Hypermethylation of ASC/TMS1 Is a sputum marker for late-stage lung cancer

Cancer Research

Volumn 66, Issue 12, 2006, Pages 6210-6218

  Machida, Emi Ota ^a,b   Brock, Malcolm V ^a   Hooker, Craig M ^a   Nakayama, Jun ^b   Ishida, Akiko ^b   Amano, Jun ^b   Picchi, Maria A ^c   Belinsky, Steven A ^c   Herman, Jarnes G ^a   Taniguchi, Shun'ichiro ^b,d   Baylin, Stephen B ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

^d SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

TUMOR SUPPRESSOR PROTEIN;

ADENOCARCINOMA; ADULT; AGED; ARTICLE; ASC GENE; CANCER CLASSIFICATION; CANCER STAGING; CONTROLLED STUDY; GENE EXPRESSION; GENE SEQUENCE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INCIDENCE; LUNG CANCER; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; METHYLATION; PRIORITY JOURNAL; PROGNOSIS; SPUTUM; SQUAMOUS CELL CARCINOMA; TMS1 GENE; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; AGED; CARCINOMA, SQUAMOUS CELL; CYTOSKELETAL PROTEINS; DISEASE PROGRESSION; DNA METHYLATION; DNA, NEOPLASM; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; RISK FACTORS; SPUTUM; TUMOR MARKERS, BIOLOGICAL;

EID: 33745700196     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-4447     Document Type: Article

References (49)

1. Masumoto J, Taniguchi S, Ayukawa K, et al. ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells. J Biol Chem 1999;274:33835-8.
2. Conway KE, McConnell BB, Bowring CE, et al. TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers. Cancer Res 2000;60:6236-42.
3. McConnell BB, Vertino PM. TMS1/ASC: the cancer connection. Apoptosis 2004;9:5-18.
4. Srinivasula SM, Poyet JL, Razmara M, et al. The PYRIN-CARD protein ASC is an activating adaptor for caspase-1. J Biol Chem 2002;277:21119-22.
5. Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-β. Mol Cell 2002;10:417-26.
6. Stehlik C, Lee SH, Dorfleutner A, et al. Apoptosis-associated speck-like protein containing a caspase recruitment domain is a regulator of procaspase-1 activation. J Immunol 2003;171:6154-63.
7. Dinarello CA. Interleukin-1β, interleukin-18, and the interleukin-1β converting enzyme. Ann N Y Acad Sci 1998;856:1-11.
8. Bertin J, DiStefano PS. The PYRIN domain: a novel motif found in apoptosis and inflammation proteins. Cell Death Differ 2000;7:1273-4.
9. Masumoto J, Dowds TA, Schaner P, et al. ASC is an activating adaptor for NF-κB and caspase-8-dependent apoptosis. Biochem Biophys Res Commun 2003;303:69-73.
10. McConnell BB, Vertino PM. Activation of a caspase-9-mediated apoptotic pathway by subcellular redistribution of the novel caspase recruitment domain protein TMS1. Cancer Res 2000;60:6243-7.
11. Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 2003;349:2042-54.
12. Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002;3:415-28.
13. Guan X Sagara J, Yokoyama T, et al. ASC/TMS1, a caspase-1 activating adaptor, is down-regulated by aberrant methylation in human melanoma. Int J Cancer 2003;107:202-8.
14. Moriai R, Tsuji N, Kobayashi D, et al. A proapoptotic caspase recruitment domain protein gene, TMS1, is hypermethylated in human breast and gastric cancers. Anticancer Res 2002;32:4163-8.
15. Virmani A, Rathi A, Sugio K, et al. Aberrant methylation of TMS1 in small cell, non small cell lung cancer and breast cancer. Int J Cancer 2003;106:198-204.
16. Akahira J, Sugihashi Y, Ito K, et al. Promoter methylation status and expression of TMS1 gene in human epithelial ovarian cancer. Cancer Sci 2004;95:40-3.
17. Terasawa K, Sagae S, Toyota M, et al. Epigenetic inactivation of TMS1/ASC in ovarian cancer. Clin Cancer Res 2004;10:2000-6.
18. Yokoyama T, Sagara J, Guan X et al. Methylation of ASC/TMS1, a proapoptotic gene responsible for activating procaspase-1, in human colorectal cancer. Cancer Lett 2003;202:101-8.
19. Stone AR, Bobo W, Brat DJ, et al. Aberrant methylation and down-regulation of TMS1/ASC in human glioblastoma. Am J Pathol 2004;165:1151-61.
20. Gibbs AR, Thunnissen FB. Histological typing of lung and pleural tumours: third edition. J Clin Pathol 2001;54:498-9.
21. Mountain CF. Revisions in the international system for staging lung cancer. Chest 1997;111:1710-7.
22. Ferris BG. Epidemiology Standardization Project (American Thoracic Society). Am Rev Respir Dis 1978;118:1-120.
23. Saccomanno G, Archer VE, Auerbach O, Saunders RP, Brennan LM. Development of carcinoma of the lung as reflected in exfoliated cells. Cancer 1974;33:256-70.
24. Kennedy TC, Proudfoot SP, Franklin WA, et al. Cytopathological analysis of sputum in patients with airflow obstruction and significant smoking histories. Cancer Res 1996;56:4673-8.
25. Palmisano WA, Divine KK, Saccomanno G, et al. Predicting lung cancer by detecting aberrant promoter rnethylation in sputum. Cancer Res 2000;60:5954-8.
26. Herrmann BG, Frischauf AM. Isolation of genomic DNA. Methods Enzymol 1987;152:180-3.
27. Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 1996;93:9821-6.
28. Nakane PK. Recent progress in the peroxidase-labeled antibody method. Ann N Y Acad Sci 1975;254:203-11.
29. Nuovo GJ, Plaia TW, Belinsky SA, Baylin SB, Herman JG. In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis. Proc Natl Acad Sci U S A 1999;96:12754-9.
30. Machida E, Nakayama J, Amano J, Fukuda M. Clinicopathological significance of core 2 β1,6-N-acetylglucosaminyltransferase messenger RNA expressed in the pulmonary adenocarcinoma determined by in situ hybridization. Cancer Res 2001;61:2226-31.
31. Kim YT, Kang CH, Sung SW, Kim JH. Local control of disease related to lymph node involvement in non-small cell lung cancer after sleeve lobectomy compared with pneumonectomy. Ann Thorac Surg 2005;79:1153-61; discussion 1153-61.
32. al-Kattan K, Sepsas E, Fountain SW, Townsend ER. Disease recurrence after resection for stage I lung cancer. Eur J Cardiothorac Surg 1997;12:380-4.
33. Martini N, Bains MS, Burt ME, et al. Incidence of local recurrence and second primary tumors in resected stage I lung cancer. J Thorac Cardiovasc Surg 1995;109:120-9.
34. Inbal B, Cohen O, Polak-Charcon S, et al. DAF kinase links the control of apoptosis to metastasis. Nature 1997;390:180-4.
35. Kissil JL, Feinstein E, Cohen O, et al. DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: possible implications for role as tumor suppressor gene. Oncogene 1997;15:403-7.
36. Katzenellenbogen RA, Baylin SB, Herman JG. Hypermethylation of the DAP-kinase CpG island is a common alteration in B-cell malignancies. Blood 1999;93:4347-53.
37. Tang X, Khuri FR, Lee JJ, et al. Hypermethylation of the death-associated protein (DAP) kinase promoter and aggressiveness in stage I non-small-cell lung cancer. J Natl Cancer Inst 2000;92:1511-6.
38. Kim DH, Nelson HH, Wiencke JK, et al. Promoter methylation of DAP-kinase: association with advanced stage in non-small cell lung cancer. Oncogene 2001;20:1765-70.
39. Esteller M, Sanchez-Cespedes M, Rosell R, et al. Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients. Cancer Res 1999;59:67-70.
40. Suzuki H, Gabrielson E, Chen W, et al. A genomic screen for genes up-regulated by demethylation and histone deacetylase inhibition in human colorectal cancer. Nat Genet 2002;31:141-9.
41. Belinsky SA, Nikula KJ, Palmisano WA, et al. Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis. Proc Natl Acad Sci U S A 1998;95:11891-6.
42. Hoist CR, Nuovo GJ, Esteller M, et al. Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia. Cancer Res 2003;63:1596-601.
43. Nakagawa H, Nuovo GJ, Zervos EE, et al. Age-related hypermethylation of the 5′ region of MLH1 in normal colonic mucosa is associated with microsatellite-unstable colorectal cancer development Cancer Res 2001;61:6991-5.
44. Bachman KE, Herman JG, Corn PG, et al. Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers. Cancer Res 1999;59:798-802.
45. Belinsky SA, Palmisano WA, Gilliland FD, et al. Aberrant promoter methylation in bronchial epithelium and sputum from current and former smokers. Cancer Res 2002;62:2370-7.
46. Destro A, Blanchi P, Alloisio M, et al. K-ras and p16(INK4A)alterations in sputum of NSCLC patients and in heavy asymptomatic chronic smokers. Lung Cancer 2004;44:23-32.
47. Zochbauer-Muller S, Lam S, Toyooka S, et al. Aberrant methylation of multiple genes in the upper aerodigestive tract epithelium of heavy smokers. Int J Cancer 2003;107:612-6.
48. Konno S, Morishita Y, Fukasawa M, et al. Anthracotic index and DNA methylation status of sputum contents can be used for identifying the population at risk of lung carcinoma. Cancer 2004;102:348-54.
49. Johnson BE. Second lung cancers in patients after treatment for an initial lung cancer. J Natl Cancer Inst 1998;90:1335-45.