84879062969 scopus 로고    scopus 로고
    • Overexpression of miRNA-21 promotes radiation-resistance of non-small cell lung cancer
    • X.C. Wang, W. Wang, Z.B. Zhang, J. Zhao, X.G. Tan, and J.C. Luo Overexpression of miRNA-21 promotes radiation-resistance of non-small cell lung cancer Radiat Oncol 8 2013 146
    • (2013) Radiat Oncol , vol.8 , pp. 146
    • Wang, X.C.1    Wang, W.2    Zhang, Z.B.3    Zhao, J.4    Tan, X.G.5    Luo, J.C.6
  • 261
    • 84875911885 scopus 로고    scopus 로고
    • MiR-210 Promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines
    • S. Grosso, J. Doyen, and S.K. Parks miR-210 Promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines Cell Death Dis 4 2013 e544
    • (2013) Cell Death Dis , vol.4 , pp. 544
    • Grosso, S.1    Doyen, J.2    Parks, S.K.3
  • 262
    • 84867401163 scopus 로고    scopus 로고
    • MiRNA-214 Modulates radiotherapy response of non-small cell lung cancer cells through regulation of p38MAPK, apoptosis and senescence
    • H. Salim, N.S. Akbar, and D. Zong miRNA-214 Modulates radiotherapy response of non-small cell lung cancer cells through regulation of p38MAPK, apoptosis and senescence Br J Cancer 107 2012 1361 1373
    • (2012) Br J Cancer , vol.107 , pp. 1361-1373
    • Salim, H.1    Akbar, N.S.2    Zong, D.3
  • 263
    • 80655149145 scopus 로고    scopus 로고
    • MicroRNA-7 increases radiosensitivity of human cancer cells with activated EGFR-associated signaling
    • K.M. Lee, E.J. Choi, and I.A. Kim MicroRNA-7 increases radiosensitivity of human cancer cells with activated EGFR-associated signaling Radiother Oncol 101 2011 171 176
    • (2011) Radiother Oncol , vol.101 , pp. 171-176
    • Lee, K.M.1    Choi, E.J.2    Kim, I.A.3
  • 264
    • 79958835291 scopus 로고    scopus 로고
    • MiR-9 and let-7g enhance the sensitivity to ionizing radiation by suppression of NFkappaB1
    • H. Arora, R. Qureshi, S. Jin, A.K. Park, and W.Y. Park miR-9 And let-7g enhance the sensitivity to ionizing radiation by suppression of NFkappaB1 Exp Mol Med 43 2011 298 304
    • (2011) Exp Mol Med , vol.43 , pp. 298-304
    • Arora, H.1    Qureshi, R.2    Jin, S.3    Park, A.K.4    Park, W.Y.5
  • 265
    • 75149177193 scopus 로고    scopus 로고
    • LIN28B confers radio-resistance through the posttranscriptional control of KRAS
    • S.H. Jeong, H.G. Wu, and W.Y. Park LIN28B confers radio-resistance through the posttranscriptional control of KRAS Exp Mol Med 41 2009 912 918
    • (2009) Exp Mol Med , vol.41 , pp. 912-918
    • Jeong, S.H.1    Wu, H.G.2    Park, W.Y.3
  • 266
    • 77950809059 scopus 로고    scopus 로고
    • A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations
    • S.V. Sharma, D.Y. Lee, and B. Li A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations Cell 141 2010 69 80
    • (2010) Cell , vol.141 , pp. 69-80
    • Sharma, S.V.1    Lee, D.Y.2    Li, B.3
  • 267
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • M. Gerlinger, A.J. Rowan, and S. Horswell Intratumor heterogeneity and branched evolution revealed by multiregion sequencing N Engl J Med 366 2012 883 892
    • (2012) N Engl J Med , vol.366 , pp. 883-892
    • Gerlinger, M.1    Rowan, A.J.2    Horswell, S.3
  • 268
    • 15044343269 scopus 로고    scopus 로고
    • Suppression of phosphatidylinositol 3-kinase/Akt signaling pathway is a determinant of the sensitivity to a novel histone deacetylase inhibitor, FK228, in lung adenocarcinoma cells
    • M. Kodani, T. Igishi, and S. Matsumoto Suppression of phosphatidylinositol 3-kinase/Akt signaling pathway is a determinant of the sensitivity to a novel histone deacetylase inhibitor, FK228, in lung adenocarcinoma cells Oncol Rep 13 2005 477 483
    • (2005) Oncol Rep , vol.13 , pp. 477-483
    • Kodani, M.1    Igishi, T.2    Matsumoto, S.3
  • 269
    • 34347261742 scopus 로고    scopus 로고
    • Apoptosis induced by depsipeptide FK228 coincides with inhibition of survival signaling in lung cancer cells
    • X.D. Yu, S.Y. Wang, and G.A. Chen Apoptosis induced by depsipeptide FK228 coincides with inhibition of survival signaling in lung cancer cells Cancer J 13 2007 105 113
    • (2007) Cancer J , vol.13 , pp. 105-113
    • Yu, X.D.1    Wang, S.Y.2    Chen, G.A.3
  • 270
    • 33644688961 scopus 로고    scopus 로고
    • Induction of apoptosis by trichostatin A, a histone deacetylase inhibitor, is associated with inhibition of cyclooxygenase-2 activity in human non-small cell lung cancer cells
    • Y.H. Choi Induction of apoptosis by trichostatin A, a histone deacetylase inhibitor, is associated with inhibition of cyclooxygenase-2 activity in human non-small cell lung cancer cells Int J Oncol 27 2005 473 479
    • (2005) Int J Oncol , vol.27 , pp. 473-479
    • Choi, Y.H.1
  • 271
    • 9444238027 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor FR901228 induces caspase-dependent apoptosis via the mitochondrial pathway in small cell lung cancer cells
    • S. Doi, H. Soda, and M. Oka The histone deacetylase inhibitor FR901228 induces caspase-dependent apoptosis via the mitochondrial pathway in small cell lung cancer cells Mol Cancer Ther 3 2004 1397 1402
    • (2004) Mol Cancer Ther , vol.3 , pp. 1397-1402
    • Doi, S.1    Soda, H.2    Oka, M.3
  • 272
    • 33747184291 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors and transforming growth factor-beta induce 15-hydroxyprostaglandin dehydrogenase expression in human lung adenocarcinoma cells
    • M. Tong, Y. Ding, and H.H. Tai Histone deacetylase inhibitors and transforming growth factor-beta induce 15-hydroxyprostaglandin dehydrogenase expression in human lung adenocarcinoma cells Biochem Pharmacol 72 2006 701 709
    • (2006) Biochem Pharmacol , vol.72 , pp. 701-709
    • Tong, M.1    Ding, Y.2    Tai, H.H.3
  • 273
    • 80053161379 scopus 로고    scopus 로고
    • Combined inhibition of DNA methyltransferase and histone deacetylase restores caspase-8 expression and sensitizes SCLC cells to TRAIL
    • V.O. Kaminskyy, O.V. Surova, A. Vaculova, and B. Zhivotovsky Combined inhibition of DNA methyltransferase and histone deacetylase restores caspase-8 expression and sensitizes SCLC cells to TRAIL Carcinogenesis 32 2011 1450 1458
    • (2011) Carcinogenesis , vol.32 , pp. 1450-1458
    • Kaminskyy, V.O.1    Surova, O.V.2    Vaculova, A.3    Zhivotovsky, B.4
  • 274
    • 1642289104 scopus 로고    scopus 로고
    • 5-Aza-2′-deoxycytidine restores the E-cadherin system in E-cadherin-silenced cancer cells and reduces cancer metastasis
    • J.S. Nam, Y. Ino, Y. Kanai, M. Sakamoto, and S. Hirohashi 5-Aza-2′-deoxycytidine restores the E-cadherin system in E-cadherin-silenced cancer cells and reduces cancer metastasis Clin Exp Metastasis 21 2004 49 56
    • (2004) Clin Exp Metastasis , vol.21 , pp. 49-56
    • Nam, J.S.1    Ino, Y.2    Kanai, Y.3    Sakamoto, M.4    Hirohashi, S.5
  • 275
    • 84869753078 scopus 로고    scopus 로고
    • Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins
    • W.W. Lockwood, K. Zejnullahu, J.E. Bradner, and H. Varmus Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins Proc Natl Acad Sci U S A 109 2012 19408 19413
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 19408-19413
    • Lockwood, W.W.1    Zejnullahu, K.2    Bradner, J.E.3    Varmus, H.4
  • 276
    • 79958822224 scopus 로고    scopus 로고
    • Inhibition of histone lysine methylation enhances cancer-testis antigen expression in lung cancer cells: Implications for adoptive immunotherapy of cancer
    • M. Rao, N. Chinnasamy, and J.A. Hong Inhibition of histone lysine methylation enhances cancer-testis antigen expression in lung cancer cells: implications for adoptive immunotherapy of cancer Cancer Res 71 2011 4192 4204
    • (2011) Cancer Res , vol.71 , pp. 4192-4204
    • Rao, M.1    Chinnasamy, N.2    Hong, J.A.3
  • 277
    • 72849111790 scopus 로고    scopus 로고
    • Oxidative stress induced lung cancer and COPD: Opportunities for epigenetic therapy
    • M.W. Lawless, K.J. O'Byrne, and S.G. Gray Oxidative stress induced lung cancer and COPD: opportunities for epigenetic therapy J Cell Mol Med 13 2009 2800 2821
    • (2009) J Cell Mol Med , vol.13 , pp. 2800-2821
    • Lawless, M.W.1    O'Byrne, K.J.2    Gray, S.G.3
  • 278
    • 84863367140 scopus 로고    scopus 로고
    • HDAC inhibitors for the treatment of cutaneous T-cell lymphomas
    • S. Rangwala, C. Zhang, and M. Duvic HDAC inhibitors for the treatment of cutaneous T-cell lymphomas Future Med Chem 4 2012 471 486
    • (2012) Future Med Chem , vol.4 , pp. 471-486
    • Rangwala, S.1    Zhang, C.2    Duvic, M.3
  • 279
    • 84655163371 scopus 로고    scopus 로고
    • Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer
    • R.A. Juergens, J. Wrangle, and F.P. Vendetti Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer Cancer Discovery 1 2011 598 607
    • (2011) Cancer Discovery , vol.1 , pp. 598-607
    • Juergens, R.A.1    Wrangle, J.2    Vendetti, F.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.