MicroRNA-21 (miR-21) expression promotes growth, metastasis, and chemo- or radioresistance in non-small cell lung cancer cells by targeting PTEN

Molecular and Cellular Biochemistry

Volumn 372, Issue 1-2, 2013, Pages 35-45

  Liu, Zhi Li ^a   Wang, He ^a   Liu, Jing ^a   Wang, Zhao Xia ^a  

^a THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Chemotherapy; Invasion; MicroRNA 21; Non small cell lung cancer; Radiotherapy

Indexed keywords

LUCIFERASE; MESSENGER RNA; MICRORNA 21; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; SMALL INTERFERING RNA;

3' UNTRANSLATED REGION; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INVASION; CANCER RESISTANCE; CANCER STAGING; CELL MIGRATION; CONTROLLED STUDY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG CARCINOGENESIS; LUNG NON SMALL CELL CANCER; LYMPH NODE METASTASIS; METASTASIS; NUCLEOTIDE SEQUENCE; PROGNOSIS; PROTEIN TARGETING; RADIOSENSITIVITY; REAL TIME POLYMERASE CHAIN REACTION; REPORTER GENE; RNA BINDING; RNA DEGRADATION; SIGNAL TRANSDUCTION; TRANSLATION REGULATION;

3' UNTRANSLATED REGIONS; ANTINEOPLASTIC AGENTS; BASE SEQUENCE; CARCINOMA, NON-SMALL-CELL LUNG; CASE-CONTROL STUDIES; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CISPLATIN; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION; HUMANS; INHIBITORY CONCENTRATION 50; LUNG NEOPLASMS; LYMPHATIC METASTASIS; MICRORNAS; NEOPLASM INVASIVENESS; PTEN PHOSPHOHYDROLASE; RADIATION TOLERANCE; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TAXOIDS; UP-REGULATION;

EID: 84870469858     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-012-1443-3     Document Type: Article

References (29)

1. Siegel R, Naishadham D, Jemal A (2012) Cancer statistics, 2012. CA Cancer J Clin 62:10-29
2. Toyooka S, Mitsudomi T, Soh J et al (2011) Molecular oncology of lung cancer. Gen Thorac Cardiovasc Surg 59:527-537
3. Wahid F, Shehzad A, Khan T et al (2010) MicroRNAs: synthesis, mechanism, function, and recent clinical trials. Biochim Biophys Acta 1803:1231-1243
4. Subramanian S, Steer CJ (2010) MicroRNAs as gatekeepers of apoptosis. J Cell Physiol 223:289-298
5. Bandres E, Agirre X, Ramirez N et al (2007) MicroRNAs as cancer players: potential clinical and biological effects. DNA Cell Biol 26:273-282
6. Di Leva G, Croce CM (2010) Roles of small RNAs in tumor formation. Trends Mol Med 16:257-267
7. Li S, Liang Z, Xu L et al (2012) MicroRNA-21: a ubiquitously expressed pro-survival factor in cancer and other diseases. Mol Cell Biochem 360:147-158
8. Markou A, Tsaroucha EG, Kaklamanis L et al (2008) Prognostic value of mature microRNA-21 and microRNA-205 overexpression in non-small cell lung cancer by quantitative real-time RT-PCR. Clin Chem 54:1696-1704
9. Wang ZX, Bian HB, Wang JR et al (2011) Prognostic significance of serum miRNA-21 expression in human non-small cell lung cancer. J Surg Oncol 104:847-851
10. Wang ZX, Lu BB, Wang H et al (2011) MicroRNA-21 modulates chemosensitivity of breast cancer cells to doxorubicin by targeting PTEN. Arch Med Res 42:281-290
11. Sandhu S, Garzon R (2011) Potential applications of microRNAs in cancer diagnosis, prognosis, and treatment. Semin Oncol 38:781-787
12. Zhao L, Chen X, Cao Y (2011) New role of microRNA: carcinogenesis and clinical application in cancer. Acta Biochim Biophys Sin (Shanghai) 43:831-839
13. da Costa Martins PA, De Windt LJ (2010) miR-21: a miRaculous Socratic paradox. Cardiovasc Res 87:397-400
14. Bonci D (2010) MicroRNA-21 as therapeutic target in cancer and cardiovascular disease. Recent Pat Cardiovasc Drug Discov 5:156-161
15. Pan X, Wang ZX, Wang R (2011) MicroRNA-21: a novel therapeutic target in human cancer. Cancer Biol Ther 10:1224-1232
16. Medina PP, Nolde M, Slack FJ (2010) OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma. Nature 467:86-90
17. Li T, Li D, Sha J et al (2009) MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells. Biochem Biophys Res Commun 383:280-285
18. Zhu S, Wu H, Wu F et al (2008) MicroRNA-21 targets tumor suppressor genes in invasion and metastasis. Cell Res 18:350-359
19. Shi SJ, Zhong ZR, Liu J et al (2012) Solid lipid nanoparticles loaded with anti-microRNA oligonucleotides (AMOs) for suppression of microRNA-21 functions in human lung cancer cells. Pharm Res 29:97-109
20. Zhang JG, Wang JJ, Zhao F et al (2010) MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC). Clin Chim Acta 411:846-852
21. Hatley ME, Patrick DM, Garcia MR et al (2010) Modulation of K-ras-dependent lung tumorigenesis by MicroRNA-21. Cancer Cell 18:282-293
22. Wei J, Gao W, Zhu CJ et al (2011) Identification of plasma microRNA-21 as a biomarker for early detection and chemosensitivity of non-small cell lung cancer. Chin J Cancer 30:407-414
23. Yang CH, Yue J, Pfeffer SR et al (2011) MicroRNA miR-21 regulates the metastatic behavior of B16 melanoma cells. J Biol Chem 286:39172-39178
24. Zhang B, Pan X, Cobb GP et al (2007) microRNAs as oncogenes and tumor suppressors. Dev Biol 302:1-12
25. Yamada KM, Araki M (2001) Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis. J Cell Sci 114:2375-2382
26. Meng F, Henson R, Wehbe-Janek H et al (2007) MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 133:647-658
27. Bai H, Xu R, Cao Z et al (2011) Involvement of miR-21 in resistance to daunorubicin by regulating PTEN expression in the leukaemia K562 cell line. FEBS Lett 585:402-408
28. Ma WJ, Lv GD, Tuersun A et al (2011) Role of microRNA-21 and effect on PTEN in Kazakh's esophageal squamous cell carcinoma. Mol Biol Rep 38:3253-3260
29. Lou Y, Yang X, Wang F et al (2010) MicroRNA-21 promotes the cell proliferation, invasion and migration abilities in ovarian epithelial carcinomas through inhibiting the expression of PTEN protein. Int J Mol Med 26:819-827